Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 37 | ECE2015 | Next issue

17th European Congress of Endocrinology

Oral Communications

Neuroendocrinology and pituitary-basic

ea0037oc7.1 | Neuroendocrinology and pituitary-basic | ECE2015

Genetic screening of regulatory regions of pituitary transcription factors among patients with idiopathic pituitary hormone deficiencies

Schuilwerve Joyce , Elizabeth Melitza , Peeters Robin , Visser Theo , Hokken-Koelega Anita , de Graaff Laura

Introduction: POU1F1 is a pituitary transcription factor, critical for differentiation of pituitary somatotrophs, thyrotrophs and lactotrophs. POU1F1 expression depends on the presence of PROP1, which attenuates expression of transcriptional repressor HESX1. Previous mutation screening of POU1F1 coding exons in our cohort of patients with combined pituitary hormone deficiency (CPHD) showed POU1F1 mutations in only 1% of the families. We hypo...

ea0037oc7.2 | Neuroendocrinology and pituitary-basic | ECE2015

KLF4 in hypothalamus regulates leptin homeostatic effects through AgRP

Sanchez-Rebordelo Estrella , Imbernon Monica , Gallego Rosalia , Gandara Marina , Lear Pamela , Lopez Miguel , Dieguez Carlos , Nogueiras Ruben

Introduction: Krüpel-like factor 4 (KLF4) is a zinc-finger-type transcription factor expressed in a range of tissues that plays multiple functions. KLF4 is expressed in neural stem cells and is critical to neuronal differentiation. Recent evidence suggests that KLF4 also plays an important role in the central regulation of energy balance. In vitro studies show that KLF4 is a transcriptional regulator of agoutiĀ–related protein (AgRP), essential to the hyperph...

ea0037oc7.3 | Neuroendocrinology and pituitary-basic | ECE2015

Maternal distress associates with placental genes regulating foetal glucocorticoid exposure and IGF2: role of obesity and sex

Mina Theresia , Raikkonen Katri , Riley Simon , Norman Jane , Reynolds Rebecca

Introduction: Maternal distress, including poorer life satisfaction, increased anxiety and depression (A&D) symptoms, are worse in Severely Obese (SO) than lean pregnancy and may alter placental genes regulating foetal glucocorticoid exposure and placental growth. We hypothesised that the associations between increased maternal distress with changes in placental mRNA levels leading to a reduced placental barrier to maternal glucocorticoids, and altered placental IGF2, are ...

ea0037oc7.4 | Neuroendocrinology and pituitary-basic | ECE2015

Gonadotropin-inhibitory hormone signalling displays sexually dimorphic roles in the control of energy homeostasis: studies in the NPFF1 receptor null mouse

Leon Silvia , Vazquez Maria Jesus , Barroso Alexia , Garcia-Galiano David , Ruiz-Pino Francisco , Manfredi-Lozano Maria , Romero-Ruiz Antonio , Sanchez-Garrido Miguel A , Dieguez Carlos , Nogueiras Ruben , Roa Juan , Pinilla Leonor , Tena-Sempere Manuel

RF-amide-related peptide-3 (RFRP-3), the mammalian orthologue of the avian gonadotropin-inhibiting hormone (GnIH), has been proposed as major inhibitory signal for the reproductive axis, acting via the NPFF1 receptor (NPFF1R). In addition, RFRP-3 has been recently suggested to modulate feeding, with reported orexigenic actions; a function that might contribute to the integrative control of energy homeostasis and reproduction. However, characterisation of the metabolic effects ...

ea0037oc7.5 | Neuroendocrinology and pituitary-basic | ECE2015

Not so giants: mice lacking both somatostatin and cortistatin have high GH levels, but show no changes in growth rate or IGF-I levels

Luque Raul M , Gahete Manuel D , Pedraza-Arevalo Sergio , Pozo-Salas Ana I , L-Lopez Fernando , de Lecea Luis , Cordoba-Chacon Jose , Castano Justo P

Somatostatin (SST) and cortistatin (CORT) are two highly related neuropeptides involved in the regulation of several endocrine secretions. In particular, SST and CORT are two primary negative regulators of GH secretion. Consequently, SST or CORT knockout (KO) mice exhibit elevated GH levels; however, this does not lead to increased IGF-I levels or somatic growth, which has been suggested that could be due to a compensatory mechanism between both peptides. In order to test this...