Endocrine Abstracts

Background: The metabolic syndrome (MetS) is a combination of unfavourable health factors including visceral obesity, dyslipidaemia, hypertension and impaired fasting glucose. It is also strongly associated with increased risk of cardiovascular disease (CVD) and type 2 diabetes. We assessed which factors contribute to the prevalence of MetS in people within different weight and age categories.Methods: 64 046 western European participants aged 18–80 ...

Introduction: To assess the effect of community-based multidisciplinary lifestyle interventions on metabolic syndrome (MetS) and its components in an urban population of Iranian adolescents.Methods: This longitudinal study was conducted on 1230 adolescents, aged 12–15 years, within the framework of the TLGS. They were categorised in three groups: those residing in the intervention area during study (complete intervention group; n=195); thos...

Introduction: While the unfavourable metabolic consequences of obesity have been clearly demonstrated at a population level, there is a wealth of evidence indicating the existence of individuals somehow protected from developing complications, named ‘metabolically healthy obese’. The aim of our study was to identify clinical and biological parameters independently associated with ‘metabolically healthy’ status.Patients and methods: 44...

Introduction: Animal studies suggest that maternal obesity may impact foetal brain structure and function and increase long-term susceptibility to neurodevelopmental and neuropsychiatric disorders. Few human studies have examined these associations with conflicting results. It is unclear if reported associations are due to genetic background or intrauterine mechanisms.Objective: To investigate the association of maternal and paternal obesity status with ...

Introduction: There are few data on renal function following bariatric surgery. We evaluated the effect of Roux-en-Y gastric bypass (RYGB), adjustable gastric banding (AGB) and sleeve gastrectomy (SG) on renal function over a 5-year post-operative period. We also evaluate the effect of these procedures on remission of diabetes and hypertension.Methods: Analysis of a prospectively collected database at Lille University Hospital. Patients were assessed pre...

Introduction: Diabetes mellitus (DM) is a very common complication of cirrhosis (prevalence: 20–60%), primary due to increased hepatic insulin-resistance (IR). After liver transplantation (LT), DM recovers in 67% of cases, while 33% of patients remain diabetic because of a concomitant decreased beta cell function. The roles played by pre-transplant factors determining changes in glucose tolerance after LT are imperfectly known.Aim of the study: To h...

Our objective was to estimate the distribution of Spanish diabetic patients attending to individualized glycaemic targets recommended by the ADA/EASD consensus with and without considering hypoglycaemia risk. We conducted a cross-sectional study in a Spanish primary care setting between 2011 and 2012. A total of 5382 type 2 diabetic subjects under antihyperglycaemic treatment for at least 3 months prior to inclusion completed a study visit in which clinical data including age,...

Context: Total pancreatectomy (TP) with islet cell autotransplantation (IAT) can reduce or prevent diabetes by preserving β-cell function, and is normally performed with on-site isolation laboratory facilities.Objective: We examined factors associated with islet yield and metabolic outcomes in patients with chronic pancreatitis undergoing TP-IAT. We report our experience of TP-IAT with an off-site islet isolation laboratory.Pa...