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Endocrine Abstracts

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17th European Congress of Endocrinology

Eposter Presentations

Steroids, development and paediatric endocrinology

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Adrenal cortex
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Reproduction, endocrine disruptors and signalling

ea0037ep95 | Steroids, development and paediatric endocrinology | ECE2015

Linear growth and endocrine function in patients with ataxia telangiectasia; a cohort of 13 patients in Qatar

Ehlayel Mohammad , Soliman Ashraf

Introduction: Ataxia telangiectasia (AT) is a rare, genetic, primary immune deficiency disease characterised by immunodeficiency and neurological manifestations, with increased tendency to infection, malignancy, and autoimmune diseases. Both growth delay and endocrine abnormalities are occasionally reported in these patients.Aim: To study linear growth in relation to endocrine and immune functions in a cohort of children with AT.Pa...
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ea0037ep96 | Steroids, development and paediatric endocrinology | ECE2015

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ea0037ep97 | Steroids, development and paediatric endocrinology | ECE2015

Unusual presentation of the apparent mineralocorticoid excess, triggered by mild Cushing's disease in an adult

Zavratnik Andrej , Zavrsnik Matej , Ksela Urska , Homsak Evgenija , Rajic Antonela Sabati , Gruson Damien , Pfeifer Marija

Introduction: The syndrome of apparent mineralocorticoid excess (AME), a genetic disorder, resembles findings similar to those in primary aldosteronism, but aldosterone levels are low. AME is due to deficiency in the 11-beta-hydroxysteroid-dehydrogenase-enzyme-type-2 isoform (11-beta-HSD2), which normally converts cortisol to cortisone to prevent its mineralocorticoid activity at the aldosterone-sensitive sites. The deficiency in 11-beta-HSD2 leads to marked elevation in net m...
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ea0037ep98 | Steroids, development and paediatric endocrinology | ECE2015

Evaluation of β-oestradiol induced DNA damage in the leukocytes of young, elderly and Alzheimer's disease patients in the comet assay

Zivkovic Lada , Spremo-Potparevic Biljana , Djelic Ninoslav , Bajic Vladan

Oestrogen has very complex effects on the CNS. It protects neurons from noxious effects of β amyloid in vitro, ameliorates the cerebral metabolism and increases the level of acetylcholine in the basal forebrain and hippocampus. Its beneficial impact in Alzheimer disease may be attributed in part to its antioxidant activity. On the other hand, it has been demonstrated that oestrogens may exhibit genotoxic effects, especially at elevated tissue concentrations. Ther...
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ea0037ep99 | Steroids, development and paediatric endocrinology | ECE2015

Serum alanine aminotransferase and γ-glutamyltranspeptidase activities: new markers for polycystic ovary syndrome

Kilic Halime , Aydin Fatma , Uz Burak , Karakurt Feridun , Koroglu Mustafa , Carlioglu Ayse Kargili

Objective: Polycystic ovary syndrome (PCOS) is associated with insulin resistance, central obesity and dyslipidaemia. Furthermore, abnormal aminotransferase activity is common in women with polycystic ovary syndrome. The aim of this study is to assess the γ-glutamyltranspeptidase (GGT) and alanine aminotransferase (ALT) levels in women with PCOS in whom non-alcoholic fatty liver disease was excluded by history, serum testing and abdominal ultrasonography.<p class="abs...
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ea0037ep100 | Steroids, development and paediatric endocrinology | ECE2015

Achievement of therapy targets in children and adolescents with type 1 diabetes mellitus at the ‘Diabetes School'

Tashmanova Akmaral

Aim: To assess efficacy of training and achievement of therapy targets in children and adolescents with type 1 diabetes mellitus in ‘Diabetes Schools’.Materials and methods: The 5-day training course was conducted in ‘Type 1 Diabetes School’ at the Center for the Scientific and Clinical Study of Endocrinology, Uzbekistan Public Health Ministry (Tashkent). The training was conducted by means of a structured program containing all appro...
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ea0037ep101 | Steroids, development and paediatric endocrinology | ECE2015

Interrelation between level of knowledge and type 1 diabetes mellitus compensation degree in children and adolescents

