Reproduction, endocrine disruptors and signalling

Introduction: Low serum levels of 25-hydroxyvitamin D (25(OH)D3) lower than has been reported to be prevalent in several autoimmune diseases. The aims of the study were i) to evaluate the 25(OH)D3 levels in patients with Hashimatos thyroiditis (HT) and ii) to investigate the relationships between 25(OH)D3, TSH, free T4, free T3, and anti-thyroid peroxidase (anti-TPO) levels in elderly patients with HT.Subjects and method: Stud...

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ea0037ep132 | Reproduction, endocrine disruptors and signalling | ECE2015

How much insulin resistance in polycystic ovary syndrome: comparison of HOMA and insulin resistance (Belfiore) index models

Lewandowski Krzysztof , Lukasiak Katarzyna , Marczuk Katarzyna , Dukowicz Aleksandra , Cedro Magdalena , Bienkiewicz Malgorzata , Skowronska-Jozwiak Elzbieta , Lewinski Andrzej

Background: Polycystic ovary syndrome (PCOS), the commonest endocrinopathy of women in the reproductive age is often accompanied by insulin resistance (IR). The aim of the study was to assess the prevalence of IR in women diagnosed with PCOS, where IR was assessed by methods most commonly used in clinical practice, i.e. homeostatic model assessment (HOMA) and insulin resistance index (IRI), also known as the Belfiore index.Patients and methods: The study...

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ea0037ep133 | Reproduction, endocrine disruptors and signalling | ECE2015

Surrogate markers of insulin resistance obtained from oral glucose tolerance test in different phenotypes of polycystic ovary syndrome

Antic Ivana Bozic , Bjekic-Macut Jelica , Milutinovic Danijela Vojnovic , Ilic Dusan , Popovic Bojana , Bogavac Tamara , Kastratovic-Kotlica Biljana , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Damjanovic Svetozar , Macut Djuro

Introduction: Insulin resistance (IR) is a well recognised feature in women with polycystic ovary syndrome (PCOS). The aim of this study was to analyse IR indices obtained from oral glucose tolerance test (OGTT), in different PCOS phenotypes.Methods: We evaluated 240 PCOS women (PCOS: 24.86±5.97 kg/m2; 25.25±4.98 years) diagnosed using ESHRE/ASRM criteria and 70 BMI-matched healthy women (controls: 26.14±4.86 kg/m2; 3...

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ea0037ep134 | Reproduction, endocrine disruptors and signalling | ECE2015

A case of dyskeratosis congenita associated with hypothyroidism and hypogonadism

Kutbay Nilufer Ozdemir , Erdemir Zehra , Yurekli Banu Sarer , Karaca Emin , Erdogan Mehmet , Cetinkalp Sevki , Kandiloglu Gulsen , Ozgen Gokhan , Ozkinay Ferda , Saygili Fusun

Introduction: Dyskeratosis congenita is a rare multisystemic disease characterised with atrophy on skin, pigmentation, nail dystrophy, leukoplakia in mucous membrane, bone marrow failure, and tendency to malignancy. We present a rare case of dyskeratosis congenita associated with hypothyroidism and hypogonadism.Case: A 30-year-old male patient was referred to Endocrinology Department with the findings of micropenis and atrophic testicles. His parents had...

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ea0037ep135 | Reproduction, endocrine disruptors and signalling | ECE2015

NMDA receptor mediated limbic encephalitis in a woman with mature cystic ovarian teratoma: a case report

Vanya Melinda , Kovacs Zoltan , Gorgoraptis Nikos , Salek-Haddadi Afram , Kovacs Laszlo , Bartfai Gyorgy

Objective: Our aim was to present a case of paraneoplastic NMDA-R antibody-mediated limbic encephalitis in a woman with OT thereby providing information facilitating diagnosis of OT in women, who present with symptoms of paraneoplastic limbic encephalitis (LE) for obstetricians and gynaecologists with appropriate.Case: We report the case of a 25-year-old women, who developed NMDA-R-antibody mediated autoimmune encephalitis and who displayed confusion, di...

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ea0037ep136 | Reproduction, endocrine disruptors and signalling | ECE2015

The impact of bleeding patterns and hormonal contraceptives on migraine headache: a retrospective cross-sectional study

Vanya Melinda , Devosa Ivan , Bokros Fanni , Szucs Marta , Szok Delia , Bartfai Gyorgy

Introduction: Clinical studies revealed an increased incidence of migraine attacks in conditions with falling levels of plasma oestrogen in the perimenstrual phase of the menstrual cycle and during the hormone-free interval in women taking combined oral contraceptives.Objective: The purpose of the study was to assess the connection between menstrual cycle, bleeding patterns of women with migraine and the clinical characteristics of the migraine attacks.<...

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ea0037ep137 | Reproduction, endocrine disruptors and signalling | ECE2015

Constitutive and inducible regulation of PEPCK isoform genes in human cells

Seenappa Venu , Joshi Manjunath B , Das Bidyadhar , Kappaettu Satyamoorthy

Introduction: Phosphoenolpyruvate carboxykinase (PEPCK) is the key rate determining enzymes of gluconeogenesis pathway. PEPCK exists in cytosolic (PEPCK-C) and mitochondrial (PEPCK-M) isoforms. PEPCK isoforms maintain glucose/lipid homeostasis and is being explored as a therapeutic target for treating metabolic diseases. We tested the influence of a naturally occurring compound Genistein (a soy derived isoflavone) to constitutively regulate PEPCK isoforms to address its potent...

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ea0037ep138 | Reproduction, endocrine disruptors and signalling | ECE2015

Study on the correlation between serum androgens and sexual function in post-menopausal women

Nazarpour Soheila , Simbar Masome , Tehrani Fahimeh Ramezani , Tohidi Maryam , Majd Hamid Alavi

Introduction: Sexual dysfunction could be under the influence of menopause and the changes it causes in hormone levels. The purpose of this study is to examine the correlation between serum levels of androgens and sexual function in post-menopausal women.Methods: This is a community-based, descriptive-analytical study involving 405 post-menopausal women, aged 4065 years, who had reached menopause up to 3 years prior to the study. A multi-stage, ran...

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ea0037ep139 | Reproduction, endocrine disruptors and signalling | ECE2015

Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome

Temur Muzaffer , Yilmaz Ozgur , Aksun Saliha , Ozbay Pelin Ozun , Calan Mehmet , Kume Tuncay , Karakulak Murat , Korkmaz Huseyin Anil

Purpose: This study aims to compare serum urocortin-3 levels in women with PCOS and healthy women, and establish what role urocortin-3 levels play in PCOS.Methods: Fifty-two patients with PCOS and 55 healthy women were included in the study, matched for age and BMI. Fasting blood glucose (FBG), insulin, hs-CRP, urocortin-3, and free testosterone levels of the all participants were measured. HOMA-IR was used to calculate the insulin resistance.<p clas...

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ea0037ep140 | Reproduction, endocrine disruptors and signalling | ECE2015

Implication of non polar phytocomponents of aloe vera gel in management of polycystic ovarian syndrome

Nampoothiri Laxmipriya , Maharjan Radha , Dey Arpi

Background: Aloe vera gel has been proven to have hypoglycaemic, hypolipidemic, and steroid enzyme regulating properties. These are of clinical significance in reproductive pathology namely polycystic ovary syndrome (PCOS). Preliminary, in-vitro studies suggested that non-polar component is responsible for the steroid enzyme modulating effect. This study investigates the role of non polar phytocomponents of aloe vera gel, which could be responsible i...

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ea0037ep141 | Reproduction, endocrine disruptors and signalling | ECE2015

Abstract withdrawn....

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ea0037ep142 | Reproduction, endocrine disruptors and signalling | ECE2015

Is idiopathic hirsutism associated with an increase in metabolic disturbances?

Behboudi-Gandevani Samira , Tehrani Fahimeh Ramezani , Simbar Masoomeh , Azizi Fereidoon

Introduction: Idiopathic hirsutism (IH) is one of the most frequent complaints affecting 13% of reproductive aged women. The relationship between IH and metabolic abnormalities are not fully understood. The aim of this study was to evaluate the relationship between IH and metabolic abnormalities.Methods: A total number of 100 idiopathic hirsute women (range 1545 years) recruitment from a population based cohort study of Tehran Lipid and Glucose Stu...

