Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

ea0037oc9.1 | Adrenal 2 | ECE2015

Effects of dexamethasone and adrenocorticotropin on circulating microRNA expression in humans

Igaz Ivan , Nyiro Gabor , Nagy Zoltan , Perge Pal , Toth Miklos , Racz Karoly , Igaz Peter , Patocs Attila

Objective: MicroRNAs are short non-protein coding RNA molecules involved in the regulation of numerous homeostatic processes via modulating gene expression. There are some data that the expression of microRNA might be modulated by hormones, but the interaction of hormones and circulating microRNAs of adrenocortical origin is mostly unknown.Methods: The expression of six selected circulating microRNAs (hsa-miR-27a, hsa-miR-125b-2, hsa-miR-200b, hsa-miR-21...

ea0037oc9.2 | Adrenal 2 | ECE2015

Alternative pathway synthesis dominates androgen production in patients with congenital adrenal hyperplasia and is decreased by Chronocort® more than by conventional glucocorticoid therapy

Jones Christopher , Mallappa Ashwini , Reisch Nicole , Hughes Beverley , O'Neil Donna , Krone Nils , Whitaker Martin , Eckland David , Merke Deborah , Ross Richard , Arlt Wiebke

Suppression of excess androgen production poses a considerable clinical challenge in the management of patients with congenital adrenal hyperplasia (CAH). Whilst the major route of androgen synthesis in humans is the classic pathway via androstenedione and testosterone, the relative contribution of the alternative pathway originating from 17-hydroxyprogesterone to androgen excess in CAH has not been defined. Androgen effects of both pathways are elicited in androgen target tis...

ea0037oc9.3 | Adrenal 2 | ECE2015

Modelling the salivary cortisone to serum cortisol inter-relationship to predict serum cortisol under physiological conditions and after hydrocortisone

Debono Miguel , Harrison Robert , Keevil Brian , Whitaker Martin , Digweed Dena , Arlt Wiebke , Ross Richard

Introduction: Measuring serum cortisol to evaluate the normal circadian rhythm and adequacy of hydrocortisone replacement levels requires multiple readings; an expensive, cumbersome process. Conversely, salivary cortisone, a surrogate marker for free cortisol levels is non-invasive and well suited for out-patient settings. We hypothesised that salivary cortisone predicts circulating cortisol levels and can be used as an alternative marker of serum cortisol in a physiological s...

ea0037oc9.4 | Adrenal 2 | ECE2015

More than 2.5-fold increased risk for adrenal crises in patients with Addison's disease and the autoimmune polyglandular syndrome compared with secondary adrenal failure: German health insurance data 2010--2013

Meyer Gesine , Badenhoop Klaus , Linder Roland

Introduction: Adrenal crises are potentially life-threatening complications in patients with adrenal insufficiency (AI). Our objective was to investigate the frequency of adrenal crises in patients with different forms of AI in the Techniker Krankenkasse (TK), one of the largest German Health Insurance providers, covering more than 12% of the German population.Design: The Statutory Health Insurance (SHI) database of the TK was analysed for diagnostic cod...

ea0037oc9.5 | Adrenal 2 | ECE2015

The Notch ligand Jagged1 is up-regulated in adrenocortical carcinomas and is associated with a favourable clinical outcome

Ronchi Cristina , Sbiera Silviu , Altieri Barbara , Steinhauer Sonja , Wild Vanessa , Bekteshi Michaela , Kroiss Matthias , Fassnacht Martin , Allolio Bruno

Background: Adrenocortical tumours consist of frequent adrenocortical adenomas (ACA) and highly malignant (ACC) with a still incompletely understood pathogenesis. Dysregulation of Notch signalling pathway is implicated in several cancers with oncogenic or tumour suppressor functions. Copy number gains and over-expression of Jagged1, a ligand of Notch receptor, was reported in ACC. The aim of the study was to evaluate the expression of Jagged1 and other Notch-r...