ECE2015 Eposter Presentations Diabetes (complications & therapy) (143 abstracts)
Glycaemic variability and subclinical inflammation in type 2 diabetes: experience of a Portuguese centre in the last decade
Carlos Tavares Bello , Ricardo Castro Fonseca , Ricardo Capitão , Francisco Sousa Santos , João Sequeira Duarte , Manuela Oliveira , Catarina Saraiva , Clotilde Limbert , Carlos Vasconcelos & Jorge Azinheira
Hospital de Egas Moniz, Hospital de Egas Moniz, Portugal.
Introduction: Adequate glycaemic, along with other cardiovascular risk factor control in type 2 Diabetes (T2D), and its beneficial impact on subclinical inflammation is associated with better microvascular outcomes.
Objectives: To analyse the correlation between glycaemic control adequacy and systemic inflammatory markers, renal disease progression and cardiovascular risk factors.
Material and methods: Retrospective cohort observational study of T2D patients (n=1900) with a minimum of 2 year follow up in the Endocrinology Department of Hospital de Egas Moniz from the year 2005 until 2014. Patients younger than 18 years of age and/or suffering from secondary diabetes were excluded. Fasting blood glucose and glycated hemoglobin variation were analysed and correlated with blood pressure control and renal function, systemic inflammatory and blood lipid profile markers. Descriptive statistical methods were employed: t-test student, ANOVA for continuous and chi-square for categorical variables.
Results: The patient sample had an average age of 61.2 years, being 59.7% female. A statistical significant relationship was documented between the glycaemic variation and renal disease progression (CKD-EPI P 0.045; spot urinary albumin P<0.001), lipid profile (non-HDL Cholesterol P<0.001) and inflammatory markers (CPR P 0.028; ESR P 0.01; Leucocyte count P 0.004).
Conclusions: Despite having the known limitations of a retrospective study, the sample size allowed the authors to document a possible association between glycaemic variation, renal disease progression, subclinical inflammation and blood lipid profile.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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