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16th European Congress of Endocrinology

Oral Communications


ea0035oc9.1 | Reproduction | ECE2014

High frequency of FGFR1 mutations in patients with congenital hypogonadotropic hypogonadism and split hand/foot malformation

Villanueva Carine , Jacobson-Dickman Elka , Xu Cheng , Dwyer Andrew , Sykiotis Gerasimos , Tommiska Johanna , Hu Youli , Leger Juliane , Carel Jean-Claude , Gerard Marion , Polak Michel , Tiosano Dov , Drouin-Garraud Valerie , Raivio Taneli , Bouloux Pierre , Sidis Yisrael , Mohammadi Moosa , Manouvrier Sylvie , De Roux Nicolas , Pitteloud Nelly

Background: Congenital hypogonadotropic hypogonadism (CHH) is characterized by absent puberty and infertility due to a lack of GnRH secretion/action. In addition, patients exhibit variable non-reproductive phenotypes such as anosmia, cleft palate, synkinesia, and others. As many as 10% of CHH patients harbor mutations in FGFR1; this group is enriched for skeletal anomalies. We report here a novel CHH-associated skeletal phenotype, split hand/foot malformation (SHFM), ...

ea0035oc9.2 | Reproduction | ECE2014

Tadalafil ameliorates metabolic syndrome-induced alterations in visceral adipose tissue and liver: an experimental study in the rabbit

Vignozzi Linda , Filippi Sandra , Cellai Ilaria , Comeglio Paolo , Maneschi Elena , Galli Andrea , Maggi Mario

Visceral adipose tissue (VAT) dysfunction is closely associated with the rising incidence of cardiovascular diseases (CVD) and type 2 diabetes mellitus. Two distinct types of adipose tissue, white (WAT) and brown (BAT), are present in mammals. Development of ‘brown-like’ adipocytes within white adipose tissue has potential antiobesity and insulin-sensitizing effects. Genetic manipulation of cGMP formation suggests a new role for this pathway in preadipocytes commitme...

ea0035oc9.3 | Reproduction | ECE2014

Late onset hypogonadism influences the endothelial function in men with coronary artery disease

Wierzbicka-Chmiel Joanna , Chmiel Artur , Bienkowski Janusz , Kajdaniuk Dariusz , Marek Bogdan

Late onset hypogonadism (LOH) is common in men with coronary artery disease (CAD) but its interaction with endothelial function and arterial structural changes is debatable.Aim: To investigate whether the LOH in men with CAD predicts endothelial dysfunction.Methods: Two hundred consecutive men with CAD and successful coronary stent implantation or coronary artery bypass grafting were included to the study group (mean age 59±10...

ea0035oc9.4 | Reproduction | ECE2014

Kisspeptin – a novel physiological trigger for oocyte maturation in IVF treatment

Abbara Ali , Jayasena Channa , Comninos Alexander , Nijher Monica , Christopoulos Georgios , Narayanaswamy Shakunthala , Izzi-Engbeaya Chioma , Sridharan Mathini , Mason Alexina , Warwick Jane , Ashby Deborah , Ghatei Mohammad , Bloom Stephen , Carby Anna , Trew Geoffrey , Dhillo Waljit

Background: In vitro fertilisation (IVF) is an effective treatment for infertility, but can cause the ovarian hyper-stimulation syndrome (OHSS), which is associated with serous effusions, circulatory collapse, and even death. The use of human chorionic gonadotrophin (hCG) stimulates oocyte maturation during IVF, but is also the major cause of OHSS. The hypothalamic neuropeptide kisspeptin stimulates endogenous LH secretion in a GnRH-dependent manner. A more physiologi...

ea0035oc9.5 | Reproduction | ECE2014

IGF1 gene polymorphism in Polycystic Ovary Syndrome

Tural Mehmet , Akin Fulya , Turgut Sabahat , Yaylali Guzin Fidan , Ata Melek Tunc , Ozkan Seyma , Erturk Mehmet Sercan

Introduction: IGFs (Insulin like growth factors) are important regulators of pancreatic β-cell development, growth and maintanence. Mutations in the IGF genes have been found to be associated with type 2 diabetes, myocardial infarction, birth weight and obesity. These associations could result from changes in insulin secretion. Insulin resistance plays a key role in PCOS. Based on these findings, we aimed to investigate IGF1 gene polymorphism in polycystic ovary syndrome ...