Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2015) 37 EP148 | DOI: 10.1530/endoabs.37.EP148

ECE2015 Eposter Presentations Reproduction, endocrine disruptors and signalling (92 abstracts)

Prevalence of autoimmune thyroid markers in euthyroid women with polycystic ovary syndrome

Ahmed Bahaa El-Din , Alyaa El-Sherbeny & Emad Abd El-Hadi


Ain Shams University Hospital, Cairo, Egypt.


Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women in reproductive age. A condition that causes irregular menstrual periods because monthly ovulation is interrupted and levels of androgens are elevated. It occurs in about 5–10% of women and is considered to be the most common cause of anovulatory infertility in reproductive age.

Objectives: To compare the prevalence, levels of thyroid auto-antibodies in a group of Egyptian women with PCOS and a control group in reproductive age to determine whether women with PCOS have a greater risk of thyroid autoimmune diseases, thyroid dysfunction or not.

Patients and methods: This study was conducted on 45 euthyroid women with PCOS and 18 healthy women as a control in the Outpatient Clinics of Endocrinology, Ain Shams University Hospital. PCOS was defined by the revised 2003 Rotterdam criteria. Thyroid function was evaluated by measurement of TSH and FT4 levels, anti-thyroid peroxidase, and anti-thyroglobulin antibodies (anti-TPO and anti-TG respectively) as markers for thyroid autoimmunity. All parameters were measured using electrochemiluminescence immunoassay.

Results: Women with PCOS had a significantly higher levels of anti-TPO in comparison to controls (27±10 and 21±10 IU/ml, respectively; P<0.05) with no significant difference in anti-TG, TSH, or FT4 between the two groups. Patients with PCOS had a non-significant higher prevalence of positive anti-TG and/or anti-TPO in comparison to controls (40 and 22.2%, respectively; P>0.05), anti-TPO alone (28.9 and 16.7, respectively; P>0.05), and anti-TG alone (22.2 and 11.1%, respectively; P>0.05).

Conclusions: Women with PCOS had a significantly higher levels of anti-TPO than controls that may put them at a higher risk for thyroid autoimmune disease.

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