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ea0037ep143 | Reproduction, endocrine disruptors and signalling | ECE2015

Prevalence and pattern of menstrual disorders and related factors among Iranian women in reproductive ages: a population based study

Dovom Marzieh Rostami , Tehrani Fahimeh Ramezani , Farahmand Maryam , Hashemi Somayeh , Azizi Freydoun

Introduction: Menstrual disturbances can be considered as a sign of reproductive system disorders in women in reproductive ages. These disturbances can be indicators of serious underlying problems. The aim of this study was to determine the prevalence and pattern of menstrual related manifestation among Iranian women.Methods: This was a population-based study conducted among women (n=941) aged 1845 years. The participants who met the eligi...

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ea0037ep144 | Reproduction, endocrine disruptors and signalling | ECE2015

Testosterone level in men correlates with BMI and cardiorespiratory fitness but is not related to age

DeFina Laura , Radford Nina , Leonard David , Howard Erica , Wilson Rick , Cooper Tyler , Clark Michael , Gruntmanis Ugis

Background: Presently it is unknown how much of testosterone decline associated with aging is actually due to ageing per se, and how much is related to weight gain, decreased activity, and other age-related factors. Understanding the modifiable factors associated with low testosterone, such as obesity or cardiorespiratory fitness (fitness) is critical.Methods: The observational, cross-sectional study included 1653 men, ≥50 and <80 year...

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ea0037ep145 | Reproduction, endocrine disruptors and signalling | ECE2015

Analysing by decade, testosterone undecanoate depot injectable does not increase prostate volume: study during up to 7 years on hypogonadic patients

Pisoschi Matei , Carsote Mara , Poiana Catalina , Staicu Dana Cristina , Peretianu Dan

Aim: Re-analysing the effect of injectable testosterone undecanoate depot (TUD) in hypogonadic patients.Materials and method: (A) Patients: at onset 210 men with hypogonadism (median age: 61.5 years). (B) Distribution: by decade; n=4, 12, 21, 54, 59, 43, 16, and 1. (C) TUD (NebidoR-Bayer-Schering) 1000 mg was injected one per 3 months i.m. (D) Prostate volume (PV) appreciated by per-abdominal ultrasound: 3.5 MHz probe, elliptical volume (cm...

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ea0037ep146 | Reproduction, endocrine disruptors and signalling | ECE2015

Testosterone undecanoate 1000 mg at 3 months did not increased prostatic specific antigen level: January 2015

Pisoschi Matei , Carsote Mara , Poiana Catalina , Staicu Dana Cristina , Peretianu Dan

Aim: To find if testosterone undecanoate (TUD) 1000 mg injection (NebidoR; Bayer-Schering) at 3 months has a negative effect on prostate.Materials and method: i) PSA (ng/ml) registred before (T0) and after TUD at T1 (2 weeks) to T10 (7 years) (see Pisoschi, this Congress); ii) statistical analysis: t-test, simple correlation, and multiple regression.Results: (A) Patients at onset: 143 men, 1896 years, average: 60.38;...

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ea0037ep147 | Reproduction, endocrine disruptors and signalling | ECE2015

Role of elevated serum adiponectin in delayed puberty of thalassemic patients

Mekawy Mohamed , Nasr Merhan , Youssef Soha , Almogy Mahira , Gamal Nevine

Background: Adipose tissue dysfunction can play a role in the neuroendocrine and haematopoietic dysfunctions affecting thalassaemic patients.Aim of the work: In this work, we aimed to study the serum levels of adiponectin, an adipocytokine, in Egyptian β-thalassemia patients in relation to their endocrinal complications.Subjects and methods: The study included 60β-thalassaemia patients; (major, intermedia, and minor) and ...

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ea0037ep148 | Reproduction, endocrine disruptors and signalling | ECE2015

Prevalence of autoimmune thyroid markers in euthyroid women with polycystic ovary syndrome

El-Din Ahmed Bahaa , El-Sherbeny Alyaa , El-Hadi Emad Abd

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women in reproductive age. A condition that causes irregular menstrual periods because monthly ovulation is interrupted and levels of androgens are elevated. It occurs in about 510% of women and is considered to be the most common cause of anovulatory infertility in reproductive age.Objectives: To compare the prevalence, levels of thyroid auto-antibodies in a group ...

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ea0037ep149 | Reproduction, endocrine disruptors and signalling | ECE2015

Stereoselective effects of statins on xenobiotic-metabolising pathways

Korhonova Martina , Dvorak Zdenek

Several of currently used drugs are chiral compounds. Majority of them are clinically administered as a racemic (equimolar) mixture of enantiomers. Individual enantiomers of one drug can qualitatively and quantitatively differ in their biological activities (pharmacology, toxicology, pharmacokinetics, etc.). Therefore, enantiopure drugs have been developed and introduced to the therapy. Statins are drugs used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reducta...

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ea0037ep150 | Reproduction, endocrine disruptors and signalling | ECE2015

Serum N-terminal pro-B-type brain natriuretic peptide levels detection and cardiac interventricular septum tissue Doppler echocardiographic evaluation of women with polycystic ovary syndrome

Ayhan Mehmet Emin , Durmaz Senay Arikan , Carlioglu Ayse , Demirelli Selami

Introduction: The aim of this study, left ventricular systolic and diastolic function by echocardiography and tissue Doppler echocardiographic evaluation and relationship serum N-terminal pro-B-type brain natriuretic peptide (NT-proBNP) levels of women with polycystic ovary syndrome (PCOS).Materials and method: Thirty-two women with PCOS (age: 23.44.6 years; BMI: 23.84.8 kg/m2), similar age and BMI have features 30 healthy womens c...

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ea0037ep151 | Reproduction, endocrine disruptors and signalling | ECE2015

The effects of endocrine disruptors on the in vitro hormone regulation of rat pituitary

Valkusz Zsuzsanna , Radacs Marianna , Palfoldi Regina , Molnar Zoltan , Sepp Krisztian , Laszlo Anna , Alapi Tamas , Galfi Marta

Endocrine disruptor compounds (EDCs) may cause disorders and alter the normal hormone synthesis and/or release.Aim was to investigate the effects of EDCs on normal hypophysis regulation; particularly the argininevasopressine (AVP) activated ACTH release from adenohypophysis cells and the monoamine activated AVP release from neurohypophysis cells.Primary monolayer cell cultures prepared from Wistar rat hypophyses. Separated ad...

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ea0037ep152 | Reproduction, endocrine disruptors and signalling | ECE2015

Endocrine disruptive effect of plastic byproduct bisphenol A on GH activity

Zadjali Fahad , Al Masroori Mohammed , Habais Mohammed

Bisphenol A (BPA) is a byproduct of polycarbonate plastic widely present in food containers. BPA is historically a known endocrine disruptor and due to its oestrogen agonist activity, BPA consumption is associated with hypothyroidism and reproductive disorder. Recent studies have shown that oestrogen antagonised GH actions. Since BPA has oestrogen agonist activity, the effect of BPA exposure on GH activity has not yet been investigated.Aim: To study the ...

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ea0037ep153 | Reproduction, endocrine disruptors and signalling | ECE2015

A possible link between LH and macrophage migration inhibitory factor levels in polycystic ovary syndrome

Calan Mehmet , Kume Tuncay , Yilmaz OzgUr , Arkan Tugba , Kocabas Gokcen Unal , Dokuzlar Ozge , Aygun Kemal , Oktan Mehmet Asi , Danis Nilay , Temur Muzaffer

Purpose: Macrophage migration inhibitory factor (MIF) is a multi-functional cytokine which plays a role in metabolic and inflammatory processes. Increasing evidence suggests that there is a link between MIF and ovulation. We aimed to evaluate plasma MIF levels in women with polycystic ovary syndrome (PCOS) and to determine whether MIF levels differ between the follicular phase and mid-cycle of the menstrual cycle in eumenorrheic women.Methods: Ninety wom...