Tashmanova Akmaral

Aim: To assess level of knowledge and compensation degree in children and adolescents with type 1 diabetes mellitus in “Type 1 Diabetes School”.Materials and methods: The 5-day training course was conducted in ‘Type 1 Diabetes School’ at the Center for the Scientific and Clinical Study of Endocrinology. The training was conducted by means of a structured program containing all appropriate sections. In total 137 children and adolescent...
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ea0037ep102 | Steroids, development and paediatric endocrinology | ECE2015

Influence of ecologically adverse factors on physical and sexual development of children living in the Aral Sea area

Ibragimova Nilufar , Hojaeva Feruza

Drying of the Aral Sea resulted in serious problems including pollution of air, water (mineralization of clear water) and soil which in its turn caused rise in various somatic diseases in population and produced a negative effect on health of children and adolescents.Purpose: To study the influence of ecologically adverse factors on physical and sexual development of children of the Aral Sea area.Drying of the Aral Sea resulted in ...
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ea0037ep103 | Steroids, development and paediatric endocrinology | ECE2015

Leptin and kisspeptin evaluation in childhood obesity

Leo Francesco , Mancini Antonio , Segni Chantal Di , Raimondo Sebastiano , Barini Angelina , Curro Diego , Rossodivita Aurora Natalia

Kisspeptin is a neuropeptide secreted in anteroventral-periventricular and arcuate hypothalamic nuclei involved pubertal onset and in other functions of adult life. Kisspeptin levels are sex dependent, so they are higher in prepubertal girls and in adult women compared to age-matched male. This sex-related pattern has been reported in adult obesity, but few data are reported in childhood obesity. In order to evaluate correlations between metabolic status and kisspeptin, we stu...
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ea0037ep104 | Steroids, development and paediatric endocrinology | ECE2015

Kisspeptin hormone levels in girls and adolescent girls

Gumeniuk Olga , Chernenkov Yuriy , Zakharova Natalia , Ivanenko Inna

Kisspeptin (formerly known as metastin) is a neuropeptide, has an important role in initiating secretion of gonadotropin-releasing hormone at puberty. Kisspeptin hormone levels disorders cause hypogonadism or premature sexual development and sterility.Aims: The study was undertaken to research the kisspeptin level in healthy girls and adolescent girls and in girls and adolescents with gynaecological and endocrine disorders.Patients...
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ea0037ep105 | Steroids, development and paediatric endocrinology | ECE2015

Clinical and endocrine features Hashimoto thyroiditis in children and adolescents

Markovic Slavica , Igrutinovic Zoran , Vuletic Biljana , Medovic Rasa , Stankovic Lidija

Introduction: Hashimoto’s thyroiditis (HT) is the most common autoimmune thyroid disease and the most common cause of euthyroid goitre and acquired hypothyroidism in childhood.Objective: To describe the clinical manifestations, course and outcome of HT in children and adolescents.Method: The study included 43 patients with HT, aged 3–16 years, mean age 12.5 years, 36-girls, seven boys; 15 (35%) prepubertal, 28 (65%) puber...
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ea0037ep106 | Steroids, development and paediatric endocrinology | ECE2015

Neonatal screening for hypothyroidism in Romania

Ardeleanu Ioana , Nanu Michaela , Moldovanu Florentina , Nanu Andrei

Introduction: Neonatal screening is an effective method for early detection of congenital hypothyroidism, a disorder that requires the prompt initiation of the treatment, in order to prevent the subsequent neuropsychiatric impairments. Neonatal screening for hypothyroidism in Romania was initiated as a pilot project in 1979, has been expanded since 2002, and is currently conducted through the National Health Program funded by the Ministry of Health.Objec...
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ea0037ep107 | Steroids, development and paediatric endocrinology | ECE2015

Paediatric hypothyroidism: effect of thyroxin replacement therapy on growth hormone secretion and linear growth velocity

Saqib Sadia , Kiani Amjad Rashid , Anwar Urooj , Akram Maleeha , Shahid Gulbin , Ishtiaq Osama , Ahmad Afzaal , Qayyum Mazhar , Rizvi Shakeel Raza

