Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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17th European Congress of Endocrinology

Eposter Presentations

Diabetes (complications & therapy)

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Diabetes (pathiophysiology & epitemiology)
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Obesity and cardiovascular endocrinology

ea0037ep399 | Diabetes (complications & therapy) | ECE2015

Obstructive sleep apnoea and type 1 diabetes mellitus

Tan Hiang Leng , Babwah Feaz , Waheed Najeeb , Butt Muhammad Imran

Introduction: Obstructive sleep apnoea (OSA) is common and frequently found in patients with obesity and type 2 diabetes mellitus. This case report shows the infrequently documented link between OSA and type 1 diabetes and highlights the need to confirm the type of diabetes especially in complex and atypical cases.Case report: A 44-year-old gentleman, with a BMI of 34, was diagnosed with type 2 diabetes and was treated with metformin and given lifestyle ...
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ea0037ep400 | Diabetes (complications & therapy) | ECE2015

Efficacy of sitagliptin added on to intensive insulin therapy in type 2 diabetic patients

Taskiran Bengur , Cansu Guven Baris

Aim: Despite multiple dose injections some patients still fail achieving HbA1c target. We aimed to evaluate the effect of sitagliptin add on therapy to multiple dose insulin injections.Method: Data of 47 (seven males and 40 females) type 2 diabetic patients who had HbA1c over 7% were retrospectively evaluated. They were already treated with premix lispro or aspart insulin (n=28), glargine plus premeal regular or aspart or lispro insulin (n</...
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ea0037ep401 | Diabetes (complications &amp; therapy) | ECE2015

Abstract withdrawn....
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ea0037ep402 | Diabetes (complications &amp; therapy) | ECE2015

Is vitamin D a predictor of premature atherosclerosis in type 2 diabetic patients?

Hammdy Nehal , Abd El Gaffar Nagwa , Abdo Randa , Wadia Mary

Introduction: A poor vitamin D status has been related to an increased risk of cardiovascular disease. Carotid intima–media thickness (IMT) has shown to be an early marker of subclinical atherosclerotic Therefore, we aimed at examining the association between vitamin D status and the extent of carotid IMT in type 2 diabetics.Subjects and methods: In a cross sectional study 78 type 2 diabetic patients attending the Diabetes and Endocrinology Clinic i...
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ea0037ep403 | Diabetes (complications &amp; therapy) | ECE2015

Long-term use of insulin pump vs pens in treating young children with type 1 diabetes

Soliman Ashraf , Alkhalaf Fawzia , Alzyoud Mahmoud , Alhumaidi Noura , Elawwa Ahmed , Sabt Aml , Alyafie Fawzia , Aldersy Nagwa

Introduction: Unequivocal evidence for the benefit of MDI, the analogs and CSII-treatment in children is lacking. This study assesses the effects of insulin pump (CSII) vs pens in treating children with type 1 diabetes for more than 2 years.Research design and methods: Diabetes control and anthropometric data of 94 children with type 1 diabetes who were on continuous s.c. insulin therapy using insulin pump were compared with those for 40 children with ty...
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ea0037ep404 | Diabetes (complications &amp; therapy) | ECE2015

Effect of liraglutide 1.8 mg in patients with non-controlled type 2 diabetes mellitus at an endocrinology clinic: LIED-2 Study

Muriel Alvaro J , Herrera Alvaro A , Lomba Alin Abreu

Background and aims: To describe the characteristics of patients with non-controlled type 2 diabetes mellitus with liraglutide treatment.Materials and methods: Retrospective descriptive study. 85 outpatients (women 49, ages 18–86 years old with non-controlled type 2 diabetes mellitus were evaluated between July 2013 and March 2014 and received treatment with liraglutide 1.8 mg Q18/day (0.6 mg Q18 during the first week, 1.2 mg Q18 during the send wee...
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ea0037ep405 | Diabetes (complications &amp; therapy) | ECE2015

Correlation of left ventricular hypertrophy and left ventricular diastolic dysfunction with HbA1c in newly diagnosed type 2 diabetics

Gutch Manish , Razi Syed Mohd , Gupta Abhinav , Kumar Sukriti , Gupta Keshav

Introduction: Diabetes is associated with dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Diabetic macrovascular complications are the leading cause of deaths in diabetics. The correlation between LVH and LVDD with HbA1c is not clear in newly diagnosed T2DM Indian diabetics.Aims and objective: To study the frequency of left ventricular hypertrophy (LVH) and left ventricular diastolic dysfuncti...
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ea0037ep406 | Diabetes (complications &amp; therapy) | ECE2015

The frequency of fall and risk factors in elderly patients with type 2 diabetes

Tutuncuoglu Pelin , Sarac Fulden , Savas Sumru , Kilavuz Asli , Akcicek Fehmi

The aims of the study were to determine the frequency of falls in elderly patients with type 2 diabetes mellitus and to evaluate the risk factors for falls. In the study, 100 (mean age 64.9±11.0 years) (65 females, 35 males) elderly patients with type 2 DM were enrolled. Medical record abstraction of sociodemographic, clinical, and laboratory data was performed retrospectively. Medication characteristics, comorbidities, location and height of fall, associated injuries and...
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ea0037ep407 | Diabetes (complications &amp; therapy) | ECE2015

Factors influencing prognosis in patients hospitalised with diabetic ketoacidosis

Gutch Manish , Kumar Sukriti , Razi Syed Mohd , Gupta Abhinav , Gupta Keshav Kumar

Background: Diabetic ketoacidosis is characterised by biochemical tired of hyperglycemia, acidosis, and ketonemia. It remains a life threatening condition despite improvement in diabetic care, timely identification and intervention remains the backbone of treatment.Aim and objectives: i) To evaluate the clinical and biochemical prognostic markers in diabetic ketoacidosis. ii) To correlate the various prognostic markers with mortality in diabetic ketoacid...
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ea0037ep408 | Diabetes (complications &amp; therapy) | ECE2015

Microalbuminuria in children and adolescents with type 1 diabetes mellitus: predictive factors

Nunes Joana , Monteiro Ricardo , Amaral Daniela , Pina Rosa , Lopes Lurdes , Limbert Catarina

Objective: Microalbuminuria is usually the first microvascular complication of type 1 diabetes mellitus (T1DM). We aimed to identify its frequency, time of occurrence and related risk factors.Methods: Clinical reports of 201 children followed in our institution were retrospectively analysed (diabetes duration 3.8±3.6 years, age at diagnosis 8.1±3.7 years, HbA1c value 9.0±1.7%). Statistical analysis was performed with SPSS version.21 for Wi...
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ea0037ep409 | Diabetes (complications &amp; therapy) | ECE2015

Assessment of iodine status and thyroid structure changes in a cohort of patients with diabetes mellitus type 1 and comorbid chronic kidney disease in Belarus

Sazonava Alena , Mokhort Tatiana , Astapovich Marina , Petrenko Sergei

The aim was to assess iodine status and thyroid structure changes in a cohort of patients with diabetes mellitus type 1 (DM1) at different stages of comorbid chronic kidney disease (CKD) after achievement of adequate iodine status in Belarus. We examined 62 patients (20m; 42f; age 42.1±12.07 years; BMI 26.14±5.27 kg/m2; duration of DM1 22.9±8.67 years; age at DM1 onset 19.89±12.72 years) at CKD stages 1, 2, 3, 5 (n=28; 21; 12; 1 respecti...
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ea0037ep410 | Diabetes (complications &amp; therapy) | ECE2015

Association of dyslipidaemia, chronic kidney disease and hypertension with carotid atherosclerosis in patients with type 2 diabetes mellitus

Vasilkova Volha , Mokhort Tatiana , Naumenko Elena , Filipcova Natalia

Introduction: Atherosclerotic complications are the leading causes of morbidity and mortality among patients with DT2.Aim: To investigate the possible role of dyslipidaemia, hypertension and chronic kidney disease (CKD) on the characteristics of carotid atherosclerosis (presence of plaque, carotid IMT and total plaque area) in patients with DT2.Material and methods: Patients aged 60–75 years with DT2 were included in this stud...
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ea0037ep411 | Diabetes (complications &amp; therapy) | ECE2015

Validation of self-reported oral health measures for predicting periodontitis among adult Filipinos with type 2 diabetes mellitus

Lo Tom Edward , Lagaya-Estrada Ma. Cristina , Jimeno Cecilia , Jasul Gabriel

Diabetes mellitus is currently being recognised as a global health problem. The likelihood of periodontal disease among diabetics is thrice and progresses rapidly when uncontrolled. Diabetics were less likely to see a dentist than to seek consult with a doctor for diabetes care. A cheap and easy way of clinical assessment via self-reported oral health questionnaire would be of great use especially in a developing country like The Philippines. This study aims to validate self-r...
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ea0037ep412 | Diabetes (complications &amp; therapy) | ECE2015

The effect of MCP-1 A-2518G polymorphism on development of diabetic coronary artery disease

Bagci Gokhan , Bagci Binnur , Cakmakoglu Bedia

Introduction: Inflammatory markers play an important role in the development of type 2 diabetes and coronary artery disease. Monocyte chemoattractant protein-1 (MCP-1) is a member of the C-C chemokine family and a potent chemotactic factor for monocytes.The aim of our study was to investigate the effect of MCP-1 A-2518G polymorphisms on the development of diabetic coronary heart disease.Subjects and methods: 53 diabetic patients wi...
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ea0037ep413 | Diabetes (complications &amp; therapy) | ECE2015

Phenotype-directed personalisation of therapy in type 2 diabetes mellitus patients and criteria of prescription

Mikijanska Tatjana , Snigirovs Viktors , Pirags Valdis

Methods: We studied 228 patients with T2DM treated in Pauls Stradins Clinical University Hospital in Endocrinology Department from Jan 2013 to Sep 2014. The greatest attention was paid to the patients’ biochemical analyses, such as triglycerides (TG), c-peptide, HbA1c and prescribed treatment, as well as BMI and the doctor who treated each patient. Phenotypically patients were divided into four major groups. The first group included 73 patients with chronic kidney disease...
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ea0037ep414 | Diabetes (complications &amp; therapy) | ECE2015

Glucogenic hepatopathy: a rare and underdiagnosed condition in type 1 diabetes

Yetkin Demet Ozgil

Introduction: Glycogenic hepatopathy (GH) has been reported as a very rare and under recognized complication in longstanding poorly controlled type 1 diabetes patients. GH is characterised by transient elevation of liver transaminase and hepatomegaly caused by reversible and excessive glycogen accumulation in hepatocytes. Here we report a 20 years old type 1 poorly controlled diabetic female patient with elevated transaminases.Clinical presentation: A 20...
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ea0037ep415 | Diabetes (complications &amp; therapy) | ECE2015

Assessment of dependence of the hypoglycaemic episodes frequency on gender factor

Mahlina Elena , Navmenova Yana , Mokhort Tatiana

Objective: Assessment of the frequency of hypoglycaemic episodes during daily monitoring of glucose in the subcutaneous water of women and men with type 1 diabetes mellitus.Methods: The study of daily dynamics of glucose has been performed with continuous glucose monitoring system (CGMS) Medtronik MINIMED company (USA). The study involved 162 patients with type 1 diabetes mellitus. The patients were divided into two groups: group 1 – women with regu...
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ea0037ep416 | Diabetes (complications &amp; therapy) | ECE2015

Comparison of umbilical cord ghrelin concentrations in full-term pregnant women with or without gestational diabetes

Karakulak Murat , Saygili Ugur , Temur Muzaffer , Yilmaz Ozgur , Ozbay Elif Pelin Ozun , Calan Mehmet , Cosar Hese

Purpose: The purpose of this study was to analyse ghrelin concentrations in the umbilical cord of pregnant women with a diagnosis of gestational diabetes mellitus. The relationship between ghrelin concentrations and birth weights was investigated.Materials and methods: Sixty pregnant women with gestational diabetes mellitus and 64 healthy pregnant women with three oral glucose tolerance test results within normal limits were included in the study. Follow...
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ea0037ep417 | Diabetes (complications &amp; therapy) | ECE2015

The relationship between metabolic syndrome and albuminuria in patients with type 2 diabetes mellitus

Sahin Osman , Sahin Serap Baydur , Ayaz Teslime , Algun Ekrem

Background and aims: Obesity, as a central piece inside metabolic syndrome, is as an independent risk factor for the onset, aggravated course, and poor outcomes of chronic kidney disease (CKD) including diabetic nephropathy (DN). Our aim was to investigate the relationship between metabolic syndrome (MS), diabetic nephropathy and renal function in patients with type 2 diabetes mellitus (T2DM).Materials and Methods: 197 patients with T2DM (mean age; 56.1&...
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ea0037ep418 | Diabetes (complications &amp; therapy) | ECE2015

