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Endocrine Abstracts (2015) 37 EP597 | DOI: 10.1530/endoabs.37.EP597

1Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil; 2Kansas University, Kansas City, Missouri, USA.


Recent evidence shows that are modifiable risk factors and preventable, the most responsible for the high morbidity and mortality secondary to multiple chronic conditions (MCC), and smoking is one of the most important representatives. However, we still lack studies of populations with MCC and its association with smoking status.

Objectives: To identify clinical and psychosocial characteristics according to the status of smoking among users with MCC, at high cardiovascular risk.

Methods: Cross-sectional study with evaluation of socio-demographic, clinical and laboratory data, in HIPERDIA Center Juiz de Fora, Minas Gerais (CHM-JF), Brazil, assisting users with MCC (hypertension, diabetes mellitus and chronic kidney disease). To check the status of smoking was considered smokers (S), former smokers (FS) and nonsmokers (NS). Control blood pressure (systolic blood pressure <130 mmHg); metabolic (normal fasting blood glucose <100 mg/dl and/ or regular glycated hemoglobin <7%, for users <60 and <8% for those with ≥60 years); Normal LDL-cholesterol (<100 mg/dl); chronic kidney disease absent, the glomerular filtration rate (GFR) >60 ml/min per SC. Depression (PHQ-2 ≥3 points) and alcohol abuse (AUDIT-C >5 points). Declared atherosclerotic disease, DAD (vascular damage documented, regardless of the affected territory).

Results: 1558 users reviews, of which 12% were S; 41% and 47%, FS and NS. Compared to FS and NS, S were younger, less obese and more often female, higher prevalence of low education, physical inactivity, depression, alcohol abuse and lack lipid. Additionally, FS had better lipid control in relation to S and NS. Chronic obstructive pulmonary disease (COPD) and DAD were more prevalent among S and FS, even after adjusting for confounding variables.

Conclusion: The current smoking was more common in the younger population, sedentary, alcohol abuse, depressive symptoms, users declared atherosclerotic disease, COPD and a history of cancer. These data gave to S, a worse clinical profile compared to the NS. For despite the termination, the FS remained with similar comorbidities that active smokers.

Disclosure: The project was approved by the Research Ethics Committee of the Federal University of Juiz de Fora, Opinion 283/2011 in 24/04/2012, funded by the National Institutes of Health Fogarty.

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