ECE2014 Poster Presentations Growth hormone IGF axis basic (16 abstracts)
The etiologies of growth hormone insufficiences: about 170 cases
Soumeya Fedala 1 , Ali El Mahdi Haddam 2 , Farida Chentli 1 , Akila Zenati 1 , Thierry Brue 3 , Serge Amselem 4 & Fetta yaker 1
1Bab El Oued hospital, Algiers, Algeria; 2Bologhine Hospital, Algiers, Algeria; 3Lattimone Hospital, Marseille, France; 4Armand Trousseau Hospital, Paris, France.
The GH deficiency (GHD) may be congenital with or without cause identified or acquired secondary to organic lesion in the hypothalamic region (HH). In all cases a magnetic resonance imaging is necessary.
Aim: Investigate the causes of GHD Population and methodology GHD children were followed at the department of endocrinology. In addition to clinical examination, a testing hypophysiogramme is made with glucagon/propranolol/GH testing insulin on GH/cortisol, IGF1, FT4, TSH, ACTH, prolactin and urinary density ± Restriction Test water). The exploration was completed by a pituitary magnetic resonance imaging (MRI) and a molecular study
Results: The GHD is congenital in 84.3% of cases. An interruption of the pituitary stalk syndrome is found in 2/3 of the cases. Cause acquired is gained rare (2.5%). It is represented by a case of radiotherapy and 5 tumoral lesions (4craniopharyngioma, arachnoid cyst). In 13% of cases the GHD is ‘idiopathic’.
Congenital GHD is related to molecular abnormalities in 13.7% of cases: Mutation of transcription factors (Prop1n: 14; Pit 1n: 1) and the GHRH-R (n=7). no molecular abnormality is found in patients with ectopic neurohypophysis
Discussion and conclusion: ‘Idiopathic’ GHD has become almost exceptional due to the advent of MRI and the development of molecular biology.
The high frequency of malformations anomalies is explained by the method of recruitment of patients, and the insufficiency of organic acquired lesions observed. many practitioners don’t know, the effects of chronic illness and/or their treatment, especially intracranial tumors on the somatotropic axis.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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