Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

Guided Posters

Diabetes and obesity – Clinical diabetes

ea0037gp.14.01 | Diabetes and obesity – Clinical diabetes | ECE2015

What components drive the metabolic syndrome? Results from the population-based LifeLines Cohort Study

Slagter Sandra N , Waateringe Robert P van , Wendker Marjolein , Vliet-Ostaptchouk Jana V van , Lutgers Helen L , Beek Andre P van , Klauw Melanie M van der , Wolffenbuttel Bruce H R

Background: The metabolic syndrome (MetS) is a combination of unfavourable health factors including visceral obesity, dyslipidaemia, hypertension and impaired fasting glucose. It is also strongly associated with increased risk of cardiovascular disease (CVD) and type 2 diabetes. We assessed which factors contribute to the prevalence of MetS in people within different weight and age categories.Methods: 64 046 western European participants aged 18–80 ...

ea0037gp.14.02 | Diabetes and obesity – Clinical diabetes | ECE2015

Changes of metabolic syndrome and its components in early adolescents through a 9.9 year community-based lifestyle intervention: Tehran Lipid and Glucose Study

Amiri Parisa , Jalali-Farahani Sara , Hanifi Sakine , Cheraghi Leila , Momenan Amir Abbas , Hosseini-Esfahani Firoozeh , Mirmiran Parvin , Ghanbarian Arash , Azizi Fereidoun

Introduction: To assess the effect of community-based multidisciplinary lifestyle interventions on metabolic syndrome (MetS) and its components in an urban population of Iranian adolescents.Methods: This longitudinal study was conducted on 1230 adolescents, aged 12–15 years, within the framework of the TLGS. They were categorised in three groups: those residing in the intervention area during study (complete intervention group; n=195); thos...

ea0037gp.14.03 | Diabetes and obesity – Clinical diabetes | ECE2015

Clinical and biological determinants of metabolically healthy obese status

Sirbu Anca , Martin Sorina , Barbu Carmen , Florea Suzana , Copaescu Catalin , Fica Simona

Introduction: While the unfavourable metabolic consequences of obesity have been clearly demonstrated at a population level, there is a wealth of evidence indicating the existence of individuals somehow protected from developing complications, named ‘metabolically healthy obese’. The aim of our study was to identify clinical and biological parameters independently associated with ‘metabolically healthy’ status.Patients and methods: 44...

ea0037gp.14.04 | Diabetes and obesity – Clinical diabetes | ECE2015

Parental obesity in association with offspring cognitive and psychomotor development at 4 years of age: the mother child ‘Rhea' cohort in Crete, Greece

Daraki Vasiliki , Georgiou Vaggelis , Koutra Katerina , Kyriklaki Andriani , Kampouri Mariza , Sarri Katerina , Vassilaki Maria , Papavasiliou Stathis , Kogevinas Manolis , Chatzi Leda

Introduction: Animal studies suggest that maternal obesity may impact foetal brain structure and function and increase long-term susceptibility to neurodevelopmental and neuropsychiatric disorders. Few human studies have examined these associations with conflicting results. It is unclear if reported associations are due to genetic background or intrauterine mechanisms.Objective: To investigate the association of maternal and paternal obesity status with ...

ea0037gp.14.05 | Diabetes and obesity – Clinical diabetes | ECE2015

The effect of Roux-en-Y gastric bypass, sleeve gastrectomy and adjustable gastric banding on renal function and remission of metabolic disease: a five-year longitudinal study

Neff Karl , Baud Gregory , Raverdy Violeta , Roux Carel le , Pattou Francois

Introduction: There are few data on renal function following bariatric surgery. We evaluated the effect of Roux-en-Y gastric bypass (RYGB), adjustable gastric banding (AGB) and sleeve gastrectomy (SG) on renal function over a 5-year post-operative period. We also evaluate the effect of these procedures on remission of diabetes and hypertension.Methods: Analysis of a prospectively collected database at Lille University Hospital. Patients were assessed pre...

ea0037gp.14.06 | Diabetes and obesity – Clinical diabetes | ECE2015

Higher HOMA levels and failed decrease in body fat can be considered unfavourable predictors of restoring euglycaemia in diabetic cirrhotic patients undergoing liver transplantation

Grancini Valeria , Lunati Elena , Resi Veronica , Spada Anna , Orsi Emanuela

Introduction: Diabetes mellitus (DM) is a very common complication of cirrhosis (prevalence: 20–60%), primary due to increased hepatic insulin-resistance (IR). After liver transplantation (LT), DM recovers in 67% of cases, while 33% of patients remain diabetic because of a concomitant decreased beta cell function. The roles played by pre-transplant factors determining changes in glucose tolerance after LT are imperfectly known.Aim of the study: To h...

ea0037gp.14.07 | Diabetes and obesity – Clinical diabetes | ECE2015

Degree of control of type 2 diabetes in Spain according to individualised glycaemic targets

Minambres Inka , Mediavilla Jose Javier , Gonzalez-Segura Diego , Perez Antonio

Our objective was to estimate the distribution of Spanish diabetic patients attending to individualized glycaemic targets recommended by the ADA/EASD consensus with and without considering hypoglycaemia risk. We conducted a cross-sectional study in a Spanish primary care setting between 2011 and 2012. A total of 5382 type 2 diabetic subjects under antihyperglycaemic treatment for at least 3 months prior to inclusion completed a study visit in which clinical data including age,...

ea0037gp.14.08 | Diabetes and obesity – Clinical diabetes | ECE2015

Factors associated with islet yield and insulin independence after total pancreatectomy and islet cell autotransplantation in patients with chronic pancreatitis utilising off-site islet isolation: Cleveland Clinic experience

Johnston Philip C , Lin Yu , Walsh Matthew , Stevens Tyler , Bottino Rita , Trucco Massimo , Bena James , Hatipoglu Betul

Context: Total pancreatectomy (TP) with islet cell autotransplantation (IAT) can reduce or prevent diabetes by preserving β-cell function, and is normally performed with on-site isolation laboratory facilities.Objective: We examined factors associated with islet yield and metabolic outcomes in patients with chronic pancreatitis undergoing TP-IAT. We report our experience of TP-IAT with an off-site islet isolation laboratory.Pa...