Achievement of recommended glucose, lipid, and blood pressure targets in patients with type 2 diabetes mellitus

Barka Ines , Slim Ines , Ouerdeni Senda , Ach Koussay , Maaroufi Amel , Hasni Yosra , Kacem Maha , Chaieb Molka , Chaieb Larbi

Background: Patients with type 2 diabetes mellitus (T2DM) have a greater risk for cardiovascular morbidity and mortality than those without T2DM. This risk is even further aggravated if they also suffer from hypertension and/or dyslipidaemia. However, better cardiovascular outcome can be reached by tight control of blood glucose, serum lipids, and blood pressure (BP).Patients and methods: One hundred and nineteen patients were consecutively enrolled. Wel...
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ea0037ep419 | Diabetes (complications &amp; therapy) | ECE2015

Staphylococcus aureus nasal carriage and related risk factors in diabetic foot patients

Kurultak Ilhan , Altay Mustafa , Cesur Salih , Yildiz Eda , Duranay Murat

Introduction: Infections are the major cause of increased mortality and morbidity rate in diabetic foot patients. There are little data in literature about the effects of Staphylococcus aureus nasal carriage on DF infection, the risk factors that influence nasal carriage and its incidence in diabetics. We aimed to detect of the incidence, risk factors and relationship between wound culture and S. aureus nasal carriage in diabetic patients who have DF with thi...
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ea0037ep420 | Diabetes (complications &amp; therapy) | ECE2015

The role of fetuin A as a biomarker of atherosclerosis and its relation to type 2 diabetes

Sheriba Nermeen , Sayed Rania , Nasr Merhan , Shelbaya Sara , Abbas Magdy

Background: Hyperglycaemia produces various changes in the vascular tissue at the cellular level that accelerates the atherosclerosis. There is a direct correlation among carotid arterial stiffness and serum fetuin-A level. Fetuin-A is a marker of the inflammatory nutritional state and acts as a protective agent because it solubilises the calcium phosphate salt.Aim of this work: To study the role of fetuin A in atherosclerosis and its association with ty...
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ea0037ep421 | Diabetes (complications &amp; therapy) | ECE2015

Association of plasma fetuin-A levels and peripheral vascular disease in type 2 diabetic patients

Shelbaya Salah , Sayed Rania , Nasr Merhan , Abd El Aziz Ahmed

Background: Diabetes is a risk factor for both PAD and PAD-associated mortality. Diabetic patients have worse arterial disease and a poorer outcome than nondiabetic patients. Fetuins are blood proteins made in the liver more abundant in fetal blood. Fetuin-A is regarded as an inhibitor of systemic calcification.Aim of this work: To assess the relationship between plasma fetuin-A levels and peripheral vascular disease in type 2 diabetes mellitus.<p cl...
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ea0037ep422 | Diabetes (complications &amp; therapy) | ECE2015

Glycaemic variability in pregnant women with gestational diabetes

Oztop Nida , Celik Selda , Tutuncu Yildiz , Bagdemir Elif , Idiz Cemile , Uzum Ayse Kubat , Satman Ilhan , Dinccag Nevin

Introduction: The accurate and comprehensive assessment of glycaemic control in pregnant with gestational diabetes (GDM) is important for preventing foetal complications. We aimed to determine glycaemic variation on women with GDM with using a continuous glucose monitoring system (CGMS) and to investigate the relationship between reflecting glucose markers such as HbA1c, fructosamine (FRM), and 1,5-anhydroglucitol (1,5-AG).Materials and methods: 31 women...
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ea0037ep423 | Diabetes (complications &amp; therapy) | ECE2015

Sexual function in women with diabetes at a Diabetes Care Unit

Brannestam Eva-Karin

The true prevalence of sexual dysfunction in women with diabetes is difficult to estimate. Studies of the area have shown varying and conflicting results. There is also disagreement about the conditions that influence this relationship and the risk factors that can be linked to the phenomenon. The purpose of this study was to investigate sexual function in women with diabetes at a Diabetes Care Unit. The study was conducted using a quantitative approach. Fifty women aged 18&#1...
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ea0037ep424 | Diabetes (complications &amp; therapy) | ECE2015

Particular characteristics of breath during night sleep in type 1 diabetes patients

Darashkevich Ina , Mokhort Tatsiana , Nikonova Lola , Tishkovsky Serhej , Davydchik Elina

Objective: Assessing the impact of glycaemic control on indicators of breathing during night sleep in type 1 diabetes patients.Methods: Continuous blood glucose monitoring by ‘SGMSGold’ (Medtronik MINIMED) with estimation of average glycaemic value (AG) and other parameters; polysomnographic monitoring by ‘SOMNOlab 2 (PSG) Polysomnography (R&K)’. Group 1 included patients with AG levels <8.0. Group 2: AG >8.0 mmol/l regard...
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ea0037ep425 | Diabetes (complications &amp; therapy) | ECE2015

Obstructive sleep apnoea, incident type 2 diabetes mellitus, and cardiovascular risk

Munoz-Rivas N , Mendez-Bailon M , Buendia M J , del Canizo-Gomez F J , Partido A , Alcorta A , de Miguel-Llanes J , Solis-Villa F J

Obstructive sleep apnoea (OSA) is a condition strongly associated with cardiovascular disease. Obesity is often related to both clinical problems and it is also a risk factor for incident type 2 diabetes mellitus (T2DM).Aim: To assess cardiovascular risk among a cohort of patients with OSA in order to identify and optimise treatment of high risk patients.Methods: Prospective study that included 72 patients with OSA under continuous...
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ea0037ep426 | Diabetes (complications &amp; therapy) | ECE2015

Simultaneous pancreas–kidney transplantation effect on stabilisation/progression of diabetic complications in patients with type 1 diabetes

Glazunova Alexandra , Arutyunova Margarita , Musaeva Gulia , Shamkhalova Minara , Shestakova Marina , Moysyuk Yan , Pinchuk Alexey , Dmitriev Ilya , Arzumanov Sergey

Objective: To evaluate the simultaneous pancreas–kidney transplantation (SPK) effect on stabilisation/progression of complications in patients with T1DM.Materials and methods: The study included 16 patients after SPK. Eleven peoples received standard triple immunosuppressive therapy during the study period, five patients canceled steroid therapy after 6 months. The average age was 34 years old (31; 40), duration of T1DM 22 years (20.5; 28), the dura...
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ea0037ep427 | Diabetes (complications &amp; therapy) | ECE2015

Influence of diabetic polyneuropathy on the severity of pain in patients with osteoarthritis of the knee joints and type 2 diabetes mellitus

Strongin Leonid , Korneva Ksenia , Trifonova Elena

Introduction: Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) are common diseases among middle-aged and elderly persons. Aim of our study was to assess the influence of diabetic polyneuropathy (DPN) on the severity of pain in OA in patients with concomitant T2DM.Methods: 80 female patients with OA of the knee joints in combination with T2DM were examined. The severity of gonarthrosis were assessed by Lequesne index (IL) (version 1997) using a val...
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ea0037ep428 | Diabetes (complications &amp; therapy) | ECE2015

Lixisenatide clinical experience on patients with type 2 diabetes and obesity in Endocrinology Offices

Mar Roca-Rodriguez M , de Fuentes Maria Teresa Muros , Piedrola-Maroto Gonzalo , Quesada-Charneco Miguel , Maraver-Selfa Silvia , Tapia-Guerrero M Jose , Cepero-Garcia Daniel , Orduna-Espinosa Rosa , Pechuan-Asensio Joaquin , Ferrandiz-Millon Elena , Galera-Martinez Purificacion , Vazquez-Gutierrez Mercedes , Mancha-Doblas Isabel

Introduction: Some treatments of diabetes, such as lixisenatide, improve global metabolic status beyond glycaemic control.Aim: To evaluate tolerance to lixisenatide and its effects on weight and metabolic control in type 2 diabetes and obese patients attended in Endocrinology Offices.Material and method: A prospective study of patients with type 2 diabetes and obesity. In an intra-subject analysis, clinical and analytical data were...
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ea0037ep429 | Diabetes (complications &amp; therapy) | ECE2015

Nonglycemic effects of incretins in patients with long history diabetes type 1 and chronic kidney disease

Arutyunova Margarita , Glazunova Alexandra , Klephortova Inna , Martynov Sergey , Manchenko Oxana , Ulianova Irina , Ilin Alexandr , Shamkhalova Minara , Shestakova Marina

Aims: To estimate the nonglycaemic effects of incretins in patients with long history of type 1 diabetes (T1D) and chronic kidney disease (CKD).Materials and methods: We examined 75 patients with a long history T1D (more than 20 years) and CKD on the different stages: 32 patients with CKD at the stages 1–4, 17 patients on haemodialysis, 11 with kidney transplantation, and 15 patients without CKD. In addition to routine methods of investigation we ha...
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ea0037ep430 | Diabetes (complications &amp; therapy) | ECE2015

COMMODITY12 telemedicine system is effective in primary care setting in patients with type 2 diabetes

Lewandowski Krzysztof , Mazurkiewicz Maciej , Kardas Przemyslaw

Background: The COMMODITY12 is a telemedicine system designed for continuous monitoring of diabetes type 1 (DM1) and DM2, as well as the cardiovascular comorbidities. The system has been created in collaboration of nine European academic and industrial partners under FP7 (www.commodity12.eu).Aim: The aim of this study was to assess clinical utility of the COMMODITY12 system in DM2 patients, under a design of a mini...
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ea0037ep431 | Diabetes (complications &amp; therapy) | ECE2015

Microangiopathic complications in latent autoimmune diabetes in adults: relationship with thyroid autoimmunity

Reghina Aura , Sava Elisabeta , Florea Suzana , Fica Simona

Background: Patients with latent autoimmune diabetes in adults (LADA) are a clinically, immunologically, genetically heterogeneous group and the presence of thyroid autoimmunity (TA) appears to contribute to his heterogeneity.The aim was to evaluate the impact of TA on microangiopathic complications in LADA patients.Materials and method: LADA has been defined by the onset of diabetes at ages above 30 years, the lack of need for ins...
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ea0037ep432 | Diabetes (complications &amp; therapy) | ECE2015

Evaluation series on safety and efficacy of nutritional supplements (ESSENS) in newly diagnosed hyperglycaemia

Kalra Sanjay

Diabetes is endemic in society. Beyond lifestyle modification (often short lived) and metformin, which while effective has gastrointestinal side effects, other available pharmacological options are challenging to implement across populations of newly diagnosed patients. The recent position statement by ADA/EASD calls for patient-centred individualised therapies to suit patients’ need. Glucose-lowering nutritional supplements may be an effective and safe option for newly d...
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ea0037ep433 | Diabetes (complications &amp; therapy) | ECE2015

Association between cardiovascular disease and microvascular complications in diabetic patients

Miguel Gonzalo Allo , Fernandez Elena Garcia , Rodriguez Juan Carlos Romero , Diaz-Guerra Guillermo Martinez , Carranza Federico Hawkins

Introduction: Diabetes mellitus is a condition on the increase, carrying a high risk of cardiovascular complications. It is, also, well known that diabetes confers a substantial burden of microvascular disease. Previous studies suggest a link between microvascular and macrovascular events in diabetes. However, just a few studies have investigated whether the presence of previous cardiovascular events is associated with microvascular disease in diabetes patients. So, this is th...
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ea0037ep434 | Diabetes (complications &amp; therapy) | ECE2015

Intima–media thickness of internal carotid arteries in the diagnosis of coronary atherosclerosis in patients with type 2 diabetes and silent ischaemia

Zhuravlyova Larysa , Lopina Natalia

Aims: To determine the role of intima–media thickness (IMT) of internal carotid artery (ICA) in the diagnosis of coronary atherosclerosis in patients with type 2 diabetes (T2D) and silent ischaemia (SI).Methods: We provide a retrospective analysis of 60 cases of patients with T2D (24 men, age 60.5±4.7 years), history of diabetes – 4.7±0.5 years. SI was diagnosed by comparing complaints, anamnesis, ECG data and daily ECG monitoring. Al...
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ea0037ep435 | Diabetes (complications &amp; therapy) | ECE2015

The relationship between adipokines and diastolic dysfunction in patients with type 2 diabetes mellitus with overweight

