Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

Published by BioScientifica
Previous issue | Volume 37 | ECE2015 | Next issue

17th European Congress of Endocrinology

Eposter Presentations

Thyroid (non-cancer)

Previous section
Thyroid cancer
Table of contents
Next section
Endocrine tumours

ea0037ep923 | Thyroid (non-cancer) | ECE2015

Histopathological results of suspicious nodules in the patients with Hashimoto thyroiditis

Ozmen Sevilay , Calik Ilknur , Can Yusuf , Timur Ozge , Carlioglu Ayse , Sevimli Hakan , Durmaz Senay Arikan , Kabalar Esref , Cadirci Kenan

Introduction and aim: The most endocrinologists in routine practice are used to Bethesda classification for evaluation of thyroid nodule in fine needle aspiration biopsy (FNA). It is accepted that FNA biopsy is an accurate diagnostic and gold standard test. However, false-positive diagnosis may sometimes occur as a patient with a ‘malign’ lesion is found incorrectly rather than an actually benign lesion on histological examination. Hashimoto’s thyroiditis probab...
shares

ea0037ep924 | Thyroid (non-cancer) | ECE2015

The evaluation of demographic features and histopathological results in patients with reoperative thyroid surgery

Cuhaci Fatma Neslihan , Baser Husniye , Aydin Cevdet , Yazgan Aylin Kilic , Turkolmez Seyda , Kilic Mehmet , Ersoy Reyhan , Cakir Bekir

Introduction: Reoperative surgery for thyroid disease is rare. It is sometimes indicated for nodular recurrence after partial surgery for initially benign thyroid disease or for a completion total thyroidectomy when a final diagnosis of thyroid cancer is confirmed on a permanent section of a partially removed thyroid gland. We aimed to investigate the demographic features and reoperation indications in patients with reoperative thyroidectomy.Methods: Thi...
shares

ea0037ep925 | Thyroid (non-cancer) | ECE2015

A case of primary hypothyroidism initially presenting with massive pericardial effusion

Apaydin Mahmut , Beysel Selvihan , Demirci Taner , Cakal Erman , Delibasi Tuncay

Introduction: Although pericardial effusion is a common finding in primary hypothyroidism, massive pericardial effusion or pericardial tamponade are rare. Herein, we describe a newly diagnosed case of primary hypothyroidism initially presenting with massive pericardial effusion.Case report: A 64 years old male patient attended to the emergency unit with worsening dyspnea over the past 1 month. ECG showed a low voltage QRS wave. Chest X-ray showed increas...
shares

ea0037ep926 | Thyroid (non-cancer) | ECE2015

Usefulness of Body Adiposity Index % in comparison to body composition analyser parameters among patients with and without autoimmune thyroid diseases hospitalised on Endocrinology Department-preliminary report

Koszowska Aneta , Nowak Justyna , Puzon Anna Bronczyk , Kupka Karolina Kulik , Dittfeld Anna , Szkodzinska Barbara Zubelewicz

Introduction: Anthropometric parameters such like BMI aren’t suitable enough for each type of figure and leads to misinformation about body composition. Body Adiposity Index (BAI) is suggested as an alternative for BMI.Aim: The aim of the study was to compare the usefulness of BAI in context to body composition parameters.Materials and methods: The BAI index was calculated for 86 patients according to previously described form...
shares

ea0037ep927 | Thyroid (non-cancer) | ECE2015

Health-related quality of life is reduced in treated primary hypothyroidism and with lower fT3/fT4-ratio

van Loon Hannah C M , Wouters Hanneke J C M , Kobold Anneke Muller , Slagter Sandra N , Links Thera P , van der Klauw Melanie M , Wolffenbuttel Bruce H R

Introduction: Despite adequate treatment with LT4 monotherapy, many patients with primary hypothyroidism still report complaints, as this treatment can not exactly imitate the endogenous homeostasis. We examined whether the different domains of HR-QOL were affected by the existence of a thyroid disorder and use of LT4 substitution, and whether a lower ratio of free triiodothyronine (fT3)–free thyroxine (fT4)</sup...
shares

ea0037ep928 | Thyroid (non-cancer) | ECE2015

Assessment of vitamin D (25-OH vitamin D3) concentration among patients with and without autoimmune thyroid diseases hospitalised on Endocrinology Department-preliminary report

Koszowska Aneta , Nowak Justyna , Puzon Anna Bronczyk , Dittfeld Anna , Kupka Karolina Kulik , Kulpok Agata , Szkodzinska Barbara Zubelewicz

Introduction: Vitamin D is important for proper functioning of all body tissues. Receptors for vitamin D are also presence in thyroid gland. It’s open questions how this vitamin could modulate the thyroid function.Aim: The aim of the study was assess the concentrations of vitamin D as well as antiTPO level among patients with thyroid dysfunction hospitalised on Endocrinology Department.Materials and methods: The study was cond...
shares

ea0037ep929 | Thyroid (non-cancer) | ECE2015

Renal involvement in Graves' disease patients treated with Benzylthiouracyl

Oueslati Ibtissem , Melki Amel , Kaaroud Hayet , Nacef Ibtissem Ben , Mchirgui Nadia , Khiari Karima , Abdallah Nejib Ben

Introduction: Renal complications in Graves’ disease are rare and may be related either to the disease itself or secondary to antithyroid drugs.Methods: We report seven cases of renal damage in patients with Graves’ disease treated with Benzylthiouracyl collected over a period of 14 years.Results: There were seven women with a mean age of 37.86±14.25 years (19–61 years).Six patients develo...
shares

ea0037ep930 | Thyroid (non-cancer) | ECE2015

Indications and outcomes of repeated thyroid fine-needle aspirations: a retrospective evaluation from a tertiary centre

Firat Sevde Nur , Iyidir Ozlem Turhan , Isildak Mehlika , Anil Cuneyd , Gursoy Nazli Kirnap , Nar Asli , Tutuncu Neslihan Bascil

Introduction: Fine needle aspiration (FNA) is the first-line diagnostic test for evaluating thyroid nodules. This test can effectively distinguish between neoplastic and non neoplastic nodules. The Bethesda System suggest that thyroid nodules with non diagnostic (ND), atypia/follicular lesions of undetermined significance (A/FLUS) aspiration should undergo repeat sampling. We aimed to investigate the clinical validity of repeated FNA in the management of patients with thyroid ...
shares

ea0037ep931 | Thyroid (non-cancer) | ECE2015

The efficacy of radioiodine therapy in patients with non-toxic nodular goitre with large cold nodule

Abdelrazek Saeid , Szumowski Piotr , Siewko Katrzyna , Mysliwiec Janusz , Szelachowska Malgorzata , Garkowski Marcin

Most of the patients with the benign cold nodule refuse surgical operation. Radioiodine therapy (RIT) is the choice for these patients. The aim of our study was to evaluate the efficacy of radioiodine therapy to reduce thyroid volume in patients with cold nodule by the use of two doses of radioiodine.Methods: We treated 40 patients with non-toxic nodular goitre with large cold nodule, aged 18 and 48 years; initial 24 h radioiodine uptake (RAIU) was range...
shares

ea0037ep932 | Thyroid (non-cancer) | ECE2015

Fibromyalgia in patients with euthyroid Hashimoto's thyroiditis

Bilge Muge , Adas Mine , Yanmaz Muyesser Nergiz , Helvaci Aysen

Introduction: The aims of this study are to evaluate fibromyalgia (FM) in patients with euthyroid Hashimoto’s throiditis (HT) and whether antithyroperoxidase antibody (TPOAb) positivity is associated with the FM.Methods: We have studied 167 patients with HT and 83 healthy controls followed in our hospital. Single researcher took the history and did physical examination including manual tender point examination according to Manuel Tender Point Survey...
shares

ea0037ep933 | Thyroid (non-cancer) | ECE2015

False positive post RAI scan in a subject with papillary thyroid cancer secondary to urine contamination

Aydin Sebnem , Ozmen Nafiye Direktor , Mousa Umut , Koseoglulari Osman , Sav Hasan

Introduction: Radioactive iodine (RAI) for remnant ablation and post RAI scanning are very frequently employed modalities in differentiated thyroid cancers (DTC). Radioactive iodine is secreted into physiological secretions such as tears and urine. In this case report we present a case who received RAI for DTC with a surprising post RAI scan compatible with multiple metastases.Case report: A 53-year-old male subject underwent total thyroidectomy and ipsi...
shares

ea0037ep934 | Thyroid (non-cancer) | ECE2015

Smoking associated with TSH receptor antibody and serum IL17A elevation in hyperthyroid Graves' disease

Molnar Ildiko , Bohaty Ilona , Somogyine-Vari Eva

Th17 cells represent newly discovered CD4+T cells producing predominantly IL17A cytokines, which are involved in inflammations and autoimmune diseases. Elevated IL17 levels were demonstrated in thyroid autoimmunity and the activity of Graves’ ophthalmopathy. The relationship among IL17A, anti-thyroid antibodies, smoking, and clinical activity score of ophthalmopathy was investigated in hyperthyroid Graves’ disease. One hundred and thirty-eight patients, 62 with Grave...
shares

ea0037ep935 | Thyroid (non-cancer) | ECE2015

Evaluation of acoustic voice analysis in patients with subclinical thyrotoxicosis

Demirci Taner , Uyar Mehmet , Catalli Emel Tatar , Caliskan Mustafa , Ucan Bekir , Demiral Dilek , Arslan Muyesser Sayki , Ozbek Mustafa , Korkmaz Mehmet Hakan , Delibasi Tuncay

Introduction: The relationship between hyperthyroidism and voice disorders has not been identified before. The aim of this study was to investigate the changes in the acoustic values in patients with subclinical thyrotoxicosis.Methods: In this study, acoustic voice analysis was evaluated in a total of 115 cases. Sixty of 115 individuals (18 men and 42 women) had subclinical thyrotoxicosis, aged between 18 and 65 years, and all had no history of laryngeal...
shares

ea0037ep936 | Thyroid (non-cancer) | ECE2015

Transient pulmonary hypertension in patients with Graves' disease

Marmouch Hela , Boubaker Fadia , Arfa Sondes , Slim Tansim , Sayadi Hanene , Jmal Manel , Khochtali Ines

Introduction: Hyperthyroidism produce changes in cardiac contractility, blood pressure, and systemic or pulmonary vascular resistance. In almost all cases these cardiovascular changes are reversible when the underlying thyroid disorder is recognised and treated. Pulmonary hypertension (PAH) has been associated with thyroid dysfunction, but primarily with hyperthyroidism. The vast majority of patients with this form of PAH are usually older with toxic multinodular goitre. The a...
shares

ea0037ep937 | Thyroid (non-cancer) | ECE2015

Side effects of steroid therapy in Graves' orbitopathy: comparison of two different protocols: parenteral vs combined parenteral and oral

Beleslin Biljana , Ciric Jasmina , Stojkovic Mirjana , Savic Slavica , Ciric Slavica , Lalic Tijana , Nisic Tanja , Stojanovic Milos , Zarkovic Milos

Introduction: Glucocorticoids (GCs) are the treatment of choice for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still undefined as serious side effects are great concern of GC therapy. The aim of the present study was to evaluate tolerability and safety of two different treatment protocols.Methods: Consecutive patients were divided according to the protocol of GC therapy into two groups: combined intravenous and ...
shares

ea0037ep938 | Thyroid (non-cancer) | ECE2015

Isolated cutaneous findings of systemic lupus erythematosus due to propylthiouracil

Erfan Gamze , Tasolar Kaan , Oznur Meltem , Yilmaz Murat

Propylthiouracil (PTU), used to treat thyroid dysfunctions such as Graves’ disease, rarely induces lupus-like syndrome. A 52-year-old woman developed dermatological findings of systemic lupus erythematosus with malar rash, photosensitivity and discoid lupus erythematosus-like lesions, after 3 weeks of exposure to the drug. ANA and anti-dsDNA were positive. Skin biopsy of face revealed vacuolar changes in basal layer and lymphoid infiltration in perivascular region of derm...
shares

ea0037ep939 | Thyroid (non-cancer) | ECE2015

Seasonality in paediatric Graves' disease compared to the general population: impact of month of birth: a national study

da Silva Tiago Nunes , Pereira Bernardo Dias , Luiz Henrique Vara , Matos Ana Catarina , Cordeiro Maria Carlos , Raimundo Luisa , Portugal Jorge

Paediatric Graves’ disease (PGD) is an uncommon autoimmune disorder with a multifactorial origin. Although, in some autoimmune endocrinophaties the seasonality of month of birth (MOB) distribution differed from the general population, this association has not been study in PGD. The aim of this work was to analyse the impact of seasonality of MOB on PGD incidence in Portugal.In 2013, the Portuguese Paediatric Society of Diabetes and Endocrinology und...
shares

ea0037ep940 | Thyroid (non-cancer) | ECE2015

Late onset of amiodarone-induced thyrotoxicosis causing pharmacoresistant atrial fibrillation with subsequent development of serious heart failure

Nyvltova Monika , Drbalova Karolina , Jarkovsky Patrik , Vodak Miroslav , Krejci Petr , Zavoral Miroslav

Amiodarone is a potent and among cardiologists still very popular anti-arrhythmic drug. This case report describes severe course of amiodarone-induced thyrotoxicosis (AIT) which is one of the most serious side effects of the treatment. The patient (J S born in 1950) was first hospitalised in June 2012 for atrial fibrillation with rapid ventricular response and tachycardia-induced cardiomyopathy with a decreased ejection fraction (EF). Thyroid hormones were normal at that time ...
shares

ea0037ep941 | Thyroid (non-cancer) | ECE2015

Ultrasonography-guided fine-needle aspiration biopsies of thyroid nodules: single-centre experience

Susuz Salim , Kebapci Nur , Kasapoglu Emine Dundar , Kebapci Mahmut , Cevikalp Ozge , Efe Belgin , Akalin Aysen

In the present study, we aimed to investigate the efficiency of ultrasound-guided fine-needle aspiration biopsy in our clinic. Totally, 701 patients followed at Department of Endocrinology, Faculty of Medicine, Eskisehir Osmangazi University with nodular thyroid disorder were included in this study during January 2000 and January 2011. Ultrasound-guided thyroid fine-needle aspiration biopsy was performed in these 701 cases at Interventional Radiology Department. Throid nodules...
shares

ea0037ep942 | Thyroid (non-cancer) | ECE2015

The evaluation of TSH-receptor antibody in hyperthyroid patients treated with surgery or radioactive iodine

Dirikoc Ahmet , Cuhaci Fatma Neslihan , Baser Husniye , Aydin Cevdet , Topaloglu Oya , Kilic Mehmet , Turkolmez Seyda , Ersoy Reyhan , Cakir Bekir

Introduction: Radioactive iodine (RAI) therapy is widely used in the treatment of hyperthyroidism especially in patients with Graves’ disease (GD), toxic multinodular goitre (TMNG), and toxic adenoma. RAI may lead to worsening of the autoimmunity with the elevation of TSH-receptor antibody (TRAB). In this study, we aimed to compare the effects of surgery or RAI treatment on TRAB.Methods: Hyperthyroid patients were divided into three groups; patients...
shares

ea0037ep943 | Thyroid (non-cancer) | ECE2015

Dynamic thiol/disulfide homeostasis in patients with autoimmune subclinical hypothyroidism

Ates Ihsan , Altay Mustafa , Yilmaz Fatma Meric , Topcuoglu Canan , Neselioglu Salim , Erel Ozcan , Yilmaz Nisbet

Objective: To investigate dynamic thiol/disulphide homeostasis in autoimmune subclinical hypothyroidism.Materials and methods: 48 patients with newly diagnosed subclinical hypothyroidism due to Hashimoto’s thyroiditis and not yet on any treatment and 48 healthy subjects without any known disease were enrolled. Thiol/disulfide homeostasis (native thiol(-SH)–disulphide(-S-S-) exchanges) was measured in both groups with new method developed by Ere...
shares

ea0037ep944 | Thyroid (non-cancer) | ECE2015

Is oxidative stress an effective risk factor in the development of overt hypothyroidism in Hashimoto's thyroiditis?

