Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

Eposter Presentations

Diabetes (pathiophysiology & epitemiology)

ea0037ep319 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Insulin receptor substrate 1 and 2 genes polymorphisms are associated with metabolic syndrome but not cardiovascular risk factors in patients with metabolic syndrome

Sarac Fulden , Sarac Sefa , Savas Sumru , Akcicek Fehmi

Objective: The aim of our study was to investigate the relationships between insulin receptor substrat-1 (IRS-1) and insulin receptor substrat-2 (IRS-2) gene polymorphisms and cardiovascular factors such as blood pressures, BMI, LDL- cholesterol, triglyceride, HOMA-IR, homocysteine, hsCRP and fibrinogen levels in patients with metabolic syndrome (MetS).Subjects and methods: The study population included 100 patients with MetS and 30 patients without MetS...

ea0037ep320 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Changing of expression of NOD-like receptors in GALT of rats at an experimental diabetes mellitus and pentoxifylline administration

Kamyshny Alex , Degen Anna

Introduction: Changing of expression of pattern-recognition receptors (PRR) of innate immune response by the gut-associated lymphoid tissue (GALT) can play a critical role in an induction and progression of T1DM.Aim: To study the peculiarities of NOD2 receptors in gut-associated lymphoid tissues (GALT) of rats with experimental STZ-induced diabetes mellitus and pentoxifylline (PTX) administration.Methods: Researches were made on Wi...

ea0037ep321 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Vitamin B12 levels and relationship between B12 and fasting insulin levels elderly patients with metabolic syndrome

Sarac Fulden , Savas Sumru , Sarac Sefa , Akcicek Fehmi

Introduction: Biochemical and clinical vitamin B12 deficiency has been demonstrated to be highly prevalent among patients with diabetes mellitus. The aims of the study were 1. to compare the vitamin B12 (VB12) levels, and 2. to investigate the relationship between VB12, fasting insulin and HOMA-IR levels in elderly patients with metabolic syndrome (MetS).Subjects and method: Study population included 121 (mean age 64.3±14.1 years) (80 female, 41 mal...

ea0037ep322 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Does hepatitis C virus (HCV) infection has a role in the pathogenesis of diabetes mellitus in patients with β thalassemia

De Sanctis Vincenzo , Soliman Ashraf , Candini Giancarlo , Elsedfy Heba

Introduction: In patients with β thalassemia major (TM) The interplay between liver siderosis and hepatitis C virus (HCV) infection may facilitates the progression to insulin resistance (IR) and diabetes mellitus (DM).Objectives: Many TM patients are infected with either HCV. Therefore, we aimed to explore if there is any association between DM and HCV-RNA positivity with different genotypes.Patients and methods: 148 TM patien...

ea0037ep324 | Diabetes (pathiophysiology & epitemiology) | ECE2015

The relationship between higher left ventricular mass index and plasma total homocysteine levels in patients with type 2 diabetes mellitus

Kundi Harun , Ates Ihsan , Ozkayar Nihal , Ulusoy F Vasfi

Purpose: The aim of the present study was left ventricular mass index (LVMI) in type 2 diabetes mellitus (T2DM) patients may be related increased circulating homocysteine (Hcy) levels.Methods: The study group comprised 130 patients, and all patients were newly diagnosed with diabetes and were not taking any medication. Measures of left ventricular mass (LVM) were assessed using Devereux formula and left ventricular mass index (LVMI) was calculated as LVM...

ea0037ep325 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Description of practices related to insulin injection therapy and sharp disposal among patients attending the diabetic clinic, Colombo North Teaching Hospital, Sri Lanka

Atukorala Kushani , Sumanasekera Deepama , Wickramasinghe Kumudu , Wickramasinghe Sumudu

Introduction: Diabetic patients on insulin therapy are compelled to use sharps such as insulin needles and lancets on a regular basis. As a result thousands of used sharps and bloodstained materials are generated daily by them. While there is a huge concern over sharps disposal practices in healthcare settings, the sharps disposal practices of diabetic patients living at home has been poorly documented.Methodology: Randomly selected sample of 158 diabeti...

ea0037ep326 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Vaccination status and factors affecting vaccination among diabetics

Onbasi Kevser , Taskiran Bengur , Keskin Lezan , Kilit Turkan Pasali , Ucgun Serdar

Vaccines are the most effective tools for preventing some infections. World Health Organization (WHO) and Ministry of Health (MoH) in Turkey recommends vaccination for people with diabetes. Our aim was to determine the prevalence of vaccination rates among diabetes in three different cities (Kütahya, Eskisehir and Malatya) in Turkey. 475 patients (307 female, 168 male) attending outpatient clinics for endocrinology were asked to fill in a questionnaire. The vaccination ra...

ea0037ep327 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Prevalence of orthorexia in diabetic patients

Anil Cuneyd , Aritici Gozde , Ari Hacer , Tutuncu Neslihan Bascil

Introduction: Orthorexia (nervosa) is an eating disorder, characterised by an obsession with avoiding foods perceived to be unhealthy. Though it has not been recognised as a pathological entity in Diagnostic and Statistical Manual of Mental Disorders – IV yet, interest in the condition has increased recently. This study aimed to determine the prevalence and risk factors of orthorexia in a group of diabetic patients.Methods and design: 134 (63 female...

ea0037ep328 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Metabolic control in patients with 1 diabetes mellitus associated with depression

Navmenova Yana , Mokhort Tatiana , Mahlina Elena , Rusalenko Maria

Objective: The assessment of glycemic control and concentration of lipids in the blood in patients with type 1 diabetes mellitus (DM-1), depending on the presence of depression (DP).Methods: There were examined 163 patients with DM-1. To assess severity of DP there was used Hospital Anxiety and Depression Scale (HADS). There were determined the level of fasting blood glucose (BG), BG level in 2 hours after a meal, the average daily BG level for 3 days an...

ea0037ep329 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Trends in diabetic ketoacidosis presentations at a major rural referral centre in Australia

Young Tamara

Aim: To study trends in presentation and management of diabetic ketoacidosis (DKA) at a rural referral centre, to ultimately assist with development of a formal management protocol.Methods: A retrospective audit of medical records for all presentations of DKA over a two year period was conducted to source age of patient, distance from Orange Health Service, new onset vs known type 1 diabetes mellitus, initial pH, time to normalisation of ketones, any epi...

ea0037ep330 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Clinical characteristics in patients with type 2 diabetes mellitus: a cohort study

Antolin Sandra Herranz , de Frutos Visitacion Alvarez , Folgado Ascension Sutil , Pascual Dolores Mateo , Rodrigo Eduardo Platero