Thyroid gland secretes thyroid hormones, which play a critical role in growth, differentiation, reproduction and metabolism, whereas hypothyroidism in children is associated with short stature and normalisation of thyroid function with thyroxin replacement therapy increases linear growth velocity (LGV). In stimulating LGV, thyroxin may have its direct effects on bone cells or it may affect LGV through its effect on growth hormone (GH) secretion. The present study attempted to ...
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ea0037ep108 | Steroids, development and paediatric endocrinology | ECE2015

Evolution of the signs of true precocious puberty under suppressive treatment by LH RH analogues in girls

Haddam Ali El Mahdi , Fedala Nora Soumeya , Ali Leyla Ahmed , Meskine Djamila , Chentli Farida

Introduction: Impact of suppressive therapy with LH RH analogues is more stop the premature pubertal development, reduce the acceleration of bone maturation that compromises the final size and avoid psychological disturbances caused by hormonal imbalance.Aim: To study the effects of treatment on pubertal development, bone maturation and evolution of the size during and at the end of treatment and final height in 20 patients with central precocious pubert...
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ea0037ep109 | Steroids, development and paediatric endocrinology | ECE2015

DHEA and its metabolites – daily profile

Sramkova Monika , Duskova Michaela , Starka Luboslav , Racz Beata , Hill Martin

Introduction: DHEA is a well-known neurosteroid. Its plasmatic level is reduced with ageing in most individuals. A non-negligible portion of DHEA is hydroxylated at C7 and C16 to 7α-, 7β- and 16α- and 16β-hydroxyderivatives. A part of the antiglucocorticoid function of DHEA has been described to its 7-oxygenated metabolites, namely to 7α-hydroxy-DHEA. Due its anti-glucocoticoid action it is also considered a factor in fat deposition processes. Thus, we...
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ea0037ep110 | Steroids, development and paediatric endocrinology | ECE2015

Aetiologies of thick stalks pituitaries: about 24 observations

Haddam Ali El Mahdi , Fedala Nora Soumeya , Ali Leyla Ahmed , Meskine Djamila , Chentli Farida

Introduction: The inflammatoirs background processes, and infiltrating tumour of the pituitary stalk are rare. They are a heterogeneous group of lesions responsible of partial or global hypopituitarism.Aim: Search for thickening of the pituitary stalk aetiologies and specify the clinical aspects.Population methodology: This is a retrospective study of 24 patients with thickening of the pituitary stalk. All patients benefited from a...
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ea0037ep111 | Steroids, development and paediatric endocrinology | ECE2015

The beast behind the dwarf

Rimbu Cosmina , Damian Lisandra , Leustean Letitia , Miron Ingrith , Florescu Alexandru , Vulpoi Carmen , Ungureanu Maria Christina

Abnormalities of growth are one of the most common reasons for the paediatric–endocrinology consults. It’s an obvious manifestation with countless possible causes behind, and sometimes we can have unexpected diagnosis.Case presentation: we investigated the case of a 4 years old girl, born at term, naturally, SGA: birth weight=1950 g, who presented in the Endocrinology Department for short stature. Clinical evaluation: 89.5 cm (−4 DS), 11 ...
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ea0037ep112 | Steroids, development and paediatric endocrinology | ECE2015

Final size of turner patients: about 40 patients

Siyoucef Hafsa , Haddam Ali El Mahdi , Fedala Nora Soumeya , Meskine Djamila , Chentli Farida

Introduction: The growth failure constant in turner syndrome is responsible for a spontaneous reduction in adult height with an average of 143 cm. Treatment with growth hormone has enhanced the stature prognosis.Aim: Studying the final size of turner patients who have completed their growth.Population, methodology: 40 patients became adult patients were assessed on linear growth. The following factors were studied: The age and size...
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ea0037ep113 | Steroids, development and paediatric endocrinology | ECE2015

Sarcopenia, more that dehydration, may be associate to underweight Portuguese centenarians

Silva Alda Pereira da , Matos Andreia , Valente Ana , Gil Angela , Alonso Isanete , Ribeiro Ricardo , Clara Gorjao , Bicho Manuel