Ates Ihsan , Altay Mustafa , Yilmaz Fatma Meric , Topcuoglu Canan , Yilmaz Nisbet , Guler Serdar

Objective: We aimed to investigate the effects of oxidative stress in the pathhogenesis and progression of thyroiditis in patients with Hashimoto’s thyroiditis whose aetiopathogenesis includes environmental and genetic factors.Methods: 80 patients (40 euthyroid and 40 subclinical hypothyroidism) older than 18 years with newly diagnosed Hashimoto’s thyroiditis and not yet on any treatment were enrolled. Patients were followed up for 9 months. Bl...
shares

ea0037ep945 | Thyroid (non-cancer) | ECE2015

Does treatment with levothyroxine sodium decrease oxidative stress in Hashimoto's thyroiditis?

Ates Ihsan , Altay Mustafa , Yilmaz Fatma Meric , Yilmaz Nisbet , Guler Serdar

Background: In Hashimoto’s thyroiditis, chronic inflammation and autoimmunity increases oxidant radicals and cause oxidative stress. However, the effect of levothyroxine therapy on the oxidant and antioxidant systems is not known in overt hypothyroidism. Therefore, we sought to investigate the effect of levothyroxine sodium therapy on oxidative stress in patients with Hashimoto thyroiditis and overt hypothyroidism.Materials and methods: 36 patients ...
shares

ea0037ep946 | Thyroid (non-cancer) | ECE2015

Concomitant Graves' disease and primary hyperparathyroidism: case report

Cosar Ramazan , Sari Isilay Kalan , Durmaz Senay Arikan

Introduction: Hyperthyroidism is associated with asymptomatic hypercalcaemia due to increased calcium mobilization from bone and catecholamine metabolism. Hypercalcaemia secondary to hyperthyroidism coexist with decreased or normal parathyroid hormone level. We reported case of 30-year-old man who suffered from Graves’ disease and primary hyperparathyroidism.Case report: A 30-year-old male patient was admitted to our hospital suffered from palpitati...
shares

ea0037ep947 | Thyroid (non-cancer) | ECE2015

Measurement of epicardial adipose tissue (EAT) thickness in subclinical hypothyroid patients and to determine the relationship between EAT and abdominal/visceral fat mass

Arpaci Dilek , Tocoglu Aysel Gurkan , Yilmaz Sabiye , Korkmaz Sumeyye , Ergenc Hasan , Gunduz Huseyin , Keser Nurgul , Tamer Ali

Background: Subclinical hypothyroidism (SH) is defined as high TSH accompanied with normal free thyroxine (FT4). SH has found to be associated with cardiovascular disease (CVD) and increased mortality. Epicardial adipose tissue (EAT) is now considered to be a new noninvasive measurement method used for the early detection of CVD susceptibility. EAT has vasocrine and paracrine actions which lead to CVD. We aimed to evaluate measurement of EAT and to detect relationsh...
shares

ea0037ep948 | Thyroid (non-cancer) | ECE2015

High circulating levels of SICAM-1 and SVCAM-1 in patients with Hashimoto's thyroiditis

Ozderya Aysenur , Aydin Kadriye , Temizkan Sule , Abbasoglu Semra Dogru , Vural Pervin , Altuntas Yuksel

Objective: Elevated levels of the soluble adhesion molecules, sICAM-1 and sVCAM-1 reflect chronic inflammatory state. Increased levels of sICAM-1 and sVCAM-1 were demonstrated in various autoimmune thyroid diseases with abnormal thyroid function, but their clinical significance is undefined, especially in the euthyroid patients with Hashimoto’s thyroiditis (HT). Increased levels of soluble adhesion molecules are also associated with components of the metabolic syndrome li...
shares

ea0037ep949 | Thyroid (non-cancer) | ECE2015

Elevated neutrophil/lymphocyte ratio in patients receiving any replacement therapy with euthyroid Hashimoto

Keskin Havva , Kaya Yasemin , Cadirci Kenan , Kucur Cuneyt , Ziypak Elif , Simsek Eda , Gozcu Hakan , Arikan Senay , Carlioglu Ayse

Introduction: Neutrophil lymphocyte rate (NLO), which is obtained from peripheric blood and used as mathematical rates of lymphocyte numbers, is accepted as available and practical indicator of systemic inflammation existence. We aimed to search NLO between Hashimoto’s thyroids patients who have autoimmune thyroid and also include an aetiopathogenesis auto-inflammatory process, and healthy control group with this study.Method: 59 patients who have b...
shares

ea0037ep950 | Thyroid (non-cancer) | ECE2015

Radioiodine treatment of Graves' disease: dose–response analysis

Cepkova Jitka , Svilias Ioannis , Krcalova Eva , Horacek Jiri

Introduction: Despite more than 60 years’ experience with radioactive iodine 131I (RAI) treatment of Graves’ disease (GD) about the most appropriate dosing regime is still controversial. The objective of our research was to analyse the outcome of RAI therapy in our cohort of patients.Methods: Retrospectively, we analysed 603 patients with GD (500 women and 103 men, mean age 51.5±12.7 years) treated with RAI. According to recomme...
shares

ea0037ep951 | Thyroid (non-cancer) | ECE2015

Serum H-FABP levels in patients with overt hypothyroidism

Tutal Esra , Ozbek Mustafa , Arslan Muyesser Sayki , Topaloglu Oya , Demirci Taner , Karakose Melia , Caliskan Mustafa , Unsal Ilknur Ozturk , Gungunes Askin , Cakir Evrim , Ucan Bekir , Bozkurt Nujen Colak , Ozturk Gulfer , Sahin Mustafa , Cakal Erman , Delibasi Tuncay

Aim: Overt hypothyroidism affects mostly women with an increased prevalence in individuals by age. Hypothyroidism is associated with accelerated atherosclerotic cardiovascular diseases, possibly caused by the higher incidence of hyperlipidemia, insulin resistance, hypertension which all are associated to hypothyroidism. Heart-type fatty acid binding protein (H-FABP) is specific for cardiomyocytes and a sensitive marker of myocardial injury. The purpose of this study is examini...
shares

ea0037ep952 | Thyroid (non-cancer) | ECE2015

Evaluation of geriatric patients with hyperthyroidism treated with radioactive iodine-131

Elboga Umut , Ozkaya Mesut , Basibuyuk Mustafa , Eraydin Ayten , Celen Y Zeki

Introduction: In this study, we aimed to evaluate radioiodine (RAI) treatment efficacy in geriatric patients with hyperthyroidism.Design: Patients older than 65 years who received RAI treatment were included via retrospective data analyses. Eighty-two patients with hyperthyroidism (average age: 69.9 years, age range: 64–81 years) who received RAI treatment and then followed up for at least 6 months were included in the study. Patients’ clinical...
shares

ea0037ep953 | Thyroid (non-cancer) | ECE2015

Safety and efficacy of rapid thyroid blockade with Lugol's iodine in the pre-surgical management of Graves' thyrotoxicosis

Mohammed Azmi , Elsaify W , Mukhtar Rasha , Nag Sath

Introduction: A significant number of patients are intolerant of anti-thyroid drugs (ATD) and thyroidectomy remains the only treatment option available to patients who decline radioiodine as definitive therapy. As patients with poorly controlled thyrotoxicosis are at risk of developing thyroid storm, optimal pre-operative control of hyperthyroidism is essential. Rapid thyroid blockade (RTB) with the contrast agents sodium ipodate and iopanoic acid were attractive treatment opt...
shares

ea0037ep954 | Thyroid (non-cancer) | ECE2015

Higher titre of TSH receptor antibody was associated with better responsiveness of thyroid hormone to antithyroidal drug in Graves' disease

Choi Hoonsung , Yoo Won Sang

Introduction: Antithyroidal drug (ATD) therapy is considered as choice of treatment for Graves’ disease; however, the response of treatment varied between patients. Although several studies reported risk factors for relapse after initial treatment, there were few studies for the responsiveness during early treatment period.Method and design: We reviewed 94 patients with Graves’ disease and used their initial TSH receptor antibody (TSHRAb) titre...
shares

ea0037ep955 | Thyroid (non-cancer) | ECE2015

Shear-wave elastography in diagnostics of primary hyperparathyroidism – new application of the method

Stangierski Adam , Wolinski Kosma , Szczepanek-Parulska Ewelina , Ruchala Marek

Introduction: Shear wave elastography (SWE) is a reliable, objective and reproducible technique in sonographic assessment of tissue stiffness. It is considered to be an improvement of conventional ultrasonographic examination. It was demonstrated to be useful in the diagnosis of many thyroid disorders, such as thyroid cancer, Hashimoto’s thyroiditis or Graves’ disease. The aim of our study was to check if SWE can be supportive in the diagnosis of primary hyperparathy...
shares

ea0037ep956 | Thyroid (non-cancer) | ECE2015

The role of antithyroglobulin, antiperoxidase and anti-TSH autoantibodies in amiodarone induced thyrotoxicosis or amiodarone induced hypothyroidism (a two-center study)

Czarnywojtek Agata , Zgorzalewicz-Stachowiak Malgorzata , Fichna Marta , Wolinski Kosma , Plazinska Maria Teresa , Stangierski Adam , Gut Pawel , Miechowicz Izabela , Komarowska Hanna , Czepczynski Rafal , Krolicki Leszek , Ruchala Marek

Purpose: In the recent study it has been reported, that elevated serum concentrations of TSH receptor (TSH-R), antithyroglobulin (Tg), antiperoxidase (TPO) autoantbodies (Abs) may be observed in the subjects treated for amiodarone induced thyrotixicosis (AIT) type I, decreased in type II of AIT, or changed in amiodarone induced hypothyroidism (AIH). This study was done to analyse the changes of Tg-Abs, TPO-Abs and TSH-R-Abs titer in euthyroid, hyperthyroid (AIT), and hypothyro...
shares

ea0037ep957 | Thyroid (non-cancer) | ECE2015

Rho/Rho-kinase gene expressions in Graves' disease and Hashimoto's thyroiditis

Tabur Suzan , Oztuzcu Serdar , Oguz Elif , Ozkaya Mesut , Demiryurek Abdullah Tuncay

Introduction: Autoimmune thyroid diseases result from a dysregulation of the immune system leading to an immune attack on the thyroid. Autoimmune thyroid diseases, which include Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), are characterised by lymphocytic infiltration of the thyroid parenchyma. The mechanisms that trigger the autoimmune attack to the thyroid are not entirely known. The aim of this study was to investigate the possible contribution of Rho/Rh...
shares

ea0037ep958 | Thyroid (non-cancer) | ECE2015

Survey on the steroid dose for patients with subacute thyroiditis in a Korean tertiary hospital

Kim Won Jun , Hong Sangmo , Shim Myoung Sook , Kim Jin Yeob

Introduction: Subacute thyroiditis (SAT) is most common cause of painful thyroiditis. Although prednisolone at 40 mg/d has been preferred as initial dose for moderate to severe SAT, there have also been other recommendations as 25–60 mg/day in many reports. We retrospectively assessed the effect of steroid dose on the SAT.Methods: We examined 132 patients with SAT who visited our endocrinology clinic at least three times between January 2005 and Dec...
shares

ea0037ep959 | Thyroid (non-cancer) | ECE2015

Difficulties in the interpretation of urinary iodine excretion in pregnant women

Szanto Zsuzsanna , Csiszer Attila , Croitorescu Zsuzsanna , Kun Imre Zoltan

Introduction: The urinary iodine excretion (UIE) from fasting morning urine sample is a good epidemiologic indicator for iodine state, used in populational groups (schoolchildren, pregnant women) at risk to develop iodine deficiency disorders. It is not adequate to evaluate individual iodine intake. In pregnant women, especially with chronic autoimmune thyroiditis, it is important to estimate iodine state.Objectives: To evaluate the individual iodine sta...
shares

ea0037ep960 | Thyroid (non-cancer) | ECE2015

Surgical and pathological changes after radiofrequency ablation of thyroid nodules

Dobrinja Chiara , Bernardi Stella , Fabris Bruno , Eramo Rita , Makovac Petra , Bazzocchi Gabriele , Zanconati Fabrizio , Stacul Fulvio