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ea0037ep154 | Reproduction, endocrine disruptors and signalling | ECE2015

Analysis of gonadal steroid secretion in the serum of women during ovarian stimulation

Menet Marie Claude , Damiens Guillaume , Metenier Erwan , Sraouia Nacera , Leguy Marie Clemence , Gayet Vanessa , Guibourdenche Jean

Introduction: Biochemical follow up of the ovarian function after ovarian stimulation is restricted to the measurement of serum oestradiol and progesterone. We aim to investigate the entire ovarian steroidognesis after ovarian stimulation.Materials and methods: 50 women (26 IVF and 24 ICSI) who underwent AMP induction (based on rFSH stimulation after GnRH agonist or antagonist) for the same cause of infertility were retrospectively involved and compared ...

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ea0037ep155 | Reproduction, endocrine disruptors and signalling | ECE2015

Lower peripheral fat persists in HIV-infected subjects despite viral suppression in the era of highly-active antiretroviral therapy

Gangcuangco Louie Mar , Wong Jennifer , Chow Dominic , Shikuma Cecilia

Background: We compared body composition parameters in older HIV-positive individuals on stable antiretroviral therapy to age-matched HIV-seronegative individuals to assess whether differences in body composition parameters persist in the era of potent antiretroviral therapy.Methods: Inclusion criteria to the ageing HIV cohort required subjects to be >40 years old and be on stable antiretroviral therapy for >6 months. Only subjects with undetecta...

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ea0037ep156 | Reproduction, endocrine disruptors and signalling | ECE2015

An audit of prevalence and management of erectile dysfunction and LUTS in a diabetes clinic?

Haley Anna , De Parijat

Introduction: UK NICE guidelines recommend that men with diabetes mellitus (DM) should be reviewed annually regarding symptoms of erectile dysfunction (ED) in view of possible phosphodiesterase-5 (PDE-5) inhibitor treatment. Previous studies have shown that 70% of men with ED have concomitant lower urinary tract symptoms (LUTS). It has been suggested that there may be some common patho-physiology accounting for the improvement in LUTS seen in men with ED and LUTS treated with ...

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ea0037ep157 | Reproduction, endocrine disruptors and signalling | ECE2015

Maternal obesity in pregnant rats is associated to increased levels of oestradiol during early postnatal life and altered ovarian follicular development in the offspring

Reyes Aldo , Ramirez Luisa , Ambrosetti Valery , Guerra Marcelo , Alvarez Daniela , Olguin Sofia , Fernandois Daniela , Sotomayor-Zarate Ramon , Cruz Gonzalo

Obesity during gestation has been related to predisposition to endocrine and metabolic diseases in the offspring. Regarding reproductive effects, an increase in BMI in pregnant mothers is associated with precocious puberty in their offspring. This has been replicated in animal models of high fat diet (HFD) administration to mothers. Also, gestational obesity has been associated to higher susceptibility to developing breast cancer in the offspring. As both precocious puberty an...

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ea0037ep158 | Reproduction, endocrine disruptors and signalling | ECE2015

Glucagon-like peptide-1 stimulates insulin secretion and then somatostatin secretion in rat islets

Oh Seungjoon , Park So Young , Suh Kwang Sik , Kim Sung-Woon

Glucagon-like peptide-1 (GLP-1) is known to stimulate insulin and somatostatin secretion in pancreatic islet cells. The exogenous somatostatin inhibits insulin secretion, but GLP-1 increases insulin secretion in spite of stimulating somatostatin secretion from δ-cell. So, we investigated whether there exists a time difference of insulin and somatostatin secretion inside the islets after GLP-1 stimulation or insulin secretion depends on secreted GLP-1 or somatostatin conce...

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ea0037ep159 | Reproduction, endocrine disruptors and signalling | ECE2015

Treatment with antifungal agents, fenhexamid and cyprodinil, resulted in an increase of cell cycle- and metastasis-related genes in an oestrogen receptor-dependent pathway in cellular and xenografted mouse models with BG-1 ovarian cancer cells

Go Ryeo-Eun , Choi Kyung-Chul

Fenhexamid and cyprodinil are antifungal agents used in agricultural applications and present at measurable amounts in fruits and vegetables. In this study, the effects of fenhexamid and cyprodinil on cancer cell viability and metastasis were examined and the expression levels of proteins such as cyclins D1 and E, and cathepsins B and D were analysed in BG-1 ovarian cancer cells with oestrogen receptors (ERs). BG-1 cells were cultured with 0.1% DMSO (control), 17β-oestrad...

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ea0037ep160 | Reproduction, endocrine disruptors and signalling | ECE2015

Ovarian cancer growth was induced by 2,3,7,8-tetrachlorodibenzo-ρ-dioxin through the regulation of CYP1A1 gene in an oestrogen receptor-dependent pathway in BG-1 ovarian cancer cells

Go Ryeo-Eun , Choi Kyung-Chul

Environmental factors such as high meat consumption, caffeine, cigarette smoking, and endocrine disrupting chemical (EDCs) may enhance the risk of ovarian cancer. Cytochrome P450 (CYP) 1A1 may play a major role in metabolic activation of procarcinogens to carcinogens. 2,3,7,8-Tetrachlorodibenzo-ρ-dioxin (TCDD) is a commonplace pollutant and a promoter of carcinogenesis as the most potent substance. In this study, we examined the effects of TCDD in the presence of...

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ea0037ep161 | Reproduction, endocrine disruptors and signalling | ECE2015

Hormonal disorders in adult women with acne

Naumova Liudmyla

Introduction: Up to 30% of women of reproductive age suffer from acne. In most cases, acne leads to different reproductive disorders.The purpose of the study: To determine the frequency of hormonal disorders in women with acne and acne-similar changes of the skin.Methods and materials of research: The study involved 30 female patients of 1855 years old. Examined were their stature, the spread of acne and its predominant local...

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ea0037ep162 | Reproduction, endocrine disruptors and signalling | ECE2015

Modulation of the circadian clock by glucocorticoid receptor in H295R cell line

Nagy Zsolt , Butz Henriett , Liko Istvan , Racz Karoly , Patocs Attila

Background: Peripheral clocks are set by different nervous, hormonal and metabolic stimuli and regulate the circadian expression of several genes. It has been demonstrated that circadian oscillation of gene expression can be detected in various cell lines in vitro.Aim: To explore whether a peripheral clock could be induced in human adrenocortical cell line H295R and what are the effects of glucocorticoids on this clock system.<p class="abste...

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ea0037ep163 | Reproduction, endocrine disruptors and signalling | ECE2015

An information theoretic approach to GnRH signalling

Garner Kathryn , Perrett Rebecca , Voliotis Margaritis , Pham Thanh , Tsaneva-Atanasova Krasimira , McArdle Craig

One way in which cells receive information about their environment is through hormones binding to appropriate receptors on their cell surface. Single cell measurements of signalling proteins typically reveal high cellcell variability raising questions about how reliably individual cells sense their environment in order to make decisions. Information theoretic approaches can be used to explore such sensing, treating cell signalling pathways as noisy communicat...

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ea0037ep164 | Reproduction, endocrine disruptors and signalling | ECE2015

Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities

Figurova Jana , Dravecka Ingrid , Javorsky Martin , Petrikova Jana , Lazurova Ivica

Objective: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder characterised by menstrual dysfunction, infertility, presence of polycystic ovaries and biochemical and clinical hyperandrogenism affecting up to 418% women of reproductive age. Vitamin D is thought to influence the development of PCOS through gene transcription and hormonal modulation of insulin metabolism and fertility regulation. The aim of this prospective casecontrol study was to...

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ea0037ep165 | Reproduction, endocrine disruptors and signalling | ECE2015

Identification of p53 regulation site on the p27 promoter

Hsu Sung-Po , Lin Po-Han , Lee Wen-Sen

Angiogenesis is a crucial physiological phenomenon in female reproductive cycle. Our previous studies have shown that progesterone could inhibit proliferation of human umbilical vein endothelial cells (HUVEC) through a p53-dependent mechanism, by which the levels of p21 and p27 protein were increased, subsequently inhibiting the CDK2 kinase activity, and finally impaired the transition of the cell from the G1 phase to the S phase. While previous studies had clearly demonstrate...

