Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2014) 35 S24.1 | DOI: 10.1530/endoabs.35.S24.1

ECE2014 Symposia Nutrient regulation of metabolism and endocrine systems (3 abstracts)

Nutrient regulation of metabolism and endocrine systems: using low-carbohydrate/high-fat diets to dissect macronutrient effects on endocrine systems

Martin Bidlingmaier

Medizinische Klinik und Poliklinik IV, Endocrine Research Unit, Munich, Germany.

Low-carbohydrate/high-fat diets (LC–HFD) are a popular way of dieting among the general population as several reports in humans indicate that LC–HFD induce weight loss in overweight subjects without caloric restriction and may improve glucose metabolism. However, regarding this type of diet there is also much controversy in scientific literature because clinical studies and data from animal experiments suggest severe side effects and thus warrant caution. Furthermore, the mechanism of action for weight loss remains unclear. This presentation will therefore show some of these controversial findings and the theories behind them as well as discuss success or failure of LC–HFD in humans and animal models. In addition to the use of LC–HFD for weight loss purposes, diets with such a drastic change in macronutrient composition may also be used as a research tool to investigate how nutrients regulate metabolism and endocrine systems. Another focus of this presentation will therefore be the dissection of the mechanisms which allow carbohydrates, fat and protein to exert an impact on physiology. The concept of using unique and precisely defined experimental diets in a rat model, will be introduced to demonstrate how LC–HFD with differing amounts of protein and fat affect growth, body composition, ketosis, bone metabolism, glucose metabolism and the GH/IGF-system.

Article tools

My recent searches

No recent searches.