Background: Radiofrequency ablation (RFA) is an effective technique for the treatment of symptomatic benign thyroid nodules. It is not known to what extent RFA may affect thyroid surgery and/or histological diagnosis.Materials and methods: patients were treated with RFA and then followed for 2 years. RFA was performed on 64 symptomatic Thy2 nodules and on six symptomatic Thy3 nodules, without atypical cells nor BRAF or NRAS mutations, in surgically high-...
shares

ea0037ep961 | Thyroid (non-cancer) | ECE2015

Serum total sialic acid levels in overt and subclinical hypothyroid patients and its relationship with atherosclerotic risk factors

Altay Mustafa , Karakoc Mehmet Ayhan , Cakir Nuri , Cerit Etem Turgay , Akturk Mujde , Demirtas Canan Yilmaz , Bukan Neslihan , Arslan Metin

Objective: Serum total sialic acid(SA) concentration is assessed as an up to date risk indicator of atherosclerosis and cardiovascular diseases.Methods: It was aimed to investigate about how SA levels are effected in overt or subclinical hypothyroidism (SH) and how it’s associated with other atherosclerosis risk factors because there is no study about these topics, though SA is intensively studied in recent years.Patients: Six...
shares

ea0037ep962 | Thyroid (non-cancer) | ECE2015

Lifestyle intervention reduces TPO antibody level in euthyroid patients: a retrospective cohort study

Chen Liang , Kuang Jian , Pei Jianhao , Chen Hongmei , Chen Zhong , Li Zhongwen , Yang Huazhang , Fu Xiaoyin , Wang Long , Chen Zhijiang

Objective: To investigate the impact of lifestyle intervention on elevated thyroid peroxidase (TPO) antibody levels in outpatients with normal thyroid function.Methods: A retrospective cohort study was performed to observe and evaluate euthyroid patients with excessive TPO antibodies that presented to the authors’ hospital between March 2013 and October 2014 for routine medical examinations. The subjects were randomly divided into the lifestyle inte...
shares

ea0037ep963 | Thyroid (non-cancer) | ECE2015

Beware Carbimazole induced agranulocytosis in amiodarone induced thyrotoxicosis: recovery with Filgrastim

O'Hare James , Sebatian Alwin , Casserly Liam

Agranuloctosis is a rare and serious complication of Carbimazole. (risk <1/106 of population/year. It is associated with higher doses. We report two cases over 1 year in patients exposed to amiodarone.Case 1: A 63 year old man with ischemic cardiomyopathy had been treated with amiodarone for atrial fibrillation for 3 years. 6 months after stopping he developed symptomatic thyrotoxicosis and started on carbimazole 60 mg per day. Thyroid T<s...
shares

ea0037ep964 | Thyroid (non-cancer) | ECE2015

Elevated TSH (in upper limit of normal) and insulin resistance

Boz Mustafa , Muderrisoglu Cuneyt , Altunoglu Esma , Akbas Feray , Erdenen Fusun , Polat Hayri

Introduction: Level of TSH respond to fluctuations in serum free (FT4) but remain in a very narrow individial range. Thyroid function tests are intrinsically linked to variables of insulin resistance and endothelial function. It is possible that underlying factors lead simultaneously to increased serum TSH, insulin resistance, even within current normal TSH levels.Description of methods and design: We aimed intestigate the patients with upper ...
shares

ea0037ep965 | Thyroid (non-cancer) | ECE2015

Hypothyroidism and platelet parameters evaluation: a preliminary study

Scavuzzo Francesco , Genna Maria Ludovica , Nastri Gianluca , Serino Domenico , Volpe Raffaele

According to the findings of recent epidemiological research, thyroid complaints are among the most frequent endocrine illnesses in Italy. Being positively correlated to MPV, the mean platelet volume, in subjects with hypothyroidism, it has been hypothesised in literature that TSH can have a probable prothrombotic effect. The mean platelet volume (MPV), PCT (plateletcrit), PDV (platelet distribution width) and P-LCR (platelet large scale ratio) indicate the dimensions of plate...
shares

ea0037ep966 | Thyroid (non-cancer) | ECE2015

Decreased ultrasound echogenity as a thyroid hypofunction marker

Dimic Dragan , Golubovic Milena Velojic , Pesic Milica , Radenkovic Sasa

Objectives: The value of ultrasound in functional disorders can be significant. That is why the question arises on the use of ultrasound examination of thyroid gland and its echogenity as a screening method in early detection of disfunctions, primarily subclinical and clinical forms of hypothyreosis.Methods: Testing included 328 patients. All examinees underwent ultrasound examination of thyroid gland, the blood was taken for determination of FT4</s...
shares

ea0037ep967 | Thyroid (non-cancer) | ECE2015

Immunohistochemical expression of Claudin-1 in Hashimoto's thyroiditis and Graves' disease patients

Zake Tatjana , Skuja Sandra , Pekarska Katrina , Groma Valerija , Konrade Ilze , Kleina Regina

Introduction: Autoimmune thyroid diseases, including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), are complex diseases combining genetic susceptibility and environmental encounters leading to the breakdown of immune tolerance. The relationship between thyroid cancer (TC) and HT has been proven (Guarino et al. 2010), and the antibody specific association has been demonstrated (Azizi et al. 2014). Overexpression of claudin-1 appears to be an...
shares

ea0037ep968 | Thyroid (non-cancer) | ECE2015

The effect of thyroid hormone replacement on treatment schedule

Apaydin Mahmut , Beysel Selvihan , Kan Seyfullah , Ucan Bekir , Tutal Esra , Demirci Taner , Caliskan Mustafa , Kizilgul Muhammed , Ozbek Mustafa , Cakal Erman , Delibasi Tuncay

Introduction: Levothyroxine sodium (LT4) is widely used thyroid hormone to treat hypothyroidism. It is generally recommended to take it in the morning and hungry. Several studies about timing of thyroid hormone administration have shown different effects on TSH and FT4. The aim of this study is to determine the effects of timing of LT4 administration on TSH and the clinical outcomes.Method: The study group includes 65 pat...
shares

ea0037ep969 | Thyroid (non-cancer) | ECE2015

Estimation of iodine intake in pregnant women living in Northern Ireland using a validated food frequency questionnaire

McMullan Paul , Hamill Lesley , Woodside Jayne , Mullan Karen

Adequate iodine intake during pregnancy is required for the production of thyroid hormones and brain development in the foetus. Recent evidence has suggested re-emergence of mild iodine deficiency in the UK but there are few studies that have specifically looked at iodine intake in pregnant women. Current World Health Organisation recommendation is for 250 μg per day intake of iodine in pregnancy and the following are good sources of dietary iodine: 1 pint milk (~140&#150...
shares

ea0037ep970 | Thyroid (non-cancer) | ECE2015

Iodine status of school girls living in Northern Ireland cities: a cross-sectional survey

McMullan Paul , Hamill Lesley , Woodside Jayne , Mullan Karen

Iodine deficiency is the most common cause of preventable mental impairment worldwide. Recent evidence suggests the re-emergence of mild iodine deficiency in the UK possibly due to changing farming practice. A recent multicentre survey in the UK reported that 68% of school girls were iodine deficient with the lowest levels seen in Northern Ireland (NI). Unlike many countries, the UK does not have a salt or food iodination programme. A cross-sectional survey of 264 schoolgirls,...
shares

ea0037ep971 | Thyroid (non-cancer) | ECE2015

The role of detecting BRAF T199A mutation in fine-needle aspiration biopsy in pre-operative diagnosis of nodular goitre

Syrenicz Anhelli , Koziolek Monika , Kiedrowicz Bartosz , Parczewski Milosz , Stepaniuk Maria , Andrysiak-Mamos Elzbieta , Obloza Joanna , Sieradzka Anna , Binczak-Kuleta Agnieszka

Introduction: Molecular testing play increasingly a significant role in pre-operative diagnosis of nodular goiter, as standard methods may not give conclusive decision in choosing optimal treatment approach. BRAF gene mutations are often discovered in the cytological specimens among the patients with papillary thyroid cancer. The aim of the study was to assess the incidence of BRAF T1799A mutation in cellular specimens derived from fine needle aspiration biopsy (FNAB)...
shares

ea0037ep972 | Thyroid (non-cancer) | ECE2015

Pentraxin 3 levels in patients with Hashimoto disease

Aydin Unsal , Culha Cavit , Aktas Aynur , Keskin Muge , Ozcan Muge , Karaca Anara , Omma Tulay , Gulcelik Nese Ersoz , Koc Gonul , Aral Yalcin

Pentraxin 3 (PTX3) is produced from several cell types in case of inflammation. PTX3 has been investigated in several autoimmune diseases. As Hashimoto disease is an autoimmune disease of thyroid, we investigated the role of PTX3 levels in patients with Hashimoto disease.Objective: The aim of this study was to investigate the relationship between PTX3 and autoimmune thyroiditis.Methods: The study subjects were classified as four gr...
shares

ea0037ep973 | Thyroid (non-cancer) | ECE2015

Morphological and functional alterations of thyroid gland during treatment with tyrosine kinase inhibitors in advanced renal cell carcinoma

Rizza Laura , Giannetta Elisa , Sbardella Emilia , Lauretta Rosa , Gianfrilli Daniele , Lenzi Andrea , Longo Flavia , Isidori Andrea M

Background: Sunitinib (SUN) is a novel oral multitarget tyrosine-kinase inhibitor (TKI) that has demonstrated its efficacy in the treatment of metastatic renal cell carcinoma (mRCC). The thyroid dysfunction is one of the most common side effects of SUN. The mechanisms inducing thyroid dysfunction are still poorly understood.Aim: Identify the incidence, severity, ultrasonographic changes and pattern of response of thyroid function tests during treatment w...
shares

ea0037ep974 | Thyroid (non-cancer) | ECE2015

Thyroid autoimmunity may effect on mean platelet volume

Kalan Isilay , Durmaz Senay Arikan , Yavuz Seyma , Carlioglu Ayse , Cosar Ramazan , Cifci Aydin

Aim: Mean platelet volume (MPV) is considered a new indicator of atherosclerosis. Activated platelets and subclinical inflammation predispose to create for atherosclerotic heart disease. Larger platelets are metabolically more active than smaller ones and have more protrombotic potential. We have recently demonstrated that MPV levels in Hashimoto’s patients tend to be higher than healthy controls even if in euthyroid state. In present study we aimed to investigate a relat...
shares

ea0037ep975 | Thyroid (non-cancer) | ECE2015

Body composition after treatment of subclinical hyperthyrodism

Boj-Carceller Diana , Sanz-Paris Alejandro , Espejo-Nino Johanna , de Castro-Hernandez Paloma , Monreal-Villanueva Marta , Alvarez-Ballano Diego , Abos-Olivares Maria Dolores

Background: Subclinical hyperthyroidism (SHT) is associated with harmful effects on cardiovascular system, bone metabolism and progression to clinical hyperthyroidism. Loss of weight is a common fact in patients with clinical hyperthyroidism and of particular relevance in elderly patients, who are vulnerable to sarcopenia.Objective: To assess changes in body composition after radioiodine therapy for SHT due to toxic nodular goitre....
shares

ea0037ep976 | Thyroid (non-cancer) | ECE2015

Efficacy of two different L-thyroxine formulations in dyspeptic patients with subclinical hypothyroidism

Ribichini Danilo , Vaira Berardino , Pasquali Renato

Levo-thyroxine (LT4) formulations are available on tablets (TAB) or liquid solution (SOL). LT4 TAB absorption could be affected by several gastric diseases as Helicobacter pylori (HP) infection or chronic atrophic gastritis (CAG), instead no data are available on absorption of the LT4 SOL in these conditions. The aim of the study was to compare the efficacy of TAB or SOL LT4 formulations in patients with dyspeptic syndrome (DS) and subclinical ...
shares

ea0037ep977 | Thyroid (non-cancer) | ECE2015

Clinical case of amyloid goitre due to idiopathic AA-amyloidosis

Pasechnik Dmitry , Sinelnik Elena , Volkova Natalya , Porksheyan Maria

Introduction: Amyloid goitre is a rare cause of thyroid enlargement, especially as a reason of fast growth. Here we present unusual case of idiopathic AA-amyloidosis as a cause of rapidly growing goitre.Clinical case: Patient 36-year-old presented with complaints of shortness of breath and deglutitive problems during 2 months. His medical history was notable for nephrotic syndrome due to AA-amyloid nephropathy and chronic hepatitis C that were diagnosed ...
shares

ea0037ep978 | Thyroid (non-cancer) | ECE2015

Pseudothrombocytopenia improved with antithyroid treatment in Graves' disease: a case report

Yalcin Mehmet Muhittin , Toruner Fusun Balos , Arslan Emre , Altinova Alev , Saygili Zubeyde , Aksoy Sena , Akturk Mujde , Yegin Zeynep Arzu , Cakir Nuri

Thrombocytopenia can be seen rarely in Graves disease (GD). In this report we present a case of pseudothrombocytopenia in a 21-year-old woman who had hyperthyroidism due to GD. A 21-year-old female admitted to our clinic with symptoms such as hair loss, anxiety, nervousness and tremor in hands. Considering her symptoms, thyroid function tests were evaluated to screen for presence of hyperthyoidism. Her TSH level was low while free T3 and free T4 levels we...
shares

ea0037ep979 | Thyroid (non-cancer) | ECE2015

Ogilvie's syndrome and myxoedema crisis: a case report

Barbosa David , Freire Sara , Simas Nadia , Barreira Joao , Velhinho Emilia , da Silva Gloria Nunes

Introduction: Ogilvie’s syndrome (acute colonic pseudo-obstruction) is a syndrome in which the clinical features resemble those of mechanical obstruction with massive colonic dilatation, in the absence of any demonstrable evidence of such an obstruction in the intestine. The exact pathophysiology of intestinal pseudo-obstruction remains to be elucidated. Current theories continue to suggest the idea of an imbalance in the autonomic nervous system. The initial therapy rema...
shares

ea0037ep980 | Thyroid (non-cancer) | ECE2015

Effect of L-thyroxine on left ventricular function in subclinical hypothyroidism

Nakova Valentina Velkoska , Krstevska Brankica , Kostovska Elizabeta Srbinovska , Pemovska Gordana

Introduction: Thyroid hormone deficiency can lead to the impairment of cardiac function. Whether subclinical hypothyroidism (ScH) is a risk factor for left ventricular (LV) dysfunction is controversial. Aim of the study was to assess whether ScH is associated with LV systolic and diastolic dysfunction and it’s reversibility after treatment with L-thyroxine.Material and methods: Twenty-seven consecutive patients with newly diagnosed Sc...
shares

ea0037ep981 | Thyroid (non-cancer) | ECE2015

Is there any effect of the treatment on mean platelet volume in patients with hypothyroidism and hyperthyroidism?

