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42nd Meeting of the British Society for Paediatric Endocrinology and Diabetes

Oral Communications

Oral Communications 6

ea0036oc6.1 | Oral Communications 6 | BSPED2014

Exploring variation in treatment targets across paediatric diabetes units in England and Wales

Charalampopoulos Dimitrios , Amin Rakesh , Viner Russell , Warner Justin , Stephenson Terence

Background: Achievement of treatment targets in children and young people (CYP) with diabetes represents an important intermediary step between delivery of care and ‘hard’ outcomes such as complications. Funnel plots have been proposed as a useful tool for visualising variation in performance indicators across centers and distinguishing between common-cause (centers lying within the control limits) and special-cause variation (centers lying outside the control limits...

ea0036oc6.2 | Oral Communications 6 | BSPED2014

The diabetic pregnancy and offspring adiposity in infancy and childhood: a meta-analysis

Logan Karen , Gale Chris , Hyde Matthew , Santhakumaran Shalini , Modi Neena

Introduction: Offspring of mothers with diabetes have greater risk of adverse metabolic outcome in later life. Increased adiposity is a plausible mediator. We performed a meta-analysis of studies examining adiposity in infants and children in relation to maternal diabetes.Methods: Citations were identified in PubMed and authors contacted for additional data. Fat free mass, fat mass, body fat %, and skinfold thickness were compared in offspring of mothers...

ea0036oc6.3 | Oral Communications 6 | BSPED2014

Comparison of breath acetone, with blood glucose and blood ketones in children and adolescents with type 1 diabetes

Edge Julie , Blaikie Tom , Megson Clare , Hancock Gus , Lunn Daniel , Peverall Robert , Richmond Graham , Ritchie Grant , Taylor David

Aims: Studies have suggested that breath gases, including acetone, may be related to simultaneous blood glucose (BG) and blood ketone levels in adults with types 2 and 1 diabetes. We aimed to study these relationships in children and young people with type 1 diabetes to assess the efficacy of a simple breath test as a non-invasive means of diabetes monitoring.Methods: Gases were collected in breath bags and measurements were compared with capillary BG an...

ea0036oc6.4 | Oral Communications 6 | BSPED2014

The role of the AMPK pathway in mediating the effects of metformin on mesenchymal stem cell differentiation

Chen Suet Ching , Brooks Rebecca , Ahmed S Faisal , Yarwood Stephen J

Introduction: Insulin sensitising agents are reported to have a diverse range of effects on bone with metformin exerting positive effects and thiazolidinenediones (TZDs) exerting negative effects. 5′AMP-activated protein kinase (AMPK) plays a critical role in cellular energy homeostasis. It is widely expressed in the body and can be activated by metformin.Aim: We investigated the role of AMPK pathway in mediating the effects of metformin on the ost...

ea0036oc6.5 | Oral Communications 6 | BSPED2014

Capillary beta-hydroxybutyrate levels reliably predicts clinical severity in established diabetes but not in first presentations of type 1 diabetes in children

Cooper Chris , Leach Miriam

Background: Near-patient capillary beta-hydroxybutyrate (BOHB) meters have been available for several years but evidence as to their clinical utility and reliability in children is still growing. Anecdotal evidence suggests that patients may have a significantly high level of capillary ketones but look clinically well, little evidence is available as to the kind of levels of blood ketones that paediatric patients can clinically compensate for. There is a move towards home bloo...

ea0036oc6.6 | Oral Communications 6 | BSPED2014

Comparison of type 1 diabetic control before and 5 years after transfer to adult services: audit of the 2008 cohort from the Royal Hospital of Sick Children (RHSC), Glasgow

Wang Jessie R , Chen S Ching , Robertson Kenneth J

Background: Within the NHS Greater Glasgow and Clyde (GGC), many children with type 1 diabetes mellitus (T1DM) are looked after at the RHSC until the age of 16 years, after which they are transferred to their local adult diabetes services. This is the first longitudinal audit within the GGC looking at the changes in diabetic control of the patient pre-and post-transfer.Method: A cohort of 75 patients referred onto the adult diabetes service from RHSC in ...