ECE2014 Poster Presentations Steroid metabolism and action (12 abstracts)
Role of clinical risk factors and polymorphisms in glucocorticoid receptor gene in the determining the risk of developing new-onset diabetes after kidney transplantation
Grazia Michetti 1 , Laura Trementino 1 , Giorgia Marcelli 1 , Gloria Apolloni 1 , Domenica Taruscia 2 , Giovanni Maria Frasca 2 , Marco Boscaro 1 , Emanuela Faloia 1 & Giorgio Arnaldi 1
1Division of Endocrinology, Polytechnic University of Marche, ANCONA, Italy; 2Nephrology and Dialysis Uinit, Polytechnic University of Marche, ANCONA, Italy.
Introduction: New onset diabetes after transplantation (NODAT) is a recognized metabolic complication of kidney transplantation: its rates at 12 months after transplantation is between 20 and 50% for kidney recipients and it is associated with increased risks of graft rejection, infection, cardiovascular disease and death. Transplant-specific risk factors for NODAT,such as corticosteroids and calcineurin inhibitors, play a dominant role in its pathogenesis. Furthermore polymorphisms in GR gene are common in the human population and play a role in regulation of glucocrticoid sensitivity.
Objective: Determine the incidence genetic and clinical risk factors for NODAT among kidney recipients in our centre.
Patients and methods: We studied 96 kidney allograft recipients without preexisting diabetes. The presence of arterial hypertension, blood chemistry and BMI were assessed at 3, 6 and 12 months. GR gene polymorphism (BclI, A3669G) were analyzed using RT-PCR System and Taqman allelic discrimination assays.
Results: Three months after renal transplantation 27% recipients developed NODAT. There were no significant differences in age, mean daily steroids doses and genetic polymorphism in GR between patients with NODAT and healthy control. Patients with NODAT had a BMI significantly increased compared with healthy control (25.4 vs 21.8, P=0.02).
Conclusions: The prevalence of NODAT in our center is similar to that found in the literature. BMI and obesity are a risk factors for NODAT. Age, daily steroids doses and genetic polymorphism in GR are not correlates with its development.
Volume 35
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Endocrine Abstracts
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