Okuturlar Yildiz , Soylu Aliye , Tekin Enver , Mert Meral , Harmankaya Ozlem , Kumbasar Abdulbaki

Introduction: Mean platelet volume (MPV) which is part of a complete blood count measures the platelet size. There are many studies in the literature that it is an indicator of platelet function in thrombotic and inflammatory diseases. However, the number of studies about changes in MPV after treatment in thyroid disease is very limited. In this study, we aimed to reveal the MPV change with treatment in patients with hypothyroidism and hyperthyroidism.Ma...
shares

ea0037ep982 | Thyroid (non-cancer) | ECE2015

Co-occurrence of Graves' disease and immune thyrombocytopenia: a case report

Yalcin Mehmet Muhittin , Arslan Emre , Toruner Fusun Balos , Altinova Alev , Akturk Mujde , Dumludag Burak , Yagci Munci , Yetkin Ilhan , Arslan Metin

Also cytopenies can be established in the evaluation of Graves’ disease (GD), isolated thrombocytopenia is very rare. Here, we present a case of immune thrombocytopenia incidentally found in the evaluation of GD. A 48-year-old female was admitted to our hospital with palpitation and anxiousness. The thyroid function tests were concordant with thyrotoxicosis. She had two subcentimetre nodules in the right thyroid lobe. Thyroid gland had increased iodine uptake. And thyroid...
shares

ea0037ep983 | Thyroid (non-cancer) | ECE2015

Insulin resistance and low folate levels are associated with hyperthyroidism in Graves' disease

Neves Celestino , Esteves Cesar , Neves Joao Sergio , Sokhatska Oksana , Pereira Miguel , Palmares Carmo , Dias Camila , Carvalho Davide , Delgado Luis , Medina Jose Luis

Objective: To evaluate the interrelationships between thyroid function, insulin resistance, lipid profile, homocysteine, C-reactive protein (CRP), folic acid, and vitamin B12 levels, in Graves’ disease (GD).Methods: We recorded thyroid function tests, BMI, insulin resistance markers, lipid profile, homocysteine, CRP, folic acid, and vitamin B12 levels, in 104 subjects with GD in the first cycle of treatment with methimazole, 94% of whom were female....
shares

ea0037ep984 | Thyroid (non-cancer) | ECE2015

Urinary iodine concentrations in pregnant women with gestational and pregestational diabetes mellitus

Vitkova Hana , Anderlova Katerina , Radimerska Veronika , Kratky Jan , Fait Tomas , Jiskra Jan

Introduction: Urinary iodine concentration (UIC) can reflex recent changes in iodine status and serve as a sensitive marker of current iodine intake. The cut-off value of UIC was determined as the level lower than 100 μg/l. Adequate median urinary iodine for iodine intake in pregnancy is 150–249 μg/l. The aim of this study was to map the situation of iodine intake in pregnant women with pregestational and gestational diabetes and to explore relationship with thy...
shares

ea0037ep985 | Thyroid (non-cancer) | ECE2015

Beware false positive lymph node biopsies in patients with chronic lymphocytic thyroiditis

Salazar Lorelei , Kyriacou Angelos

A 40-year-old lady who was 4 months postpartum, presented with clinical and biochemical features consistent with post partum thyroiditis associated with neck swelling. She had a family history of autoimmune thyroid disease. She underwent ultrasound guided fine-needle aspiration (FNA) biopsy which was reported as Thy3f and listed for diagnostic hemithyroidectomy. She presented to us for a second opinion. She was on replacement therapy and the anterior neck swelling has...
shares

ea0037ep986 | Thyroid (non-cancer) | ECE2015

Propylthiouracil induced anti-neutrophil cytoplasmic antibody-associated vasculitis with skin lesions and granulocytopenia

Tanrikulu Seher , Ince Burak , Selcukbiricik Ozlem Soyluk , Tekin Sakin , Aral Ferihan , Tanakol Refik

Propylthiouracil (PTU) is a widely used drug, and can cause drug-induced vasculitis which is characterized by inflammation and cellular infiltration of small vessels and presence of anti-neutrophil cytoplasmic antibodies (ANCA). We report a case of perinuclear antineutrophil cytoplasmic antibody-associated vasculitis developed during treatment with PTU for Graves’ disease. A 58-year-old woman admitted to the Emergency Department with painful necrotic lesion at her right e...
shares

ea0037ep987 | Thyroid (non-cancer) | ECE2015

Haemorrhagic thyroid cyst after breathing exercise

Lulsegged Abbi , Moonim Mufaddal , Ngu Rose

A 40-year-old gentleman was referred with sudden onset discomfort in the neck associated with the development of a lump. Earlier that morning he had carried out breathing exercise known as surya krishna at 0600 h and noticed the lump 3 h later whilst shaving. Thyroid USS showed a right-sided thyroid cyst, aspiration of which yielded haemorrhagic contents. FNA of the solid component of the wall did not reveal any malignant cells. The fluid re-accumulated with pressure symptoms ...
shares

ea0037ep988 | Thyroid (non-cancer) | ECE2015

Levothyroxine therapy in comparison: fixed vs alternating dosage in subclinical hypothyroidism

Pastore Renato , Cannuccia Amalia , Simona Frontoni

Introduction: Oral levothyroxine (L-T4) is the standard treatment for hypothyroidism and serum TSH represents the best marker for assessing the proper L-T4 dose. The absorption and bioequivalence of different commercial L-T4 preparations might be variable. The aim of this study is to compare the efficacy of L-T4 using alternating doses vs fixed ones.Me...
shares

ea0037ep989 | Thyroid (non-cancer) | ECE2015

The relationship between vitamin D deficiency and thyroid autoimmunity in Graves' disease

Arkan Tugba

Context: Graves’ disease (GD) is the most common cause of hyperthyroidism. It occurs more commonly amongst women, smokers and patients with other autoimmune diseases or a family history of thyroid autoimmunity. Peak incidence occurs between 40 and 60 years of age but any age group may be affected. Vitamin D deficiency has been reported to link with a variety of autoimmune diseases. However, the relationship between the thyroid autoimmunity in GD and vitamin D deficiency i...
shares

ea0037ep990 | Thyroid (non-cancer) | ECE2015

Thyroid hormone resistance: a case report

Sisman Pinar , Peynirci Hande , Gul Ozen Oz , Cander Soner , Bulbul Esra Nur , Erturk Erdinc , Ersoy Canan

Classic thyroid hormone resistance (THR) occurs per every 400 000 live birth. THR should be considered along with TSH-producing adenomas when normal or high levels of TSH not consistent with hyperthyroidism is present. A 45-year-old female patient who was operated three times for multinodulary goitre had been treated with L-thyroxine. Mamillary biopsy had performed after detection of mass localized in right breast by mammography performed during regular follow-u...
shares

ea0037ep991 | Thyroid (non-cancer) | ECE2015

Relationship of thyroid function and central obesity

Zabuliene Lina , Petrenaite Agne , Minkeviciute Ieva , Urboniene Jurgita

The objective of the study was to investigate association between BMI, waist circumference, and measures of thyroid function among euthyroid adult women.Material and methods: We analysed retrospective data of 119 euthyroid women participating in Lithuanian screening and prevention program for patients with high cardiovascular risk at Vilnius Antakalnio Outpatient Clinic from Jul 2013 to Dec 2013. Glucose, lipid profile, TSH, and fT4 tests and ...
shares

ea0037ep992 | Thyroid (non-cancer) | ECE2015

Ultrasonographic and cytopathological characteristics of thyroid nodules in Graves' disease

Anil Cuneyd , Kirnap Nazli Gulsoy , Iyidir Ozlem Turhan , Firat Sevde Nur , Tutuncu Neslihan Bascil

Introduction: The risk of malignancy has often been reported to be more frequent in Graves’ disease (GD) than non-autoimmune thyroid nodules. However, frequency of thyroid nodules, diagnostic yield of fine-needle aspiration (FNA), and their potential for bearing malignancy in GD are still debatable issues. We aimed to determine the prevalence, ultrasonographic and cytological features, and the rate of malignancy outcome of thyroid nodules in a group of patients with GD.</...
shares

ea0037ep993 | Thyroid (non-cancer) | ECE2015

Thyroid disorders in patients with type 2 diabetes mellitus

Zengi Ayhan , Tilki Serap Unal , Kose Timur

Aim: Increased thyroid volume and thyroid dysfunction (TD) in diabetics have been reported. The aim of this study is to investigate the prevalence of thyroid disorders in patients with type 2 diabetes mellitus in formerly iodine deficient area.Methods: We included 131 (73 females and 58 males) diabetics without a history of previous thyroid disease and symptoms. The demographic, medical and clinical data, laboratory results (fasting plasma glucose (FPG),...
shares

ea0037ep994 | Thyroid (non-cancer) | ECE2015

The occurrence of newly diagnosed thyroid diseases during 13 years follow-up

Buziak-Bereza Monika , Trofimiuk-Muldner Malgorzata , Kolodziej Maciej , Hubalewska-Dydejczyk Alicja

The increase in thyroid disease frequency has been observed recently. It may be attributed to the changing iodine status, endocrine disruptors, as well as better availability of ultrasound and laboratory tests. The aim of the study was to assess the occurrence of newly recognized thyroid diseases during long-term follow-up.Material and methods: Study was carried out in 2010–2012 in Krakow area. It included 266 patients aged 23–81 years (168 fem...
shares

ea0037ep995 | Thyroid (non-cancer) | ECE2015

E-selectin in women with autoimmune thyroiditis and the relationships with metabolic syndrome

Sieminska Lucyna , Kos-Kudla Beata , Marek Bogdan , Nowak Mariusz , Kajdaniuk Dariusz , Foltyn Wanda , Walczak Krzysztof , Borowski Artur

Autoimmune thyroiditis (AIT) is characterised by infiltration of the thyroid by lymphocytes and other immune cells. Autoantibodies to thyroid-specific antigens: thyroglobulin (TG) and thyroperoxidase (TPO) are also produced. The penetration of inflammatory cells into target organ is regulated by cytokines and adhesion molecules expressed on thyroid endothelial cells. E-selectin is one of the selectin family, and is responsible for interaction between leukocytes and endothelium...
shares

ea0037ep996 | Thyroid (non-cancer) | ECE2015

Ultrasound-guided fine-needle aspiration biopsy is an efficient diagnostic tool in thyroid nodules

Armasu Ioana , Ciobanu Delia , Istrate Andra , Vasiliu Ioana , Ionescu Lidia , Preda Cristina , Mogos Voichita , Vulpoi Carmen

Introduction: Thyroid nodules are commonly encountered in clinical practice, the main diagnostic problem being the benign or malignant nature of the nodules. Fine-needle aspiration biopsy (FNAB) is a standard diagnostic test for evaluating thyroid nodules. Several studies have showed that the use of ultrasound guidance (US-FNAB) improves the diagnostic accuracy of aspiration biopsies in comparison with palpation guidance (P-FNAB) alone.Patients and metho...
shares

ea0037ep997 | Thyroid (non-cancer) | ECE2015

Two cases with primary thyroid lymphoma developed on the basis of Hashimoto's thyroiditis

Peynirci Hande , Sisman Pinar , Aksu Cigdem , Gul Ozen Oz , Cander Soner , Erturk Erdinc , Ersoy Canan

Introduction: Primary thyroid lymphomas are rare cancers and account 1–5% of all thyroid cancers and 3% of all extranodal non hodgkin lymphomas (NHLs). We aimed to present cases of thyroid lymphoma encountered in our clinic.Case 1: A 54-year-old female patient admitted with pain and swallow on the cervical region. In ultrasonographic (USG) thyroid examination, it was found that both thyroid lobes were very large with routh parenchyme consis...
shares

ea0037ep998 | Thyroid (non-cancer) | ECE2015

Factors affecting the efficacy of radioiodine therapy in patients with Graves' disease

Pogwizd Magdalena , Baldys-Waligorska Agata , Pach Dorota , Buziak-Bereza Monika , Hubalewska-Dydejczyk Alicja

Introduction: In treating hyperthyroidism in Graves’ disease (GD) patients with 131-iodine, the optimum activity of radioiodide is yet to be established. We analysed factors affecting the efficacy of 131I radiotherapy in GD patients.Materials and methods: The analysed group consisted of 362 (80.9% females and 19.1% males) GD patients, of median age 53 (min: 14 and max: 85) years. GD was diagnosed from clinical features, laboratory tests, ...
shares

ea0037ep999 | Thyroid (non-cancer) | ECE2015

Descriptive analysis of a series of 1567 thyroidectomies in Castilla La Mancha and its association with thyroid cancer

Castro Enrique , Herranz Sandra , Delgado Manuel , Calderon Dulce , Alfaro Jose Joaquin , Sastre Julia , Del Val Florentino

Introduction: We wanted to analyse the descriptive variables of a series of 1567 thyroidectomy patients between 2010 and 2013 and its association with malignancy in our series.Material and methods: Retrospective, multicentre study done by review of the medical records of 1567 patients who became thyroidectomy between 2010 and 2013 in eight sanitary areas. This is an analysis of clinical and demographic variables.Results: The percen...
shares

ea0037ep1000 | Thyroid (non-cancer) | ECE2015

Incidence of autoimmune thyroid disorders following treatment with pegylated interferon therapy for HCV infection among Egyptian patients

Shelbaya Salah Eldin , Mahmoud Makboul Khaled , Abdelsalam Mona Mohamed , Zakaria Zaki Doaa , Ghazy Manar Alshahawey Alsayed

