Subclinical hypothyroidism in young women with polycystic ovary syndrome

Yllka Themeli; Kozeta Mustafaraj; Gjergji Dilo; Lindita Hoxha

doi:10.1530/endoabs.37.EP218

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Endocrine Abstracts (2015) 37 EP218 | DOI: 10.1530/endoabs.37.EP218

ECE2015 Eposter Presentations Reproduction, endocrine disruptors and signalling (92 abstracts)

Subclinical hypothyroidism in young women with polycystic ovary syndrome

Yllka Themeli ^1, , Kozeta Mustafaraj ^2, , Gjergji Dilo ⁴ & Lindita Hoxha ⁴

Author affiliations

¹‘IKEDA’ Hospital, Tirana, Albania; ²DC‘Med.al’, Tirana, Albania; ³DC‘La vita’, Tirana, Albania; ⁴DC‘Dermolife’, Tirana, Albania.

Background: Separately, polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) exert adverse effects on metabolic parameters. This study evaluated whether SCH in women with PCOS affects clinical, hormonal, and metabolic parameters.

Aim: To analyse the relationship between selected clinical and metabolic parameters in young women with PCOS and normal thyroid function or SCH.

Materials and methods: In this cross-sectional cohort study were enrolled 80 women diagnosed with PCOS. Their clinical, hormonal, and metabolic parameters were evaluated. SCH was defined as TSH levels of 4.5–10 mIU/l.

Results: The mean age of the 80 women was 26±4.6 years. Mean BMI was 34.1±6.4 kg/m². Thyroid function was normal in 64 women, and 16 had SCH. Prolactin and serum LDL cholesterol levels were significantly higher in the women with SCH (18.2±6.2 ng/ml and 131.3±17.4 mg/dl, respectively) compared with those with normal thyroid function (13.2±9.7 ng/ml and 107.2±29.4 mg/dl, respectively). No changes in other lipid profile parameters, insulin resistance or phenotypic manifestations were observed.

Conclusions: In young women with PCOS, SCH is associated with higher LDL cholesterol and prolactin levels. These two altered parameters should be considered as the SCH predictors in women diagnosed with PCOS.