Zhuravlyova Larysa , Sokolnikova Nelya

The mechanisms of myocardial damage are complex and studied insufficiently in patients with diabetes mellitus type 2 (DM2) with overweight. The contribution of adipokines leptin and resistin into the formation of diastolic dysfunction (DD) in patients with DM2 remains understudied. The purpose of the study was to evaluate the relationship between the state of leptin and resistin activity and DD in patients with DM2 with normal and overweight.Methods: 94 ...
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ea0037ep436 | Diabetes (complications &amp; therapy) | ECE2015

Stroke in prediabetic patients

Silva-Fernandez Julia , Garcia-Ruiz Rafael , Moreno-Moreno Paloma , Garcia-Ruiz Rosa Maria , Gonzalez-Pereira Carolina

Objective: To describe the clinical characteristics of stroke in patients with prediabetes mellitus (pre-DM) and to compare them with DM and non-DM patient characteristics.Methods: Retrospective analysis of a prospective series of acute stroke patients. Demographic and clinical characteristics were compared among the three groups, along with outcome data. Stroke severity was evaluated by modified Rankin scale (mRS) and NIHSS (NIH stroke scale).<p cla...
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ea0037ep437 | Diabetes (complications &amp; therapy) | ECE2015

Diabetes mellitus as a conformational disease: a novel potential therapeutic approach

Fernandez-Gomez Isaac , Sablon-Carrazana Marquiza , Bencomo Alberto , Pasten-Hidalgo Karina , Castillo-Rodriguez Rosa Angelica , Dominguez Guadalupe , Lara Reyna , Jimenez Luis Felipe , Moran Julio , Altamirano-Bustamante Nelly , Islas-Andrade Sergio , Rodriguez-Tanty Chryslaine , Garrido-Magana Eulalia , Altamirano-Bustamante Myriam M

Introduction: Type 2 diabetes mellitus is a conformational disease (CD), characterised by deposition (fibrils and cytotoxic oligomers) of the human islet amyloid peptide (hIAPP). CDs have devastating effects on the sufferers and their caregivers, as well as a tremendous economic impact on families and the health system. Novel molecule candidates targeting self-assembled amyloidogenic proteins represent a potential therapeutic approach for CDs.Methods/des...
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ea0037ep438 | Diabetes (complications &amp; therapy) | ECE2015

Continuous glucose monitoring systems and the improvement in hypoglycaemic awareness post-islet transplantation: a single-centre cohort study

Flood Clare , Forbes Shareen

Background: Islet transplantation is an NHS-funded procedure introduced to the UK in 2011 for patients with the most severe type 1 diabetes mellitus (T1DM). These particular patients have unstable blood glucose, frequently occurring episodes of severe hypoglycaemia and impaired awareness of hypoglycaemia (IAH).Objectives: To evaluate the effectiveness of islet transplantation in improving glycaemic control, reducing the burden of hypoglycaemia and improv...
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ea0037ep439 | Diabetes (complications &amp; therapy) | ECE2015

HDL levels is associated with left ventricular ejection fraction in type 2 diabetic patients

Kim Eui-Hyun , Seo Hyun-Ae

Introduction: Considering the high prevalence and significant morbidity and mortality of heart failure in type 2 diabetic patients, identification of risk factors for cardiac dysfunction is important. The ejection fraction represents how well the heart is pumping out blood and is used to diagnose heart failure. In this study, we investigated the factors associated with left ventricular ejection fraction (LVEF) in type 2 diabetic patients.Methods: A total...
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ea0037ep440 | Diabetes (complications &amp; therapy) | ECE2015

Low testosterone and erectile function in male patients with type 2 diabetes

Luchytskiy Vitaliy , Luchytskiy Eugen

Erectile dysfunction (ED) – frequent disease that accompanies diabetes or is its complication. According to various reports the prevalence of ED in males with type 2 diabetes (T2DM) varies from 25 to 90%. In recent years, the ED is considered as predict factor in the development of T2DM in men and as a marker of vascular complications progression.Aim: To examine the state of androgens in men suffering from T2DM and erectile dysfunction.<p class=...
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ea0037ep441 | Diabetes (complications &amp; therapy) | ECE2015

Glargine insulin treatment during pregnancy in type 1 diabetes mellitus

Moreno-Moreno Paloma , Palomares-Ortega Rafael , Munoz-Jimemez Concepcion , Galvez-Moreno Maria Angeles

Objective: The aim of this study was to evaluate maternal and neonatal outcomes in women with type 1 diabetes mellitus (DM1), and analysing differences associated to insulin glargine exposure during pregnancy.Patients and methods: Retrospective descriptive study of pregnancies in women with DM1 (2004–2012). Variables analysed: baseline characteristics (age, time of diabetes evolution, microvascular complications, and weight), maternal outcomes (weig...
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ea0037ep442 | Diabetes (complications &amp; therapy) | ECE2015

Hemorheological alterations in type 2 diabetes patients with nephropathy

Lee Min Young , Jo Sehee , Kim Min Jin , Nam Ji Sun , Kang Shinae , Park Jong Suk , Ahn Chul Woo , Kim Kyung Rae

Background: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters in type 2 diabetes patients at different stages of chronic kidney disease (CKD) and assessed their possible role as early markers of diabetic nephropathy and renal insufficiency.Methods: One hundred and five patients with type 2 diabetes were divide...
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ea0037ep443 | Diabetes (complications &amp; therapy) | ECE2015

Impact on quality of life in peoples with painful diabetic peripheral neuropathy

Kim Chong Hwa , Jeong Su Jin , Mok Ji Oh , Lee Ki Young , Kim Sung Rae

Objective: This study was performed to determine the impact on quality of life and sleep impairment of painful diabetic peripheral neuropathy (PDPN).Research design and method: The study pool consisted of 200 randomly selected peoples with type 2 diabetic peripheral neuropathy. PDPN was diagnosed using visual analogue scales (VAS) and medical history. The patients were asked to answer the Brief Pain Inventory-Short Form (BPI-SF), Medical Outcomes Study S...
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ea0037ep444 | Diabetes (complications &amp; therapy) | ECE2015

Prevalence and management of peripheral diabetic neuropathic pain in a hospital diabetes clinic: how are we doing?

Haley Anna , De Parijat

Introduction: Peripheral diabetic neuropathic pain (PDNP) as a significant complication of diabetes mellitus (DM), which is present in 16–26% of patients. NICE UK guidelines recommend that physicians should make an formal enquiry about distressing neuropathic symptoms annually and that either duloxetine, amitriptyline, gabapentin, or pregabalin should be used as first-line treatment for neuropathic pain.Aims: To assess the prevalence PDNP in a diabe...
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ea0037ep445 | Diabetes (complications &amp; therapy) | ECE2015

The effect of metformin on spontaneous apoptosis in patients with type 2 diabetes

Panchenko Aleksandra , Iryna Kondratska , Boris Mankovsky

Today, there are 382 million people living with diabetes. The overwhelming majority have a type 2 diabetes. Metformin is first-line drug is for many of them.Materials and methods: The study involved 26 patients in mean age 54.46±1.2 years (from 41 to 65), among them, 14 women and 12 men. 21 patients with newly diagnosed diabetes and five patients receiving treatment with sulfonylureas. All patients were prescribed metformin in mean dose 2000 mg. Dur...
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ea0037ep446 | Diabetes (complications &amp; therapy) | ECE2015

Microalbuminuria by concentration serum and urine levels of adropin in patients with type 2 diabetes mellitus

Ugur Kader , Oz Burak , Ozkan Yusuf , Sener Selcuk Yusuf , Orhan Bedrettin , Aydin Suleyman

Introduction: Diabetes mellitus is an important public health problem due to defects of the effect of the insulin or insulin deficiency, accompanied by chronic microvascular complications with diabetic nephropathy is characterised by proteinuria that the increasing number of patients progress to end stage renal disease. Many peptide hormone made in etiopathogenesis is situated, although adropin which discovered in recent years involves in glucose homeostasis, its relation to d...
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ea0037ep447 | Diabetes (complications &amp; therapy) | ECE2015

Abstract unavailable....
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ea0037ep448 | Diabetes (complications &amp; therapy) | ECE2015

Remitting seronegative symmetrical synovitis with pitting oedema syndrome in association with saxagliptine: case report

Bilge Muge , Adas Mine , Helvaci Aysen , Bayraktarli Recep Yilmaz

Background: Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE syndrome) is a very rare clinical entity including a tenosynovitis of the hands and wrists, and marked pitting oedema on upper and lower extremities. RS3PE has been suggested to be associated with many disease conditions and drugs. Saxagliptine is DPP4 inhibitor that relatively new oral hypoglycaemic agent. This case is the second report of the occurrence of RS3PE in patients receiving a DPP4 i...
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ea0037ep449 | Diabetes (complications &amp; therapy) | ECE2015

Effects of dietary nitrate on metabolic status and myocardial ischaemia–reperfusion injury in type 2 diabetic rats

Ghasemi Asghar , Jeddi Sajad , Khalifi Saeedeh , Ghanbari Mahboubeh , Rahimipour Ali , Kazerouni Faranak

Introduction: Considering the protective effects nitrate has against diabetes and cardiovascular diseases, we aimed to determine effects of dietary nitrate on metabolic status and myocardial ischemia–reperfusion (IR) injury in type 2 diabetic rats.Methods: Rats were divided into four groups (n=7): control, control+nitrate, diabetes, and diabetes+nitrate. Diabetes was induced by nicotinamide+streptozotocin, and nitrate added to drinking wate...
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ea0037ep450 | Diabetes (complications &amp; therapy) | ECE2015

The influence of erythropoietin therapy on serum level of tumour necrosis factor alpha in anaemic patients with early stages of diabetic nephropathy

Pchelin Ivan , Shishkin Alexander

Aims: Anaemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy. In our previous studies we have shown that haemoglobin level has a negative correlation with serum levels of proinflammatory cytokines in this clinical group. It could be hypothesised that treatment of anaemia has anti-inflammatory effects. The aim of this study was to assess the influence of treatment with erythropoietin alpha on serum level of tumour ne...
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ea0037ep451 | Diabetes (complications &amp; therapy) | ECE2015

Metabolic status in patients with type 1 diabetes mellitus

Vashchenko Elena

Objective of the study was to analyse the relationship of compensation, lipid profile parameters and androgenic status in patients with type 1 (DM1) depending on the duration of diabetes. There were examined 76 men with DM1 aged 20–49 years (mean age 35.8±8.2) and duration of diabetes more than a year. The control group consisted of 25 healthy men aged 21–41 years (mean age 34.6±7.8). Compensation of diabetes was assessed by the level of HbA1c. Also there w...
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ea0037ep452 | Diabetes (complications &amp; therapy) | ECE2015

The effect of exenatide treatment on serum ghrelin levels in patients with type 2 diabetes

Topyildiz Figen , Kiyici Sinem , Gul Zulfiye , Sigirli Deniz , Guclu Metin , Kisakol Gurcan , Cavun Sinan

Aim: Ghrelin plays an important role in stimulation of food intake and long-term regulation of body weight. In present study we aimed to investigate the effect of exenatide treatment on serum ghrelin levels in patients with type 2 diabetes.Methods: Fourteen women patients with type 2 diabetes treated with metformin and exenatide were enrolled in the study. A mixed meal test was applied to the patients while they were using their daily medications. Serum ...
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ea0037ep453 | Diabetes (complications &amp; therapy) | ECE2015

The effect of compensation of diabetes on ulcer healing in patients with diabetic foot syndrome

Prystupiuk Maksym

Introduction: Diabetic foot syndrome is a common surgical pathology. It is the main cause of lower limb amputations, which can be avoided in 85% of cases by active detection and long-term compensation of T2DM, timely diagnostics of peripheral neuropathy.Purpose: To study relation between compensation of diabetes (by HbA1c) and time needed for healing of ulcers and purulent processes in patients with neuroischaemic forms of diabetic foot.<p class="abs...
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ea0037ep454 | Diabetes (complications &amp; therapy) | ECE2015

Lixisenatide improves glycaemic control and body composition in uncontrolled type 2 diabetic patients treated with insulin

Carral Florentino , Ayala Carmen , Pinero Antonia , Jimenez Ana Isabel , Exposito Coral , Garcia Concepcion