Objective: To assess metabolic control, cardiovascular risk factors and treatments in type 2 diabetes mellitus (T2DM) patients.Methods: Observational and cross-sectional study of 238 T2DM patients who visited endocrinology clinics for the first time or those who did not undergo periodic revisions during the previous year of the study. All reported patients were outpatients, over 18 years of age and they signed informed consent statistical analysis was do...

ea0037ep331 | Diabetes (pathiophysiology & epitemiology) | ECE2015

The influence of actual and retroactive T2DM regulation on duration of hospital stay and clinical outcome of patients suffered from NSTEMI/STEMI

Gluvic Zoran , Kovacevic Pejka , Samardzic Vladimir , Jevtic Jelena Tica , Vujovic Marina , Popovic-Radinovic Vesna , Lackovic Milena , Mitrovic Bojan , Tomasevic Ratko , Panic Anastasija , Isenovic Esma R

Introduction: A link between diabetes and coronary heart disease is well-known. The aim of this study is to examine the influence of actual and retroactive diabetes regulation parameters (admission glycaemia and HbA1C value) on duration of hospital stay and clinical outcome of T2DM patients suffered from NSTEMI/STEMI.Material and methods: Cross sectional study involved 103 examinees with past history of T2DM actually hospitalised in CCU due to acute myoc...

ea0037ep332 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Serum apelin, salusin-α and salusin-β levels in type 2 diabetes mellitus and hypertension

Ugur Kader , Aydin Suleyman , Yusuf Sener Selcuk , Yildirim Kadriye , Ozkan Yusuf

Introduction: Diabetes mellitus (DM) is a metabolic illness caused by insulin resistance or lack of it. Hypertension (HT) has been seen frequently in diabetic patients, and causes morbidity and mortality with its complications. Salusins are vasodilator and hypotensive peptids which function most in cardiovascular system. Apelin is an insulin-sensitive, vasoconstructive, positive inotropic-effective peptide. In this study, determining the levels of serum salusin-α, salusin...

ea0037ep333 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Variability of anthropometric, echocardiographic and biochemical indices with comorbidity pathology – essential hypertension and type 2 diabetes

Shalimova A S , Belovol A N , Kochueva M N , Lutsyk V L , Linskaya A V

The mechanisms of development and progression of essential hypertension (EH) and concomitant type 2 diabetes (DM2) still remain not completely studied, so the comprehensive evaluation of the contribution of various indicators to the formation of this comorbidity have scientific interest.The aim of the study was comprehensive assessment of the variability of anthropometric, echocardiographic and biochemical parameters in patients with EH and concomitant D...

ea0037ep334 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Salt addition and the risk of type 2 diabetes mellitus: a case–control study

Radzeviciene Lina , Ostrauskas Rytas , Praneviciene Evelina

Introduction: Type 2 diabetes appears to involve interaction between susceptible genetic backgrounds and environmental factors. It is important to identify modifiable risk factors that may help reduce the risk of type 2 diabetes. Data on salt intake and the risk of type 2 diabetes are limited. The aim of the study was to assess the relationship between adding salt to prepared meal and the risk of type 2 diabetes mellitus.Methods: A case–control stud...

ea0037ep335 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Relationship between adiponectin and anthropometric parameters, insulin resistance and transaminase levels in patients with nonalcoholic fatty liver disease and type 2 diabetes

Zhuravlyova Larysa , Zhuravlyova Anna

The basis of the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is insulin resistance (IR) which appears on the background of abdominal obesity (AO) which, in turn, is a key factor in the emergence of an imbalance between adipocytokines entailing a disturbance of lipid and carbohydrate metabolism, which ultimately leads to the damage of the liver cells, the development of inflammation, fibrosis and apoptosis. The goal – to study features of changes in the level ...

ea0037ep336 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Diabetic gallbladder, dyspepsia and metabolic effects

Zhuravlyova Larysa , Moiseyenko Tetyana , Filonenko Maryna

The purpose of the study was to determine the functional state of the gallbladder (GB) in patients with type 2 diabetes mellitus (T2DM) in combination with metabolic syndrome (MS).Methods: 40 patients with T2DM and obesity of I–II degree were examined as well as 20 healthy volunteers. Ultrasonography, dynamic echocholecystography and duodenal intubation were performed. The motor function of GB was assessed by emptying coefficient (Kempt=(Vc</su...

ea0037ep337 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Tumour necrosis factor-α and insulin resistance in patients with nonalcoholic fatty liver disease in combination with type 2 diabetes mellitus

Zhuravlyova Larysa , Ogneva Olena

Tumour necrosis factor-α (TNF-α) impairs liver function and contributes to the pathogenesis of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (DM-2) with different trophological status.Purpose: To assess the relationship between the level of TNF-α and indices of carbohydrate metabolism in patients with NAFLD and its combination with DM-2 with different trophological status.Methods:...

ea0037ep338 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Pancreatogenic diabetes

Yahia Seif eldin , Mendis Budd , Crabtree Tom , Seevaratnam Nandini

Aims: Diabetes mellitus secondary to pancreatic disease and pancreatic surgery (pancreatogenic; type 3c) is a discrete entity to common types of diabetes and there are no well established guidelines for its management. At Nottingham University Hospitals, we have set up a multidisciplinary pancreatogenic diabetes clinic since 2008. The aim of this study is to look at the outcome of the clinic since it’s been established.Methods: Case notes and hospit...

ea0037ep339 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Vitamin D level in impaired fasting glucose and impaired glucose tolerance (prediabetic) patients

Gultekin Mehmet , Hekimsoy Zeliha , Oz Derya , Hatiboglu Ogun , Alarslan Pinar , Ozmen Bilgin , Onur Ece , Gozukara Ceyhun

Introduction: Impaired fasting glucose (IFG) is defined as being present in those whose fasting blood glucose level is consistently elevated above normal, but is not high enough to be considered as having diabetes mellitus. Impaired glucose tolerance (IGT) is defined as being present in those whose second hour plasma glucose level is higher than normal, but is not high enough to be considered as having diabetes mellitus. Low serum 25-hydroxyvitamin D levels are associated with...

ea0037ep340 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Effects of H. pylori eradication on metabolism and body weight in obese and non-obese patients

Mar Roca-Rodriguez M , Cornejo-Pareja Isabel , Coin-Araguez Leticia , Alcaide Juan , Clu-Fernandez Carlos , Vinuela-Gonzalez Laura , Duran-Martin Elena , Mora-Navas Laura , Mancha-Doblas Isabel , Tinahones Francisco J