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ea0037ep166 | Reproduction, endocrine disruptors and signalling | ECE2015

The influence of late onset hypogonadism on the formation of proinflammatory cytokines imbalance in patients with obesity and type 2 diabetes

Khripun Irina , Gusova Zalina , Dzantieva Elizaveta , Puzireva Valentina , Sultanmuradova Asiat , Vorobiev Sergey

Currently actively studied the role of certain inflammatory and proinflammatory cytokines in the pathogenesis of insulin resistance, type 2 diabetes, obesity, atherosclerosis. However, the influence of testosterone deficiency on the balance of proinflammatory cytokines is unexplored. The aim of the work was to evaluate the influence of testosterone deficiency on metabolic parameters and levels of proinflammatory cytokines in patients with obesity and type 2 diabetes.<p cla...

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ea0037ep167 | Reproduction, endocrine disruptors and signalling | ECE2015

Palmitic acid enhances TLR4 expression and promotes resistin/TLR4 signalling

Amine Hamza , Benomar Yacir , Gertler Arieh , Taouis Mohammed

Toll-like receptor 4 (TLR4) has a critical role in innate immunity, and the activation of inflammatory pathways plays an important role in the induction of insulin resistance. Indeed, we have recently demonstrated that TLR4 is implicated in resistin-induced inflammation and insulin resistance in the hypothalamus.1 We have also shown that TLR4 is up-regulated in the hypothalamus of mice fed a high-fat diet. Here, we aim to decipher the molecular mechanisms implicated...

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ea0037ep168 | Reproduction, endocrine disruptors and signalling | ECE2015

Heterogeneity of human chorionic gonadotropin (hCG) in commercial preparations of hCG and human menopausal gonadotropin

Riccetti Laura , Pignatti Elisa , Simoni Manuela

Introduction: Human chorionic gonadotropin (hCG) is a glycoprotein hormone composed by two subunits, an alpha subunit common to all gonadotropins and a specific beta subunit. hCG is produced by trophoblast cells as differently glycosylated isoforms with a wide range of molecular weight, from 30 to 50 KDa (regular hCG is 37 KDa). hCG is used in the treatment of infertility. The aim of this study is to analyse and compare the composition of different commercial hCG.<...

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ea0037ep169 | Reproduction, endocrine disruptors and signalling | ECE2015

Differential cell cycle control protein profiles characterise bronchial carcinoids sensitive to mTOR inhibitors

Benfini Katiuscia , Gagliano Teresa , Gentilin Erica , Riva Eleonora , Falletta Simona , Di Pasquale Carmelina , Bondanelli Marta , Ambrosio Maria Rosaria , degli Uberti Ettore Ciro , Zatelli Maria Chiara

Background: Bronchial carcinoids (BC) are rare neoplasm, still orphan of medical therapy, which arise from neuroendocrine cells. It has been previously demonstrated that the atypical BC human cell line NCI-H720 is sensitive to everolimus (E), an m-TOR inhibitor, in terms of cell viability reduction, with a G0 cell-cycle arrest and a Cyclin D1 protein reduction. On the contrary, the typical human BC cell line NCI-H727 is not sensitive to E, despite the Cyclin D1 reduction. The ...

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ea0037ep170 | Reproduction, endocrine disruptors and signalling | ECE2015

Influence of mTOR and ERK 1/2 pathways on the IGF1 negative feedback in GH secreting pituitary adenoma cell line

Di Pasquale Carmelina , Bellio Mariaenrica , Gentilin Erica , Gagliano Teresa , Falletta Simona , Benfini Katiuscia , Ambrosio Maria Rosaria , degli Uberti Ettore , Zatelli Maria Chiara

Background: Gigantism and acromegaly are the main consequences of GH excess, mainly due to a pituitary adenoma. Surgery is the first therapeutic option, but also medical therapy is employed, being mostly represented by somatostatin analogues (SSA), that reduce both tumour mass and GH hypersecretion. However about 10% of patients is resistant to SSA.PI3K/Akt/mTOR pathway, activated by growth-factors such as IGF1, is important in regulating many cellular p...

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ea0037ep171 | Reproduction, endocrine disruptors and signalling | ECE2015

Role of TGFβ1 in pancreatic neuroendocrine tumour

Falletta Simona , Gagliano Teresa , Gentilin Erica , Di Pasquale Carmelina , Benfini Katiuscia , Polenta Vanessa , Falconi Massimo , Ambrosio Maria Rosaria , Partelli Stefano , degli Uberti Ettore , Zatelli Maria Chiara

Introduction: Neuroendocrine tumours (NETs) are heterogeneous neoplasms arising from neuroendocrine cells spread in the respiratory and gastro-entero-pancreatic epithelium. The role of transforming growth factor beta-1 (TGFβ1) in NET biology is largely unknown. TGFβ1 signalling pathway is tumour suppressive in most non-transformed epithelial cell lines. In contrast, many human carcinomas are refractory to the growthinhibitory effects of TGFβ1.<p class=...

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ea0037ep172 | Reproduction, endocrine disruptors and signalling | ECE2015

Reduction of growth and lesser utilisation of energy reserves in heroin addicted boys during pubertal development

Saqlain Muhammad , Raja Ghazala Kaukab , Akram Maleeha , Minallah Samar , Ahmad Afzaal , Qayyum Mazhar , Rizvi Shakeel Raza

The secretion of leptin, an indicator of energy reserves, declines as energy stores are consumed in growth and development at puberty. The pubertal growth and development are often altered under different kinds of stresses. Usually, stress stimulates the release of cortisol, which is a labelled marker of stress. Early teens are inclined to drug abuse that may put their bodies under stress and may induce excessive secretion of cortisol. Since, sustained high levels of cortisol ...

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ea0037ep173 | Reproduction, endocrine disruptors and signalling | ECE2015

Persistent Mullerian duct syndrome: a case report

Almeida Raquel , Canha Antonio , Santos Jorge , Rocha Anabela , Dores Jorge

Persistent Mullerian duct syndrome (PMDS) is a rare disorder of sex development characterized by the persistence of Mullerian duct derivatives in a genotypic (46,XY) and phenotypic normally virilised male. PMDS is transmitted in an autosomal recessive manner, caused by mutations in the anti-Mullerian hormone gene or in the gene encoding the AMH receptor. The authors report a case of a male patient aged 62 years, with bipolar disorder, referred to the endocrinologist by inciden...

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ea0037ep174 | Reproduction, endocrine disruptors and signalling | ECE2015

47,XYY syndrome and hypogonadotropic hypogonadism: is this coincidence or a diverse spectrum of the syndrome?

Dellal Fatma Dilek , Aydin Cevdet , Bestepe Nagihan , Ersoy Reyhan , Cakir Bekir

Introduction: 47,XYY syndrome is characterized by an extra copy of the Y chromosome in each cells of a male. It occurs in about 1/1000 of newborn boys and most males with this syndrome have normal sexual development and fertility. They tend to have tall stature and mild motor and language developmental problems. Testosterone levels are normal. Increased rate of criminal activity in XYY males was related to a lack of judgement and lower socioeconomic status due to a lower mean ...

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ea0037ep175 | Reproduction, endocrine disruptors and signalling | ECE2015

Endocrine disorders in women with Turner syndrome

Zwolak Agnieszka , Dabrowska Anna , Tarach Jerzy

Introduction: Turner syndrome (TS) is the most common chromosomal abnormality in women. It occurs in 1/2500 to 1/3000 live-born females and results from a total or partial absence of the X chromosome. The clinical manifestations are diverse and TS is accompanied by multiple medical problems.Methods: We analysed retrospectively six cases of women with TS aged 2066 years, treated at Endocrinology Department between 2003 and 2014, to describe endocrin...

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ea0037ep176 | Reproduction, endocrine disruptors and signalling | ECE2015

In vitro effects of aspartic acid, coenzyme Q10 and zinc on sperm function

Giacone Filippo , Condorelli Rosita , Vignera Sandro La , Calogero Aldo Eugenio

Introduction: D-aspartic acid (D-AA) is involved in the regulation of spermatogenesis by influencing hormonal biosynthesis and secretion, resulting in an increased sperm concentration and progressive motility. Coenzyme Q10 (CoQ10) correlates positively with sperm concentration and motility at high concentrations, and it plays an antioxidant role, improving sperm motility and fertilization rate in ICSI cycles. Finally, low concentrations of zinc (Zn) have been found in azoosper...

