ECE2015 Eposter Presentations Pituitary: basic and neuroendocrinology (62 abstracts)
The higher gastrin levels were associated with better glycaemic control
Georgios Boutzios 1 , Krystallenia Alexandraki 1 , Panagiotis Moschouris 1 , Eleni Lampropoulou 1 , Anastasia Evaggelatou 2 , Antigoni Velidaki 2 , Eufrosyni Kitsou 2 & Gregory Kaltsas 1
1Endocrine Unit, Department of Pathophysiology, Medical School, Laiko Hospital, University of Athens, Athens, Greece; 2Department of Nuclear Medicine, Laiko University Hospital, Athens, Greece.
Background: Gastrin is an early incretin candidate, since it is released by oral glucose and potentiates the glucose-induced insulin secretion. It has been shown that only in hypoglycaemic or hyperglycaemic conditions gastrin release is influenced by changes in blood glucose and insulin concentrations.
Aim: To evaluate whether there is a relation between fasting serum glucose and serum gastrin concentrations.
Methods: Gastrin and glucose levels and HbA1c were measured in 202 blood samples. We studied gastrin serum concentrations dividing the samples in three subgroups with glucose concentrations <100, 101–126, >126 mg/dl, and in three subgroups with HbA1c <5.7, 5.7–6.4, >6.5%, and glucose levels in three subgroups with different gastrin levels 100–200, 200–500, and >500 ng/ml.
Results: Gastrin and HbA1c were negatively correlated (r=−0.27, P=0.04) in the total population of samples studied. No difference was found in gastric concentration in the subgroups of normal, moderately increased, increased glucose concentrations (462.2±311.9, 568.1±164.9, and 387.8±46.2 respectively), or in the subgroups of normal, prediabetic, diabetic range of HbA1c (520.8±285.3, 428.7±327.1, and 297.9±236.5 respectively) but a trend value between normal and diabetic values (P=0.08). In low, mid-high, high gastrin levels HbA1c (6.3±9.7, 6.14±0.7, and 5.8±0.6) values but not glucose (109.2±35.9, 111.6±30.6, and 106.2±25.4 respectively) levels different only between low and high gastrin levels (P<0.001).
Conclusion: A negative correlation between glucose and gastrin levels has been shown in the present study. In patients with higher gastrin levels, HbA1c was statistically significant lower compared to patients with lower gastrin levels, indicating a better glycaemic control. Nevertheless further studies are needed to confirm these findings.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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