Objective: Evaluate the efficacy and safety of adding lixisenatide to uncontrolled type 2 diabetic (T2DM) patients treated with insulin.Methods: A prospective uncontrolled study was designed. Primary endpoints (measured at 3 and 6 months) were change in HbA1c, weight, and insulin doses. Variables analysed were: HbA1c level, insulin and other hypoglycaemic agents doses, capillary glucose tests, number and type of hypoglycaemias, side effects and body comp...
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ea0037ep455 | Diabetes (complications &amp; therapy) | ECE2015

Liraglutide improves β-cell function, measured by the C-peptide/glucose ratio, in obese patients with type 2 diabetes

Ramos-Levi Ana M , Rubio Miguel A

Introduction: β-cell function declines progressively in patients with type 2 diabetes (T2D). the fasting C-peptide/glucose ratio (Cp/G) is used for its evaluation. The GLP1 receptor agonist liraglutide improves glucose and weight control, presumably due to improvement of β-cell function and/or mass. This study evaluates the effect of a 6-months’ treatment with liraglutide in β-cell function, measured by Cp/G, in patients with obesity and T2D.<p class="a...
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ea0037ep456 | Diabetes (complications &amp; therapy) | ECE2015

Study of irisin hormone level in type 2 diabetic patients with and without diabetic neuropathy

Halawa Mohammad , Abushady Manal , Fattah Mohammed Abd El , Hassan Mohammed

Background and aims: Irisin is a novel myokine that promote energy expenditure. It could act on adipocyte metabolism through a novel neural pathway and on the other hand irisin induces neural proliferation and adequate neural differentiation. We aimed to assess serum irisin level in type 2 diabetics (T2DM) and correlate it with metabolic parameters. Also, we assessed the relation between irisin level and diabetic peripheral neuropathy (DPN).Methods: We r...
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ea0037ep457 | Diabetes (complications &amp; therapy) | ECE2015

Clinical experience with lixisenatide in patients with obesity and type 2 diabetes

Tejera Cristina , Delgado Esther , Porca Cristina , Morales Francisco , Bellido Diego , Diaz Jose

Introduction: Agonist receptor-GLP1 (AR-GLP1) had demonstrated its utility in obese patients with diabetes type 2. Since August 2013 we have available in Spain a new AR-GLP1 with prandial action in a single daily dose, lixisenatide. There are different clinical trials that support its efficacy and security but the dates from real clinical practice are scarce.Aim: To analyse the efficacy and security in real clinical practice for the treatment of diabetic...
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ea0037ep458 | Diabetes (complications &amp; therapy) | ECE2015

Controlled attenuation parameter have close relationship with the prevalence and the severity of non-alcoholic fatty liver disease in a type 2 diabetes mellitus population

Lee Jaehyuk , Kim Kwang Joon , Cha Bong Soo , Kang Eun Seok

Background: The severity of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM) population compared with that in normal glucose tolerance (NGT) individuals has not yet been assessed by a quantitative method. We investigated the prevalence and the severity of NAFLD in a T2DM population using controlled attenuation parameter (CAP).Methods: Subjects who underwent testing for biomarkers related to T2DMand CAP using Fibroscan during a...
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ea0037ep459 | Diabetes (complications &amp; therapy) | ECE2015

Risk factors, aetiology, and prognosis in patients with ischaemic stroke and diabetes mellitus

Silva-Fernandez Julia , Garcia-Ruiz Rafael , Moreno-Moreno Paloma , Garcia-Ruiz Rosa M , Gonzalez-Pereira Carolina

Objective: To describe the clinical, aetiological and prognostic differences in diabetic and non-diabetic ischaemic stroke (IS) patients.Materials and methods: Retrospective analysis of prospective series of IS patients. Patients were classified as non-DM and DM patients. Demographic and clinical characteristics were compared between two groups. IS prognosis was evaluated by modified Rankin scale (mRS) and NIHSS (NIH stroke scale)....
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ea0037ep460 | Diabetes (complications &amp; therapy) | ECE2015

Establishing the relationship between third-trimester foetal abdominal circumference, birthweight, and neonatal morbidity in gestational diabetes

Pereira Maria Teresa , Garrido Susana , Almeida Raquel , Vilaverde Joana , Pichel Fernando , Pinto Clara , Goncalves Joaquim , Dores Jorge

Introduction: Gestational diabetes (GD) is associated with a significantly higher risk of perinatal complications. It has been suggested that third-trimester (3thT) foetal abdominal circumference (fAC) determination is an important predictor of macrossomia and large for gestational age (LGA).Aims: The purpose of this study was to evaluate the association between the 3thT fAC percentile with birthweight (BW) and adverse neonatal outc...
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ea0037ep461 | Diabetes (complications &amp; therapy) | ECE2015

Usefulness of carotid ultrasonography as a screening test for coronary artery disease in Korean diabetic patients

Cho In-Jin , Baik Sei Hyun , Hwang Yoo-Chul , Ahn Kyu Jeung , Chung Ho-Yeon , Jeong In-Kyung

Carotid intima–media thickness (IMT) has been shown an independent predictive marker of coronary artery disease (CAD) and cardiovascular disease in many studies. We investigated the usefulness of carotid IMT as a screening test for CAD in Korean diabetic patients. We conducted retrospective study and found the type 2 diabetic patients without cardiovascular disease history who underwent carotid ultrasonography (US) and stress echocardiography (SE) from June 2006 to Decemb...
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ea0037ep462 | Diabetes (complications &amp; therapy) | ECE2015

Beneficial effects of antioxidant property of Aegle marmelos leaves serum antioxidant status on blood glucose levels in diabetes type 2 subjects

Nigam Vinita , Nambiar Vanisha

Background: Diabetes mellitus is one of the most recognized and clinically significant disorders of the endocrine system, Based on recent advances and involvement of oxidative stress in complicating diabetes mellitus, efforts are on to find suitable antidiabetic and antioxidant therapy. Aegle marmelos (L.) Corr. is one of the most important Indian medicinal plants which has enormous traditional values against various diseases and many bioactive compounds have been iso...
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ea0037ep463 | Diabetes (complications &amp; therapy) | ECE2015

Male patients benefit from initial exenatide treatment: a real-world experience

Chen Liang , Kuang Jian , Pei Jianhao , Chen Hongmei , Chen Zhong , Li Zhongwen , Yang Huazhang , Fu Xiaoyin , Wang Long , Chen Zhijiang

Objective: The purpose of this study was to describe the outcome after initiation of exenatide therapy and to determine whether the impact of adverse drug reactions on compliance was affected by gender.Methods: A retrospective study was performed of 18 diabetic patients (eight males) that were prescribed exenatide between June 2013 and September 2014. Each included patient received exenatide for ≥1 month. Age, disease course, race, BMI, medical his...
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ea0037ep464 | Diabetes (complications &amp; therapy) | ECE2015

Occurrence frequency of diabetic foot syndrome in three pilot regions of Uzbekistan

Ibragimova Nilufar , Kamalov Telman , Shokirov Khamidulla , Kokareva Lyudmila , Platonova Oxana

Goal: To study occurrence frequency of diabetic foot syndrome (DFS) in three pilot regions of Uzbekistan.Material and methods: Upon WDF project, ‘UMID’ Association of Tashkent and RRPMCE have screened T1DM and T2DM patients for DFS in three pilot regions (Andizhan, Tashkent, and Kashkadarya areas). 663 patients examined; of them 581 T2DM patients and 82 T1DM peoples in the 25–65 age groups with duration of the disease 5–15 years. Resu...
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ea0037ep465 | Diabetes (complications &amp; therapy) | ECE2015

Nocturnal blood pressure is related to the progression of retinopathy in type 1 diabetic patients

Vilchez-Lopez Francisco Javier , Mateo-Gavira Isabel , Larran-Escandon Laura , Montero-Galvan Ana , Ortego-Rojo Jose , Garcia-Palacios Maria Victoria , Aguilar-Diosdado Manuel

Introduction: The objective is to evaluate the relationship between early blood pressure alterations (detected by ambulatory blood pressure monitoring (abpm)) and the development/progression of retinopathy in patients with type 1 diabetes clinically normotensive.Methods: We designed a prospective observational study of 85 patients, clinically normotensive and without microalbuminuria, monitored over 7 years. Abpm was performed over 24 h and subclinical h...
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ea0037ep466 | Diabetes (complications &amp; therapy) | ECE2015

Nocturnal blood pressure is related to the development of microalbuminuria and established hypertension in patients with type 1 diabetes

Vilchez-Lopez Francisco Javier , Mateo-Gavira Isabel , Larran-Escandon Laura , Montero-Galvan Ana , Ortego-Rojo Jose , Garcia-Palacios Maria Victoria , Aguilar-Diosdado Manuel

Introduction: The objective is to evaluate the relationship between early blood pressure alterations (detected by ambulatory blood pressure monitoring (abpm)) and the development of microalbuminuria and arterial hypertension in patients with type 1 diabetes clinically normotensive.Methods: We designed a prospective observational study of 85 patients, clinically normotensive and without microalbuminuria, monitored over 7 years. Abpm was performed over 24 ...
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ea0037ep467 | Diabetes (complications &amp; therapy) | ECE2015

Subclinical blood pressure alterations are related to proinflammatory markers in type 1 diabetes mellitus

Vilchez-Lopez Francisco Javier , Mateo-Gavira Isabel , Montero-Galvan Ana , Visiedo-Garcia Francisco , Garcia-Palacios Maria Victoria , Larran-Escandon Laura , Aguilar-Diosdado Manuel

Introduction: The objective is to evaluate the relationship between precocious subclinical hypertension and inflammatory and endothelial dysfunction markers in normotensive and normoalbuminuric patients with type 1 diabetes.Methods: We designed an observational transversal study of 85 patients, clinically normotensive and without microalbuminuria. Ambulatory blood pressure monitoring (abpm) was performed over 24 h and subclinical hypertension was conside...
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ea0037ep468 | Diabetes (complications &amp; therapy) | ECE2015

Different stress hormone response in insulin pump treatment compared with multiple daily injection: preliminary data

Mancini Antonio , Pareo Jacopo , Di Segni Chantal , Raimondo Sebastiano , Rizzi Alessandro , Pitocco Dario

It is known that in type 1 diabetes mellitus (T1DM) continuous subcutaneous insulin infusion (CSII) therapy improves metabolic control and reduces risk of hypoglycaemia in comparison with multiple daily injection (MDI). Metabolic outcomes usually considered are HbA1c, BMI, and inflammatory parameters. However few data are available on pituitary and gonadal hormone responses, which are involved in metabolic processes. In order to study the response of anabolic hormones in patie...
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ea0037ep469 | Diabetes (complications &amp; therapy) | ECE2015

Evaluating analogue vs human insulin efficacy in real life: observational study in type 2 Albanian diabetic patients, previously insulin treated

Toti Florian , Gjoncaj Gjinal , Resulaj Blerina , Bruka Luftime , Lapardhaja Adriana , Carcani Manjola , Tare Rajmonda , Lile Varvara

Background and aims: Insulin therapy is an important part of diabetes treatment. A lot of studies have compared the efficacy of new insulin therapies, but in our country, specialists still have to demonstrate at the institutions the treatment’s efficacy and cost-effectiveness for new insulin analogues. The aims of our study is to evaluate the efficacy of analogues vs human insulins and differences between various analogue insulin, in type 2 diabetes patients, previously t...
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ea0037ep470 | Diabetes (complications &amp; therapy) | ECE2015

Telemedicine as a motivational tool to optimise metabolic control in patients with diabetes in Turkey: results from a randomised controlled trial

Satman Ilhan , Bagdemir Elif , Turker Fulya , Celik Selda , Idiz Cemile , Ozsari Haluk

Objective: Our purpose was to evaluate the impact of a transmission system on metabolic control of patients with diabetes.Research design and methods: This ongoing-prospective, randomized, comparative study included adult patients with type 1 (n=71) and type 2 diabetes (n=139). Consecutive patients were equally allocated into two groups. Both groups received routine care by the same health care professionals (HCPs) 3-monthly. TeleDiab g...
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ea0037ep471 | Diabetes (complications &amp; therapy) | ECE2015

Long-term tele-monitoring of patients with type 2 diabetes mellitus: ancillary analysis of the results of the Greek pilot of the renewing health multicentre randomised control trial

Dafoulas George E , Mavrodi Afentoula , Giannakakos Charalampos , Gkiata Paraskevi , Theodorou Kyriaki , Aletras Vasilios , Stafylas Panagiotis , Koukoulis Georgios , Bargiota Alexandra

Introduction: To evaluate the impact of a long-term telemonitoring programme for patients with type 2 diabetes mellitus (DMT2) on glycaemic control and lipid disorders.Methods/design: In the Greek pilot of a prospective, randomised, single-blinded, multicentre study 154 patients with DMT2, HbA1c >53 mmol/mol (7.0% according to NGSP) and capable of using the telemonitoring device, were studied after randomly assigned in the telemonitoring (IG) (n<...
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ea0037ep472 | Diabetes (complications &amp; therapy) | ECE2015

Is diabetes an independent risk factor of perioperative complications after abdominal gynecologic interventions?