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ea0037ep177 | Reproduction, endocrine disruptors and signalling | ECE2015

The effect of androgen replacement therapy on platelet aggregation in male patients with isolated hypogonadotropic hypogonadism

Oguz Ayten , Tuzun Dilek , Sahin Murat , Guvenc Numan , Inanc Elif , Gokalp Irem , Gul Kamile

Aim: To evaluate the effect of androgen replacement therapy on lipid profile and platelet aggregation in in male patients with isolated hypogonadotropic hypogonadism (IHH).Material and methods: 36 male patient, mean age 32.2 (1854)with IHH, admitted to the outpatient clinic of Endocrinology and Metabolism were included to the study. Patients in the study were divided into two groups as Testosterone (n=18) and human chorionic gonadotropin (...

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ea0037ep178 | Reproduction, endocrine disruptors and signalling | ECE2015

Visceral adiposity index – new anthropometric marker in women with polycystic ovary syndrome: preliminary reports

Bronczyk-Puzon Anna , Jagielski Pawel , Kulik-Kupka Karolina , Nowak Justyna , Koszowska Aneta , Zubelewicz-Szkodzinska Barbara

Introduction: Early detection of carbohydrate and fat metabolism disorders in women with polycystic ovary syndrome allows the early prevention of cardiovascular diseases and type II diabetes.Aim: The purpose of this study was to assess the selected metabolic indicators and anthropometric measurements in two groups of women: metabolically healthy polycystic ovary syndrome (MH-PCOS) and metabolically unhealthy PCOS (MU-PCOS).Material...

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ea0037ep179 | Reproduction, endocrine disruptors and signalling | ECE2015

Evaluation of most common symptoms and findings in Turkish adolescent girls with polycystic ovary syndrome

Kaya Mina Gulfem , Aydin Cevdet , Polat Sefika Burcak , Demirseren Duriye Deniz , Ersoy Reyhan , Cakir Bekir

Objective: Polycystic ovary syndrome (PCOS) is a complex endocrinopathy affecting 510% of women in reproductive period. Our goal is to determine which symptoms and findings are the most common in Turkish adolescents with PCOS.Material and method: Ninety three adolescents (1519 years old) who admitted to our outpatient clinic with at least one of the complaints (acne, obesity, menstrual irregularities and hirsutism) were enrolled in the study....

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ea0037ep180 | Reproduction, endocrine disruptors and signalling | ECE2015

Post load insulin vs fasting levels in prediction of type 2 diabetes in women with PCOS

Sumarac-Dumanovic Mirjana , Micic Dragan , Stamenkovic-Pejkovic Danica , Gligic Ana , Jeremic Danka , Milin-Lazovic Jelena , Cvijovic Goran

Introduction: Women with polycystic ovary syndrome (PCOS) are at increased risk of developing insulin resistance (IR) and T2DM. In this study, we attempted to detect IR parameters that could be the best predictor T2DM in PCOS comparing to controls.Description of methods/design: In 130 women with PCOS (BMI=29.7±0.66 kg/m2; age: 25.6±0.59 years) and 41 controls (age and BMI matched) (BMI=28.5±1.35 kg/m2; age: 26.5±...

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ea0037ep181 | Reproduction, endocrine disruptors and signalling | ECE2015

Ameliorated effects of allium sativum against bisphenol A-induced reproductive toxicity in male rats

Yousef Mokhtar Ibrahim , Newairy Al-Sayeda A , Salama Afrah F , Saber Shaimaa E M

There is growing evidence that bisphenol A (BPA) may adversely affect humans. BPA is an endocrine disruptor that has been shown to be harmful in laboratory animal studies. A comprehensive literature search found 91 studies linking BPA to human health; 53 published within the last year. This body of literature is showing associations between BPA exposure and adverse perinatal, childhood, and adult health outcomes, including reproductive and developmental effects, metabolic dise...

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ea0037ep182 | Reproduction, endocrine disruptors and signalling | ECE2015

Is serum estradiol really increased in patients with Klinefeler syndrome? Results from a meta-analysis study

Santi Daniele , Scaltriti Sara , Rochira Vincenzo

Background and aim: KS has been classically described as characterized by hyperestrogenism and elevated serum E2 together with increased gonadotropins and low-to-normal serum testosterone (T). In literature, data on increased serum E2 are not solid. The aim of this study is to meta-analyse data from studies evaluating serum E2 in both KS and healthy subjects (HS) in order to verify if E2 is increased in KS.Meth...

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ea0037ep183 | Reproduction, endocrine disruptors and signalling | ECE2015

Relationship between diabetes mellitus type 1 and male reproductive function

Vignera Sandro La

Diabetes mellitus type 1 (DM1), an autoimmune disease, affects an increasing number of young men in reproductive age. It has been estimated that its prevalence increases at a rate of ~3% per annum. Diabetes may affect male reproductive function by acting on the hypothalamic-pituitary-testicular axis, causing sexual dysfunction and disrupting male accessory gland function. According a recent study shows that men with DM1 have a smaller number of live births than controls. Despi...

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ea0037ep184 | Reproduction, endocrine disruptors and signalling | ECE2015

Serum dihydrotestosterone equivalent levels in women: a new index of hyperandrogenemia

Sung Yeon-Ah , Song Do Kyeong , Baik Sei Hyun , Kim Dong Sun

The measurement of androgens is critical for the diagnosis of polycystic ovary syndrome (PCOS) but it has been difficult based on poor specificity and sensitivity of assays in the female range. The direct total androgen activity can be measured with dihydrotestosterone equivalent concentration (DEQ) using chemically activated luciferase gene expression (CALUX) bioassays. The aim of the study is to determine whether DEQ levels can be the index for hyperandrogenemia to be requir...

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ea0037ep185 | Reproduction, endocrine disruptors and signalling | ECE2015

Eating habits of women without hormonal contraception depends on menstrual cycle - preliminary report

Spalik-Bytomska Anna , Nowak Justyna , Koszowska Aneta , Bronczyk-Puzon Anna , Kulik-Kupka Karolina , Kulpok Agata , Zubelewicz-Szkodzinska Barbara

Introduction: Hormonal changes during menstrual cycle among women without hormonal contraception could probably influence the food intake. Sex hormones modulate body energy expenditure by affecting hypothalamus neurohormones.Aim: The aim of the study was to assess the way of nutrition among menstruating women without hormonal contraception, depend of menstrual cycle.Materials and methods: 77 menstruating women in age 1926 ent...

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ea0037ep186 | Reproduction, endocrine disruptors and signalling | ECE2015

Relationship between polycystic ovary syndrome and platelet distribution width

Yilmaz Ozgur , Temur Muzaffer , Calan Mehmet , Ozbay Elif Pelin Ozun , Karakulak Murat , Kume Tuncay

Purpose: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive period, and it has been considered as a risk factor in cardiovascular disease due to increased prevalence of hypertension, dyslipidaemia, obesity, and insulin resistance. Platelets have a pivotal role in the development of atherothrombosis. Platelet distribution width (PDW) is a marker of platelet size that reflects the heterogeneity of the platelets. This arithmetical inde...

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ea0037ep187 | Reproduction, endocrine disruptors and signalling | ECE2015

Clinical significance of ADAMTS1, ADAMTS5, ADAMTS9 aggrecanases and IL17, IL23, IL33 cytokines in polycystic ovary syndrome

Karakose Melia , Demircan Kadir , Tutal Esra , Demirci Taner , Arslan Muyesser Sayki , Sahin Mustafa , Celik Huseyin Tugrul , Kazanci Fatmanur , Cakal Erman , Delibasi Tuncay

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) are involved in inflammation and fertility. The aim of this investigation was to evaluate to serum levels of ADAMTS1, ADAMTS5, ADAMTS9, IL17, IL23, IL33 and to find out the relationship between these inflammatory cytokines and ADAMTSs in PCOS patients.Met...

