Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2015) 37 EP201 | DOI: 10.1530/endoabs.37.EP201

ECE2015 Eposter Presentations Reproduction, endocrine disruptors and signalling (92 abstracts)

Association of rs1800790 in fibrinogen beta polypeptide chain gene (FGB) with endometrium in Iranian women

Zohreh Omidi 1 & Ahmad Ebrahimi 2

1Department of Medical Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; 2Cellular and Molecular Research Center, Obesity Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Endometriosis is a common disease in women and considered as one of the most important reasons infertility, and it means abnormal growth of the endometrial tissue outside of the uterine. The exact prevalence of endometriosis disease is unknown. estimated that the endometriosis exists in 10% of women in productivity. Possibly, several genes interacting with each other as well as environment to result endometriosis. Given that one of the cellular pathways involved in endometriosis coagulation is since beta fibrinogen level rise increases the fibrin and it is an increasing cause of venous thrombosis? association of this gene and gene polymorphism FGB-455 (rs-1800790) was examined in Iranian women.

Materials and methods: After isolation of genomic DNA from the blood lymphocytes, assessing of this polymorphism was conducted by using TETRA ARMs–PCR method in 100 endometriosis patients and 100 control individuals.

Results: FGB gene polymorphism genotype frequencies were compared in the patients and control individuals. Abundance of AA, AG, and GG genotypes of the gene polymorphism FGB were 28, 48, and 24% in patients respectively, and 66, 31, and 3% in control group respectively. Results showed that there is meaningful relation between patients and control group (P=4.619×10−11).

Conclusion: Our findings showed that there was significant relationship between FGB gene polymorphism and increased risk of endometriosis in women studied. Therefore can be a determining predictive molecular biomarker identification faster and better treatment of endometriosis should be used.

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