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17th European Congress of Endocrinology

Guided Posters

Endocrine tumours and neoplasia – NETS

ea0037gp.28.01 | Endocrine tumours and neoplasia – NETS | ECE2015

Clinicopathologic features, treatments, and survival of patients with ectopic Cushing's syndrome from neuroendocrine tumours: data from an Italian multicentre study

Davi Maria Vittoria , Cosaro Elisa , Piacentini Serena , Reimondo Giuseppe , Albiger Nora , Arnaldi Giorgio , Faggiano Antongiulio , Mantovani Giovanna , Fazio Nicola , Grimaldi Franco , Mannelli Massimo , Giraldi Francesca Pecori , Martini Chiara , Ferone Diego , Campana Davide , Scaroni Carla , Terzolo Massimo , DeMarinis Laura , Francia Giuseppe

Introduction: Available literature on series of patients affected by ectopic Cushing’s syndrome (ECS) deriving from neuroendocrine tumours (NETs) is relatively scarce. This is the first Italian multicentre study regarding clinicopathologic features, modalities of treatment, and survival of patients with NETs and ECS.Patients and methods: Retrospective analysis of data from patients with ECS from NETs collected in 14 centres between 1986 and 2014, ob...

ea0037gp.28.02 | Endocrine tumours and neoplasia – NETS | ECE2015

Localisation of insulinoma: comparison of glucagon-like peptide 1 receptor SPECT/CT, PET/CT, and MRI: preliminary results of a prospective clinical study

Antwi Kwadwo , Fani Melpomeni , Heye Tobias , Nicolas Guillaume , Merkle Elmar , Reubi Jean Claude , Gloor Beat , Fischli Stefan , Wild Damian , Christ Emanuel

Purpose: We aim at prospectively comparing the detection rate of glucagon-like peptide 1 receptor (GLP1R) PET/CT vs GLP1R SPECT/CT vs standardised contrast enhanced 3T MRI in patients with endogenous hyperinsulinaemic hypoglycaemia.Methods: 14 patients with neuroglycopenic symptoms due to endogenous hyperinsulinaemic hypoglycaemia were already enrolled (mean age 56 years, ten females and four males). A standardized contrast enhanced 3T MRI was performed....

ea0037gp.28.03 | Endocrine tumours and neoplasia – NETS | ECE2015

Could 99mTc labelled glucagon-like peptide 1 analogue scintigraphy be an answer for patients with persistent hypoglycaemia?

Hubalewska-Dydejczyk Alicja , Sowa-Staszczak Anna , Stefanska Agnieszka , Pach Dorota , Buziak-Bereza Monika , Trofimiuk-Muldner Malgorzata , Gilis-Januszewska Aleksandra , Jabrocka-Hybel Agata , Tomaszuk Monika , Tomaszewska Romana , Malecki Maciej , Bednarczuk Tomasz , Kaminski Grzegorz , Kowalska Aldona , Mikolajczak Renata , Janota Barbara

Surgery is the only effective therapy for insulinoma patients, therefore there is a necessity to develop diagnostic strategies in cases of unknown tumour location, possibly through the use of new biomarkers. 99mTc labelled glucagon-like peptide 1 analogue (99mTc-GLP1) scintigraphy has been developed in our centre as an imaging technique of insulinoma. Labelled GLP1 analogue might also be applied in diagnosis of various forms of nesidioblastosis allowing t...

ea0037gp.28.04 | Endocrine tumours and neoplasia – NETS | ECE2015

Receptor tyrosine kinase expression and their role in the response to target therapy in bronchopulmonary NET

Gagliano Tersa , Benfini Katiusci , Gentilin Erica , Falletta Simona , Bondanelli Marta , Di Pasquale Carmelina , Riva Eleonora , degli Ubertu Ettore , Zatelli Maria Chiara

Surgery is not feasible for infiltrating and metastatic bronchopulmonary NET (BP-NET). In those cases, medical therapy is tried with controversial results. Thus, it is important to identify new therapeutic targets to provide adequate medical treatment for patients with BP-NET. Sunitinib, is a multi-targeted receptor tyrosine kinase inhibitor (TKI), mainly described to inhibit VEGFR.The aim of our study is to verify whether insulin receptor (IR), IGF1R, a...