Introduction: Egypt has an epidemic of HCV. Interferon (IFN) is the drug of choice for treatment induces autoimmune thyroiditis. The biochemical characteristic of the autoimmune thyroid disorder is the presence of autoantibodies against thyroid peroxidase and thyroglobulin. Chemokine ligand 10 (CXCL10) is an IFN inducible chemokine involved in the autoimmune thyroid disease.Aim: To assess the incidence of autoimmune thyroid disorder following treatment w...
shares

ea0037ep1001 | Thyroid (non-cancer) | ECE2015

Does vitamin D differ among the different thyroid states? A pilot study in Egyptian patients

Abdelaziz Mohamed Fahmy , Hosney Salwa Seddik , Abdelsalam Mona Mohamed , Alsherbeny Alyaa Ahmed , Rashwan Yassmin Yehia

Introduction: Vitamin D plays an essential role in calcium homeostasis and bone metabolism, immune modulation, and control of other hormonal systems. Vitamin D deficiency is also common for many reasons. On the other hand, thyroid diseases have widespread systemic manifestations including their effect on bone metabolism.Aim: To assess vitamin D status among Egyptian patients with different thyroid states: euthyroid, hypothyroid, or hyperthyroid states.</...
shares

ea0037ep1002 | Thyroid (non-cancer) | ECE2015

Prevalence of thyroid dysfunction in Spain: diabetes study

Valdes Sergio , Maldonado-Araque Cristina , Tapia Maria Jose , Lago Ana , Perez-Valero Vidal , Goday Albert , Castano Luis , Delgado Edelmiro , Vendrell Joan , Rojo-Martinez Gemma , Soriguer Federico

Introduction: Thyroid dysfunction is a common health problem. Its prevalence may vary in different populations, and in Spain, it has not been sufficiently studied. The aim of this study was to evaluate the prevalence of thyroid dysfunction (clinical and subclinical) in our country.Materials and methods: The diabetes study is a national, cross-sectional, population-based survey. Target population: the entire Spanish population >18 years. Sample: >...
shares

ea0037ep1003 | Thyroid (non-cancer) | ECE2015

Presentations and outcome of thyroiditis from an Outpatient Clinic of Endocrinology

Shahid Muhammad , Mahar Saeed , Shaikh Shiraz

Background: Thyroiditis is ‘the disorder in which there is inflammation of the thyroid gland’. If diagnosed earlier have often good chances of recovery. Limited data is available related to this problem from low income countries and hence there is delay in the diagnosis and management of this important disorder. The objective of the study was to assess the clinical presentations and early outcome of patients presenting with thyroiditis in a tertiary care hospital.</p...
shares

ea0037ep1004 | Thyroid (non-cancer) | ECE2015

Association between fibromyalgia and thyroid autoimmunity

Shirzad Nooshin , Movassaghi Shafieh , Karmostaji Hoda , Esfahanian Fatemeh , Hemmatabadi Mahboobeh , Qorbani Mostafa

Fibromyalgia is a disorder characterised by fatigue, generalised body pain and cognitive symptoms, and the aetiology has not been clearly described. Because similar symptoms are frequently found in Hashimoto’s thyroiditis and there is not an optimal response to the treatment of hypothyroidism, the aim of this study is to determine the prevalence of fibromyalgia in patients with Hashimoto’s thyroiditis, to explain the symptoms and to select the appropriate treatment. ...
shares

ea0037ep1005 | Thyroid (non-cancer) | ECE2015

A case report of Hoffmann's syndrome

Uc Ziynet Alphan , Gorar Suheyla

Introduction: Hoffman’s syndrome is a rare form of hypothyroid myopathy characterised with muscle hypertrophy, stiffness and wakefulness.Case report: A 43-years-old woman admitted to our hospital with a complaint of fatigue and progressive muscular weakness with cramps and myalgia started 3 months before.Thyroid gland examination was normal. On neurological examination she had proximal and lower limb muscle weakness(3/4) and hyporeflexia. Her calf m...
shares

ea0037ep1006 | Thyroid (non-cancer) | ECE2015

Successful treatment with radiotherapy in a patient who developed severe Graves'-like ophthalmopathy after treatment with pegylated interferon Alpha-2a for hepatitis C

Acosta-Calero Carmen , Arnas-Leon Claudia , Carmona-Vigo Ruth , Martinez-Martin Francisco Javier , Jimenez-Santana Pedro Conrado

Introduction: Interferon treatment for hepatitis C has been associated with Graves’-like thyroiditis, developing in rare instances severe ophthalmopathy. The usual management is interferon withdrawal and high-dose corticosteroids, but it may interfere with the resolution of hepatitis. Hereby we report a case successfully treated with radiotherapy, which in our knowledge has never been previously reported.Case report: A 52-year-old woman was diagnose...
shares

ea0037ep1007 | Thyroid (non-cancer) | ECE2015

Hypothyroidism in clinical practice

Qari Faiza

Hypothyroidism is the most common endocrine disease that was seen in the clinical practice especially for family. What issues about hypothyroidism should be covered in clinical practice? A 36-year-old woman who was diagnosed with hypothyroidism 3 years ago tells her endocrinologist that she wants to conceive in the next year. She was treated with LT4, 0.1 mg per day. Her last serum TSH was 0.7 mIU/l. She is instructed to notify her endocrinologist as soon as she fin...
shares

ea0037ep1008 | Thyroid (non-cancer) | ECE2015

Graves' disease with autoimmune haemolytic anemia

Salam Randa , Ramadan Nagwa , Gaber Fatma

Introduction: Haematologic involvement is not uncommon in Graves’ disease. Autoimmune haemolytic anaemia is occasionally reported in patients with other autoimmune illnesses. However very rarely reported in Graves’ disease.Case report: We report a 19-year-old female with reactive arthritis, Graves’ disease and autoimmune haemolytic anaemia while under treatment with methimazole. Physical examination: Under built female BMI 17, Blood pressu...
shares

ea0037ep1009 | Thyroid (non-cancer) | ECE2015

Successful treatment of hypothyroidism with rectal thyroxine can be achieved with variable dose response: a case report

Durrani Muhammad Naeem , Islam Najmul , Ram Nanik , Malik sarwar

Introduction: Hypothyroidism is a common endocrine disorder worldwide. Its treatment is with oral thyroxine, but when this route cannot be utilised then intravenous thyroxine is an alternate but not available in some countries so rectal thyroxine administration can be used but clinical experience is lacking.Case report: This is a case of a 55-years-old Pakistani male known case of hypothyroidism since July 2007 and was maintaining normal TSH and FT4...
shares

ea0037ep1010 | Thyroid (non-cancer) | ECE2015

1 year response rate to 10 mCi radioactive iodine (I131) in patients with relapsed Graves' disease

Salman Khaled , Zatary Safwan , Wagieh Shereen , Munshy Tarek , Kareem Maha Abd-El , Mohammad Yasser , Al-Ezzi Manal

Introduction: Failure of medical treatment in patients with primary diffuse toxic goitre (Graves’disease) was reported in around 50% of patients and can occur few months after cessation of therapy. Radioactive I131 therapy is a good therapeutic alternative that can be used safely in patients with relapsed Graves’ disease and achieve good response rate with hypothyroisdism representing the main side effect.Aim: The...
shares

ea0037ep1011 | Thyroid (non-cancer) | ECE2015

Correlation of midkine levels in serum and thyroid nodules with histopathological, haematological and radiological variables

Kuzu Fatih , Arpaci Dilek , Altas Ayfer , Haytaoglu Gurkan , Can Murat , Barut Figen , Bayraktaroglu Taner

Aim: To evaluate serum (SMK) and nodular (NMK) midkine levels in thyroid nodules and explore its relevance to ultrasound feature/pathological results.Methods: A total of 80 patients (56 women, 24 men) with thyroid nodules were included in this prospective study. Hemograms, thyroid function tests, fine needle aspiration biopsies, ultrasonographic evaluation were routinely made. In addition, levels of SMK and NMK were measured. Any possible correlations be...
shares

ea0037ep1012 | Thyroid (non-cancer) | ECE2015

Correlation of VEGF, VEGFR-1 levels in serum and thyroid nodules with histopathological and radiological variables

Haytaoglu Gurkan , Arpaci Dilek , Kuzu Fatih , Altas Ayfer , Can Murat , Barut Figen , Kokturk Firuzan , Ilikhan Sevil Uygun , Bayraktaroglu Taner

Aim: To evaluate serum and intranodular vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-1 (VEGFR-1) level thyroid nodules and explore its relevance to ultrasound feature/pathological results.Methods: A total of 80 patients (62 women and 18 men) with thyroid nodules were included in this prospective study. Thyroid function tests, fine needle aspiration biopsies, ultrasonographic and scintigraphic evaluation were r...
shares

ea0037ep1013 | Thyroid (non-cancer) | ECE2015

Iodine nutrition status among neonates in Uttarakhand, India (for ESE Young Investigator Award)

Sareen Neha , Kapil Umesh , Nambiar Vanisha S

Introduction: Iodine deficiency (ID) is an endemic health problem in Uttarakhand State. ID leads to mental retardation, deaf mutism, squint, dwarfism, spastic diplegia, neurological defects and congenital anomalies. Iodine nutrition status amongst neonates can be assessed by estimating thyroid stimulating hormone (TSH).Objectives: Current study aimed to assess iodine nutrition status among Neonates in Uttarakhand, India, a known endemic region for ID.</p...
shares

ea0037ep1014 | Thyroid (non-cancer) | ECE2015

Prevalence of short stature in juvenile hypothyroidism and the impact of treatment in tertiary care centre

Kumar Sukriti , Gutch Manish

Background: Juvenile hypothyroidism is very common problem in developing part of world, and produces various skeletal manifestations and one of them is short stature and it is the most common reason for referral to endocrinologist. It has very wide etiology and one of them is hypothyroidism, which needs special attention, as the treatment impact of thyroxin replacement has favourable outcome.Aim and objectives: To study the prevalence of juvenile hypothy...
shares

ea0037ep1015 | Thyroid (non-cancer) | ECE2015

The role of circulating sTWEAK in the pathogenesis of Hashimoto's thyroiditis and its relationship with other cytokines: a pilot study

Altay Mustafa , Ates Ihsan , Yilmaz Fatma Meric , Topcuoclu Canan , Kaplan Mustafa , Altay Fatma Aybala

Objective: We aimed to investigate the role of sTWEAK in the pathogenesis of Hashimoto’s Thyroiditis (HT) and its relationship with IL-12, IL 17-A and TGF-β1.Methods: Serum TSH, FT4, anti-TG and anti-TPO were measured and thyroid USG was performed to both group. In addition serum samples were collected and sTWEAK, IL 17-A, IL-12 and TGF-β1 were measured.Patients: Six patients (20 patients were euthyroid, 2...
shares

ea0037ep1016 | Thyroid (non-cancer) | ECE2015

Serum selenium levels in euthyroid nodular thyroid diseases

Sakiz Davut , Kaya Ahmet , Kulaksizoglu Mustafa

Introduction: Thyroid gland is susceptible for nodulation. It is not clear which mechanism is responsible for the growth of only some follicular cells resulting in nodule formation. Selenium deficiency may a risk factor in the development of thyroid nodules. The aim of this study was to investigate the relationship between selenium levels in patients with euthyroid nodular thyroid diseases.Design: Euthyroid 70 patients with solitary thyroid nodule, euthy...
shares

ea0037ep1017 | Thyroid (non-cancer) | ECE2015

Technique of story-telling in Patient care with reference to endocrine surgery

Mayilvaganan Sabaretnam , Bansal Naval , Mishra Saroj

Background: In the modern day busy clinical practice the communication between patient/relative and care giver is at minimal level. The patients and relatives feel apprehensive when advised about the surgical/interventional treatment. In such situation they feel the need of detail information from the care givers which on many occasions is not available. Story telling is such a technique of health communication made out in common man language which can be made animated and int...
shares

ea0037ep1018 | Thyroid (non-cancer) | ECE2015

Adiponectin and gut hormones in thyroid dysfunction: a new concept (PFG axis)

Emami S Ali , Hedayati Mehdi , Nazem M Reza

Background: Integration between fat tissue, gastrointestinal tract, and the brain has attracted scientific interest in recent years. Thyroid hormones influence carbohydrate mechanisms via its interaction with adipocytokines and gut hormones. Adiponectin, ghrelin and obestatin play important roles in metabolism regulation. TSH receptors have been reported to be present in adipose tissue. Moreover, gut peptides signal to their functional cogna...
shares

ea0037ep1019 | Thyroid (non-cancer) | ECE2015

A case of unilateral Graves' disease

Cansu Baris , Taskiran Bengur , Bahceci Tatiana

Introduction: Thyroid hemiagenesis is a congenital developmental disorder. Most cases are euthyroid although hyperthyroidism, hypothyroidism, and malignancy may develop. We present a case of hemiagenesis with Graves’ disease.Case: A 45-year-old female patient was admitted to the endocrinology ward due to nausea and diarrhoea. She had hyperthyroidism for 1 year. She did not have any family member with thyroid disease. She was already on propylthioura...
shares

ea0037ep1020 | Thyroid (non-cancer) | ECE2015

Evaluation of oxidative stress in patients with euthyroidism and with subclinical hypothyroidism

Yildiz Sati Sena , Serin Sibel , Olcum Gulcin Gungor , Basat Sema

Objective: There is not sufficient data about oxidative stress in euthyroid Hashimoto (EH) and subclinical hypothyroid Hashimoto (SHH) disease. We studied oxidative stress with more oxidative stress tests in EH and SHH patients and assessed whether there is an association betweeen Hashimoto disease and PON1 phenotype.Materials and method: 35 EH and SHH patients and 38 control was included to the study. Comprehensive biochemistry, routine blood analysis, ...
shares

ea0037ep1021 | Thyroid (non-cancer) | ECE2015

Circulating levels of irisin is elevated in patients suffering from hypothyroidism and obesity in Hashimoto's thyroiditis: original article