Introduction: Many studies showed that H. pylori infection could be an independent predictor for insulin resistance and could regulate metabolism and body weight.Aim: To evaluate changes in metabolism induced by an oral glucose tolerance test (OGTT) before and after antibiotic eradication treatment in patients colonized by H. pylori.Materials and method: Prospective case-controlled study with a sample of patients colonized by H. py...

ea0037ep341 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Discrepancies between the glycosylated haemoglobin based criteria and glucose based criteria for diagnosis of diabetes and pre-diabetes

Sharma Sujan , Rana Magar Siddha Bahadur

Objectives: The number of people with diabetes is increasing globally; hence necessitate identifying diabetes earlier and more efficiently. Recently, American Diabetes Association (ADA) recommended the use of glycated haemoglobin (HbA1c) as an alternative to glucose based criteria for diagnosing type 2 diabetes and pre-diabetes. Hence, we aimed to evaluate the discrepancies between HbA1c- and glucose-based criteria for diagnosis of diabetes and pre-diabetes in Nepalese populat...

ea0037ep342 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Familial partial lipodystrophy linked to a novel peroxisome proliferator activator receptor-γ mutation, H449L

Demir Tevfik , Onay Huseyin , Savage David B , Kuruuzum Ayse Kubat , Erdeve Senay Savas , Altay Canan , Ozen Samim , Demir Leyla , Cavdar Umit , Akinci Baris

Introduction: Familial partial lipodystrophy (FPL) is a rare genetic disorder characterised by a selective lack of subcutaneous fat that is associated with insulin resistance and diabetes. FPL has been reported to be caused by mutations in the peroxisome proliferator activator receptor-γ (PPARG) gene, which encodes a key transcription factor that regulates adipocyte differentiation and insulin sensitivity.Material and methods: The objective of this ...

ea0037ep343 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Irisin plasma level is connected with the android adipose tissue deposit

Pukajlo Katarzyna , Kolackov Katarzyna , Laczmanski Lukasz , Kuliczkowska-Plaksej Justyna , Bolanowski Marek , Milewicz Andrzej , Daroszewski Jacek

Irisin (Ir), a recently identified adipomyokine, cleaved and secreted to the circulation from the FNDC5 protein in response to physical activity and some environmental conditions has been postulated to induces the differentiation of a subset of white adipocytes into brown fat and mediates the beneficial effects of exercise on metabolic homeostasis. Polycystic ovary syndrome (PCOS) – one of the most frequent endocrinopathies affecting women of child-bearing age is associat...

ea0037ep344 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

The GH treatment results in the increase of irisin concentration in plasma

Wikiera Beata , Pukajlo Katarzyna , Laczmanski Lukasz , Sloka Natalia , Basiak Aleksander , Bolanowski Marek , Noczynska Anna , Daroszewski Jacek

Brown adipose tissue metabolism is of remarkable pathophysiological interest, because it could be a target for future therapies for obesity and metabolic syndrome. Irisin (Ir), recently identified novel adipomyokine is essential in a white-to-brown fatty tissue transdifferentiation, and mediates some of the positive influences on metabolic disorders through increase of energy expenditure. The exact regulation of Ir secretion and action is unknown but significant positive assoc...

ea0037ep345 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Acquired partial lipodystrophy is associated with increased risk for metabolic complications

Akinci Baris , Koseoglu Fatos , Onay Huseyin , Yavuz Sevgi , Altay Canan , Simsir Ilgin Yildirim , Ozisik Secil , Demir Leyla , Korkut Meltem , Yilmaz Nusret , Ozen Samim , Akinci Gulcin , Atik Tahir , Calan Mehmet , Secil Mustafa , Comlekci Abdurrahman , Demir Tevfik

Objective: Acquired partial lipodystrophy (APL) is a rare disorder characterized by progressive selective fat loss. In previous studies, metabolic complications were reported to be relatively rare in APL, while they were quite common in other types of lipodystrophy syndromes. However, so far, there has been no systematic study on metabolic complications in APL.Methods: We have systematically evaluated 21 APL patients in the Turkish Lipodystrophy Study Gr...

ea0037ep346 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Association between +276 G>T polymorphism of the adiponectin gene (ADIPOQ) and insulin resistance in Ukrainian patients with type 2 diabetes mellitus (T2DM)

Karachentsev Yuri , Kravchun Nonna , Gorshunska Maryanna , Atramentova Lubov , Krasova Nataliia , Tyzhnenko Tatyana , Leshchenko Zhanna , Gladkih Alexander , Pochernyaev Artyom , Opaleiko Yuliia , Plohotnichenko Olga , Poltorak Victoria

Variants of ADIPOQ have been inconsistently associated with adiponectin level in diverse populations. We explored association of single nucleotide polymorphism (SNP) in the ADIPOQ (+276 G>T, rs1501299) with circulating total adiponectin and insulin resistance (IR) in Ukrainian T2DM cohort.Materials and methods: 544 T2DM patients (M/F: 241/303, age 56.3±0.4 years, diabetes duration 7.8±1.0 years, BMI 31.7&...

ea0037ep347 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Vitamin D level in diabetic retinopathy

Erol Rumeysa Selvinaz , Erol Muhammet Kazim , Zuhur Sayid Shafi , Ozturk Feyza Yener , Sen Esra Cil , Mavi Aysegul , Canat Masum , Cakmak Dilek Guven , Altuntas Yuksel

Purpose: To determine the relationship between grade of diabetic retinopathy and serum vitamin D levels in diabetic patients.Materials and methods: A total of 173 diabetic patients consisting of patients without retinopathy (n=67), patients with non proliferative diabetic retinopathy (NPDRP group n=47), patients with proliferative diabetic retinopathy (PDRP group n=59) was included in the study. Age and sex matched 55 healthy s...

ea0037ep348 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Abnormalities in glucose metabolism are present in HCV/HIV co-infected patients with severe liver fibrosis even in the absence of diabetes

Blanco Manuel Cayon , Mateos Carolina Garcia-Figueras , Nieto Gloria Baena , Herrera Patricia Bancalero , Cortes Salvador Perez , Pernia Alberto Terron

Rationale: Type 2 diabetes mellitus (T2DM) is a well known independent prognosis factor associated with cirrhosis. Nevertheless, few studies are focused on the association between glucose metabolism and liver fibrosis in HCV/HIV patients and their conclusions are contradictory. The aim of our study was to investigate the relationship between glucose homeostasis and liver fibrosis in these patients.Methods: In a cross-sectional study, we compared prevalen...

ea0037ep349 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Gamma glutamyl transferase and C-reactive protein in type 2 Saudi diabetic patients in relation to management modality and components of metabolic syndrome

