ea0037s15.1 | Puberty: new mechanisms | ECE2015
, Lomniczi Alejandro
, Wright Hollis
, Toro Carlos
A prevailing concept regarding the mechanism controlling the timing of puberty proposes that GnRH release from the hypothalamus increases at puberty due to a loss of transsynaptic inhibition, accompanied by an increase in neuronal/glial excitatory inputs to GnRH neurons. Without negating the importance of this intercellular communication process, recent evidence suggests that a critical inhibitory/excitatory Yin-Yang mechanism regulating the advent of puberty is epigenetic in ...