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Endocrine Abstracts (2014) 35 P837 | DOI: 10.1530/endoabs.35.P837

1Bologhine Hospital, Algiers, Algeria; 2Bab el oued Hospital, Algiers, Algeria.

Introduction: Acromegalia is frequently associated to a glucidic metabolic disorders. Hyperinsulinemia and insulin resistance play an important part in the cardiovascular risk and the surmortality of this pathology.

Aim: Study of changes in carbohydrate disorders after cure of acromegalia.

Materials and Methods: This is a retrospective study of 36 patients (16 men and 12 women) hospitalized between 1985 and 2013. Pituitary macro adenoma was found in 27 cases. The seniority of the disease is 07 years (2–15 years). Average age: 42 years (12–68 years). Rate of GH is 218 mUI/l (3–750). All patients were reassessed on the hormonal level and carbohydrate level: IGF1, OGTT/GH, plasma glucose before and after surgery.

Results: Prediabetes was found in 36.1% of cases and diabetes mellitus in 42%. One diabetes mellitus curing after pituitary necrosis and three after stabilization of the disease 5/12 treated by insulin switched to oral treatment and half of patients with prediabetes were curing.

Conclusion: The GH reduce the insulin sensitivity and increase the neoglucogenas and the hepatic glycogenolyse. 1/3 of the patients with diabetes cured after guerison of acromegalia – the diabetes mellitus appear and remains more frequently in aged subjects, having a family predisposition of diabetes and in the patients with a long history of hypersomatotropism.

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