Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology


Glucocorticoid action in health and disease

ea0037s1.1 | Glucocorticoid action in health and disease | ECE2015

Dietary regulation of cortisol production and metabolism in humans

Walker Brian R

The hypothalamic-pituitary adrenal (HPA) axis plays a key role in the metabolic response to stress, so it is to be anticipated that cortisol signalling might in turn be regulated by nutritional status. This regulation might operate either centrally, controlling ACTH and hence plasma cortisol, or peripherally, controlling metabolism of cortisol in target tissues.Plasma cortisol levels are elevated during starvation in animals and a recent meta-analysis co...

ea0037s1.2 | Glucocorticoid action in health and disease | ECE2015

Subclinical Cushing's syndrome and cardiovascular disease

Dalmazi Guido Di

Subclinical Cushing’s syndrome, defined as evidence of alterations of the HPA axis in patients without stigmata of hypercortisolism, is a frequent finding among patients with adrenal incidentalomas. It is well-known that this condition is associated with several co-morbidities, such as hypertension in 2/3 of the cases, diabetes in 1/3, and dyslipidemia, which impair the cardiovascular risk profile of those patients. Recently, different independent reports on the natural h...

ea0037s1.3 | Glucocorticoid action in health and disease | ECE2015

11β-hydroxysteroid dehydrogenase type 1: substrate promiscuity, implications for local glucocorticoid activation?

Odermatt Alex

11β-hydoxysteroid dehydrogenase type 1 (11β-HSD1) essentially catalyzes the conversion of the inactive endogenous glucocorticoid cortisone (11-dehydrocorticosterone in rodents) and the synthetic prednisone into the active cortisol (corticosterone in rodents) and prednisolone. The association of an elevated expression of 11β-HSD1 with metabolic disease has been extensively studied in humans and in rodent models. It is generally assumed that the effects that are o...