Introduction: Fat-free mass has a functional significance in aging. The objective of this study was to evaluate the prevalence of underweight in a Portuguese population of centenarians and their relationship with dehydration or sarcopenia.Methods/design: Anthropometric data were obtained using standard procedures from 252 centenarians (100.26±1.99 years), 77.8% women (W). Body composition was assessed by tetrapolar bioimpedance. It was considered de...
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ea0037ep114 | Steroids, development and paediatric endocrinology | ECE2015

Salt and puberty: self-regulated salt intake and the effect of salt on puberty

Pitynski Dori , Flynn Francis , Skinner Donal

The onset of puberty is changing in western countries. Puberty is the activation of the reproductive system, and is initiated by a complex series of events that are not fully understood. BMI has been linked to the advancement of puberty, but is unlikely to be the whole story as girls with a normal BMI are also advancing through puberty earlier. It is well known that western diets are high in calories, but the high salt content in these diets has been overlooked as a potential ...
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ea0037ep115 | Steroids, development and paediatric endocrinology | ECE2015

Exploring the psychosocial impact of congenital adrenal hyperplasia on children and their parents

Simpson Amy , Hunter Amy

Congenital adrenal hyperplasia (CAH) is a genetic condition associated with a deficiency in cortisol and an overproduction of androgens, requiring life-long, daily medication. Little is known about the psychosocial impact of living with and treating CAH, particularly for the parents of young patients. The study was conducted by Genetic Alliance UK as part of the European Commission funded Treatment of Adrenal Insufficiency in Neonates (TAIN) Project, which aims to develop a ne...
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ea0037ep116 | Steroids, development and paediatric endocrinology | ECE2015

Biochemical and molecular modelling analyses explain the functional loss of HSD17B3 mutant G133R in three Tunisian patients

Engeli Roger , Rhouma Bochra Ben , Sager Christoph R , Fakhfakh Faiza , Keskes Leila , Vedani Angelo , Belguith Neila , Odermatt Alex

17β-Hydroxysteroid dehydrogenase type 3 (encoded by HSD17B3) catalyses the conversion of Δ4-androstene-3.17-dione to testosterone and has a key role in male sexual development. Mutations in the HSD17B3 gene can result in reduced enzyme activity and decreased testosterone synthesis, leading to a rare autosomal recessive aetiology of 46, XY Disorders of Sex Development (46, XY DSD) named 17β-HSD3 deficiency. Here, we characterised three Tunisian ...
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ea0037ep117 | Steroids, development and paediatric endocrinology | ECE2015

Search for DHEASism and DHEASoma

Kurakovas Tomas , Banisauskaite Ilona , Zilaitiene Birute , Ostrauskas Rytas , Urbanavicius Vaidotas , Matulevicius Valentinas , Bilodid Irina

Recently we described clinical case of 38-year-old fertile woman with sudden onset of a multiple clinical symptoms: weight gain, secondary amenorrhea, hirsutism and seizures. Adrenal tumour co-secreted high amounts of DHEA sulfate, testosterone (T) and aldosterone (A) (Matulevicius et al. 2014). The symptoms of the disease disappeared after laparoscopic removal of adrenal tumour, which proved to be an adrenocortical oncocytoma. A hypersecretion of A remained after res...
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ea0037ep118 | Steroids, development and paediatric endocrinology | ECE2015

Psychological problems in children with diabetes mellitus type 1

Solntsava Anzhalika , Zagrebaeva Olga , Peskavaya Nadeya , Kozel Viktoryia , Mikhno Hanna

Objectives: The prevalence of diabetes mellitus type 1 (DM 1) had increased nowadays in children in Belarus. Psychological problems are one of side-effects of the disease.Aim: To determine the presence of psychological problems in children with DM 1.Methods: We examined 45 children (boys – 23, girls – 22) age 14.4±0.8 years, with DM 1 in University hospital (Minsk) in 2014–2015 years. All children underwent psyc...
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ea0037ep119 | Steroids, development and paediatric endocrinology | ECE2015