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ea0037ep188 | Reproduction, endocrine disruptors and signalling | ECE2015

Effects of thiouracil compounds on chemically induced rat mammary gland carcinogenesis

Macejova Dana , Ondkova Slavomira , Liska Jan , Brtko Julius

Introduction: Thyroidal status can play important role in progression mammary gland tumour growth. We have already shown that hypothyroidism induced by application of 6-n-propylthiouracil (PTU) inhibitor of type I iodothyronine 5′-deiodinase (5′-DI) prolonged tumour latency and reduced number, volume and burden of 1-methyl-1-nitrosourea (MNU) induced rat mammary gland tumours in SpragueDawley female rats.1<p class="abstex...

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ea0037ep189 | Reproduction, endocrine disruptors and signalling | ECE2015

The role of tailored treatment on conception and pregnancy at patients with insulin resistance

Nas Katalin , Breyer Helga , Tuu Laszlo

Patients with insulin resistance are often confronted with conception difficulties. Our database of 1178 conceivable female patients with metabolic disorder shows that more than 40% of them suffer from menstrual cycle disorders. More than 25% out of 480 pregnant women with hyperinsulinaemia had at least one assisted reproduction procedure in their lives. 42% of patients with insulin resistance experienced missed abortion, out of them 26% one time, 12% two times. Our aim was to...

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ea0037ep190 | Reproduction, endocrine disruptors and signalling | ECE2015

Eating pattern does not depend on the menstrual cycle phase in a group of women taking hormonal contraceptives: preliminary reports

Spalik-Bytomska Anna , Nowak Justyna , Bronczyk-Puzon Anna , Koszowska Aneta , Kulik-Kupka Karolina , Dittfeld Anna , Zubelewicz-Szkodzinska Barbara

Introduction: Sex hormones, such as estrogens or progesterone may have, both directly and indirectly, an influence on the appetite changes in. In addition, exogenous sex hormones are commonly used as one method of contraception.Aim: The purpose of this study was to assess whether the eating style in a group of menstruating women, taking oral hormonal contraceptives, is different in the individual menstrual cycle phases.Material and...

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ea0037ep191 | Reproduction, endocrine disruptors and signalling | ECE2015

The PCOS demographic in a dedicated University Hospital Clinic

Durkan Maeve , Kennedy Bernard

This retrospective review of all adult women referred to a dedicated University Clinic for presumed polycystic ovarian syndrome (PCOS) aims to determine i) the true PCOS prevalence and ii) to evaluate baseline demographics by diagnostic criteria and their relationship to metabolic and cardiovascular risk parameters. All charts were reviewed. The diagnosis of PCOS rests on excluding another endocrinopathy, and fulfilling any two of the three criterias as per the Rotterdam state...

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ea0037ep192 | Reproduction, endocrine disruptors and signalling | ECE2015

Hypercoagulable overall haemostatic potential is not intrinsically associated with PCOS but worsens with increasing BMI

Rakusa Matej , Jensterle Mojca , Janez Andrej , Mijovski Mojca Bozic

Introduction: Growing evidences imply a role of coagulation system in the development of thromboembolic events and progression of atherosclerosis in PCOS. The aim of the study was to identify potential relationship of overall haemostatic potential (OHP) with a syndrome per se, BMI and androgens. OHP has not yet been assessed in PCOS.Methods: In 89 women with PCOS aged 30.9±8.1 years (50 obese, 13 overweight, and 27 normal weight) and 21 hea...

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ea0037ep193 | Reproduction, endocrine disruptors and signalling | ECE2015

PZ-TR: a novel human luciferase reporter cell line for assessment of thyroid receptor transcriptional activity

Illes Peter , Dvorak Zdenek

Regulation of gene expression mediated by thyroid hormones (THs) plays an essential role in variety of physiological processes. It is known that large group of natural and synthetic compounds, generally termed endocrine disruptors, can interfere with endocrine system and thus disrupt homeostasis of hormonal regulation processes in human organism. In order to screen for substances with potential disrupting effects on TH pathway, we developed and characterized human luciferase r...

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ea0037ep194 | Reproduction, endocrine disruptors and signalling | ECE2015

Evaluation of an automatic referral system for inpatients with hyponatraemia: prompt referral leads to active intervention

Mannan Jayamalathy Mannar , Joshi Mamta , Vincent Roy , Sherwood Roy , Jafar-Mohammadi Bahram , Gilbert Jackie , Whitelaw Benjamin , Aylwin Simon

Inpatients with hyponatraemia have a high mortality and longer length of stay. We instituted a system of automatic referral to the endocrinology team where any inpatient with a serum (Na+) ≤125 mmol/l was referred automatically from their biochemical results.Aims: We evaluated the diagnosis, management, and outcome of the patients referred with hyponatraemia over 6 months.Methods: Data were prospectively captured e...

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ea0037ep195 | Reproduction, endocrine disruptors and signalling | ECE2015

Klinefelter syndrome: a small sample retrospective analysis

Balsa Ana Margarida , Bastos Margarida , Moreno Carolina , Guelho Daniela , Cardoso Luis , Vicente Nuno , Martins Diana , Oliveira Diana , Alves Marcia , Guimaraes Joana , Carrilho Francisco

Introduction: Klinefelter syndrome (KS) is characterized by the presence of supernumerary X-chromosome and thus a 47,XXY karyotype. This syndrome remains underdiagnosed, with only about 25% of patients being identified, and only 10% during childhood.Methods: Retrospective analysis of 11 KS patients followed-up in the Endocrinology Department of Coimbras Hospital and Universitary Center. The registered data included education and occupation, time an...

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ea0037ep196 | Reproduction, endocrine disruptors and signalling | ECE2015

Endocrinopathies associated with lithium therapy in an Irish tertiary referral centre

Dineen Rosemary , Bogdanet Delia , Thompson C J , Thompson D , Boran Gerard , Gibney James , Keane Veronica , Sherlock Mark

Lithium is used in psychiatric practice as maintenance therapy in bipolar disorder. It has a narrow therapeutic index with serious toxic potential. Lithium is associated with multiple endocrine and metabolic disturbances but data regarding the rates of these in individual patients is lacking. In a tertiary referral centre, all patients on lithium therapy from 2000 to 2014 were identified. The aim of this study was to assess the impact of lithium therapy on the development of e...

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ea0037ep197 | Reproduction, endocrine disruptors and signalling | ECE2015

The connection between serum prolactin, TSH, and insulin resistance in polycystic ovary syndrome patients

Albu Alice , Radian Serban , Florea Suzana , Fica Simona

Introduction: Both TSH and prolactin serum levels within normal range were previously reported to be associated with metabolic parameters.Aim: To analyse the connections between serum levels of prolactin, TSH, and insulin resistance in polycystic ovary syndrome patients.Material and methods: 322 PCOS patients (mean age 24.3±5.16 years and mean BMI 28±7.57 kg/m2) with normal serum prolactin and without thyroid d...

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ea0037ep198 | Reproduction, endocrine disruptors and signalling | ECE2015

The serum AMH/total follicle count ratio is equal in women with and without PCOS

Christiansen Sverre Christian , Eilertsen Tina Bjorsvik , Vanky Eszter , Carlsen Sven Magnus

Background: Anti-Müllerian hormone (AMH) has a positive linear relationship to antral follicle count (AFC) in healthy women. However, studies of intra-follicular AMH-levels indicate a non-linear relation to AFC. It is speculated whether high AMH in polycystic ovary syndrome (PCOS) women is due to overactive follicles rather than directly reflect AFC.Study design: We used data from a previous casecontrol study, including 262 women with prior te...

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ea0037ep199 | Reproduction, endocrine disruptors and signalling | ECE2015

Endocrine emergencies as problem in Emergency Department 6 years observation including over 200 000 admissions

Marczewski Krzysztof , Slomian Michal , Boniek-Poprawa Dorota , Maciejewski Marek

Introduction: Emergencies in endocrinology often require a doctors high-speed operation, which is closely related to the ability to fast obtain a diagnosis. To remain a champion requires exercise. Therefore, we decided to check how often the doctors in the Emergency Department (ED) meet such patients.The aim of our study was to investigate the frequency of endocrine emergencies in Department of Emergency in Tertiary Care Hospital with Department of...