Swirska Joanna , Matyjaszek-Matuszek Beata , Czuczwar Piotr , Zwolak Agnieszka

Purpose: We sought to determine if in the group of patients who underwent gynecologic abdominal interventions diabetes was an independent risk factor of perioperative complications.Material and methods: The study group included 62 women from both the diabetic and the control group who underwent elective gynecologic laparotomies such as hysterectomy or adnexectomy. The patients from diabetic group were pair-matched with patients without diabetes based on ...
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ea0037ep473 | Diabetes (complications &amp; therapy) | ECE2015

Education for diabetes self-management improves quality of life and reduces HbA1c levels in people with diabetes

Toti Florian , Sokoli Elvisa , Kulluri Eliora , Lapardhaja Adriana , Carcani Manjola

Backgrounds and aims: Knowing about patient’s quality of life (QoL) is becoming increasingly important in delivering diabetes care and education. The purpose of our study was to estimate if the diabetes education improves patient QoL and reduces HbA1c levels.Material and methods: The study sample included diabetic patients who attended a 5-day educational sessions at the Service of Endocrinology in Tirana/Albania. Patients were evaluated regarding t...
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ea0037ep474 | Diabetes (complications &amp; therapy) | ECE2015

Prevalence of microalbuminuria and predictive factors in a group of Albanian diabetic adults

Spahiu Eduard , Ismaili Mimoza , Shehu Aldi , Thengjilli Erion , Doko Albana , Toti Florian

Background and aims: Diabetic nephropathy is one of the most prevalent and dangerous chronic complication of diabetes mellitus. Its end-stage, renal chronic failure is the most important cause of premature death in diabetic patients. Microalbuminuria (MA), one of the first signs of diabetic nephropathy, may be present from the moment of diagnosis in type 2 diabetes. The aim of our study was to determine the prevalence of microalbuminuria and to identify predictor factors in a ...
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ea0037ep475 | Diabetes (complications &amp; therapy) | ECE2015

Glycaemic control and weight evolution in type 2 diabetic patients with dapagliflozina in addition to their previous treatment

de Linares Lidia Urbon Lopez , Soto Maria Cristina Crespo , Vina Marta Ventosa , Larumbre Concepcion Terroba , Monclus Claudia Martin , Martin Tomas Martin , Olmedo Luis Cuellar

Introduction: From November 2013 it is available in Spain a new drug to treat type 2 diabetes (DM2): dapagliflozina. The new mechanism of action consists in the inhibition of the sodium–glucose co transporters (SLGT2) inhibiting glucose reabsorption in the proximale tubule and increasing glucose excreted in the urine. Therefore hyperglycaemia decreases and so does weight as a consequence of glycosuria. This is a very convenient side effect since DM2 is highly associated w...
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ea0037ep476 | Diabetes (complications &amp; therapy) | ECE2015

Pregnancy planning in type 1 diabetes mellitus

Moreno-Moreno Paloma , Palomares-Ortega Rafael , Barrera-Martin Ana , Galvez-Moreno Maria Angeles

Objective: The aim of this study was to determine the prevalence of pregnancy planning in women with type 1 diabetes mellitus (DM1) and analysing differences associated with unplanned pregnancy.Patients and methods: Retrospective descriptive study of pregnancies in women with DM1 (2004–2012). Variables analysed: age, time of diabetes evolution, microvascular complications, and maternal outcomes (HbA1c, preeclampsia, abortions, and Caesarean section)...
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ea0037ep477 | Diabetes (complications &amp; therapy) | ECE2015

Web-based telemedicine system is useful for monitoring glucose control in pregnant women with diabetes

del Carmen Ayala Ortega Maria , San Laureano Florentino Carral , Macias Carmen Gonzalez , Millan Ana Isabel Jimenez , Fernandez Alba Juan Jesus , Zaldivar Antonia Pinero , Calzado Concepcion Garcia

Objective: The aim of this study was to examine the impact of a web-based telemedicine system for monitoring glucose control in pregnant women with diabetes on health care visits, metabolic control and pregnancy outcomes.Subjects and methods: A prospective, single-centre, and interventional study with two parallel groups was performed in Puerto Real University Hospital (Spain). Women were assigned to two different glucose monitoring groups: control group...
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ea0037ep478 | Diabetes (complications &amp; therapy) | ECE2015

Changes in diabetes related quality of life and clinical outcomes in patients with type 2 diabetes, after initiation of injectable treatment

Georgas Georgios

In this study, we enrolled 123 patients with DM2 that accordingly to the based on evidence clinical judgment, needed injectable treatment for the achievement of good glycaemic control. There was not significant changes at the whole sample in anthropometrics, but there was increase in insulin treated subgroup and decrease in GLP1 treated subgroup. Glycaemic control was improved (P<0.001), without differences between detemir vs glargine subgroups, but with more impr...
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ea0037ep479 | Diabetes (complications &amp; therapy) | ECE2015

Does a nurse-led Diabetic Renal Clinic improve outcomes?

Irwin Susan , Shrestha Alvin , De Parijat

Aim: To audit outcomes and adherence to prescription recommendations in a nurse-led Diabetic Renal Clinic.Method: Baseline data at time of referral to the clinic was compared to the final clinic visit within a 12-month period (T1) of the first visit (T0), using information from clinic letters and electronic records of patients attending the clinic in our hospital between 2010 and 2014. Patients without at least one follow-up data within a 12-month period...
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ea0037ep480 | Diabetes (complications &amp; therapy) | ECE2015

Effect of liraglutide 1.8 mg in patients with non-controlled type 2 diabetes mellitus at an Endocrinology Clinic: LIED-2 study

Muriel Alvaro J , Herrera Alvaro A , Lomba Alin Abreu

Background and aims: To describe the characteristics of patients with non-controlled type 2 diabetes mellitus with liraglutide treatment.Materials and methods: Retrospective descriptive study. 85 outpatients (women 49, ages 18–86 years old with non-controlled type 2 diabetes mellitus) were evaluated between July 2013 and March 2014 and received treatment with liraglutide 1.8 mg SQ/day (0.6 mg SQ during the first week, 1.2 mg SQ during the second wee...
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ea0037ep481 | Diabetes (complications &amp; therapy) | ECE2015

Initial experience of SGLT2 inhibitor use in type 2 diabetes

Cooke Barbara , Ryan Kathryn , Gormley Mark , Lindsay John

Introduction: SGLT2 inhibitors offer a novel approach to improve glycaemic control in patients with type 2 diabetes through inhibition of renal glucose reabsorption. Phase 3 clinical trials demonstrated consistent glucose lowering effects and weight loss. The objective of our audit was to assess the early effects of treatment with dapagliflozin 10 mg in our clinic population.Methods: We performed a retrospective audit of clinical parameters in patients (...
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ea0037ep482 | Diabetes (complications &amp; therapy) | ECE2015

Fungal sinusitis caused by Aspergillus in a patient with type 1 diabetes

Yorulmaz Goknur , Erben Nurettin , Acikalin Mustafa , Kaya Ercan , Akcan Esra , Carmik Nilay Unal

Objective: Aspergillosis is defined as the infection of the Aspergillus type mold and is commonly seen in hematologic malignancies, hematopoietic stem cell transplantation, aplastic anemia, primary immunodeficiency, and immunocompromised patients. Fungal sinusitis in diabetes mellitus is generally presented as rhinoorbitocerebral involvement of mucormycosis. Herein, a fungal sinusitis caused by Aspergillus case presented with headache is reported.<p class...
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ea0037ep483 | Diabetes (complications &amp; therapy) | ECE2015

Once-weekly exenatide in a real-world clinical setting: clinical outcomes and analysis of potential predictors of response

del Mar Roca-Rodriguez Maria , Fernandez-Garcia Jose Carlos , Cortes-Salazar Carmen Maria , Moya-Carmona Isabel , Gomez-Perez Ana Maria , Cornejo-Pareja Isabel , Munoz-Garach Araceli , Molina-Vega Maria , Doblas Isabel Mancha , Tinahones Francisco

Objective: The aim of this study is to evaluate the effectiveness of once-weekly exenatide on metabolic control, weight, blood pressure, and lipid profile in obese patients with type 2 diabetes (T2DM), and to assess possible predictive factors of response.Material and methods: Retrospective observational study, conducted with adult obese (BMI ≥30 kg/m2) T2DM subjects that had been initiated once-weekly exenatide following routine clinica...
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ea0037ep484 | Diabetes (complications &amp; therapy) | ECE2015

Association between peripheral vascular disease and other macrovascular and microvascular complications in diabetic patients

Miguel Gonzalo Allo , Fernandez Elena Garcia , Bracamonte Milagros Sierra , Diaz-Guerra Guillermo Martinez , Carranza Federico Hawkins

Introduction: Diabetes mellitus is a condition on the increase, carrying a high risk of macro and microvascular disease. Previous studies suggest a link between microvascular and macrovascular complications in diabetes. However, just a few studies have investigated whether the presence of peripheral vascular disease (PVD) is associated with other macrovascular and microvascular complications in diabetes patients. So, this was the aim of our study.Patient...
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ea0037ep485 | Diabetes (complications &amp; therapy) | ECE2015

Diabetic kidney disease and its association with macrovascular disease in diabetic patients

Fernandez Elena Garcia , Miguel Gonzalo Allo , Villa Lucas Arroyave , Diaz-Guerra Guillermo Martinez , Carranza Federico Hawkins

Introduction: It is well known that diabetes confers a substantial burden of macrovascular disease. However, just a few studies have investigated the association between diabetic kidney disease (DKD) and cardiovascular disease. The purpose of this study is to investigate whether the presence of DKD is associated with macrovascular disease in diabetic patients.Patients and methods: 98 diabetic patients (48 males/50 females) were included in the study. DKD...
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ea0037ep486 | Diabetes (complications &amp; therapy) | ECE2015

Intensive glycemic control fails to improve indices of vascular dysfunction in patients with type 2 diabetes; results at 6–12 months follow-up

Antoniou Sofia , Naka Katerina , Bechlioulis Aris , Michalis Lampros , Tsatsoulis Agathocles , Tigas Stelios

Background: In subjects with long duration of type 2 diabetes (T2DM), strict glycaemic control fails to decrease the incidence of cardiovascular disease (CVD). Impaired vascular indices have been associated with adverse cardiovascular prognosis in T2DM. We examined whether intensive glycaemic control in T2DM patients improves vascular indices.Methods: We studied 68 T2DM patients (64±9 years, 52% males, and T2DM duration 14±10 years) with poor g...
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ea0037ep487 | Diabetes (complications &amp; therapy) | ECE2015

Intraocular pressure change during oral glucose tolerance test in non-diabetic individuals

Yildiz Pinar , Kebapci Medine Nur , Mutlu Fezan , Yasar Harun Servet , Yildirim Nilgun

Introduction: A significance of chronic hyperglycaemia related to the rising intraocular pressure are discussed in the previous studies. The purpose of the present study was to investigate changes of intraocular pressure induced by acute changes of glucose levels during oral glucose tolerance test in non-diabetic subjects.Methods: Fifty-one individuals who were needed to be screened for diabetes, were scheduled for oral glucose tolerance test according t...
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ea0037ep488 | Diabetes (complications &amp; therapy) | ECE2015

Hypoglycaemia due to drug interaction with clarithromycin

Silva Joao , Ivo Catarina , Marcelino Mafalda , Lopes Luis , Passos Dolores , Simoes Helder , de Castro Joao Jacome

Introduction: Interaction between diabetes mellitus (DM) and an infection usually results in hyperglycaemia. However, there is data describing hypoglycaemia events related with the association between certain antibiotics and oral anti-diabetic drugs or insulin.Case report: Male, 73 years old, with history of hypertension, obesity and dyslipidaemia. DM type 2 was diagnosed 13 years ago with any macro or microvascular complications so far. Currently he&#14...
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ea0037ep489 | Diabetes (complications &amp; therapy) | ECE2015

