Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2014) 35 P67 | DOI: 10.1530/endoabs.35.P67

1European Medical Research Institute by Pharmaserve-Lilly SACI, Athens, Greece; 2Private Medical Office, Thessaloniki, Greece; 33rd Orthopedics Clinic, University of Thessaloniki, ‘Papageorgiou’ General Hospital, Thessaloniki, Greece.


Introduction: ExFOS is a multinational, non-interventional, prospective, observational study to evaluate fracture outcomes, back pain, compliance and health-related quality of life in osteoporotic patients treated with teriparatide for up to 24 months. We present the baseline characteristics of the Hellenic subpopulation.

Methods: In Greece, 439 consenting patients with osteoporosis (92.3% females), suitable for prescribing teriparatide in the course of normal clinical practice, were enrolled in the study and provided medical history, clinical data, estimations on back pain and quality of life through validated questionnaires, for which descriptive statistics were calculated.

Results: These were rather elderly (mean(S.D.) age 70.1 (9.8) years (36.4% aged 75 years or older)), slightly overweight (BMI 26.7 (4.3) kg/cm2) patients, with predisposing factors for fracture: hip fracture in biological mother (18.1%), falls in the last year (37.1%), no exercise (49.2%), current smoking (12.1%), sight problems (37.9%), immobilization for >12 months (1.6%), muscle weakness recorded as assistance with arms when standing up from chair (41.3%). Public health insurance coverage for reimbursement of the medicine is almost complete.

Low bone mineral density with T-score <−3 in lumbar spine or total hip and at least one fracture in 55.1% of patients have been recorded (70.2% of patients had vertebral and 44.2% non vertebral fractures) while 21.6% had two or more fractures.

Of enrollers, 19.8% were antiosteoporotic treatment naïve, 69.5% used at least one osteoporosis/falls related medication (specifically glucocorticoids were reported by 8.9% of patients). 88.4% experienced back pain during the last 12 months while 68.1% experienced back pain at least fairly often during the last month. Moderate to severe limitation of activities was reported by half the participants with mean 4.2 (7.7) bed days because of back pain during the previous to enrollment month.

Conclusions: Greek patients enrolled in ExFOS are severely osteoporotic with increased risk of fractures and back pain. Results should be interpreted in the context of observational studies.

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