Ates Ihsan , Altay Mustafa , Topcuoglu Canan , Yilmaz F Meric , Toprak Guvenc

Background and objectives: Our objective in this study was to discover the relationship of irisin hormone, which acts on adipose tissue and the metabolism as thyroid hormones, with the thyroid functions and the obesity secondary to thyroid disease.Methods: A total of 74 patients were included in the study, of the patients, 37 were newly diagnosed with Hashimoto’s thyroiditis dependent hypothyroidism but not received a treatment yet, and the remainin...
shares

ea0037ep1022 | Thyroid (non-cancer) | ECE2015

The serum irisin level in non-diabetic patients with chronic kidney disease

Ates Ihsan , Ozkayar Nihal , Topcuoglu Canan , Dede Fatih

Background and objectives: Our objective in this study was to discover the relationship of irisin hormone, which acts on adipose tissue and the metabolism as thyroid hormones, with the thyroid functions and the obesity secondary to thyroid disease.Methods: A total of 74 patients were included in the study, of the patients, 37 were newly diagnosed with Hashimoto’s thyroiditis dependent hypothyroidism but not received a treatment yet, and the remainin...
shares

ea0037ep1023 | Thyroid (non-cancer) | ECE2015

The relationship between oxidative stress and thyroid autoantibodies in patients with Hashimoto's thyroiditis

Ates Ihsan , Yilmaz F Meric , Altay Mustafa , Yilmaz Nisbet , Guler Serdar

Background: The relationship between Hashimoto’s thyroiditis (HT) and oxidative stress (OS) has been investigated in several studies that have included a limited number of patients, the findings have not been conclusive, which indicates that additional research that investigates parameters of OS in larger patient populations is needed. As such, this dissertation study aimed to determine the levels of parameters of OS and their relationship with thyroid antibodies in HT pa...
shares

ea0037ep1024 | Thyroid (non-cancer) | ECE2015

The relationship between procalcitonin and thyroid autoantibodies in patients with Hashimoto's thyroiditis

Ates Ihsan , Oncul Ali , Altay Mustafa , Topcuoglu Canan

Background: Procalcitonin (PCT) is often an increased acute phase reactant in the bacterial infection-related inflammation, and its serum level is reported elevated in several autoimmune disease. However, the level of PCT and its relationship with autoimmunity remain unknown in Hashimoto’s thyroiditis (HT). Our objective was to investigate the serum levels of PCT and its association with autoantibodies in patients with euthyroid HT.Methods: A total ...
shares

ea0037ep1025 | Thyroid (non-cancer) | ECE2015

Mimic the symptoms of thyroid disorders in pregnant women

Nazarpour Sima , Tehrani Fahimeh Ramezani , Simbar Masoumeh , Tohidi Maryam , Azizi Fereidoun , Majd Hamid Alavi

Introduction: The prevalence of these disorders in pregnant women is relatively high and may affect mother and foetus adversely if they are not evaluated and treated appropriately. Therefore, their diagnosis and treatment is very important. On the other signs and symptoms of thyroid disease can often be masked by the physiologic changes of pregnancy and are not found. The aim of this study was to evaluate the physiological symptoms similar to thyroid disorders and their incide...
shares

ea0037ep1026 | Thyroid (non-cancer) | ECE2015

An unusual clinical presentation of subacute thyroiditis in a patient with Hashimoto thyroiditis

Yalin A Serap , Turemen Erdem , Biyikli Mithat , Aydiner Omer , Sarica Ozgur , Ramadan Saime , Berberoglu Kezban

Hashimoto thyroiditis (HT) is the most common cause of hypothyroidism. Subacute thyroiditis (SAT) is an uncommon disease with characteristic clinical features. Co-existence of HT and SAT is very rare and diagnosis can be challenging.Case: A 42-year-old woman with HT and multinodular goitre under levothyroxine sodium (LT4) therapy admitted to internal medicine clinic with 1 month history of anterior neck pain radiating to jaw. Thyroid function ...
shares

ea0037ep1027 | Thyroid (non-cancer) | ECE2015

Association between thyroid specific genotypic variation and phenotypic expression of dyshormogenetic goitre and Hashimoto's thyroiditis in children and adolescents: a South Indian experience

Ramesh B , Aparna Verma B , Vijayaraghavan R , Ramakanth Bhargav P , Rajesh B

Background: Thyroid disorders are the commonest endocrine disorder after diabetes in most of the populations worldwide. Though, hypothyroidism is extremely common in children, there is acute scarcity of genetic studies leading to improper screening and treatment protocols in developing countries. The aim of this ambitious study was to screen for NIS, DUOX2 and TPO mutations in south Indian children and adolescent patients with dyshormogenetic goiter (DH) and Hashimoto’s t...
shares

ea0037ep1028 | Thyroid (non-cancer) | ECE2015

Evaluation of unknown thyroid disorders in nursing home people

Kucukler Ferit Kerim , Simsek Yasin , Guler Serdar

Introduction: The prevalence of thyroid diseases increase with age. Mostly, they are undiagnosed. The lack of overt clinical appearance of hypo-hyperthyroidism in elder people increases the need for an attentive clinician to suspect and investigate for their presence. Thyroid dysfunctions, especially subclinics, are more frequently seen in older populations, have been linked to increased morbidity and mortality. Therefore, elderly people should evaluate in terms of thyroid fun...
shares

ea0037ep1029 | Thyroid (non-cancer) | ECE2015

Thyroid switching and D727E polymorphism

Altay Mustafa , Dagdeviren Murat , Guven Gulsum Biten , Ertugrul Derun Taner

Introduction: Graves’ disease and Hashimoto’s hypothyroidism are common thyroid diseases. However, occurrence of both clinical disorders one after the other in the same patient, is not common.Case report: In this article, we presented two hypothyroid patients who developed clinical thyrotoxicosis during levothyroxine treatment. Both patients were treated with levothyroxine for a long time. Due to occurrence of clinical hyperthyroidism, levothyr...
shares

ea0037ep1030 | Thyroid (non-cancer) | ECE2015

Relationship between thyroid function tests and all-cause mortality in patients on peritoneal dialysis: a prospective analysis

Diez Juan J , Romero-Perez Sara , Bajo Maria A , Iglesias Pedro , Grande Cristina , Peso Gloria Del , Madero Rosario , Ossorio Marta , Selgas Rafael

Background: Alterations in thyroid function tests results in patients on peritoneal dialysis (PD) might represent a risk factor for cardiovascular disease (CVD) and mortality.Objective: To investigate the relationship of serum TSH, free thyroxine (FT4), and triiodothyronine (T3) concentrations with incident CVD and mortality in PD patients.Methods: Prospective study including all patients attending our PD unit...
shares

ea0037ep1031 | Thyroid (non-cancer) | ECE2015

Role of regulatory T cell and CTLA-4 gene as risk factor relapse in Graves' disease

Eliana Fatimah , Suwondo Pradana

Introduction: Graves’ disease (GD) management in Indonesia are generally preceded by administration of antithyroid drugs. Antithyroid drug delivery requires a long time to achieve remission, even more than 50% of patients who had remission can recur after antithyroid medication is stopped. The purpose of this study was to determine the role of CTLA-4 gene and regulatory T cells against recurrence in patients GD in Indonesia.Methods: The study was co...
shares

ea0037ep1032 | Thyroid (non-cancer) | ECE2015

Iodine supplementation to pregnant women is scarcely available in Brazil

Villagelin Danilo , Ward Laura , Santos Roberto , Tiago Douglas , Azevedo Giovana , Zolio Sarah , Romaldini Joao

Introduction: A woman’s iodine requirements increase substantially during pregnancy to ensure adequate supply to both mother and fetus. The deficiency of this element may cause several maternal-fetal repercussions. For this reason, iodine supplementation for pregnancy has been recommended and the World Health Organization (WHO) commends an iodine urinary concentration at a median UIC 150–249 μg/l. As in many other countries around the world, there is evidence of...
shares

ea0037ep1033 | Thyroid (non-cancer) | ECE2015

Is there any effect of the treatment on MVP in patients with hypothyroidism and hyperthyroidism?

Okuturlar Yildiz , Soylu Aliye , Tekin Enver , Mert Meral , Cakmak Serdal , Harmankaya Ozlem , Kumbasar Abdulbaki

Introduction: In this study, we aimed to reveal the mean platelet volume (MPV) change with treatment in patients with hypothyroidism and hyperthyroidism.Materials and methods: Two groups were retrospectively evaluated as 200 patients (21 male, 179 female) with hypothyroidism and 200 patients (26 male, 174 female) with hyperthyroidism. Before and after treatment in the outpatient follow. MPV values were compared.Results: There is si...
shares

ea0037ep1034 | Thyroid (non-cancer) | ECE2015

Triiodothyronine is independently associated with metabolic syndrome in euthyroid middle-aged subjects

Kim Hye Jeong , Park Hyeong Kyu , Byun Dong Won , Suh Kyoil , Yoo Myung Hi , Kim Jae Hyeon , Min Yong-Ki , Kim Sun Wook , Chung Jae Hoon

Background: Recent studies have shown associations of thyroid hormone levels with metabolic syndrome (MetS) among euthyroid individuals, though there have been some inconsistencies. We evaluated the relationships between thyroid hormones and MetS in euthyroid middle-aged subjects in a large cohort.Methods: Retrospective analysis of 13 496 euthyroid middle-aged subjects who participated in comprehensive health examinations was performed. Subjects were gro...
shares

ea0037ep1035 | Thyroid (non-cancer) | ECE2015

Hypothyroidism related to blocking TSH receptor antibodies after allogenic haematopoietic stem cell transplantation

Benomar Kanza , Massart Catherine , Magro Leonardo , Parent Anne Sophie , D'Herbomez Michele , Yacoub-Agha Ibrahim , Wemeau Jean Louis , Vantyghem Marie Christine

Besides total body irradiation and immunosuppressive drugs, massive iodine supply and stress might participate in thyroid dysfunction, described in 50% of allo-HSCT. We report on a rare case of hypothyroidism related to blocking TRAb. A 55-year-old man was admitted for asthenia, dyspnea, myalgia, 8 kg-weight gain, constipation, dry skin, hoarse voice, recent deafness. He had moon face without any goiter. He had received, 1 year before, an unrelated 9/10 human leukocyte antigen...
shares

ea0037ep1036 | Thyroid (non-cancer) | ECE2015

Prevalence of hypothyroidism in a large series of adult thalassemic patients

Radin Raffaella , Danesi Leila , Ambrogio Alberto , Cassinerio Elena , Zanaboni Laura , Cappellini Maria Domenica , Baldini Marina , Poggi Maurizio , Ottaviani Chiara , Toscano Vincenzo , Zavattaro Marco , Cavagnini Francesco , Persani Luca , Scacchi Massimo

Hypothyroidism has been traditionally described as a frequent endocrine complication of thalassemic children: in these patients hypothyroidism is mainly of primary origin and not linked to autoimmunity (Mariotti et al., Pediatr Endocrinol Rev 2011). Fewer data are available on the prevalence and nature of this complication in adult age thalassemia. Therefore, we elected to evaluate thyroid function and autoimmunity in a large series of adult patients.<p class="abs...
shares

ea0037ep1037 | Thyroid (non-cancer) | ECE2015

Thyroidectomy: analysis of 184 cases in a single centre

Gallardo Gema Lopez , Alfonso Francisco Javier Gomez , Fernandez Julia Silva , Manzanares Alvaro Garcia , Gomez Ines Rosa , Iglesias Maria Lopez

Aim: To evaluate whether differences exist in terms of patient, radiological, tumour characteristics and surgical complications between malignant and benign thyroidectomy.Materials and methods: 184 correlatives cases of thyroidectomy during the period from October 2011 to October 2013 are analysed. Patient, ultrasound, tumour and complication characteristics are compared. Categorical data are reported as percentages. Characteristics between the two group...
shares

ea0037ep1038 | Thyroid (non-cancer) | ECE2015

IL-2, IL-4, IL-5, IFN-γ and TNF-α levels in Turkish patients with Hashimoto's thyroiditis

Yaylali Guzin Fidan , Guleryuz Bedia , Akin Fulya , Turgut Sebahat , Topsakal Senay , Ata Melek Tunc , Dalyanoglu Mukaddes Mengen

Background: Hashimoto’s thyroiditis (HT) is one of the most common autoimmune thyroiditis that characterised by lymphocytic infiltration and thyroid hormonal disturbances. Genetic and environmental factors play a role in etiology of the disease, but genetic factors are most common. In this study, we investigated the association between Hashimoto’s thyroiditis and IL-2, IL-4, IL-5, TNF-α and IFN-γ levels.Methods: We performed a case&#1...
shares

ea0037ep1039 | Thyroid (non-cancer) | ECE2015

Descriptive analysis of the histopathological findings of a series of 1567 thyroidectomies

Ma Calderon Dulce , Delgado Manuel , Castro Enrique , Alfaro Jose Joaquin , Lopez Gema , Lopez Jose , Aranda Jaime

Introduction: We wanted to analyse the pathology results of thyroidectomies performed in the hospitals of Castilla La Mancha (Spain) between the years 2010 and 2013, inclusive.Material and methods: A retrospective, multicentre, descriptive study of the histopathological results of the 1567 thyroidectomies performed in the hospitals of the eight health districts in our region between the years 2010 and 2013.Results: The histopatholo...
shares

ea0037ep1040 | Thyroid (non-cancer) | ECE2015

Sensitivity and specificity of thyroid cytology in the diagnosis of malignancy: results of a series of 1567 thyroidectomies

Ma Calderon Dulce , Herraiz Sandra , Sastre Julia , Gonzalez Abel , Fernandez Belen , Valero Miguel Angel , Aguirre Miguel

Introduction: Sensitivity and specificity of thyroid cytology in our series of thyroidectomies were evaluated.Material and methods: A retrospective, multicentre study of 1567 thyroidectomies performed in the eight hospitals of Castilla La Mancha (Spain) during the years 2010–2013.Results: The cytological results were benign in 37.6% of cases, malignant or suspicious of malignancy in 17.3% (10 and 7.3% respectively). In 4.1% of...
shares

ea0037ep1041 | Thyroid (non-cancer) | ECE2015

Surgical treatment of thyroid disease: descriptive analysis and histopathology of a series of 92 cases

Ma Calderon Dulce , Aranda Jaime , Mondejar Jose , Alramadan Mubarak , Martin David , Perez Jose