Influence of food on daily profiles of steroids

Duskova Michaela , Racz Beata , Sramkova Monika , Hill Martin , Starka Luboslav

Introduction: Whereas the daily profiles of the main steroid hormones are well known, minor differences in the course of their levels related to defined and standardised food intake were studied rarely.Methods: Eight women (mean age 29.48±2.99 years, mean BMI 21.3±1.3 kg/m2) in follicular phase of menstrual cycle were examined. The levels of C-peptide, glucose, LH, FSH, SHBG, cortisol, testosterone, dihydrotestosterone, progesterone,...
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ea0037ep120 | Steroids, development and paediatric endocrinology | ECE2015

Six-month interim safety and efficacy of different dose levels of transCon hGH administered once weekly versus standard daily human growth hormone replacement therapy in pre-pubertal children with growth hormone deficiency (GHD)

Chatelain Pierre , Malievsky Oleg , Radziuk Klaudziya , Elsedfy Heba Hassan , Mikhailova Evgenia , Beckert Michael

Background: TransCon hGH is a long-acting prodrug of recombinant human GH (hGH) that releases into the blood compartment fully active unmodified hGH. TransCon hGH was shown in two Phase 1 studies and a Phase 2 study in AGHD to be safe and well tolerated and inducing an IGF-I pharmacodynamic response within the normal range throughout the dosing period. This interim analysis consists of 25 patients completing all 6 months of treatment.Objectives: The obje...
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ea0037ep121 | Steroids, development and paediatric endocrinology | ECE2015

Analysis of androgen profile in teenage girls and young women with acne of various severity

Sowinska-Przepiera Elzbieta , Andrysiak-Mamos Elzbieta , Walkowiak Aleksandra , Niedzielska Mirela , Jarzabek-Bielecka Grazyna , Kedzia Witold , Syrenicz Anhelli

Introduction: Acne is the most commonly diagnosed skin condition in teenage girls and young women. Acne results from androgen excess or hypersensitivity of the skin to normal androgen levels. Therefore, determination of androgen concentrations in patients with acne may facilitate early implementation of appropriate treatment. The aim of the study was to retrospectively analyse the profiles of androgen concentration in female patients with acne of various severity.<p class=...
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ea0037ep122 | Steroids, development and paediatric endocrinology | ECE2015

The NCEP ATP III criteria may overestimate the diagnosis of metabolic syndrome in obese and overweight adolescents

Sav Hasan , Mousa Umut , Koseoglulari Osman , Bundak Ruveyde

Introduction: The diagnosis of the metabolic syndrome is less definite in children and adolescents compared to adults. The International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment III guidelines (NCEP ATP III) have proposed two different criteria for its diagnosis in these age groups. In this study we planned to compare these two criterias in detecting the metabolic syndrome in obese and overweight adolescents in a study group in North...
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ea0037ep123 | Steroids, development and paediatric endocrinology | ECE2015

Is there a link between lipid profile and thyroid function modification during somatropinum treatment for GH deficiency in children?

Stejereanu Lavinia , Cima Luminita , Albu Alice , Barbu Carmen , Fica Simona

Background: Previous studies suggested that treatment with somatropinum in children with GH deficiency (GHD) may alter lipid profile and pituitary–thyroid axis function. However, results are divergent and data regarding a possible association between changes of thyroid function and of circulating lipids are scarce. The aim of this study was to report the changes of the lipid profile in children with GHD treated with somatropinum and the relationship between thyroid functi...
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ea0037ep124 | Steroids, development and paediatric endocrinology | ECE2015

Haploinsufficiency of the SHOX gene associated with mosaicism 45,X/46,XY with chromosome Y ring as causes of delayed growth and puberty

Martins Diana , Baptista Carla , Bastos Margarida , Garabal Ana , Sa Joaquim , Moreno Carolina , Guelho Daniela , Vicente Nuno , Cardoso Luis , Balsa Margarida , Oliveira Diana , Carrilho Francisco

Introduction: The height growth is regulated by multiple factors, including specific genetic mutations that ensure correct differentiation and proliferation of chondrocytes. We present a case of double association of haploinsufficiency of the SHOX gene with a mosaic 45,X/46,X,r(Y) karyotype responsible for growth and pubertal delay.Case: Male patient, observed in endocrinology consultation at age of 12, with constitutional delay of grow...
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ea0037ep125 | Steroids, development and paediatric endocrinology | ECE2015