Bahijri Suhad , Ahmed Maimoona , Al-Shali Khalid , Bokhari Samia , Alhozali Amani , Borai Anwar , Gusti Amani , Noor Ghada Ajab , Al Ahmadi Jawahir , Alghamdi Ahmed , Asiri Mohammed , Bashawieh Osamah , Aljahdali Abeer , Tuomilehto Jaakko

Background: Different management modalities are used to control hyperglycaemia associated with type 2 diabetes (T2DM). Research has indicated an association of single or combined insulin therapy with increased cardiovascular events. Metabolic syndrome (MS), as well as increased levels of C-reactive protein (CRP), and gamma glutamyl transferase (GGT) are also associated with increased CVD risk.Aim: To study the relationship between management modality, gl...

ea0037ep350 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

The prevalence of metabolic syndrome in patients with diagnosed type 2 diabetes

Shehu Aldi , Thengjilli Erion , Doko Albana , Toti Florian

Background and aims: The identification of metabolic syndrome (MS) is important for the appropriate management of associated cardiovascular risk factors. There are different criteria for the diagnosis of the metabolic syndrome proposed by the WHO and the National Cholesterol Education Program 2001 – NCEP/ATP III. The aim of our study was to determine the prevalence of the MS as the NCEP/ATP III criteria in a selected population of type 2 diabetes.Pa...

ea0037ep351 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Insulin-induced lipohypertrophy diagnostics in diabetic patients: subcutaneous fat ultrasonography

Volkova Natalya , Davidenko Ilya , Rudakova Julya , Sesukina Anna

Introduction: Lipohypertrophy (LH) is a chronic complication of diabetes mellitus that caused by frequent s.c. injections of insulin. Nowadays, LH were modified due to good quality modern insulin and expansion their concentration. As a result, some difficulties of diagnosis were appeared.Design: The aim of this study has been to compare the frequency of insulin induced LH in diabetic patients revealed by ultrasonography of subcutaneous fat with those fou...

ea0037ep352 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Unvisible lipohypertrophy and diabetes compensation: is there link?

Volkova Natalya , Davidenko Ilya , Rudakova Julya

Introduction: Lipohypertrophy (LH) is a chronic complication of diabetes mellitus that could develop in any age, any injection site, and be any size. At present time, new method, as ultrasonography of subcutaneous fat, of LH diagnostics were appeared.Design: The aim of this study has been to estimate efficiency of insulinotherapy in diabetic patients after LH was diagnosed by ultrasonography. This study was done on 50 diabetic patients (31 females and 19...

ea0037ep353 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Glycoregulation during pregnancy

Mladenovic Violeta , Djukic Aleksandar , Djukic Svetlana , Macut Djuro

Background: Pregnancy presents a state of insulin resistance that can predipose diabetes development in some women, and is associated with increased risk for neonate and for mother. Gestational diabetes is a period of glucose intolerance that manifests at the beginning of the third trimester.Aim: The aim of this study is to analyse glycoregulation in healthy pregnant women.Materials and methods: This study included 77 healthy pregn...

ea0037ep354 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Smoking habits and the risk of type 2 diabetes mellitus in women

Radzeviciene Lina , Ostrauskas Rytas , Praneviciene Evelina

Introduction: Type 2 diabetes appears to involve interaction between susceptible genetic backgrounds and environmental factors. It’s important to identify modifiable risk factors for type 2 diabetes, which may help reduce the risk of the disease. The aim of the study was to assess the relationship between smoking and the risk of type 2 diabetes in women.Methods: In case–control study included 168 cases with a newly confirmed diagnosis of type 2...

ea0037ep355 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Optimal glycaemic control and a low rate of micro and macrovascular complications in patients with HNF1A–MODY treated in a dedicated tertiary referral centre

Bacon Siobhan , Kyithar Ma Peyh , McCarthy Ailbhe , Burke Marie , Byrne Maria

Objective: HNF1A gene mutations are the most common cause of monogenic diabetes. Patients with HNF1A–MODY display sensitivity to sulphonylurea therapy, however the long term efficacy has yet to be established. There is also limited literature as to the prevalence of complications in this unique cohort. The aim of the study was to determine the natural progression of HNF1A–MODY diabetes in a dedicated MODY clinic.Design: n=60 H...

ea0037ep356 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Plasma omentin-1 level does not change in the first trimester in women with gestational diabetes mellitus

Sancak Seda , Aydin Hasan , Sargin Mehmet , Orcun Asuman , Ozdemir Ali , Celik Ayhan , Aslan Gulgun

Objective: Gestational diabetes mellitus (GDM) is strongly associated with maternal obesity. Omentin-1 is secreted from the adipose tissue and enhances insulin action. Circulating levels are inversely correlated with body weight, decreased in type 2 diabetes. Pre-existing maternal obesity has been shown to be associated with lower omentin-1 expression in placenta, adipose tissue and maternal plasma. In our previous study, we had shown that plasma omentin-1 level is decreased i...

ea0037ep357 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

The role of TCF7L2 polymorphism in the development of type 2 diabetes in subjects with metabolic syndrome

Katsoulis Konstantinos , Paschou Stavroula , Hatzi Elissavet , Tigas Stelios , Georgiou Ioannis , Tsatsoulis Agathocles

Introduction: Transcription factor 7 like-2 (TCF7L2) gene variants (rs12255372 and rs7903146) have been consistently shown to raise genetic risk for type 2 diabetes (T2D). The aim of this study was to investigate the possible role of these variants in the development of dysglycemia (T2D or impaired fasting glucose (IFG)) in patients with metabolic syndrome (MS).Patients and methods: The study population consisted of 228 patients with MS who were...

ea0037ep358 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Serum irisin level increases throughout the gestational period and it does not play role in development of gestational diabetes mellitus

Seda Seda , Aydin Hasan , Sargin Mehmet , Orcun Asuman , Ozdemir Ali , Celik Ayhan , Aslan Gulgun

Objective: Irisin is a novel adipomyokine that regulates the differentiation and phenotype of adipose tissue. It induces an increase in total body energy expenditure, improves insulin sensitivity, and glucose tolerance. It showed that the levels of irisin are low in obese, diabetic and impaired glucose tolerance patients. However, the information of the levels of circulating irisin in gestational diabetes mellitus (GDM) is controversial. In this study, we investigated i) the l...

ea0037ep359 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Gestational diabetes mellitus may associate with atherosclerosis due to high mean platelet volume which is a determined of platelet function

Durmaz Senay Arikan , Carlioglu Ayse , Eris Bilge , Yildiz Faruk , Kilic Halime

Aim: Mean platelet volume (MPV), which is a determinant of platelet function, is an independent risk factor for atherosclerosis. The aim of this study is to evaluate MPV values in gestational diabetes mellitus (GDM).Material and methods: Forty-nine women with gestational diabetes mellitus (mean age 28.2±4.7 years) and 40 healthy pregnant women (mean 26.2±4.6 years age) who came to our Out-Patient Clinic of Endocrinology were included in the stu...