Insulin oedema in newly diagnosed type 1 diabetes patient: a case report

Oguz Ayten , Tuzun Dilek , Sahin Murat , Atay Didem , Ganidagli Berivan , Ganidagli Safa Ersen , Gul Kamile

Aim: In this case report we present a newly diagnosed, underweight type 1 diabetes mellitus (DM) patient developed insulin oedema following high dose insulin therapy.Case: A 18-year-old male patient was admitted to the hospital with a 1-month history of excessive water consumption, pollakiuria, polyuria, and weight loss 6 kg. In laboratory examination, hyperglycaemia and ketonuria were detected; arterial blood pH was 7.38. Patient was hospitalised to the...
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ea0037ep490 | Diabetes (complications &amp; therapy) | ECE2015

Associations of serum magnesium levels with diabetes and diabetic complications

Arpaci Dilek , Tocoglu Aysel Gurkan , Ergenc Hasan , Korkmaz Sumeyye , Ucar Aysenur , Onmez Atilla , Yildirim Mehmet , Hurmeydan Ozlem , Tamer Ali

Background: Magnesium (Mg) deficiency is a common problem in diabetic patients. Deficiency of Mg may increase the incidence of diabetes. Development of hypomagnesemia may affect glycaemic regulation and trigger complications of diabetes. The aim of our present study was to explore relationships between the serum Mg level and diabetes complications.Materials and methods: In this retrospective study, we evaluated 673 diabetic patients, of whom 57.8% were m...
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ea0037ep491 | Diabetes (complications &amp; therapy) | ECE2015

Scleredema in a patient with long-standing type 2 diabetes mellitus

Sari Isilay Kalan , Durmaz Senay Arikan , Bozdogan Onder , Kocak Mukadder , Cosar Ramazan

Introduction: Scleredema is a rare skin disease, clinically presents as diffuse, painless induration, and thickening of skin. It primarily affects the upper part of body and usually occurs in association with diabetes mellitus, infections or monoclonal gammopathy. We discussed a case of scleredema in patient with history of diabetes mellitus.Case report: A 54-year-old woman with history of long-standing, poorly-controlled diabetes mellitus, hypertension,...
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ea0037ep492 | Diabetes (complications &amp; therapy) | ECE2015

Coated pellets with controlled glucose release for interdiction of hypoglycaemia in children with diabetes

Neumann David , Franc Ales , Muselik Jan , Sabadkova Dana

Introduction: A diet plan, meals with suitable glycaemic index and sophisticated insulin delivery are used for balanced sacharides–insulin intake. In specific real day-to-day life situations patients must break their activities. Urgency to east in socially inappropriate time harm their lives, especially in young children with diabetes. Night hypoglycaemia, a parental fear of insufficient snack in nursery, sports with prolonged race periods, etc. are among these situations...
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ea0037ep493 | Diabetes (complications &amp; therapy) | ECE2015

Different glycaemic patterns in patients with steroid diabetes and type 2 diabetes

Maric Andreja , Poljak Bozidar

Introduction: Long-term use of glucocorticoids has impact on reduction of β-cell function and peripheral insulin sensitivity, leading to a steroid diabetes.Aim: To assess patterns of change of glycaemia and need for insulin at admission to hospital, during days 1–5 and at discharge in patients with newly diagnosed type 2 diabetes (NST) compared with patients with a history of taking corticosteroids and newly diagnosed diabetes mellitus (ST).</p...
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ea0037ep494 | Diabetes (complications &amp; therapy) | ECE2015

Angiopoietin 1 in patients with type 2 diabetes mellitus and diabetic retinopathy

El Sattar El-Deeb Abd , Halawa Mohamed , Saad Ahmed , Sabry Inas , Mahdy Maram , Abd El Aziz Mohamed , Roshdy Nagwa

Background: Diabetic retinopathy (DR) is a clinically well-defined sight-threatening complication in type 2 diabetes. Angiopoietin 1 (Ang1) has been shown to promote endothelial cell survival without causing proliferation, stabilise endothelial interactions with surrounding support cells and can block the vascular permeability effects of vascular endothelial growth factor (VEGF). More recent data suggest that balance between these growth factors may affect vascular endothelial...
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ea0037ep495 | Diabetes (complications &amp; therapy) | ECE2015

Eighteen grams of glucose are necessary to treat severe hypoglycaemia: experience from the Emergency Medical Services Department

Cohen Charlotte , Fysekidis Marinos , Etiennar Celia , Ginaux Lucie , Sebbah Jean-Luc , Cohen Regis , Lakhnati Philippe

We know that non-severe hypoglycaemia (SH) should be treated with the immediate intake of 15–20 g of oral glucose, there are no data according to our knowledge in the current literature for the dose of glucose that is necessary to inject in SH. We have analysed retrospectively the treatment of pre hospital SHs as reported after an emergency call for intervention. Our primary objective was to know the dose of the given glucose and our secondary objective was to know the fa...
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ea0037ep496 | Diabetes (complications &amp; therapy) | ECE2015

SUMO4 163G>A variation is associated with kidney disease in type 2 diabetes in Indian population

Kumar Vinod , Sinha Nisha , Yadav Ashok K , Bhansali Anil , Dutta Pinaki , Jha Vivekanand

Background: Various genetic and environmental factors are appear to contribute to the development of kidney disease in type 2 diabetes. Small ubiquitin-related modifier 4 (SUMO4) appear to play a role in development and/or progression of diabetic nephropathy. Substitution of methionine with valine at codon 55 (M55V) of SUMO4 enhances activity of nuclear factor-kB, a central mediator of inflammation proapoptotic events.Aims: To investigate the association...
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ea0037ep497 | Diabetes (complications &amp; therapy) | ECE2015

Feasibility, acceptability, and uptake rates of gestational diabetes mellitus screening in primary care vs secondary care: findings from a randomised controlled mixed methods trial

Tierney Marie , O'Dea Angela , Danyliv Andriy , Glynn Liam , McGuire Brian , Carmody Louise , Newell John , Dunne Fidelma

Introduction: It is postulated that uptake rates for gestational diabetes mellitus (GDM) screening would be improved if offered in a setting more accessible to the patient. However, this has not been previously investigated, nor has the feasibility or the acceptability of such an alternative. The aim of this study is to evaluate the rate of uptake of GDM screening in the primary vs secondary care setting, and to qualitatively explore the providers’ experience of primary c...
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ea0037ep498 | Diabetes (complications &amp; therapy) | ECE2015

Real-time sonoelastography and ultrasound evaluation of Achilles tendon of diabetic patients

Evranos Berna , Idilman Ilkay , Ipek Ali , Polat Sefika Burcak , Cakir Bekir , Ersoy Reyhan

Introduction: Diabetes mellitus (DM) is an endocrine disease characterised by metabolic abnormalities and long-term complications. Achilles tendon (AT) play an important role in foot biomechanics. We aimed to investigate the effect of DM on the AT, which may contribute to the long-term complications in the foot–ankle complex.Materials and methods: 78 diabetic patients with (35 cases) or without (43 cases) diabetic foot ulcers were recruited from End...
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ea0037ep499 | Diabetes (complications &amp; therapy) | ECE2015

Effect of gemigliptin switching from pioglitazone with metformin in type 2 diabetes

Kim Yonghyun , Shin Donghyun

The DPP4 inhibitors that increase insulin secretion by glucose dependently can also relieve insulin resistance because they improve early phage insulin secretion and prevent late hyperinsulinaemia. It also can be more effective in controlling the blood glucose because it acts synergistically with metformin by improving insulin secretory dysfunction compared TZD with metformin that has similar action mechanism. One of those is gemigliptin that was developed in this country rece...
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ea0037ep500 | Diabetes (complications &amp; therapy) | ECE2015

Cytokine status and subpopulations of peripheral blood lymphocytes in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease

Kondratiuk Kateryna , Bodnar Petro , Lysianyj Mykola , Belska Liudmyla , Potapova Antonina

One of the leading roles in the mechanisms of type 2 diabetes mellitus (T2DM) belongs to immunopathological link of pathogenesis, which determines the development rate and severity of its specific complications, in particular, non-alcoholic fatty liver disease (NAFLD).The purpose: To examine the contents of cytokines and major lymphocyte subsets in patients with T2DM and NAFLD.Description of methods: We observed 118 patients, inclu...
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ea0037ep501 | Diabetes (complications &amp; therapy) | ECE2015

Evaluation of violation vibration sensitivity for early diagnosis of diabetic distal polyneuropathy in patients with type 1 diabetes in the Republic of Belarus

Alla Shepelkevich , Irina Bilodid , Alexandra Sosedkova , Olga Salko , Alexandra Malkevich , Nikita Volkov , Vladislav Yurkovec

Screening for diabetic polyneuropathy (DP) is advisable for all patients with type 1 diabetes mellitus (T1DM) after 5 years the detection of the disease. The aim of the study was to evaluate the vibration sensitivity disorders in T1DM patients using Vibratip device for early diagnosis of DP.Materials and methods: 509 patients with T1DM (224 women and 285 men) (mean age: 28.5±8.5 years, mean BMI −24.2±4.1 kg/m2) were examined. T...
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ea0037ep502 | Diabetes (complications &amp; therapy) | ECE2015

Disabilities of the arm, shoulder, and hand (DASH) questionnaire and diabetic complications: preliminary results

Tuzun Dilek , Bozkirli Emine Duygu Ersozlu , Oguz Ayten , Sahin Murat , Bolat Hanife , Deniz Mustafa Saygin , Akgul Omer Faruk , Gul Kamile

Aim: Disabilities of the arm, shoulder, and hand (DASH) questionnaire is a self-administered region-specific outcome instrument developed as a measure of self-rated upper-extremity disability and symptoms. The DASH consists mainly of a 30-item disability/symptom scale. In this study, we aimed to evaluate DASH questionnaire in 1000 type 2 diabetes mellitus (T2DM) patients.Material and methods: 297 patients (mean age 52.13±9.37 years, 190 women and 10...
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ea0037ep503 | Diabetes (complications &amp; therapy) | ECE2015

Can the onset of type 2 diabetes be delayed by a group-based lifestyle intervention in women with prediabetes following gestational diabetes mellitus? Findings from a randomised control mixed methods trial

O'Dea Angela , Tierney Marie , McGuire Brian , Newell John , Gibson Irene , Glynn Liam , Noctor Eoin , Connolly Susan , Dunne Fidelma

Aim: The aim of this paper is to report on the outcomes of a randomized controlled trial designed to evaluate the effectiveness of a group-based lifestyle intervention programme for reducing the risk factors associated with diabetes in women with pre diabetes following gestational diabetes. We expected that the group based intervention through its educational and supportive approach would enable improvements in psychosocial health, health behaviours, anthropometry, and glucose...
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ea0037ep504 | Diabetes (complications &amp; therapy) | ECE2015

Topical wound pressurised oxygen therapy: new approach in treatment of diabetic foot ulcers?

Naglic Maja Cavlovic , Bakula Maja , Duvnjak Lea Smircic

Introduction: Topical wound oxygen therapy (TWO2) is therapeutic modality that delivers humidified pressurised O2 directly to the specific body part to achieve tissue penetration and increased O2 levels to the open ischaemia wound. O2 is vital in the synthesis of collagen, enhancement of fibroblasts, angiogenesis, leukocyte function, energy metabolism, and the inhibition of mycrobial growth. TWO2 therapy has showed effecti...
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ea0037ep505 | Diabetes (complications &amp; therapy) | ECE2015

The use of insulin pump therapy in the paediatric age group

Mikhno Hanna , Solntsava Angelica , Volkova Natalia

The use insulin pump therapy (IPT) (continuous subcutaneous insulin infusion (CSII)) has increased dramatically in youth with type 1 diabetes (T1D) in the past decade.Objective: Rate metabolic compensation of diabetes mellitus in children on IPT on the level HbA1c and self-control of glycaemia.Methods: The examination of 19 children aged 12.55±3.75 years (boys/girls=13/6), with T1D, observed in ‘2nd City Children’s H...
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ea0037ep506 | Diabetes (complications &amp; therapy) | ECE2015

Relation between psychiatric symptoms and diabetic complications: preliminary results

Tuzun Dilek , Bozkirli Emine Duygu Ersozlu , Oguz Ayten , Sahin Murat , Yilmaz Tugba , Ganidagli Berivan , Akgul Omer Faruk , Gul Kamile

Aim: In this study, we aimed to assess psychiatric symptoms in 1000 type 2 diabetes mellitus (T2DM) patients.Material and methods: 297 patients (mean age 52.13±9.37 years, 190 women and 107 men) who had T2DM were included as a preliminary in this study. The presence of cheiroarthropathy, Dupuytren’s contracture, tinnel sign, and tendinitis was assessed. Diabetic retinopathy was assessed by direct ophthalmoscopy. Urinary albumin excretion was de...
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ea0037ep507 | Diabetes (complications &amp; therapy) | ECE2015

The diabetic hand: a forgotten complication?