Introduction: Retrospective study of patients undergoing thyroid surgery at the Hospital Virgen de la Luz, Cuenca (Spain) during the years 2010–2013.Material and methods: We evaluated data of 92 patients basically with nodular thyroid disease, who were studied and treated in our hospital.Results: Our series is made up of 92 patients (25% men and 75% women) with an average age of 52 years. The most common form of presentation (...
shares

ea0037ep1042 | Thyroid (non-cancer) | ECE2015

Iodine nutritional status among adolescent girls in Uttarakhand State, India

Kapil Umesh

Introduction: Iodine is an essential micronutrient. Iodine deficiency (ID) among adolescent girls could lead to ID amongst the newborns as they are the future mothers. Uttarakhand state is a known endemic region for ID.Objective: The present study was conducted with an objective to assess the iodine nutritional status amongst adolescent girls in districts: Udham Singh Nagar (USN), Nainital (N), and Pauri (P) of Uttarakhand state.Me...
shares

ea0037ep1043 | Thyroid (non-cancer) | ECE2015

Ultrasonographical features and cytological findings of thyroid nodules in patients with Hashimoto's thyroiditis

Ozdemir Didem , Dellal Fatma Dilek , Baser Husniye , Yazgan Aylin Kilic , Turkolmez Seyda , Ersoy Reyhan , Cakir Bekir

Introduction: It is unclear whether ultrasonographic (US) findings and fine-needle aspiration biopsy (FNAB) results of nodules accompanied with Hashimoto’s thyroiditis (HT) are affected by the presence of thyroiditis or not. In this study, we compared US features and cytological results of nodules in patients with and without HT.Methods: Patients who underwent FNAB in our clinic were evaluated prospectively. Nodules in patients with and without HT w...
shares

ea0037ep1044 | Thyroid (non-cancer) | ECE2015

Usefulness of the assessment of thyroid blood flow as a predictor of relapse of Graves' disease

Merchante Agustin Angel , Garcia-Blasco Lourdes , Perez Susana , Fabra Amparo , Cubells Pilar , Sanchez Carlos

Objective: We investigated the clinical usefulness of thyroid blood flow measurement by colour-flow Doppler ultrasonography in predicting relapse of Graves’ disease (GD).Patients and methods: In 30 euthyroid GD patients, (eight males and 23 females), aged 17–68 years (mean 43.8±12.8), after at least 1 year of treatment with anti-thyroid drug (ATD) and just before its withdrawal, we evaluate with colour-flow Doppler ultrasonography the colo...
shares

ea0037ep1045 | Thyroid (non-cancer) | ECE2015

The effect of anti-TNF therapy on thyroid function in patients with inflammatory bowel disease

Paschou Stavroula A , Kothonas Fotios , Myroforidis Alexandros , Loi Vasiliki , Karayianni Olympia , Poulou Androniki , Goumas Konstantinos , Vryonidou Andromachi

Introduction: Inflammatory bowel disease (IBD) has been associated with various disorders of thyroid function. Many of these patients are now treated with biological agents targeting on TNF-a.Aim: To investigate thyroid function in patients with IBD and the potential effect of anti-TNF therapy.Patients and methods: We studied 41 patients with IBD (25M/16F, 36.4±11 years), without any known thyroid disorder. Eighteen patients (...
shares

ea0037ep1046 | Thyroid (non-cancer) | ECE2015

Hypo- and hyperthyroidism: causes of hepatic dysfunctions

Codruta Lencu , Adrian Iacob , Monica Lencu , Carmen Georgescu

Background and aims: The aim of this study is to analyse the serum markers of liver function and the morphological hepatic changes (by ultrasound) in hypo- and hyperthyroidism.Methods: The study included 59 patients with hypothyroidism: subclinical disease 14 patients and clinically manifest disease 45 patients, and 30 patients with hyperthyroidism. All patients underwent serum liver function tests: alanine aminotransferase (ALT), aspartate aminotransfer...
shares

ea0037ep1047 | Thyroid (non-cancer) | ECE2015

TPOAb as an autoimmune response or index of thyroid hypofunction in breast cancer?

Smyth Peter , McDermott E W M , O'Higgins N J

The observed association between thyroid disorders and breast cancer has provoked many investigations. One area where there is some, although far from universal, agreement is the finding of an increased prevalence of anti-thyroid autoantibodies in breast cancer patients compared to controls. Whether this is a feature of a generalised autoimmune response to breast cancer, or provoked by the enzyme thyroid peroxidase acting as an autoantigen, remains unclear. In this study we lo...
shares

ea0037ep1048 | Thyroid (non-cancer) | ECE2015

Menstrual disturbances in thyroid dysfunction

Gungor Gokcen , Hekimsoy Zeliha , Oz Derya , Alarslan Pinar , Hatiboglu Ogun , Ozmen Bilgin

Introduction: Thyroid hormones play an important role in achieving and maintaining reproductive functions. Thyroid dysfunction affects the menstrual cycle and often leads to menstrual irregularity. We prospectively investigated untreated female patients presenting to our Endocrinology and Internal Medicine outpatient clinics.Material and methods: All the patients were of reproductive age and were newly diagnosed with thyroid dysfunction. After a detailed...
shares

ea0037ep1049 | Thyroid (non-cancer) | ECE2015

Brain, mood and cognition during treatment initiation in mild hypothyroidism

Quinque Eva Maria , Karger Stefan , Arelin Katrin , Schroeter Matthias L , Kratzsch Jurgen , Villringer Arno

In the present study, we investigated neural alterations in newly diagnosed patients with mild hypothyroidism due to Hashimoto’s thyroiditis alongside mood and cognition as well as changes with treatment initiation. Animal studies and first studies of human brain metabolism using radioactive tracers suggest neural involvement in affective and cognitive symptoms of hypothyroidism. Here, we introduce non-invasive magnetic resonance imaging (MRI) techniques that allow the an...
shares

ea0037ep1050 | Thyroid (non-cancer) | ECE2015

Thyroid function in healthy pregnant women in iodine excessive area

Cho Yoon Young , Cha Dong Ik , Kim Jae Hyeon , Chung Jae Hoon , Kim Sun Wook

Background/aims: Maternal subclinical hypothyroidism has been reported to be associated with risks of adverse pregnancy outcomes such as fetal loss and possible fetal neurodevelopmental deficit. However, current guidelines seem to overestimate subclinical hypothyroidism in pregnant women in some regions. Therefore, we aim to evaluate trimester-specific reference range of serum TSH for pregnant women in Korea and whether maternal subclinical hypothyroidism affects perinatal out...
shares

ea0037ep1051 | Thyroid (non-cancer) | ECE2015

Seaweed derived gaseous iodine: a source of iodine intake in coastal communities?

Smyth Peter , Burns Robert , Casey Michael , Andersson Maria , Mullan Karen , O'Dowd Colin

This communication tests the hypothesis that iodine (I2) gas or iodine oxides released from seaweeds previously shown to enhance atmospheric iodine adjacent to seaweed hotspots, may through being inspired by respiration, supply a significant fraction of daily iodine requirements. This could assume importance in a country such as Ireland where iodised salt availability is <5%. Iodine intake was assessed by measuring urinary iodine (UI) excretion using a dry ashing technique...
shares

ea0037ep1052 | Thyroid (non-cancer) | ECE2015

Percutaneous ethanol injection as a first line treatment of cystic thyroid nodules: experience after its introduction in a university hospital

Reverter Jordi L , Alonso Nuria , Ordonez Isabel , Cuadrado Maribel , Cano Lucia , Mauricio Didac , Domingo Manel Puig

Objectives: To evaluate the efficacy, safety and patient’s pain perception of percutaneous ethanol injection treatment (PEIT) as an alternative to surgery in symptomatic thyroid cysts.Patients and methods: Thirty consecutive patients (mean age: 46±10 years; 82% women) with symptomatic thyroid cysts relapsed after drainage were included. In all cases, cytology prior to treatment, maximum cyst diameter and volume were determined. PEIT was conduct...
shares

ea0037ep1053 | Thyroid (non-cancer) | ECE2015

Soft gel capsule vs liquid thyroxine formulation at breakfast: the results of ‘TITI' study

Pirola Ilenia , Formenti Anna Maria , Cristiano Alessandra , Daffini Linda , Gandossi Elena , Cappelli Carlo

Levothyroxine (l-T4) is the mainstay of treating hypothyroidism. Despite the ‘classic’ tablet formulation of l-T4, pharmaceutical industries have recently introduced other formulations such as liquid and a soft gel capsule in a few countries. Recent studies have shown a better absorption of these formulations compared with the traditional tablet bypassing the pH-depending dissolution phase and less suffering the binding by sequestrants in the in...
shares

ea0037ep1054 | Thyroid (non-cancer) | ECE2015

The association between sick euthyroid syndrome and hs-CRP in obese patients without comorbidities

Keskek Sakir Ozgur , Saler Tayyibe , Kirim Sinan , Kursun Ozlem , Ahbab Suleyman , Bankir Mehmet , Pamuk Omer Arif

Inflammation has been shown in obese patients in previous studies. Sick euthyroid syndrome is an expected condition in case of inflammatory diseases. In this study, we aimed to investigate the frequency of sick euthyroid syndrome in obese patients without comorbidities and evaluate the association between obesity and inflammation. A total of 390 subjects were enrolled in this case-control study. The study group consisted of 200 obese patients without comorbidities and the cont...
shares

ea0037ep1055 | Thyroid (non-cancer) | ECE2015

Efficacy and safety of radiofrequency ablation performed by an endocrinologist for large benign thyroid nodules

Kim Tae Hyun , Seo Seok Ho , Kim Soonho

Background: Radiofrequency ablation has recently been used for the treatment of benign thyroid nodules, with outstanding results. However, in most related studies, smaller nodules (<2 cm) were included and the procedure was usually performed by a radiologist or surgeon. Therefore, this study evaluated the efficacy and safety of radiofrequency ablation for nodules >2 cm performed by an endocrinologist with several years of experience performing fine-needle aspiration cy...
shares

ea0037ep1056 | Thyroid (non-cancer) | ECE2015

Prediction of the size of benign thyroid nodules and an analysis of associated factors

Seo Seok Ho , Kim Tae Hyun , Kim Soonho

Background: Most thyroid nodules are benign therefore, they are commonly only monitored. Only a few studies are available on the natural progression/regression of benign thyroid nodules, and large-scale studies on the subject are non-existent. So we identify factors that affect the size of benign thyroid nodules and to predict the potential nodule size through a model.Methods: Between January 2001 and December 2011, 2,469 benign thyroid nodules (1,564 pa...
shares

ea0037ep1057 | Thyroid (non-cancer) | ECE2015

Investigation of GLP-1 and GIP levels change in patients with hyperthyroidism before and after treatment

Cira Duygu Kalkan , Ozdem Sabahat , Sari Ramazan

The main hormones responsible for the incretin effect are GIP and GLP-1. Thyroid hormones accelerate the absorption of glucose from the intestine, increase the release of glucose from glycogen stores and affect the hepatic demolition of insulin. We aimed to assess incretin levels in patients with hyperthyroidism before and after thyroxine therapy. Total 24 subjects (12 hyperthyroid and 12 controls) were enrolled in the study. Oral glucose tolerance test was performed in patien...
shares

ea0037ep1058 | Thyroid (non-cancer) | ECE2015

Liquid vs tablet levo-thyroxine formulation in de novo treatment of hypothyroidism in patients with Hashimoto's thyroiditis: tolerability and changes in quality of life

Sidoti Marilena , Giusti Massimo

Several levo-thyroxine (L-T4) formulations are now available. However, scientific societies discourage the use of generic L-T4 owing to its uncertain bioavailability in comparison with brand L-T4. Recent literature data suggest that using a liquid formulation of brand L-T4 improves the management of hypothyroidism. However, it is not clear whether patient satisfaction improves on liquid (LI) L-T4, as patients may initially...
shares

ea0037ep1059 | Thyroid (non-cancer) | ECE2015

Serum Galectins are increased in patients with Graves' disease hyperthyroidism

Ramos-Levi Ana M , Serrano Ana , Sampedro-Nunez Miguel A , Vicuna Alicia , Rodriguez-Munoz Ana , Martinez Rebeca , De la Fuente Hortensia , Marazuela Monica

Introduction: Patients with autoimmune thyroid disease (AITD) exhibit aberrant immune-regulatory mechanisms. Galectins (Gal) are a family of glycan-binding proteins, which have been involved in immune regulation. However, the association of Gal with AITD remains unknown. In this study, we evaluated serum Gal-1 and Gal-9 in patients with AITD.Methods: Peripheral blood samples from 31 patients with Graves’ disease (GD) (14 with untreated hyperthyroidi...
shares

ea0037ep1060 | Thyroid (non-cancer) | ECE2015

Paraoxonase and arylesterase levels in autoimmune thyroid diseases

Korkmaz Hakan , Tabur Suzan , Ozkaya Mesut , Oguz Elif , Aksoy Nurten , Akarsu Ersin

Objective: The aim of this study was to evaluate paraoxonase-1 (PON1) activities and its association with oxidative stress status in autoimmune thyroid disease (AITD).Materials and methods: Patients with 25 Hashimoto thyroiditis (HT) and 25 Graves’ disease (GD) and 27 healthy controls were enrolled in the study. Blood samples were obtained in euthyroid period and 3 months after the initiation of medical treatment. ...
shares

ea0037ep1061 | Thyroid (non-cancer) | ECE2015

Reference values of TSH, FT4 and FT3 in a cohort of pregnant women in the north of Spain

Ochoa David Ruiz , Leon Maria Piedra , Calzada Maria del Carmen Baamonde , Garcia Fatima Mateos , Rodriguez Azucena Setien , Maranon Cristina Temprano , Chicote Laura Gutierrez , Valdes Raquel Zubeldia , Lopez Rosa Nuria Secadas , Zabala Sonia Ojugas , del Campo Mercedes Alvarez , Garcia Aurora Otero , Elviro Inigo Tejado , Senaris Jose Antonio Amado

Introduction: As soon as pregnancy is established, various physiological changes occur in maternal thyroid economy. Due to that, the reference limits of thyroid parameters used for the general population are no longer valid to diagnosis thyroid dysfunction during pregnancy.Methods: We included 266 pregnant women, with no thyroid disorders and resident in Cantabria, a region in northern Spain. They were questioned about iodized salt and iodine supplements...
shares

ea0037ep1062 | Thyroid (non-cancer) | ECE2015

Serum prolactin and macroprolactin levels in pregnancy and association with thyroid dysfunction and thyroid autoimmunity

Guclu Metin , Cander Soner , Kiyici Sinem , Vatansever Ebru , Hacihasanoglu Arif Bayram , Kisakol Gurcan

Aim: To assess the contribution of macroprolactin (macroPRL) to high serum prolactin (PRL) levels and association of prolactin and macroprolactin levels with thyroid status and thyroid autoimmunity during pregnancy.Methods: Pregnant women (n=138) who had undergone a thyroid-stimulating hormone (TSH) screening during the first trimester of pregnancy enrolled in the study. Serum prolactin, macroprolactin, TSH, FT4, FT3, and thyroid autoantibodies ...
shares

ea0037ep1063 | Thyroid (non-cancer) | ECE2015

The effect of vitamin D on thyroid autoimmunity

Simsek Yasin , Cakir Ilkay , Kucukler Ferit Kerim , Diri Halit , Baglicakoglu Murat , Guler Serdar

Introduction: Although, vitamin D (vit D) mainly regulates calcium and phosphate metabolisms, its deficiency may also contribute to the development of some carcinomas, autoimmune, and cardiac diseases. Vit D deficiency has been defined to correlate with increased autoimmune disease such as type 1 diabetes mellitus, rheumatoid arthritis, autoimmune thyroid diseases (AITD). Previous studies suggested that patients with AITD had lower vit D levels when compared with healthy contr...
shares

ea0037ep1064 | Thyroid (non-cancer) | ECE2015

Endocrine involvement in systemic amyloidosis.