ea0037ep360 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Role of nitrosative and oxidative stress on the development of gestational diabetes mellitus and their effect in GDM placenta

Lopez-Tinoco Cristina , Visiedo Francisco , Rosendo Celeste , Ojeda Maria Belen , Mateos Isabel , Segundo Carmen , Aguilar-Diosdado Manuel

Background and aims: The relationship between gestational diabetes mellitus (GDM) and oxidative stress is not well known and the effect of both oxidative and nitrosative stress in GDM placenta and the impact that could have on perinatal morbidity and risk of future complications is still pending to be elucidated. The aim of the study was to evaluate the relationships between maternal and placental tissue levels of markers of nitrosative and oxidative stress and antioxidants in...

ea0037ep361 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Dynamic thiol/disulfide homeostasis in patients with newly diagnosed type 2 diabetes mellitus

Bayrakci Nergiz , Ates Ihsan , Ozkayar Nihal , Yilmaz Fatma Meric , Topcuoglu Canan , Neselioglu Salim , Erel Ozcan , Altay Mustafa

Background: Thiol/disulfide homeostasis plays an important role in antioxidative defense mechanism, detoxification, signal transport, management of enzyme activity and trascription factors, and apoptosis. When thiol/disulphide homeostasis breaks down, these important cellular functions get deranged. Pathologies secondary to oxidative stress are seen in organeles in which this homeostasis is deranged. The aim of the study was to investigate dynamic thiol/disulfide homeostasis i...

ea0037ep362 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

The growth patterns in children born to mothers with gestational diabetes mellitus

Rutkowska Joanna , Bandurska-Stankiewicz Elzbieta , Wiatr-Bykowska Dorota , Myszka-Podgorska Katarzyna , Kuglarz Ewa , Matuszewski Wojciech

Introduction: The aim of the study was to assess if gestational diabetes mellitus (GDM) influence the pregnancy outcomes and the growth patterns in children.Design: Our prospective study cohort consisted of 261 children born to mothers with GDM and 153 control children born to non-diabetic mothers. In both groups children’s weight, length were assessed. Children were matched for large for gestational age (LGA) (birth weight >90th percentile for ...

ea0037ep363 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Insulin resistance is associated with larger thyroid volume in adults with type 1 diabetes

Rogowicz-Frontczak Anita , Pilacinski Stanislaw , Chwialkowska Anna , Wierusz-Wysocka Bogna , Zozulinska-Ziolkiewicz Dorota

Background: Larger thyroid volume and nodular thyroid disease were found to be associated with insulin resistance (IR) in patients with type 2 diabetes (T2DM). Similar analyses is lacking in T1DM.Aims: To check the association between thyroid volume and IR using estimated glucose disposal rate (eGDR) in patients T1DM.Materials and methods: We included 99 consecutive patients with T1DM aged 29 (mean, S.D.=6) with diab...

ea0037ep364 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Rate of impaired glucose regulation in outpatient care

Zabuliene Lina , Pauliukiene Birute , Urboniene Jurgita

The objective was to assess rate of impaired glucose regulation and progression to diabetes in adults using routinely collected health-care data.Material and methods: We conducted an audit on results of 75-g standardized oral glucose tolerance tests (OGTT) performed at Vilnius Antakalnio Outpatient Clinic from 3rd Jan 2011 to 15th Dec 2014 and analysed data of adult patients. We excluded from analysis results of 358 patients who didn’t perform 2-h p...

ea0037ep365 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

The prevalence of diabetes and associated risk factors among adult population in a Turkish population (Trabzon city)

Nuhoglu Irfan , Erem Cihangir , Ersoz Halil Onder , Kocak Mustafa , Civan Nadim

Objective: The objectives of this study were to determine the prevalence of diagnosed and undiagnosed diabetes mellitus (DM), prediabetes and to evaluate the associated risk factors in the sample of adult Turkish population.Methods: A total of 4000 eligible study subjects aged 20 years or older, chosen by multistage sampling on a field were selected. Of those 3721 subjects (2139 women and 1582 men) participated in the study. The study was performed betwe...

ea0037ep366 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Diabetes mellitus in patients with rheumatoid arthritis

Kostoglou-Athanassiou Ifigenia , Tzanavari Aikaterini , Banti Theodota , Katsavouni Charoula , Kalaycheva Natalia , Athanassiou Panagiotis

Introduction: In rheumatoid arthritis (RA) glucose metabolism may be affected either by the autoimmune inflammatory disease itself, or by the treatment used to manage the disease. Metabolic syndrome seems to be prevalent in RA patients.Aim: The aim was to study the prevalence of diabetes mellitus type 2 and metabolic factors related to the development of atherosclerosis within a cohort of RA patients cared for within a single Rheumatology Department....

ea0037ep367 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Correlation between fasting plasma glucose levels and HbA1c for diagnosis of prediabetes and diabetes: the 2011 Korea National Health and Nutrition Examination Survey

Ihm Sung-Hee , Kang Jun Goo , Kim Chul Sik , Lee Seong Jin , Kim Yoon Jung , Park Ju Ri , Yu Sung Hoon , Ryu Ohk Hyun , Hong Eun Gyung , Kim Doo-Man , Yoo Jae Myung , Choi Moon Gi , Son Ho Young , Yoo Hyung Joon

Aim: HbA1c is recommended as a diagnostic criterion for diabetes in clinical practice guidelines for type 2 diabetes in 2011 (10). Although there have been several reports that compared HbA1c-based diagnosis for diabetes with glucose-based diagnosis in Koreans, it is thought that larger epidemiological studies are required to confirm the association of HbA1c and FPG for diagnosis of diabetes for the Korean population. We conducted this study to examine the relationship between...

ea0037ep368 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Blood lead is associated with impaired fasting glucose in middle-aged population: the 2008–2011 Korean National Health and Nutrition Examination Survey

Kim Sang Yong , Kim Jin Hwa

Objective: Environmental exposure to heavy metals has affected human health. Several studies have suggested that lead increase oxidative stress and induce mitochondrial dysfunction. The objective was to determine whether there was an association between blood lead level and impaired fasting glucose (IFG) in middle-aged population.Research design and methods: This study was based on the data from the Korean National Health and Nutrition Examination Survey...

ea0037ep369 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

The state of superoxidedismutase activity as marker of oxidative stress in patients with impaired glycaemic states

Shyshko Volha , Mokhort Tatjana , Tsapaeva Natalia , Buko Inna , Konstantinova Elena