Endocrine and metabolic profiles in adults with Prader–Willi syndrome

Bogdanet Delia , Pazderska Agnieszka , Sherlock Mark , Gibney James

Introduction: Prader–Willi syndrome (PWS) is a genetic syndrome usually diagnosed in childhood. Its reported prevalence ranges from one in 8000 to one in 45 000 with geographical variation. Clinical manifestations include obesity, hyperphagia, short stature, incomplete sexual development, and cognitive disabilities. The majority of published data regarding PWS comes from paediatric populations.Materials and methods: This is a retrospective observati...
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ea0037ep126 | Steroids, development and paediatric endocrinology | ECE2015

Diagnostic value of amino-terminal peptide of type I procollagen when retesting GH deficiency in the transition period

Costache-Outas Mariana , Procopiuc Camelia , Caragheorgheopol Andra , Costache Raluca , Fica Simona

N-terminal peptide of type I procollagen (P1NP) is a marker of GH (hGH) anabolic action on bone formation. We evaluated the diagnostic value of P1NP in GH deficiency (GHD) in the transition period using receiver operating characteristic (ROC) plot analysis. We compared the diagnostic value of P1NP with IGF1. 16 male patients (chronological age, 16.6–21.5) with GH replacement therapy during childhood (ten IGHD and six MPHD) were evaluated at minimum 3 months after completi...
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ea0037ep127 | Steroids, development and paediatric endocrinology | ECE2015

Precocious puberty in the obese child as a diagnostic challenge

Matusik Pawel , Prokopowicz Zofia , Malecka-Tendera Ewa

The aim of this study was to evaluate whether the coexistence of obesity in children with precocious puberty symptoms influences significantly the diagnostic process.Material and methods: We retrospectively analysed a group of 200 children’s records (F/M 164/36) hospitalised because of precocious puberty suspicion. The analysis evaluated the nutritional status based on BMI percentile level, compatibility between the bone age and the chronological ag...
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ea0037ep128 | Steroids, development and paediatric endocrinology | ECE2015

Is thyroid function related to masked hypertension?

Ates Ihsan , Altay Mustafa , Kaplan Mustafa , Ozkayar Nihal , Alaguney Erdem , Ozkayar Adem

Background: Thyroid hormones affect almost all the tissues of the body and their cardiovascular effects are very significant. The relationship between masked hypertension (MHT) and thyroid hormones is not known. Therefore, we sought to investigate any relationship between patients with MHT, newly diagnosed by home blood pressure monitoring, and thyroid hormones.Methods: Patients older than 18 years of age without a previous diagnosis of hypertension and ...
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ea0037ep129 | Steroids, development and paediatric endocrinology | ECE2015

Effect of metformin on sex steroid levels in postmenopausal type 2 diabetic patients

Unluturk Ugur , Bakar Filiz , Urun Yuksel , Nebioglu Serpil , Uysal Ali Riza

Introduction: Metformin treatment was associated with decreased risk of various cancers including breast cancer. Exposure to sex steroid is related with increased risk of breast cancer. In this study, we aimed to evaluate the effect of metformin treatment on serum levels of sex steroids and sex hormone binding globulin (SHBG) in postmenopausal women with type 2 diabetes mellitus.Methods: Postmenopausal patients with newly diagnosed type 2 diabetes were r...
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ea0037ep130 | Steroids, development and paediatric endocrinology | ECE2015

Serum prolactin levels in transgender persons before and during cross-sex hormonal treatment

Nota Nienke , Klaver Maartje , den Heijer Martin , Dekker Marieke , Heijboer Annemieke

Introduction: Gender dysphoria refers to the incongruence between the subject’s experienced sex on the one hand and the assigned sex on the other hand. Several studies assume a relationship between oestrogen substitution therapy and serum prolactin levels.Aim: The aim of this study is to get more insight into the effect and time-course of changes in serum prolactin levels during cross-sex hormone therapy.Methods: This prospect...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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