Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 37 | ECE2015 | Next issue

17th European Congress of Endocrinology

Guided Posters


ea0037gp.01.01 | Adrenal | ECE2015

Low-dose ACTH testing does not predict treatment response to corticosteroids in community-acquired pneumonia

Blum Claudine A , Schuetz Philipp , Nigro Nicole , Winzeler Bettina , Arici Birsen , Refardt Julie , Urwyler Sandrine A , Briel Matthias , Mueller Beat , Christ-Crain Mirjam

Background: It is controversial whether the attenuated increase of circulating cortisol to ACTH stimulation predicts treatment response to corticosteroids in patients with critical illness. We investigated whether ACTH testing predicts treatment response to corticosteroids in patients with community-acquired pneumonia (CAP).Methods: We performed a low dose (1 μg) ACTH test on admission in a prospective randomised, double-blind, placebo-controlled mu...

ea0037gp.01.02 | Adrenal | ECE2015

Defining and exploring the excessive healthcare burden of adrenal insufficiency

Stewart Paul , Biller Beverly M K , Marelli Claudio , Gunnarsson Candace , Ryan Michael , Johannsson Gudmundur

Introduction: The clinical outcome of patients with adrenal insufficiency (AI) has been shown to be less favorable than previously thought. Clinical studies have shown increased mortality, reduced cardiovascular and skeletal health and compromised quality of life, but the impact of this upon healthcare burden is unknown. This research utilised real-world evidence to compare comorbidities, healthcare utilization and expenditures in patients with AI.Method...

ea0037gp.01.03 | Adrenal | ECE2015

Effect of the switch from conventional glucocorticoids to ‘dual release hydrocortisone' in adult patients with primary and secondary adrenal insufficiency: a 6-month multicentre study

Pivonello Rosario , Simeoli Chiara , Isidori Andrea M , Ciresi Alessandro , Savastano Silvia , Auriemma Renata S , Graziadio Chiara , Di Somma Carolina , Giordano Carla , Lenzi Andrea , Colao Annamaria

Adrenal insufficiency (AI) requires life-long glucocorticoid (GC) treatment, which is associated with an increased risk of metabolic syndrome (MS), probably due to cortisol overexposure for multiple drug daily doses, together with an impairment of quality of life (QoL). Moreover treatment compliance (TC) is reported to be suboptimal in AI patients. The current study aimed at investigating the impact of the switch from twice/thrice daily conventional GCs to once daily dual-rele...

ea0037gp.01.04 | Adrenal | ECE2015

Clinical and genetic findings of an Italian series of patients with ACTH resistance syndromes

Bonomi Marco , Duminuco Paolo , Libri Domenico Vladimiro , Vezzoli Valeria , Salvatoni Alessandro , Cherubini Valentino , Ficcadenti Anna , Radetti Giorgio , Meloni Antonella , Persani Luca

ACTH resistance syndromes (ARS) are rare, severe and heterogeneous diseases that include either familial glucocorticoid deficiency (FDG) or Allgrove syndrome (AS). FDG is a rare autosomal recessive disorder resulting from mutation in genes encoding either the ACTH-receptor (ACTHR) in FDG1, or its accessory protein MRAP, in FDG2. AS is characterized by adrenal insufficiency due to ACTH resistance, alacrimia, and achalasia secondary to mutations in the AAAS gene, which ...

ea0037gp.01.05 | Adrenal | ECE2015

Prevention of adrenal crisis in stress (The PACS Study): serum cortisol during elective surgery, acute trauma and sepsis in comparison to ‘stress dose' hydrocortisone administration in adrenal insufficiency

Taylor Angela , Karavitaki Niki , Smith David , Bancos Irina , Foster Mark , Meier Sibylle , O'Neil Donna , Komninos John , Vassiliadi Dimitra , Mowatt Christopher , Lord Janet , Wass John , Arlt Wiebke

Patients with adrenal insufficiency require increased hydrocortisone (HC) replacement doses during surgery, trauma and infection to avoid life-threatening adrenal crisis. However, currently administered HC doses are chosen empirically rather than on rational grounds, with huge variability in administration modes, total dose and dosing intervals. To conclusively determine serum cortisol levels observed under stress conditions, we firstly collected blood samples from healthy con...

ea0037gp.01.06 | Adrenal | ECE2015

Incidence of adrenal insufficiency and its relation to mortality in patients with septic shock

Gutch Manish , Kumar Sukriti , Razi Syed Mohd , Gupta Abhinav , Gupta Keshav Kumar

Background: The hypothalamic–pituitary–adrenal axis has a pivotal role in combating acute insults. Glucocorticoids play a role directly or indirectly in the maintenance of normal vascular tone and in potentiating the vasoconstrictor action of catecholamine, associated with septic shock.Aims: To determine the incidence of adrenal insufficiency (AI) and its relation to mortality in patients with septic shock.Settings and de...

ea0037gp.01.07 | Adrenal | ECE2015

Mild cognitive deficits in patients on long-term, stable hydrocortisone replacement for primary adrenal insufficiency: a case–control study

Andela Cornelie , Tiemensma Jitske , Biermasz Nienke , Romijn Johannes , Pereira Alberto

Background: Hydrocortisone replacement for primary adrenal insufficiency (PAI) is targeted to mimic circadian endogenous cortisol secretion. Nevertheless, patients on stable treatment report impairments in quality of life. The brain is a major target area for cortisol considering it high density of glucocorticoid receptors and previous studies in patients treated for Cushing’s disease (CD) suggest that hypothalamic-pituitary-adrenal axis dysregulation is related to cognit...

ea0037gp.01.08 | Adrenal | ECE2015

Autoimmune polyendocrine syndrome in India: clinical aspects, AIRE mutations, and functional analysis

Bhatia Eesh , Zaidi Ghazala , Sarangi Aditya , Bhatia Vijayalakshmi , Bharani Nisha , Sachan Alok , Zhang Li , Yu Liping , Jain Vandana , Sahu Saroj , Srivastava Rashmi , Bharti Niharika , Aggarwal Rakesh , Aggarwal Amita

Introduction: Autoimmune polyendocrine syndrome 1 (APS1) is an uncommon, serious autosomal recessive disorder, due to AIRE gene mutations which result in impaired central tolerance. India has a complex genetic structure and also communities with high prevalence of consanguinity, which may result in varied clinical manifestations and genetic mutations.Aims: To study clinical features, interferon-α antibodies (IFNA), AIRE mutations, ...