Tuzun Dilek , Bozkirli Emine Duygu Ersozlu , Oguz Ayten , Sahin Murat , Sahin Irem , Demir Hakan , Inanc Elif , Ganidagli Berivan , Gul Kamile

Aim: Diabetes mellitus is a chronic metabolic condition characterised by persistent hyperglycaemia with resultant morbidity and mortality related primarily to its associated microvascular and macrovascular complications In this study our aim was to investigate the prevalence of the most frequently occurring hand complications in 1000 type 2 diabetes mellitus (T2DM) patients.Material and methods: 297 patients (mean age 52.13±9.37 years, 190 women and...
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ea0037ep508 | Diabetes (complications &amp; therapy) | ECE2015

Moderate and severe hypoglycaemia associated metabolic changes in cortex and hippocampus of mice

Pitchaimani Vigneshwaran

Objective: It is common in the clinical setting that the reperfusion of glucose after severe hypoglycaemia. Starvation leads to decrease in blood glucose level (BGL) and this shifts the brain to utilize less glucose and utilize other alternative fuels. This led us investigate how the brain decreases the glucose uptake during starvation and how it utilizes the glucose under severe hypoglycaemia.Results: To understand the mechanism we checked the neuronal ...
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ea0037ep509 | Diabetes (complications &amp; therapy) | ECE2015

Diabetes mellitus and chronic kidney disease: two decades of consultation of diabetes and kidney transplant, a retrospective study

Balsa Ana Margarida , Bastos Margarida , Dantas Rosa , Batista Carla , Alves Rui , Roseiro Antonio , Moreno Carolina , Guelho Daniela , Cardoso Luis , Vicente Nuno , Martins Diana , Oliveira Diana , Alves Marcia , Guimaraes Joana , Mota Alfredo , Carrilho Francisco

Introduction: Diabetic nephropathy is the main global cause of end stage renal disease. According to the annual report from the Portuguese National Diabetes Observatory, in 2013, the prevalence of diabetes mellitus (DM) in new cases of chronic kidney disease was 31.2 and 11.1% in kidney transplant patients.Aim: To characterise the population of type 2 diabetic patients admitted in diabetes and kidney transplant consult (DKTC), comparing those admitted be...
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ea0037ep510 | Diabetes (complications &amp; therapy) | ECE2015

Study of irisin hormone level in type 2 diabetic patients and patients with diabetic nephropathy

Shelbaya Salah , Abushady Manal , Samy Merhan , Abd El Mageed Yasmin , Abbas Magdy

Background: Chronic kidney disease secondary to type 2 diabetes is associated with multifactorial energy dysmetabolism. Irisin has been identified recently as an exercise induced hormone secreted by skeletal muscles. It is hypothesised that patients with CKD may have altered irisin levels.Aim of the work: We aimed to study irisin hormone in type 2 diabetic patient and to assess its relation with diabetic nephropathy (DN).Subjects a...
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ea0037ep511 | Diabetes (complications &amp; therapy) | ECE2015

A puzzling bilateral diabetic foot problem

Denecker Nathalie , Aerden Dimitri , De Maeseneer Michel

Introduction: Charcot neuroartropathy (CN) is a devastating complication of diabetes rapidly leading to irreversible foot deformity when misdiagnosed. Differential diagnosis with foot infections and other foot-related diseases remains challenging.Case: A 58-year-old woman with type 2 diabetes was hospitalised with a red, swollen left leg and high fever. The diagnosis of erysipelas with a neuropathic wound of the first digit as the entry wound was establi...
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ea0037ep512 | Diabetes (complications &amp; therapy) | ECE2015

Continuous subcutaneous insulin infusion decreases hypoglycaemia during nighttime

Vicente Nuno , Cardoso Luis , Baptista Carla , Barros Luisa , Guelho Daniela , Oliveira Diana , Martins Diana , Carrilho Francisco

Introduction: Continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) are forms of intensified insulin therapy and the most used regimens for type 1 diabetes (T1D). Owing to its continuous basal output, hypoglycaemic events tend to be rarer with CSII. Our goal was to evaluate the differences in nocturnal hypoglycemia between these two treatment strategies.Methods: Retrospective analysis of 61 patients who had performed continu...
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ea0037ep513 | Diabetes (complications &amp; therapy) | ECE2015

Insulin prescription audit

Saeed Nabeel , Brassill Mary Jane

Insulin is a life-saving drug but can be life threatening if not prescribed properly. A prospective, consecutive audit of insulin prescription was carried out on all medical and surgical patients admitted to South Tipperary General Hospital with types 1 and 2 diabetes mellitus in November 2013. The practice was compared with hospital guidelines which are consistent with other hospitals nationally. Three prescribing practices were audited: i) the prescription of insulin on insu...
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ea0037ep514 | Diabetes (complications &amp; therapy) | ECE2015

Distribution of fat mass in young type 1 diabetic patients

Dydyshko Yulia , Shepelkevich Alla

Background: There is convincing evidence that the increasing of visceral fat is a risk factor for vascular disease. Type 1 diabetes mellitus (T1DM) is characterized by the development of micro-, and later, and macrovascular complications. The aim of the study was to examine features of body composition fat distribution parameters in T1DM patients.Materials and methods: 96 patients with T1DM (59 women and 37 men) (mean age: 32.52±10.71 years, duratio...
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ea0037ep515 | Diabetes (complications &amp; therapy) | ECE2015

Roux-en-Y gastric bypass reduces proteinuria in diabetic kidney disease to a greater extent than weight loss alone in the Zucker diabetic fatty rat without a greater improvement in renal inflammation

Neff Karl , Elliott Jessie , Jackson Sabrina , Abegg Kathrin , Corteville Caroline , Munoz Rodrigo , Docherty Neil , Lutz Thomas , le Roux Carel

Background: The effect of Roux-en-Y gastric bypass (RYGB) on diabetic kidney disease (DKD) is unclear. We used a Zucker diabetic fatty rat (ZDF) model of DKD to determine the effect of RYGB on histopathological markers of DKD, proteinuria, and MCP1 excretion.Methods: ZDF rats underwent RYGB (n=15) or sham surgery (n=14) at 18 weeks of age. Eight sham operated animals were food restricted to match the weight loss of the RYGB group (body-...
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ea0037ep516 | Diabetes (complications &amp; therapy) | ECE2015

Assessment of the myelin damage degree in patients with and without diabetic neuropathy

Kostitska Iryna

Background and aims: Diabetic neuropathy is associated with impaired neuron myelination, nerve conduction, and muscle function. The pathogenic mechanisms of reduced myelination in diabetes mellitus are poorly understood. Peripheral myelin protein 22 (PMP22) is glycoprotein with proposed roles in peripheral nerve myelin formation. This study allows us to consider the changes in the plasma levels of PMP22 in patients with and without diabetic neuropathy.Ma...
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ea0037ep517 | Diabetes (complications &amp; therapy) | ECE2015

Tear function tests in pregnant women with gestational diabetes mellitus

Kan Seyfullah , Acar Ugur , Kizilgul Muhammed , Beyazyildiz Emrullah , Cankaya Ali Bulent , Apaydin Mahmut , Beysel Selvihan , Ozbek Mustafa , Delibasi Tuncay

Aim: Gestational diabetes mellitus (GDM) is a disorder which is described as impaired glucose tolerance which firstly occurs first time during pregnancy. We aimed to evaluate the tear function tests such as Schirmer, tear break-up time (TBUT), tear film osmolarity (TFO), and ocular surface disease index (OSDI) score in pregnant with GDM.Methods: Pregnant women with GDM and healthy pregnant who were matched in both age and gestational age were enrolled in...
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ea0037ep518 | Diabetes (complications &amp; therapy) | ECE2015

The impact of non-alcoholic fatty liver disease on carotid artery intima–media thickness as a risk factor for atherosclerosis

Silaghi Cristina Alina , Craciun Anca Elena , Cosma Daniel Tudor , Silaghi Horatiu , Negru Romina , Feurdean Cristina , Oltean Andrada , Hancu Nicolae , Georgescu Carmen

Introduction: Non-alcoholic fatty liver disease (NAFLD) is considered a hepatic manifestation of metabolic syndrome and is closely associated with abdominal obesity, atherogenic dyslipidaemia, and diabetes exposing subjects with NAFLD to an increased risk of developing cardiovascular disease. The aim of this study is to determine the prevalence of NAFLD in diabetes mellitus (DM) patients, to correlate it to the subclinical atherosclerosis in these patients.<p class="abstex...
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ea0037ep519 | Diabetes (complications &amp; therapy) | ECE2015

Self-monitoring of blood glucose patterns among Turkish diabetic patients

Onbasi Kevser , Pasali Kilit Turkan , Kuet Orcun

Self-monitoring of blood glucose (SMBG) increases life expectancy and improves diabetic patients’ quality of life. 17 type 1 diabetic patients and 159 type 2 diabetic patients’ files were randomly evaluated to evaluate SMBG practice patterns in our hospital. All type 1 patients used insulin, while 38 type 2 diabetic patients used drug only, 35 type 2 diabetic patients used drugs in combination with insulin and 86 type 2 diabetic patients used insulin only. 90.3% of o...
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ea0037ep520 | Diabetes (complications &amp; therapy) | ECE2015

New-onset diabetes after renal transplantation (NODAT) and nodular glomerulosclerosis of the renal allograft

Martins Diana , Baptista Carla , Bastos Margarida , Pratas Jorge , Alves Rui , Romaozinho Catarina , Marinho Carol , Saraiva Joana , Moreno Carolina , Guelho Daniela , Vicente Nuno , Cardoso Luis , Balsa Margarida , Oliveira Diana , Mota Alfredo , Carrilho Francisco

Introduction: Diabetes mellitus is a common metabolic complication after kidney transplantation, occurring with a frequency of 15–30% in the first year. However, despite the high incidence, there are described few cases of diabetic nephropathy with nodular glomerulosclerosis of the allograft.Case: Female patient, 49, with autosomal dominant familial renal poliquistose diagnosed at 17 and progression for chronic end-stage renal disease, underwent ren...
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ea0037ep521 | Diabetes (complications &amp; therapy) | ECE2015

Sexual functioning and distress in types 1 and 2 diabetic women: a two-centres experience

Dimitropoulos Konstantinos , Tzortzis Vassilios , Vassiliou Agathi , Mparmpa Eleftheria , Mpristianou Magdalini , Bargiota Alexandra

Introduction: A high prevalence of sexual disorders has been observed in women with types 1 and 2 diabetes mellitus (DM). Here we present 4 years, two-center results of the study of disorders of female sexual functioning in female patients with diabetes.Materials and methods: During the time period 2011–2014, female DM patients and healthy controls were enrolled according to the protocol inclusion criteria. The FSFI, FSDS, and GHQ-28 questionnaires ...
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ea0037ep522 | Diabetes (complications &amp; therapy) | ECE2015

Association of SNPs in the intergenic region of OCT2 and OCT3 with short-term efficiency of metformin monotherapy in the type 2 diabetes patients

Klovins Janis , Zaharenko Linda , Geldnere Kristine , Konrade Ilze , Grinberga Solveiga , Pugovics Osvalds , Kalnina Ineta , Pirags Valdis

Clinical response to metformin is highly variable in type 2 diabetes (T2D) patients highlighting the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of this study was to evaluate the role of systematically selected tagSNPs from genomic regions coding for six organic cation transporters implicated in transport of metformin with respect to the short-term efficiency. The study involved 102 drug naïve newly diagnosed T2D patien...
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ea0037ep523 | Diabetes (complications &amp; therapy) | ECE2015

Abstract withdrawn....
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ea0037ep524 | Diabetes (complications &amp; therapy) | ECE2015

Hyperosmolar hyperglycaemic state and diabetic ketoacidosis: a 5-year retrospective study in a university hospital

Coelho Claudia , Nunes Catarina , Fernandes Vera , Pinto Maria Luisa , Souto Selma B , Marques Olinda