Oueslati Ibtissem , Khessairi Nadia , Nacef Ibtissem Ben , Mchirgui Nadia , Khiari Karima , Kaaroud Hayet , Abdallah Nejib Ben

Introduction: Systemic amyloidosis leads to functional compromise of various organs through infiltration of these tissues by amyloid protein.The aim of this study was to determine the endocrine disorders in patients with systemic amyloidosis.Methods: During the period from 1975 to 2006, we collected 580 patients with renal amyloidosis confirmed by histological exam. We selected 123 patients with hormonal exploration. 55 patients ha...
shares

ea0037ep1065 | Thyroid (non-cancer) | ECE2015

Amyloid goitre as the first manifestation of systemic amyloidosis

Oueslati Ibtissem , Hassen Hana Ben Hadj , Nacef Ibtissem Ben , Mchirgui Nadia , Khiari Karima , Abdallah Nejib Ben

Introduction: Thyroid gland may be asymptomatically involved in most patients with secondary systemic amyloidosis. However, clinically detectable amyloid goiter is quite rare; often it is seen in patient with kidney involvement. We report one case of amyloid goitre without kidney manifestation.Case report: A 30-year-old male diagnosed with bilateral bronchiectasis since 1992 was admitted with rapidly growing goiter associated with dysphagia for solids, c...
shares

ea0037ep1066 | Thyroid (non-cancer) | ECE2015

A questionnaire on quality of life identifies Graves' ophthalmopathy patients who deserve more attention

Villagelin Danilo , Nogueira Heloisa , Sandrin Ana Claudia Gomes , Carbinatto Rebeca , Giovanetti Jakeline , Campos Larissa , Santos Roberto , Bufalo Natassia , Romaldini Joao , Ward Laura

Introduction: Graves’ ophthalmopathy (GO) varies from minor changes to visible face disfigurement which may compromise the visual capacity and the aesthetics of the patient. These deformities affect the quality of life in both functional and emotional senses. There are some questionnaires designed to evaluate the patient’s health, quality of life and relationship with a specific disease. The use of these questionnaires is recommended to improve the quality of care an...
shares

ea0037ep1067 | Thyroid (non-cancer) | ECE2015

Abstract withdrawn....
shares

ea0037ep1068 | Thyroid (non-cancer) | ECE2015

Graves' disease and HIV infection: bad response to antithyroid drugs due to interaction with HIV therapy

Moniz Catarina , Campos Maria Jose , Vasconcelos Carlos

Graves’ disease is one of the multiple autoimmune diseases that have been reported in HIV-infected patients. With the upsurge of highly active anti-retroviral therapy (HAART) the incidence of autoimmune diseases in HIV-infected patients is increasing, especially after immune reconstitution. We present a male, 51-year-old, who started complaining with anxiety, sudoresis and palpitations. The laboratory workout revealed hyperthyroidism: TSH <0.02 μU/ml (0.46–4...
shares

ea0037ep1069 | Thyroid (non-cancer) | ECE2015

Abstract withdrawn....
shares

ea0037ep1070 | Thyroid (non-cancer) | ECE2015

Plasma visfatin/pre-B-cell colony enhancing factor levels in hypothyroid patients and relationship of these levels with thyroid autoimmunity and atherosclerosis

Ucan Bekir , Kebapci Nur , Uslu Sema , Kara Mehmet , Efe Belgin , Oner Setenay

Visfatin/pre-B-cell enhancement factor is an adipocytokine, which is found in the visceral fat tissue and enhances the growth of precursor of B cells through showing synergy with IL7 and stem cell factors. Other cytokines released from the adipose tissue are TNFα and IL6, which has been shown to be related with pathogenesis of insulin resistance, diabetes, dyslipidaemia, inflammation, and atherosclerosis. Our aim was to determine the relationship of plasma visfatin/pre-B-...
shares

ea0037ep1071 | Thyroid (non-cancer) | ECE2015

Could thyroid replacement therapy not be enough to reduce oxidative stress in hypothyroid patients with Down' syndrome? A cohort study

Villani Emanuele Rocco , Onder Graziano , Carfi Angelo , Pagano Francesco , Raimondo Sebastiano , Di Segni Chantal , Silvestrini Andrea , Meucci Elisabetta , Mancini Antonio

Hypothyroidism and autoimmune thyroiditis are common in patients with Down’ syndrome (DS), leading to common prescription of thyroid replacement therapy. On the other hand, thyroid function is involved in oxidative stress (OS) mechanisms. DS is a well-known high OS condition because several genes involved in OS mechanisms map on chromosome 21 and coenzyme Q10, lipophilic antioxidant, could be more correlated with hypothyroidism than TSH in DS people. To investigate relati...
shares

ea0037ep1072 | Thyroid (non-cancer) | ECE2015

Hypothyroidism and the haemodialysis patients: it is a matter for discussion

Aljefery Mohammed

149 haemodialysis chronic renal failure (CRF) patients on haemodialysis (HD) program of 4 h/three times a week investigated for thyroid gland function and try to answer the question: is the thyroid function abnormality affect the response of the haemodialysis CRF patients response to recombinant human erythropoietin (rHuEPO)? We compare the results of the thyroid gland markers; T3, T4, and TSH (which tested by minividus technique) of the patients with the...
shares

ea0037ep1073 | Thyroid (non-cancer) | ECE2015

The changes of thyroid function after coronary angiography in Koreans

Kim Dong Sun , Park Jung Hwan , Sung Yeon-Ah , Won Kyu Chang

Background: The risk of iodine-induced thyrotoxicosis is increased in patients with Graves’ disease and multi nodular goiter with thyroid autonomy. At same time, hypothyroidism can develop after iodine exposure in patients with Hashimoto’s thyroiditis. But, there are no studies about the influence of iodine containing contrast media on thyroid function in iodine excessive area. This study was done to evaluate the changes of thyroid function after coronary angiography...
shares

ea0037ep1074 | Thyroid (non-cancer) | ECE2015

Clinical and social concerns in treated patients with primary hypothyroidism in Basrah: a cross sectional study

Yassin Yassin Haider Ayad , Musa Musa Alaa Khattar , Mansour Abbas Ali

Background: Despite available treatment for hypothyroidism, levothyroxine replacement therapy in a biochemically appropriate dose does not necessarily relieve patients’ symptoms and complaints. The aim of the study was to evaluate the concerns of patients treated with hypothyroidism and to correlate these concerns with different patient characteristics and thyroid biochemical control.Method: One hundred and eighteen treated primary hypothyroid patie...
shares

ea0037ep1075 | Thyroid (non-cancer) | ECE2015

Ultrasonographical and cytological features of exophytic thyroid nodules: do exophytic nodules pretend to be malignant?

Dellal Fatma Dilek , Baser Husniye , Ozdemir Didem , Kilicarslan Aydan , Ersoy Reyhan , Cakir Bekir

Aim: Exophytic nodule refers to a nodule that sticks out of the normal thyroid boundary/outline. Other definition is a nodule with an acute angle between the lesion and adjacent thyroid capsule. In the literature, one study reported that thyroid nodules with exophytic configuration showed a high malignancy rate. We aimed to compare ultrasonographical features and cytopathologic results of exophytic and non-exophytic thyroid nodules.Material and method: T...
shares

ea0037ep1076 | Thyroid (non-cancer) | ECE2015

Dynamics of thyroid function tests during antiviral treatment of hepatitis C

Nechaeva Olga , Dreval Alexander , Matsievich Maria , Petrachenkova Maria , Kokina Kseniya , Bogomolov Pavel

Aim: To estimate the frequency of changes in thyroid function on the background of antiviral therapy in patients with chronic hepatitis C.Material and methods: The retrospective group was consists of 204 patients (mean age 35.5±8.4 years) with HCV genotype 3a, who took the antiviral therapy course with pegylated interferon and ribavirin during 24 weeks. The patients were divided for two groups: 86.3% (176) had a sustained virological response (SVR),...
shares

ea0037ep1077 | Thyroid (non-cancer) | ECE2015

Nondiagnostic fine-needle aspiration biopsy results: our clinic experience

Ozmen Sevilay , Calik Ilknur , Sener Ebru , Kabalar Esref , Timur Ozge , Sevimli Hakan , Carlioglu Ayse , Durmaz Senay Arikan

Adequacy of thyroid fine-needle aspiration (FNA) is generally defined by the thyroid follicle cells, amount, and quality of colloid. Samples priorly should be evaluated for adequacy. A set of qualifying criteria are specified in Bethesda system to remove subjectivity from the adequacy assessment. Each sample prepared from a thyroid FNA should be monitored at least six follicles cell groups containing at least ten cells. In addition to these criteria of assessing the adequacy, ...
shares

ea0037ep1078 | Thyroid (non-cancer) | ECE2015

False negatives and reasons: Erzurum Research and Training Hospital Pathology Department experience

Ozmen Sevilay , Calik Ilknur , Erdogan Senay , Timur Ozge , Sevimli Hakan , Carlioglu Ayse , Durmaz Senay Arikan , Erdogan Fazli

Fine-needle aspiration biopsies (FNAB), adequate for examination, reported as benign re-evaluated with histopathological samples. 61 patients, 52 females and nine males re-evaluated. 41 of them reported as benign. 20 of the patients, seven females and three males reported as papillary carcinoma. Six of the papillary carcinomas were single focus, two muiticentric, and 12 papillary microcarcinoma. Six of the eight patients malignant lobe was different from the lobe that FNA was ...
shares

ea0037ep1079 | Thyroid (non-cancer) | ECE2015

Multiple disease associations in autoimmune polyglandular syndromes

Dabrowska Anna , Zwolak Agnieszka , Tarach Jerzy

Introduction: Autoimmune polyglandular syndromes (APS) are a heterogeneous group of disorders characterised by autoimmune activity against endocrine and non-endocrine organs. APS type depends on the combination of the diseases (APS1, APS2, and APS3).Methods: The study was conducted in 89 patients (70F and 19M) with APS aged mean 50.00±14.80 years, treated at Endocrinology Department between 2003 and 2015. We analysed clinical manifestations, results...
shares

ea0037ep1080 | Thyroid (non-cancer) | ECE2015

Intraocular pressure, corneal, and retinal thickness in patients with euthyroid autoimmune thyroiditis

Cuhaci Fatma Neslihan , Baser Husniye , Ugurlu Nagihan , Yulek Fatma , Ersoy Reyhan , Cagil Nurullah , Cakir Bekir

Introduction: Ocular changes and ocular symptoms may be encountered in patients with hypothyroidism and hyperthyroidism. However, the data concerning the effects of thyroid disorders on intraocular pressure (IOP), central corneal thickness (CCT), and retinal thickness (RT) are very rare. Here, we aimed to evaluate the alterations in IOP, CCT, and RT in patients with euthyroid autoimmune thyroiditis (AIT).Methods: Twenty-five subjects with euthyroid AIT w...
shares

ea0037ep1081 | Thyroid (non-cancer) | ECE2015

Should fine-needle aspiration biopsy perform all of nodules in patients with nodular goitre?

Ozmen Sevilay , Calik Ilknur , Balta Hilal , Timur Ozge , Carlioglu Ayse , Sevimli Hakan , Durmaz Senay Arikan , Kurt Ali

Introduction and aim: Fine-needle aspiration (FNA) biopsy has become widely accepted as a reliable method for diagnosis of malign thyroid nodule. In our study we aimed to review results of thyroid FNA biopsy to be performed by same endocrinologist and compared to their histopathological results after thyroidectomy.Materials and methods: This retrospective study was done at the department of pathology for a period of 2 years from 2012 to 2014. The 401 pat...
shares

ea0037ep1082 | Thyroid (non-cancer) | ECE2015

Hyperthyroidism in Internal Medicine Services in Spain (2005–2012)

Duran Sandra , Lopez Judith , Ortola Ana , Crespo Irene , Gracia Teresa Ruiz , Mendez Manuel , Nunez Karla , Marco Javier

Introduction: The prevalence of hyperthyroidism in patients admitted in Internal Medicine at Spanish hospitals is 0.8%. Proper diagnosis and management of HTD in these patients is still a challenge and therefore, the analyses of the factors involved in the prognosis and survival is of interest.Methods: Data from the minimum-data-set (MDS) of Spanish National health System were collected during 2005–2012 from discharged patients of Internal Medicine ...
shares

Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2023 | Privacy policy | Cookie settings

BiosciAbstracts

Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.

Find out more