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ea0037ep200 | Reproduction, endocrine disruptors and signalling | ECE2015

ThyrART: association of embryo quality and reproductive outcome after IVF with thyroid autoimmunity

Mintziori Gesthimani , Kolibianakis Efstratios M , Slavakis Aristidis , Tarlatzis Basil C , Goulis Dimitrios G

Introduction: The role of thyroxine (T4) during embryo development is recognised as crucial. The research question of this study was if embryo quality and reproductive outcomes after IVF are affected by maternal thyroid function and/or thyroid auto-immunity (TAI).Methods/design: We conducted a prospective study (ThyrART), assessing embryo quality and reproductive outcome of women undergoing ovarian stimulation with a flexible GnRH-antagonist p...

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ea0037ep201 | Reproduction, endocrine disruptors and signalling | ECE2015

Association of rs1800790 in fibrinogen beta polypeptide chain gene (FGB) with endometrium in Iranian women

Omidi Zohreh , Ebrahimi Ahmad

Background: Endometriosis is a common disease in women and considered as one of the most important reasons infertility, and it means abnormal growth of the endometrial tissue outside of the uterine. The exact prevalence of endometriosis disease is unknown. estimated that the endometriosis exists in 10% of women in productivity. Possibly, several genes interacting with each other as well as environment to result endometriosis. Given that one of the cellular pathways involved in...

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ea0037ep202 | Reproduction, endocrine disruptors and signalling | ECE2015

A haplotype of the EPCR gene is associated is a candidate risk factor for uterine myomas in Iranian women

Fathkhani Zeinab , Ebrahimi Ahmad

Introduction: Uterine myomas are the most frequent benign uterine tumours of smooth muscle cells of myometrium. Myoma is the most common uterine tumours occurring in 2030% of women during their reproductive years. Despite this common complication of benign tumours, in most cases there are barrier of natural fertility and pregnancy continuing. Therefore, to understanding better the genetic characteristics of myoma help us in the treatment and preventive measures in these ...

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ea0037ep203 | Reproduction, endocrine disruptors and signalling | ECE2015

Sexual function in women with polycystic ovary syndrome

Sematonyte Justina , Danylaite Vilija , Ciaplinskiene Lina , Kozloviene Dalia , Sebokaite Audrone , Pagareckaite Malvina , Zilaitiene Birute

Objective: Polycystic ovary syndrome (PCOS), is a common endocrine disorder in women of reproductive age, which influences metabolic, psychological and sexual aspects of their life. We aimed to evaluate the sexual function of women with PCOS in comparison with age-matched controls.Methods: In this prospective cross-sectional study, 40 women with PCOS (mean age 27.02±4.54 years) were compared with a control group of 40 healthy volunteers (mean age 25...

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ea0037ep204 | Reproduction, endocrine disruptors and signalling | ECE2015

Salivary cortisol response to psychological stress in late adolescent and young women: impact of menstrual irregularity, hirsutism, and hyperandrogenaemia

Mezzullo Marco , Gambineri Alessandra , Fanelli Flaminia , Repaci Andrea , Prontera Olga , Di Dalmazi Guido , Pagotto Uberto , Pasquali Renato

Hyperandrogenic disorders cause psychological implication in young girls, limiting the quality of life. Salivary cortisol (SalF) testing was proved to be useful in the evaluations of acute stress responses. Aim of this study was to investigate SalF responses to a stressor event in late adolescent females. We selected 165 drug-free females aged 1619 years from a cross-sectional epidemiological study. Saliva was collected in the morning before and after a stressor event co...

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ea0037ep205 | Reproduction, endocrine disruptors and signalling | ECE2015

Leptin and insulin resistance: impact on gonadal function in Algerian obese women

Remini Djida , Smili Aziza , Meskine Djamila , Koceir El Hadj Ahmed , Soltani Yacine

Introduction: Excess of abdominal fat may disturb metabolic parameters that affect insulin level and may lead to menstrual disorders, consecutively to disturbance in sex steroids production. The aim is to link the metabolic hormones in abdominal obesity, with reproductive axis hormones in women at age.Patients and methods: 85 no menopausal women aged between 17 and 52 were recruited: 62 with abdominal obesity (BMI >30 kg/m2 and waist circu...

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ea0037ep206 | Reproduction, endocrine disruptors and signalling | ECE2015

PCOS and thyroid disorder

Kablia Samia Ould , Lechghem Aicha , Cheikh Assya

Background: PCOS and thyroid disorder are two of the most frequent endocrine disorder in the general population. Although, the aetiopathogenesis of thyroiditis and PCOS is completely different this two entities have many features in common (cystic ovaries in hypothyroidism and thyroid disorder in PCOS).Objective: Our objective was to assess the increased incidence of thyroid disorder in females with PCOS.Methods and materials: We c...

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ea0037ep207 | Reproduction, endocrine disruptors and signalling | ECE2015

Biochemical and hormonal parameters in patients presenting with hirsutism

Okuturlar Yildiz , Sayilan Samet , Mert Meral , Soyluk Ozlem , Erdogan Ezgi , Harmankaya Ozlem , Kumbasar Abdulbaki

Introduction: It was aimed to evaluate the biochemical and hormonal parameters in female patients with and without polycystic ovary and presenting with symptoms of hirsutism.Materials and methods: In this study, 217 female patients presenting with symptoms of hirsutism were enrolled. Seventy-two female patients having polycystic ovaries by ultrasonography were named as group 1 and 145 female patients with normal ovaries were named as group 2. FSH, LH, pl...

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ea0037ep208 | Reproduction, endocrine disruptors and signalling | ECE2015

An endocrine disrupting chemical, bisphenol A: could it be associated with sex differentiation in brain regarding to transsexuality?

Yurekli Banu Sarer , Kutbay Nilufer Ozdemir , Saygili Fusun

Transsexuality is characterised by a belief of having been born in a wrong body. Sexual differentiation of genitals take place in the first 2 months of pregnancy. Sexual differentiation of brain takes place in the second half of pregnancy. It is found that there is structural sex differences in the central nucleus of the bed nucleus of the stria terminalis (BSTc). Structural differences were found to be reversed in transsexual people. In humans main mechanism appears to involv...

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ea0037ep209 | Reproduction, endocrine disruptors and signalling | ECE2015

The commonly used plasticisers (bisphenols and phthalates) as endocrine disrupting chemicals in healthy women and women with polycystic ovary syndrome

Rutkowska Aleksandra , Konieczna Aleksandra , Wilczewska Kamila , Ciechanowicz Agnieszka , Czernych Radoslaw , Kowalewska-Wlas Agnieszka , Laczmanski Lukasz , Kuliczkowska Justyna , Lenarcik Agnieszka , Trzmiel-Bira Anna , Brona Anna , Kuligowska-Jakubowska Monika , Kot-Wasik Agata , Wasik Andrzej , Milewicz Andrzej , Namiesnik Jacek , Wolska Lidia , Rachon Dominik

Plasticisers such as bisphenol A (BPA), bisphenol S (BPS), and phthalates (PAE) are commonly used in daily life in electronic equipment, cans, plastic food containers, and bottles. These substances can interact with oestrogen receptors as well as androgen receptors and therefore they are called endocrine disrupting chemicals (EDC). The aim of this study was to evaluate serum concentrations of BPA, BPS, and selected PAE in healthy women and women with polycystic ovary syndrome ...

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ea0037ep210 | Reproduction, endocrine disruptors and signalling | ECE2015

Serum gonadotropins secretion is not reduced with advancing age in HIV-infected females: results of a case–control study in menopausal women

Diazzi Chiara , Brigante Giulia , Guaraldi Giovanni , Simoni Manuela , Rochira Vincenzo

Introduction: HIV infection treated with highly active antiretroviral therapy (HAART) seems to be associated with hypogonadism in men. Less is known in HIV-infected women gonadal status. The aim of this study is to investigate gonadal function, in menopausal HIV-infected women compared sex- and age-matched healthy subjects (HS).Methods: We retrospectively compared 188 HIV-infected women with 192 HS selected reviewing record charts and laboratory database...