Introduction: Hyperosmolar hyperglycaemic state (HHS) and diabetic ketoacidosis (DKA) are the two most serious acute metabolic complication of diabetes mellitus (DM). The authors propose to characterise the admissions for HHS and DKA at a univeristy hospital.Methods: An observational, descriptive, and retrospective study in adults admitted to the hospital between January 2009 and October 2013 due to HHS and DKA. The information was accessed via the patie...
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ea0037ep525 | Diabetes (complications &amp; therapy) | ECE2015

The value of ankle–brachial index in patients above 40 years old with type 2 diabetes mellitus on the diagnosis of peripheral artery disease and the association between peripheral artery disease and chronic diabetes complications

Kebapci Nur , Turkozu Tugce Nur

Peripheral artery disease (PAD); is a chronic occlusive disease in lower extremities. PAD is an important sign of atherosclerosis, and an important predictor of mortality and morbidity during the cerebrovascular and cardiovascular diseases. Since the cardiovascular diseases are the most important cause of death in type 2 DM patients, diagnosing the mortality and morbidity predictor PAD in the early period is very important. The ankle–brachial index is an easy and cheap me...
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ea0037ep526 | Diabetes (complications &amp; therapy) | ECE2015

Bone mineral density in patients with type 1 diabetes mellitus by DEXA and QCT

Mparmpa Eleftheria , Karamagiolis Spyros , Tigas Stelios , Navrozidou Parthena , Vlychou Marianna , Fezoulidis Ioannis , Koukoulis Georgios N , Bargiota Alexandra

Introduction: Type 1 DM (T1DM) has been associated with low bone mineral density (BMD) measured by dual energy X-ray absorptiometry (DEXA) but not with quantitative computed tomography (QCT). QCT provides a three-dimensional image and measures bone’s volume directly as density, independent of the surrounding tissues. The purpose of this study was to evaluate BMD in patients with T1DM using DEXA and QCT.Methods/design: We studied 81 patients with T1D...
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ea0037ep527 | Diabetes (complications &amp; therapy) | ECE2015

Is early measurement of HbA1c useful for the prediction of treatment response in type 2 diabetes?

Luconi Michaela , Nreu Besmir , Samavat Jinous , Ognibene Agostino , Monami Matteo , Mannucci Edoardo

HbA1c, which is correlated with 3-month mean glycaemia, is usually measured every 3–6 months. Effects of variations of treatment are routinely assessed through HbA1c not earlier than 3 months. Glycated albumin (GA) has been proposed as an indicator of shorter-term (2-week) glucose control Aim of the present pilot study was to explore the possibility of predicting 3-month HbA1c by measuring HbA1c or GA at 15–30 days. Twenty-seven metformin-treated patients with type 2...
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ea0037ep528 | Diabetes (complications &amp; therapy) | ECE2015

Sex steroids levels and body composition in male patients with type 1 diabetes mellitus

Mparmpa Eleftheria , Karamagiolis Spyros , Tigas Stelios , Navrozidou Parthena , Vlychou Marianna , Fezoulidis Ioannis , Koukoulis Georgios N , Bargiota Alexandra

Introduction: Limited data exists regarding testosterone levels in type 1 diabetes mellitus (T1DM). The objective of this study was to evaluate serum sex steroids levels and body composition using dual energy X-ray absorptiometry method (DEXA) in male patients with T1DM.Methods/design: We studied 36 male patients with T1DM (group D) (age: 35.3+11.66, years) and 35 healthy control (group C) matched for age, sex, and BMI. In both groups waist circumference...
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ea0037ep529 | Diabetes (complications &amp; therapy) | ECE2015

Diabetic ‘holiday' foot: cautionary tales of sun, sandals, and risk

O'Hare James , Nolan Fiona , Kavanagh Eamon , Burke Paul , Carraig Elizebeth

Diabetic polyneuropathy is the most prevalent complication of diabetes. Diabetic foot lesions become limb threatening from a combination of injury, infection and impaired micro and macrocirculation. When diabetic patients go on holiday they usually change their routine and may become careless in routine care of their feet. We report a case series of seven middle aged Irish born diabetic male patients who developed serious foot lesion on holiday. They were identified from the p...
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ea0037ep530 | Diabetes (complications &amp; therapy) | ECE2015

Macrovascular complications in type 1 diabetes mellitus

Houda Ennaifer , Fatma Chaker , Dhouha Ben Salah , Salah Hamdi Med , Mariem Yazidi , Malika Chihaoui , Hedia Slimane

Introduction: Cardiovascular complications are well known in type 2 diabetes with other factors of cardiovascular disease. Recently, with the intensive treatment of type 1 diabetes, many studies have focused on macrovascular complications in type 1 diabetes. The aim of our study was to determine the long-term cardiovascular risk factors and macrovascular complications in type 1 diabetic patients.Patients and methods: A retrospective study involving 45 pa...
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ea0037ep531 | Diabetes (complications &amp; therapy) | ECE2015

Is dyslipidaemia adequately controlled in type 2 diabetics in primary care? Analysis of 183 patients

Cortes-Salazar Carmen Maria , Fernandez-Garcia Jose Carlos

Objectives: To evaluate the degree of control of atherogenic dyslipidaemia in patients with type 2 diabetes mellitus (T2DM).Methods: Retrospective cohort study which included patients with T2DM followed in a primary care setting. Patients were classified according to the following criteria: strict control of dyslipidaemia (LDL <100 mg/dl and triglycerides <150 mg/dl), partial control of dyslipidaemia (LDL ≥100 mg/dl or triglycerides ≥...
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ea0037ep532 | Diabetes (complications &amp; therapy) | ECE2015

Evaluation of plantar pressure and force in diabetes using Tekscan F-Scan in-shoe foot force and gait analysis system

Park Ie Byung , Lee Soojung , Kim Suneung , Han Gyucheol

Background: Evaluation of plantar pressure is useful for detecting functional abnormality of foot, especially in diabetic patients. The aim of this study was to evaluate plantar pressure and force in diabetic patients using Tekscan F-Scan in-shoe foot force and gait analysis system.Methods: Plantar pressure and force were measured by selecting an area of interest under the six areas of the foot: hallux, first metatarsal, second metatarsal, 3–5 metat...
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ea0037ep533 | Diabetes (complications &amp; therapy) | ECE2015

Knowledge assessment of diabetic patients about their disease: a prospective study

Ouerdani Senda , Slim Ines , Maaroufi Amel , Hasni Yosra , Kacem Maha , Ach Koussay , Chaieb Molka , Chaieb Larbi

Introduction: Therapeutic education of diabetic patients is an integral part of management care of the disease and a permanent way to empower patients and to promote their self-care. The purpose of this study is to evaluate the knowledge of diabetic patients about their disease.Patients and methods: This prospective study has been conducted during 9 months and included 312 patients with type 2 diabetes mellitus (T2DM) diagnosed at least 3 months ago. All...
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ea0037ep534 | Diabetes (complications &amp; therapy) | ECE2015

Diabetic foot infection: study of 109 patients

Kacem Faten Hadj , Ammar Mouna , Charfi Nadia , Cheikrouhou Nesrine , Mnif Fatma , Mnif Mouna , Rekik Nabila , Abid Mohamed

Introduction: Diabetic foot infection (DFI) is a major public health problem, both for its morbid clinical consequences mainly ulcers and the economic social cost due to repeated hospitalisations and the high rate of amputation.Objectives: Analyse the clinical presentation of DFI, study risk factors of developing this infection and describe the therapeutic management.Materials and methods: Retrospective study spread over 8 years ol...
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ea0037ep535 | Diabetes (complications &amp; therapy) | ECE2015

Diabetes and ischaemic stroke: prospective study in hospitalised patients

Monteiro Ana Margarida , Cabral Catia , Fernandes Vera , Alves Marta , Marques Olinda

Introduction: Diabetes mellitus (DM) is a major risk factor for stroke and has been shown that diabetic patients who suffer stroke have a worse prognosis, with greater morbidity and mortality.Objectives: Determination of the prevalence of DM in hospitalised patients for ischaemic stroke. Comparison of demographic variables, complications prevalence, length of hospital stay and in-hospital mortality among diabetic and non-diabetic patients. Assessment of ...
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ea0037ep536 | Diabetes (complications &amp; therapy) | ECE2015

Renal disease risk in type 2 diabetic patients with metabolic syndrome

Themeli Yllka , Barbullushi Myftar , Gjokutaj Aqif

Background: Patients with diabetes mellitus (DM), diabetic nephropathy (DN), and metabolic syndrome (MS) have a high risk of cardiac morbidity and mortality. Thus, identifying and treating risk factors associated with cardiovascular disease in DM may offer the best approach for preventing and delaying adverse renal and cardiovascular outcomes.Aim: To determine the relationships between MS, DN, and renal function in type 2 DM.Method...
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ea0037ep537 | Diabetes (complications &amp; therapy) | ECE2015

Optimal regimens of the basal-bolus insulin therapy in adolescents with diabetes mellitus of type 1

Galkina Galina , Voropay Angelina , Levkovich Marina , Afonin Alexey , Komkova Marina , Morozova Natalia

To achieve the optimal glycaemic control in adolescents with type 1 diabetes mellitus (DM1) is a difficult task. The reason is a low compliance of teenagers caused by psychoemotional peculiarities as well as decreased insulin sensitivity due to a physiologically high concentration of contrainsular hormones (androgens, GH, etc.). This study was aimed to determine peculiarities in regimens of the pump insulin therapy that are necessary for achieving treatment goals in adolescent...
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ea0037ep538 | Diabetes (complications &amp; therapy) | ECE2015

Contribution of haptoglobin and MTHFR polymorphisms to hyperhomocysteinemia and hypercysteinemia in type 2 diabetic patients

Valente Ana , Bicho Manuel , Garcia Ana , Goncalves Conceicao , Duarte Rui , Raposo Joao F , Costa Helena S

Introduction: There is a lack of epidemiological data on the distribution of haptoglobin and C677T of MTHFR polymorphisms in Caucasians type 2 diabetic patients. The contribution of these two genetic factors to hyperhomocysteinemia and hypercysteinemia can be useful to prevent cardiovascular events and to reduce public health costs. The aim of this study is to evaluate the contribution of haptoglobin and C677T polymorphisms for hyperhomocysteinemia and hypercysteinemia in Port...
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ea0037ep539 | Diabetes (complications &amp; therapy) | ECE2015

Type IV renal tubular acidosis in type 2 diabetes: case report of 4 patients

Bello Carlos Tavares , Fonseca Ricardo Castro , Duarte Joao Sequeira , Vasconcelos Carlos

Introduction: Type IV Renal Tubular Acidosis (Type 4 RTA) is an underdiagnosed condition known to be more frequent in Diabetes Mellitus patients with moderate renal impairment. It is thought to be very common, with an incidence of 3.8% of hospital admissions in some series, being an increasing problem among the elderly and aggravated by polypharmacy.Methods/design: The authors describe 4 cases of Type 4 RTA associated with type 2 Diabetes diagnosed and f...
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ea0037ep540 | Diabetes (complications &amp; therapy) | ECE2015

Glycaemic variability and subclinical inflammation in type 2 diabetes: experience of a Portuguese centre in the last decade

Bello Carlos Tavares , Fonseca Ricardo Castro , Capitao Ricardo , Santos Francisco Sousa , Duarte Joao Sequeira , Oliveira Manuela , Saraiva Catarina , Limbert Clotilde , Vasconcelos Carlos , Azinheira Jorge

Introduction: Adequate glycaemic, along with other cardiovascular risk factor control in type 2 Diabetes (T2D), and its beneficial impact on subclinical inflammation is associated with better microvascular outcomes.Objectives: To analyse the correlation between glycaemic control adequacy and systemic inflammatory markers, renal disease progression and cardiovascular risk factors.Material and methods: Retrospective cohort observatio...
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ea0037ep541 | Diabetes (complications &amp; therapy) | ECE2015

Weight and weight variability correlates with subclinical inflammation and comorbidities in diabetes type 2: a retrospective study over the last decade

Roque Catarina , Duarte Sequeira , Ferreira Rute , Serra Filipa , Moniz Catarina , Azinheira Jorge , Vasconcelos Carlos

Background: Management of obesity and overweight greatly improves glycemic control in type 2 diabetic (T2DM) patients and also provides positive impact in other cardiovascular risk factors in this population.Objectives: Evaluate the impact of weight and weight variability in subclinical inflammation and comorbidities of T2DM patients, over the last decade.Methods: Retrospective study of 1900 patients with T2DM, with a minimum of 2 ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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