ea0037gp.28.05 | Endocrine tumours and neoplasia – NETS | ECE2015

Filamin-A is involved in stabilisation, signal transduction, and angiogenesis regulation mediated by somatostatin receptor 2 in pancreatic neuroendocrine tumors

Vitali Eleonora , Cambiaghi Valeria , Loiarro Federica , Zerbi Alessandro , Colombo Piergiuseppe , Spada Anna , Mantovani Giovanna , Peverelli Erika , Carnaghi Carlo , Lania Andrea

Somatostatin receptor type 2 (SST2) is the main pharmacological target of long-acting somatostatin analogues (SSA) widely used in patients with pancreatic neuroendocrine tumours (P-NETs). A subset of patients is resistant to SSA, although the molecular mechanisms responsible for resistance are poorly understood. Several studies identified cytoskeleton protein interactions as determinant in receptor anchoring, expression and signalling. Since SST2 was recently demonstrated to a...

ea0037gp.28.06 | Endocrine tumours and neoplasia – NETS | ECE2015

Patient-reported time to diagnosis of neuroendocrine tumors (NETs) in Europe: results from the first global NET patient survey: a collaboration between the International Neuroendocrine Cancer Alliance (INCA) and Novartis

Pavel Marianne , Kolarova Teodora , Goldstein Grace , Leyden John , Sissons Maia

Background: Neuroendocrine tumor (NET) symptoms are often similar to common conditions or may not arise until metastasis occurs, delaying diagnosis and impacting survival. We present data on time to diagnosis from the European (EU) NET patient perspective.Methods: In 2014, 1928 NET patients from >12 countries (Europe (n=763): Belgium, Bulgaria, France, Germany, Norway, UK, and other EU countries (not specified); Americas; Asia; Oceania) part...

ea0037gp.28.07 | Endocrine tumours and neoplasia – NETS | ECE2015

Complete remission of hepatic metastasis after total gastrectomy for a gastric carcinoid tumor type 1: a case report

Tresoldi Alberto Stefano , Bonifacio Cristina , Pepe Giovanna , Carnaghi Carlo , Lania Andrea Gerardo Antonio

Gastric carcinoids secondary to autoimmune atrophic gastritis (GC type 1) are usually well differentiated neoplasia, with an indolent course and an excellent overall prognosis. However, a subset of these tumors (<5%) may develop advanced disease, with lymph node and/or hepatic metastasis. The pathogenesis of these carcinoids is related to chronic trophic stimuli to enterochromaffin-like (ECL) cells due to chronic hypergastrinemia. Treatments directed to remove the source o...

ea0037gp.28.08 | Endocrine tumours and neoplasia – NETS | ECE2015

General characteristics and evaluation of β-cell function and insulin sensitivity in a large monocentric series of insulinomas

Furnica Raluca Maria , Istasse Laure , Gigot Jean-Francois , Deprez Pierre , Buysschaert Martin , Maiter Dominique

Background: Insulinomas are the most common functional neuroendocrine tumours of the pancreas. Hypoglycaemic manifestations are highly variable and largely independent on tumour size and severity of insulin hypersecretion.Objectives: In this study we investigated the clinical, biological and tumoural characteristics of a large series of patients with insulinoma and we evaluated the sensitivity of peripheral tissues to insulin before and after surgery.</p...

ea0037gp.28.09 | Endocrine tumours and neoplasia – NETS | ECE2015

Association of angiopoietin/TIE2 plasma level and VEGF system with progression in gastroenteropancreatic neuroendocrine tumors

Sampedro-Nunez Miguel , Ramos-Levi Ana , Vicuna Alicia , Campos Sandra , Serrano Ana , Rodriguez-Munoz Ana , Martinez-Hernandez Rebeca , Martin-Perez Elena , Adrados Magdalena , Marazuela Monica

Introduction: Angiopoietins (ANG) -1 and 2, their receptor TIE2, and the vascular endothelial growth factor (VEGF) are involved in the process of angiogenesis. However, their role in the pathogenesis and development of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) is not completely understood. In a previous study of 42 patients with GEP-NET, we observed an elevation of these serum markers, especially in those with metastatic disease. The objective of this study was ...