One of the key enzymes of antioxidant system is superoxide dismutase (SOD) that catalyses dismutation of superoxide anionic radical (O2−)l to molecular oxygen (O2) and hydrogen (H2O2). It was revealed that activity of SOD is decreased in patients with decompensated type 2 diabetes (T2D) but there is insufficient data about enzyme activity in compensated states and prediabetes.Purpose: To analys...

ea0037ep370 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Comparison between aldosterone and renin measurement by chemiluminescent immunoassay and RIA for the diagnosis of primary aldosteronism

Burrello Jacopo , Buffolo Fabrizio , Monticone Silvia , Williams Tracy Ann , Viola Andrea , Mengozzi Giulio , Veglio Franco , Mulatero Paolo

Objective: Primary aldosteronism (PA) is the most frequent cause of secondary hypertension. According to the Endocrine Society Guidelines, up to 50% of hypertensive patients should be screened for PA, using the aldosterone to renin (or plasma renin activity (PRA)) ratio (AARR and ARR respectively). The automated Diasorin LIAISON chemiluminescent immunoassay for renin and aldosterone measurement became available and in many laboratories is currently used instead of the classica...

ea0037ep371 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Listening to the patient's story: a qualitative approach to pre-gestational diabetic pregnancy

O'Hare Catherine , Greene Richard

Pre-gestational diabetics frequently rise to the challenge of pregnancy with remarkable improvements in diabetic control. Optimising pregnancy outcomes necessitates rigorous diabetes self-care, which is critically dependent on women’s capacity and the support they receive. The aim of this study was to identify self-reported drivers and inhibitors of self-care in pre-gestational diabetic pregnancies. The study was carried out at a tertiary referral maternity unit. Convenie...

ea0037ep372 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Biorhythms of contrinsular hormones in pregnant with type 1 diabetes receiving insulin with pump therapy and multiple injections

Mokhort Tatsiana , Skryplionak Tatsiana , Pancratova Olga , Rimashevskiy Vladislav

Pregnancy affects on the course type 1 diabetes (T1D), which is a result of changes in the production of hormones and their biorhythms.Aim: To examine circadian biorhythms of contrinsular hormones (BCh) contribution in the morning postprandial glycaemia depending on the type insulin therapy.Materials and methods: The study involved of 91 pregnant with T1D in 31–34 weeks on a background the maximum insulin resistance. Evaluatio...

ea0037ep373 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Higher glucose levels and prevalence of prediabetes in patients with autoimmune thyroiditis

Boutzios Georgios , Alexandraki Krystallenia , Liatis Stavros , Lampropoulou Eleni , Nikolopoulos Georgios , Bouki Aikaterini , Papaoiconomou Eleni , Paradeisi Kokkona , Tentolouris Nikolaos , Kaltsas Gregory

Introduction: Thyroid autoimmunity and diabetes mellitus type 2 (DM2) are the commonest endocrine disorders in the general population. The aim of the study was to investigate whether there is an association between thyroid autoimmunity and β-cell secretion in patients with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT).Methods/design: 501 patients (381 females) 46.5±14.2 years with IFG and/or IGT and autoimmune thyroidit...

ea0037ep374 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Effectiveness of Aβ classification of diabetes prone to ketosis in real clinical practice

Volkova Natalia , Porksheyan Maria , Rudakova Julia

Introduction: Prevalence of so-called diabetes prone to ketosis (DPK), has been increasing. The necessity of lifelong insulinotherapy is determined by Aβ classification of DPK.Design: Seven patients with atypical course of T2DM were studied. All patients had gradual development of hyperglycemia, obesity 1–2 stages, and acetonuria. Noone had acute weight loss. Stage 3 had positive GAD-AB, stage 4 – negative. Initially all patients were trea...

ea0037ep375 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Evaluation of quality indicators in hospital discharge reports in diabetic patients from an Internal Medicine Service: are we doing a good clinical practice?

Varela-Aguilar Jose M , Teran-Redondo Rafael , Calero-Bernal Maria Luz , Calzada-Valle Ana , Garcia-Contreras Rosa , Pereira-Diaz Estefania , Moreno-Verdejo Fidel , Ruiz-Ruiz Francisco , Calderon-Sandubete Enrique

Spanish Scientific Societies involved in diabetic patient care produced a consensus document with recommendations and quality indicators for hospital discharge reports (HDR).Objective: To analyse adequacy of HDR in diabetic patients from an Internal Medicine Service according to these recommendations (Med Clin (Bar) 2012 138 666.e1–666.e10).Methods: Study based on a programme continuity of care among ...

ea0037ep376 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Gonadal hormone regulates the expression MATE1 and OCT2 in type 2 diabetes mice

Ai Ligen , Zhang Dandan , Hou Wolin , Lu Junxi , Tang Junling , Lu Huijuan , Zheng Taishan , Liu Fang

Background and aims: Multi-drug and toxin extrusion 1 (MATE1) and organic cation transporters 2 (OCT2) are important proteins of metformin transport and excretion in liver and kidney. Our previous study showed that there were gender difference of metformin’s hypoglycaemic effect and it was independently linked with the oestrogen and testosterone levels in type 2 diabetes patients. This study was designed to observe the impact of oestrogen and androgen on the renal express...

ea0037ep377 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

The clinical effectiveness of screening for gestational diabetes mellitus in primary vs secondary care: results of a randomised controlled trial

O'Dea Angela , Tierney Marie , Glynn Liam , Danyliv Andrii , Carmody Louise , McGuire Brian , Newell John , Noctor Eoin , Dunne Fidelma

Aims: The aim of this paper is to report on the outcomes of a clinical trial investigating the clinical effectiveness of universal screening for gestational diabetes mellitus (GDM) in primary care vs secondary care.Design and methods: A parallel group randomised controlled trial of universal screening for GDM in primary vs secondary care. The primary outcome – uptake of screening in primary vs secondary care is reported elsewhere. In this article we...

ea0037ep378 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Risks of having gestational diabetes in the future for mothers and their offspring

Aydin Sabin Goktas , Uzum Ayse Kubat , Aydin Banu Kucukemre , Yildiz Sevda Ozel , Gedik Selda , Idiz Cemile , Canbaz Bulent , Bas Firdevs , Bundak Ruveyde , Dinccag Nevin

Introduction: Gestational diabetes (GDM) has an important short and long-term health consequences for both the mother and her offspring. The aim of this study was to evaluate current metabolic status of women with GDM history and their offspring approximately at 10th year after delivery.Methods: 24 mothers who had GDM 10 years before (mean age 41.08±4.13 years and BMI 30.3±5.9) and their children (11 females, 13 males; mean age of 11.0±1.9...

