Aggravation of the symptoms of Alzheimers disease may also underlie the functioning of receptors associated with calcium and vitamin D. Therefore, it seems reasonable to study the correlation of polymorphisms of vitamin D receptor (VDR) and calcium receptor (CASR) with symptoms of AD. Alzheimers disease, vitamin D deficiency and osteoporosis often coexist in the patient. Research suggests that vitamin D deficiency is much more frequent in the patients with AD. Expression of VDR gene occurs in a neuronal and a glial cells. VDR belongs to the nuclear receptor superfamily and acts as a ligand activated transcription factor.
During the project it was selected a 40 patients and a group of 40 healthy volunteers. There are many polymorphisms in the VDR gene. In the present work we focused on assessing the prevalence of four of them relating to the regulation of expression of this gene: TaqI, ApaI, FokI and BsmI.
Distribution of all polymorphisms were obtained according to HardyWeinberg low (ApaI: χ2=2.54, P=0.1111, TaqI: χ2=1.21, P=0.2412, BsmI: χ2=0.57, P=0.4490, and FokI: χ2=1.23, P=0.2680).
We didnt observe any significant differences in the distribution of individual genotypes of the VDR polymorphisms in patients with Alzheimers disease compared to control group.
Project requires further research with a larger group of patients and control group.
The project was funded by the National Science Centre, grant number. UMO-2011/01/B/NZ7/00656.
03 - 07 May 2014
European Society of Endocrinology