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16th European Congress of Endocrinology

Oral Communications

Pituitary clinical

ea0035oc8.1 | Pituitary clinical | ECE2014

Metabolic improvement after treatment of acromeglay is determined by the increase of gynoid fat mass and the decrease of serum vaspin and IGF1

Olarescu Nicoleta C. , Heck Ansgar , Godang Kristin , Ueland Thor , Bollerslev Jens

Context: Adipose tissue distribution is closely related to metabolic disease risk. GH reduces visceral and total body adipose tissue mass, while inducing whole body insulin resistance.Objective: To assess the role of visceral adipose tissue and derived adipokines for the systemic insulin resistance and lipid metabolism, before and after treatment in acromegaly.Patients: Sixty-six adult patients with active acromegaly diagnosed betw...

ea0035oc8.2 | Pituitary clinical | ECE2014

Soluble α-Klotho – a new serum biomarker for the activity of acromegaly

Jawiarczyk-Przybylowska Aleksandra , Bolanowski Marek , Kolackov Katarzyna

Introducing: Acromegaly is characterized by excessive GH and IGF1 secretion. Recent date suggests that soluble α-Klotho is also elevated in patients with acromegaly.Objective: The aim of this study was to assess the serum levels of soluble α-Klotho in patients in relation with the activity of disease and to compare with control group (CG). We also examine the relationship between excess GH, IGF1 and serum levels of soluble α-Klotho in pati...

ea0035oc8.3 | Pituitary clinical | ECE2014

Assessment of atrial electromechanical delay in patients with acromegaly

Topaloglu Oya , Arslan Muyesser Sayki , Turak Osman , Ucan Bekir , Cakir Evrim , Cebeci Muhammet , Sahin Mustafa , Colak Nujen , Demirci Taner , Unsal Ilknur Ozturk , Karakose Melia , Ozbek Mustafa , Delibasi Tuncay

Aim: Cardiac rhythm abnormalities have been documented in acromegalic patients. Our aim is to evaluate atrial electromechanical delay (EMD) with tissue doppler imaging (TDI) in patients with acromegaly.Material and methods: Fourty patients with acromegaly (13 patients with remission disease and 27 patients with active disease; 22 women and 18 men; mean aged 46.1±10.3 years), and 37 age- and sex-matched healthy controls were enrolled in the study. At...

ea0035oc8.4 | Pituitary clinical | ECE2014

Normalization of urinary cortisol with the potent 11β-hydroxylase inhibitor LCI699 in patients with Cushing's disease: 22-week, multicentre, open-label study

Biller Beverly , Young Jacques , Hamrahian Amir , Fleseriu Maria , Molitch Mark , Pivonello Rosario , Shimatsu Akira , Shimizu Chikara , Tanaka Tomoaki , White Tracy , Hilliard Annie , Tian Chuan , Sauter Nicholas , Bertagna Xavier

Background: A proof-of-concept study (LINC 1) demonstrated that after 10 weeks, LCI699 normalized UFC in 11/12 patients with Cushing’s disease. This interim analysis of the first eight patients enrolled into a longer-term study (LINC 2) further evaluates LCI699 in Cushing’s disease; the full analysis on all 19 enrolled patients is expected in time for the congress.Methods: There were two study groups. Previous LINC 1 participants (follow-up coh...

ea0035oc8.5 | Pituitary clinical | ECE2014

The effects of glucocorticoid treatment on cognition in patients with secondary adrenal insufficiency – results from a RCT

Buning Jorien Werumeus , Brummelman Pauline , Koerts Janneke , Dullaart Robin P.F. , van den Berg Gerrit , van der Klauw Melanie M. , Tucha Oliver , Wolffenbuttel Bruce H. R. , van Beek Andre P.

Introduction: A wide variety in hydrocortisone substitution dose-regimens are considered physiological for patients with secondary adrenal insufficiency. However, it is likely that cognition is negatively influenced by higher cortisol exposure to the brain. So far, no studies have been performed to assess the effects of treatment regimens administered for a substantial period of time with a low physiological hydrocortisone dose in comparison to a high physiological hydrocortis...