ea0037ep379 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Maintenance of risk reduction during 3-year follow up in prevention of type 2 diabetes by lifestyle intervention in primary health care setting: Diabetes in Europe Prevention using Lifestyle, physical Activity and Nutritional intervention (DE-PLAN) project

Gilis-Januszewska Aleksandra , Piwonska-Solska Beata , Szybinski Zbigniew , Kissimova-Skarbek Katarzyna , Topor-Madry Roman , Glab Grzegorz , Lindstrom Jaana , Peltonen Marku , Schwarz Peter , Pach Dorota , Tuomilehto Jaakko , Hubalewska-Dydejczyk Alicja

Introduction: Extended up to 20 years follow-up of several randomised control trials showed 34–43% diabetes risk reduction. Real life implementation studies performed worldwide in different settings and populations proved that also non-intensive, low budget lifestyle interventions can be effective. However little is known about long-term results of the translational studies.Objective: To study the risk factors changes of the DEPLAN non-intensive lif...

ea0037ep380 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Discrepancies between the HbA1c criteria and glucose-based criteria for diagnosis of diabetes and pre-diabetes

Shrestha Raj Kumar , Gyawali Prabin , Tuladhar Eans Tara , Sharma Vijay Kumar , Shrestha Sweta , Jha Bharat

The number of the people with type 2 diabetes is increasing globally, therefore there is an increasing need to identify diabetes earlier and more efficiently. Nearly 80% of people with diabetes live in low and middle income countries (LMICs). Traditionally, we have relied on glucose-based criteria (fasting, postprandial, and random) to make the diagnosis of diabetes; however, HbA1c has recently been endorsed as a diagnostic test, as superior alternative to glucose-based criter...

ea0037ep381 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

The correlation of serum ferritin and diabetes, glucose control or insulin resistance, related or not?

Li Jiang , Xiao Cheng , Cao Yongtong

Background: We have previously investigated the association between serum ferritin levels and risks of metabolic syndrome (MetS) using the same database from 2009 wave of the China Health and Nutrition Survey (2009 CHNS). We confirmed that MetS components are associated with increased serum ferritin levels in both men and women group, included abdominal obesity, hypertriglyceridemia, low HDL cholesterol, high blood pressure, and abnormal glucose level. Although, the prevalence...

ea0037ep382 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Impact of ACE gene polymorphism on preeclampsia development and insulin resistance aggravation in pregnant women with type 1 diabetes mellitus

Hrybanov Andriy , Rossokha Zoya , Avramenko Tatiana

Type 1 diabetes mellitus (T1DM) and preeclampsia (PE) in pregnant women share common pathophysiological pattern (hypovolemia, increased vascular resistance, and kidney damage) and both are genetically determined. Genetic impact on PE development and aggravation of insulin resistance in T1DM pregnant women has been underinvestigated. Thus, the aim of this case-control study was to evaluate the influence of ACE gene I/D polymorphism on risk of PE and insulin re...

ea0037ep383 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Mechanisms of development of carbohydrate metabolism disturbances in acromegalic patients depending on treatment

Dreval Alexander V , Trigolosova Irina V , Vinogradova Anna V , Wolffenbuttel Bruce H R

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. The effect of therapy of acromegaly on pathogenesis of CMD is not clear.Aim: To assess the effect of somatostatin analogues (SSA) on pathogenesis of carbohydrate metabolism disturbance in acromegaly.Patients and methods: 103 acromegaly patients were examined (31 men, 72 women; age 54 (46–61) years; 60 had newly diagnosed acromegaly (NA)...

ea0037ep384 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

TRAIL downregulates endothelin 1 and upregulates superoxide dismutase 1 in human aortic endothelial cells under pro-atherorgenic conditions

Forde Hannah , Davenport Colin , Smith Diarmuid , Cummins Phil

Introduction: Increased oxidative stress is associated with endothelial dysfunction in atherosclerosis and cardiovascular diseases (CVD). Evidence suggests that tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumour necrosis factor (TNF) superfamily, may also be involved in the pathogenesis of CVD. Observational studies have demonstrated that serum levels of TRAIL are inversely correlated with severity of coronary artery disease. This concurs ...

ea0037ep385 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Surgical trauma and insulin resistance

Polovina Snezana , Micic Dusan , Loncar Zlatibor , Sumarac-Dumanovic Mirjana , Savic Predrag , Cvijovic Goran , Resanovic Vladimir , Zoric Svetlana , Stamenkovic-Pejkovic Danica , Djukic Vladimir , Micic Dragan

Introduction: Different surgical procedures are followed by alteration in insulin sensitivity. The aim of our investigation was to analysed the influence of major (open cholecystectomy) and minor surgical stress (laparoscopic cholecystectomy) on insulin resistance.Methods: Insulin resistance was calculated by HOMA-IR before surgery and at 1st, 3rd, and 7th day after the elective operations. All participants were divided in two groups: group A with open c...

ea0037ep386 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

A case of maternally-inherited diabetes with deafness

Bakula Maja , Naglic Maja Cavlovic , Bakula Miro , Duvnjak Lea Smircic

Introduction: Maternally-inherited diabetes with deafness (MIDD) is a rare form of monogenetic diabetes caused by a point mutation in mitochondrial DNA at a position 3243A>G. The syndrome is characterised by diabetes and sensoneural hearing impairment. Additional clinical features include short stature, cardiomyopathy, myopathy, renal disease, macular dystrophy, and gastrointestinal disease. The majority of patients usually require insulin therapy within 2 years and metfor...

ea0037ep387 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Association of neutrophil to lymphocyte ratio with different glucose metabolism status

Ekiz Bilir Betul , Soysal Atile Neslihan , Bilir Bulent , Topcu Birol , Kara Sonat Pinar , Baykiz Derya , Aydin Murat

Introduction: Several studies have shown that prediabetic patients had increased concentrations of inflammatory markers and this association is independent of underlying obesity. Netrophil to lymphocyte ratio (NLR) is considered as a new inflammatory marker and has been studied extensively in a variety of clinical conditions especially in solid tumours and cardiovascular diseases. Studies evaluating the subclinical inflammation in prediabetes revealed positive association of s...

ea0037ep388 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Contribution of glucose variability to HbA1c levels in patients with type 1 diabetes

Cardoso Luis , Batista Carla , Rodrigues Dircea , Moreno Carolina , Guelho Daniela , Vicente Nuno , Balsa Margarida , Martins Diana , Oliveira Diana , Carrilho Francisco