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ea0037ep211 | Reproduction, endocrine disruptors and signalling | ECE2015

Association between Apa-I polymorphism in the vitamin D receptor gene and metabolic syndrome in polycystic ovary syndrome

Santos Betania R , Spritzer Poli Mara

Women with polycystic ovary syndrome (PCOS) have higher prevalence of metabolic disturbances such as changes in lipid profile, diabetes, hypertension and metabolic syndrome. Variants on vitamin D receptor (VDR) gene have also been related to metabolic comorbidities in general population. Therefore, the aim of the present study was to investigate whether Apa-I polymorphism (rs7974232) in the VDR gene is associated with metabolic syndrome and endocrine profile in PCOS. In this c...

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ea0037ep212 | Reproduction, endocrine disruptors and signalling | ECE2015

XbaI and PvuII oestrogen receptor alpha gene polymorphism and Y chromosome deletions in infertile vs fertile men

Vladoiu Suzana , Dinu Dana , Anton Gabriela , Botezatu Anca , Manda Dana , Oros Sabina , Ianas Olga , Paun Diana , Badiu Corin , Rosca Roxana

Only a few genes involved in spermatogenesis have clinical importance: Y chromosome micro deletions in the region called azoospermia factor (AZF) and oestrogen receptor alpha gene polymorphisms (ESR1).Objective: The study aim to evaluate ESR1 and Y chromosome deletion in infertile men.Subjects and methods: 43 infertile men, and 34 fertile men aged 2050 years 50, were enrolled after signing the informed consent. Screening for ...

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ea0037ep213 | Reproduction, endocrine disruptors and signalling | ECE2015

The impact of adiposity on serum anti-Mullerian hormone in normal and overweight women with decreased ovarian reserve

Albu Dragos , Tulin Raluca , Albu Alice

Background: Few previous studies suggested a negative impact of obesity on anti-Mullerian hormone (AMH) serum levels in patients with decreased ovarian reserve, but the data regarding the relationship between AMH and adiposity in the same category of patients without severe excess of body weight are scarce.Aim: The aim of the study was to evaluate the relationship between AMH serum levels and BMI in normal weight and overweight patients with reduced ovar...

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ea0037ep214 | Reproduction, endocrine disruptors and signalling | ECE2015

Clinical characteristics of different phenotypes of polycystic ovary syndrome

Bogavac Tamara , Macut Djuro , Antic Ivana Bozic , Bjekic-Macut Jelica , Milutinovic Danijela Vojnovic , Popovic Bojana , Kastratovic-kotlica Biljana , Ilic Dusan , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Damjanovic Svetozar

Introduction: Although phenotype D is well recognised in clinical studies about PCOS, there is still a debate if this phenotype should be evaluated as part of PCOS spectrum. The aim of this study was to evaluate usual anthropometric characteristics in PCOS phenotypes.Methodology: We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (Controls: 25.4...

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ea0037ep215 | Reproduction, endocrine disruptors and signalling | ECE2015

Effects of oral contraceptives on the periodontium

Virtej Ioana , Ikonomou Theodoros , Virtej Anca , Vartej Petrache , Poiana Catalina

Gingivitis is the most frequent periodontal manifestation during oral contraceptives therapy, mainly due to the altered oral bacterial flora under the influence of oestrogen and progesterone. The aim of this study was to investigate the influence of low-dose oral contraceptives on periodontal health in young females.Methods: 42 women aged 1838 years without systemic disease, non-smokers, were divided in two study groups: 22 women treated with low-d...

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ea0037ep216 | Reproduction, endocrine disruptors and signalling | ECE2015

Relationship between androgen levels and markers of endothelial dysfunction in men with type 2 diabetes

Khripun Irina , Belousov Igor , Vorobiev Sergey , Dzantieva Elizaveta , Gusova Zalina , Puzireva Valentina , Sultanmuradova Asiat , Haritonova Maria

It is well known that type 2 diabetes causes the endothelial dysfunction. However, insufficient attention is paid to the role of androgen deficiency in the formation of the early signs of endothelial dysfunction. The aim of the work was to evaluate the relationship between testosterone deficiency and markers of endothelial dysfunction in men with type 2 diabetes.Materials and methods: Were examined 88 men aged 4065 years with type 2 diabetes. All p...

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ea0037ep217 | Reproduction, endocrine disruptors and signalling | ECE2015

Subclinical hypothyroidism in patients with polycystic ovary syndrome

Yasar Hamiyet Yilmaz , Topaloglu Omercan , Demirpence Mustafa , Ceyhan Banu Ozturk

Objective: Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disorder that affects 510% of women of reproductive age. In various studies, it was found to be associated with subclinical hypothyroidism. Serum TSH levels were also reported to be increased in obese individuals. In order to define the impact of obesity on the subclinical hypothyroidism observed in patients with PCOS, we aimed to investigate subclinical hypothyroidism both in lean and overweight...

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ea0037ep218 | Reproduction, endocrine disruptors and signalling | ECE2015

Subclinical hypothyroidism in young women with polycystic ovary syndrome

Themeli Yllka , Mustafaraj Kozeta , Dilo Gjergji , Hoxha Lindita

Background: Separately, polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) exert adverse effects on metabolic parameters. This study evaluated whether SCH in women with PCOS affects clinical, hormonal, and metabolic parameters.Aim: To analyse the relationship between selected clinical and metabolic parameters in young women with PCOS and normal thyroid function or SCH.Materials and methods: In this cross-sectiona...

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ea0037ep219 | Reproduction, endocrine disruptors and signalling | ECE2015

The relationships of bisphenol A levels with leptin and adiponectin in premenopausal women

Polat Sevgi , Yurekli Banu Sarer , Kocabas Gokcen Unal , Durusoy Raika , Aksit Murat , Bozkaya Giray , Yuksel Arif , Saygili Fusun

Aim: Bisphenol A (BPA) is the most common endocrine disruptor among environmental estrogens. BPA is an ingredient that is commonly used in polycarbonate plastics. In this study, our main concern is to measure the levels of BPA in premenopausal obese women and to examine the relationship of BPA with adiponectin and leptin.Materials and methods: 47 obese women and 39 non-obese healthy women were enrolled in this study. All participants were premenopausal. ...

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ea0037ep220 | Reproduction, endocrine disruptors and signalling | ECE2015

Characteristics of body composition in different phenotypes of women with polycystic ovary syndrome

Ilic Dusan , Macut Djuro , Antic Ivana Bozic , Macut Jelica Bjekic , Milutinovic Danijela Vojnovic , Popovic Bojana , Bogavac Tamara , Kotlica Biljana Kastratovic , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja

Obesity is closely associated with PCOS and worsens its metabolic and reproductive characteristics. The aim of this study was to evaluate body composition in different PCOS phenotypes. We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (Controls: 25.41±5.16 kg/m2; 30.35±5.62 years). PCOS were analyzed through four phenotypes: a (anovulation (ANOV)...

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ea0037ep221 | Reproduction, endocrine disruptors and signalling | ECE2015

Copy number variations in the X chromosome of Klinefelter syndrome

Ferlin Alberto , Rocca Maria Santa , Pecile Vanna , Selice Riccardo , Caretta Nicola , Foresta Carlo

Introduction: Klinefelter syndrome (KS) is characterised by the presence of at least one extra X chromosome and represents the most common chromosomal aberration in men. Apart from infertility, the clinical spectrum of KS is variable and often not directly related to hypogonadism, whose expression is also not unpredictable. Several genetic mechanisms may explain the clinical features and variability of the phenotype in KS. In particular, gene-dosage effects and the parental or...

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ea0037ep222 | Reproduction, endocrine disruptors and signalling | ECE2015

Circulating levels of FSH in men are genetically determined: study of the combined effect of polymorphisms in FSHR and FSHB genes

Ferlin Alberto , Vinanzi Cinzia , Speltra Elena , Pengo Manuel , Rocca Maria Santa , Foresta Carlo

Introduction: Polymorphisms in the gene for FSH receptor (FSHR) and FSH β subunit (FSHB) might modulate FSH levels and represent genetic markers for a pharmacogenetic approach to male infertility treatment. rs6166 (c.2039 A>G, Asn680Ser) and rs1394205 (c.−29 G>A) in FSHR have been better analysed in women, whereas rs10835638 (−211 G>T) in FSHB seems to have a determinant role especially in men. However, studies considering the combined effect of th...

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17th European Congress of Endocrinology

BiosciAbstracts