Endocrine Abstracts

JOINT647

Introduction.: Vitamin D deficiency is prevalent among individuals with latent autoimmune diabetes in adults (LADA) and has been linked to various metabolic disturbances. In fertile women with LADA, maintaining adequate vitamin D levels is crucial, not only for metabolic health but also for reproductive health. Vitamin D deficiency has been linked to various reproductive issues, including menstrual irregularities and complications during pregnancy.

The aim of the study.: To evaluate the vitamin D status and features of carbohydrate metabolism in fertile women with latent autoimmune diabetes in adults and classical type 1 diabetes (T1DM).

Material and methods.: 15 patients with LADA as well as 16 patients with classical T1DM and 25 practically healthy individuals were examined. In addition to general clinical research methods сholecalciferol status was evaluated as well as indicators of carbohydrate metabolism (fasting glycemia, glycated hemoglobin (HbA1c)), and C-peptide level.

Results.: Cholecalciferol level was registered 45.1% lower in LADA group compared to control (20.48 [18.41;25.71] ng/ml vs 33.00 [27.00;60.00] ng/ml) (P = 0.000) and by 37.9% in T1DM (20.48 [18.41;25.71] ng/ml vs 33.00 [27.00;60.00] ng/ml) (P<0.001). In LADA patients the level of cholecalciferol was lower by 11.5% (р<0.05) compared to T1DM. The fasting plasma glucose level was 10.91 [10.00;12.30] in LADA and 10.67 [7.04;12.51] in T1DM group and probably differed between LADA/control and T1DM/control – control level 4.78 [4.40;5.05] (decrease by 2.3 times and 2.2 times, respectively (P = 0.000)). The level of HbA1c was the highest in LADA group (9.90 [7.6;10.20]%: by 46% compared with control (5.35 [5.30;5.52]%) (P = 0.000) and did not significantly differ with T1DM group where the level was 8.85 [7.90;9.55]%. The C-peptide level was significantly higher in control group (3.20 [2.10;4.00] ng/ml) by 6.4 times compared with the LADA group (0.50 [0.20;0.65] ng/ml) (P<0.05) and 32 times compared with T1DM (0.1 [0.10;0.15] ng/ml); the difference between LADA and T1DM showed that C-peptide level was higher by 5 times in patients with LADA compared to T1DM group (P = 0.000). In patients with LADA negative correlations of average strength were recorded between vitamin D level and BMI (r= 0.442; P<0.05), fasting glycemia (r= 0.348; P<0.05), HbA_1c (r= 0.414; P<0.05), HOMA-IR (r= 0.671; P<0.05).

Conclusions.: Vitamin D deficiency in fertile women with LADA is associated with reduced beta-cell function and poorer glycemic control. Ensuring sufficient vitamin D levels remains a vital component of managing overall health in this population.