Background: Optimal management of type 1 diabetes requires full understanding of the relationships between the triad: HbA1c, fasting plasma glucose, and glucose variability (GV). As GV may contribute to HbA1c we assessed the influence of GV in HbA1c levels.Research design and methods: We retrospectively analysed 9393 h of continuous glucose monitorings (CGMs) from 61 patients with type 1 diabetes. Periods of 24 h with missing values were excluded. We cal...

ea0037ep389 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Increasing NAD+ availability in skeletal muscle to augment energy metabolism

Fletcher Rachel , Doig Craig , Zielinska Agnieszka , Griffin Aliesha , Philp Andrew , Lavery Gareth

NAD+, an essential coenzyme in energy production, has recently risen to prominence as a signalling molecule central in mediating cellular metabolism and mitochondrial function. NAD+ dependent protein deacetylase sirtuin (SIRT) proteins regulate key metabolic transcription factors, including FOXOs and PGC-1α in muscle, in response to cellular energy demands and metabolic stress. Declining NAD+, metabolic and mitochondrial function are hallm...

ea0037ep390 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Prepregnancy care: an opportunity not to be missed

Egan Aoife , Danyliv Andriy , Carmody Louise , Kirwan Breda , Dunne Fidelma

Introduction: Our aim was to evaluate the effectiveness of a regional prepregnancy care (PPC) programme for women with both types 1 and 2 diabetes.Methods: This prospective cohort study included women with pregestational diabetes attending five antenatal centres in the West of Ireland between January 2006 and December 2013. Comparisons were made between those that did and did not attend the PPC programme. Primary outcomes included composite adverse neona...

ea0037ep391 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Lipoprotein associated phospholipase A2 was not associated with diabetic rethinopathy

Candan Zehra , Dellal Fatma Dilek , Dilekci Esranur Ademoglu , Alphan Uc Ziynet , Bekdemir Handan , Koc Gonul , Culha Cavit , Aral Yalcin , Uney Guner , Akkaya Zuleyha Yalniz

Aim: Diabetic rethinopathy is an important microvascular complication in diabetic patients. The association between hyperlipidemia and diabetic rethinopathy remains elusive. Lipoprotein associated phospholipase A2 (Lp-PLA2) is Ca independent serine kinase that hydrolyses oxidized LDL and forms lysilphoshotidylcholine and free fatty acid. The aim of the study was to determine serum levels of Lp-PLA2, traditional lipids, apolipoproteins in patients with diabetic rethinopathy and...

ea0037ep392 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Concentrations of the vitamin D metabolite 1,25(OH)2D and its relationship to inflammatory and metabolic parameters in diabetes type 2

Canecki-Varzic Silvija , Prpic-Krizevac Ivana , Bilic-Curcic Ines

Background: While 25-hydroxy-vitamin D (25(OH)D) has been thoroughly investigated, the role of active vitamin D metabolite 1,25(OH)2D in a metabolic syndrome still remains unclear. The aim of our study was to determine the association between 25(OH)D and 1,25(OH)2D levels and several metabolic parameters and inflammatory markers in postmenopausal women with diabetes type 2 (T2DM).Methods: Anthropometric variables, serum 25(OH)D, 1,2...

ea0037ep394 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

10 years of improving outcomes for women with pre-gestational diabetes

Owens Lisa , Carmody Louise , Egan Aoife , Dunne Fidelma

Pregnancy for women with type 1 or type 2 diabetes is a high-risk time. The Atlantic diabetes in pregnancy (DIP) programme aims to provide coordinated, optimal evidence-based clinical care for women with diabetes over five hospital centres in the West of Ireland. After previously auditing pregnancy outcomes in 2008 and again in 2011 we now look at our 10-year outcomes. Changes in clinical care delivery that have occurred over that time include; the provision of dedicated combi...

ea0037ep395 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Unawareness hypoglycaemia in patients with type 1 diabetes mellitus: prevalence and predictive clinical characteristics

Muros Mariola Mendez , Lloclla Eyvee Arturo Cuellar , Perez Fernando Garcia , de Pinillos Gordillo Guillermo Martinez , Fernandez-Ladreda Mariana Tome , Quiros Munoz Juan Manuel Garciade , Pena Jose Ignacio Fernandez , Lopez Jose Ignacio Fernandez , Fernandez Margarita Rivas , Amat Juana Magdalena Hidalgo , Garcia Santiago Duran , Leon Maria Victoria Cozar

Background: The prevalence of unawareness hypoglycaemia in patients with type 1 diabetes mellitus (T1DM) is uncertain. This study aims to determine its prevalence and predictive clinical characteristics with greater precision.Methods: Prospective study. 128 patients were recruited between September 2013 and January 2014. Awareness of hypoglycaemia was assessed using the ‘Clarke’ questionnaire and was classified into two groups, depending on the...

ea0037ep396 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Glycaemic control is comparable in patients with or without significant hepatic fibrosis as assessed by NAFLD fibrosis score

Chin Jun Liong , Chan Grace , Sea-Pui Sin Phyllis , Siddiqui Zeshan , O'Rathallaigh Eoin , Aftab Abdur Rahman , Courtney Garry , McGurk Colm

Background and aims: Non-alcohol fatty liver disease (NAFLD) is increasingly recognised in diabetic patients with metabolic syndrome. Patients with poorly-controlled diabetes and metabolic syndrome are likely to have significant liver inflammation leading to fibrosis. NAFLD fibrosis score (NFS) is a validated non-invasive scoring system that identifies liver fibrosis in patients with NAFLD. The aim of this study is to examine the glycaemic control in patients with or without s...

ea0037ep397 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Targeting optimal metabolic parameters in type 1 diabetes and concomitant coeliac disease: an extra challenge

Kiat Clifford , Cotter Tom , Dinneen Sean , O'Sullivan Esther

Patients, especially children, with type 1 diabetes (T1D) have an increased risk of developing other autoimmune disorders including coeliac disease (CD). While the general population prevalence of CD is ~1%, in patients with T1DM the prevalence of CD is higher (0.6–16%). Gluten free diet (GFD) imposes limitations in dietary options. Many of the gluten-free foods have a high glycemic index. This can influence glycemic values and metabolic parameters. We selected the subgro...

ea0037ep398 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Modulation of metabolic parameters and antioxidant enzymes in diabetic ageing female rat brains: beneficial role of metformin

Kumar Pardeep , Kale R K , Baquer N Z

Objective: The objective of this study was to investigate beneficial effects of metformin on membrane bound enzymes (monoamine oxidase, Na+K+ ATPse) and antioxidant enzymes (sueroxidase dismutase and glutathione S-transferases), lipid peroxidation, neurolipofuscin, and DNA degradation in diabetic aging female rats.Methods: Young (3 months) adult (12 months) and aged (24 months) rats will be diabetic by using alloxan monohyd...