Endocrine Abstracts

Introduction: A diet plan, meals with suitable glycaemic index and sophisticated insulin delivery are used for balanced sacharides–insulin intake. In specific real day-to-day life situations patients must break their activities. Urgency to east in socially inappropriate time harm their lives, especially in young children with diabetes. Night hypoglycaemia, a parental fear of insufficient snack in nursery, sports with prolonged race periods, etc. are among these situations. Controlled glucose release formulation with 2, 4, and 6 h lag time offers chance to substitute snacks or other meals in advance, allowing to decrease life inconvenience and improve therapy adherence of children with diabetes and their parents.

Design: A dosage form with controlled glucose release was prepared, a release period of 2–4 h was achieved. Optimal diameter, resistance of the coat, volume, taste, and acceptable form to swallow were refined in pharmaceutical treat.

Results: An amount of two exchange units is easy to add to standard meals, e.g. yoghurt. Pellets (clinically powder) do not cause abdominal discomfort. In CGM studies, formulation prevent night hypoglycaemia.

Conclusions: The formulation with controlled glucose release with specific easy-to-explain lag time offers additional means for diabetes treatment.

Disclosure: This work was supported by Grant of IGA Ministry of Health of Czech Republic NT14479/2013.