Introduction: It is known that patients with primary hyperparathyroidism (PHPT) have an increased cardiovascular morbidity and mortality. In our study, we aimed to investigate the cardiovascular risk factors in medically observed and operated PHPT patients.
Materials and methods: Twenty-nine medically observed (group A), 25 pre-operative (group B) and 23 post-operative (group C) patients with PHPT and 26 normocalcemic patients as control group (group D) were included to this study. Groups were assessed for flow mediated dilatation (FMD), carotid intima media thickness (CIMT), serum levels of sCD40L, hs-CRP and IL-8. Twelve patients with low levels of 25-hydroxy vitamin D (25OHD) in the medical treatment group were assessed in terms of these measurements before and 3 months after vitamin D replacement.
Results: Median FMD was 5, 5.1, 7.6 and 7.7% in groups A, B, C and D respectively. FMD measurement of group A was detected significantly lower than group C and D (P=0.02) and was similar with group B. FMD measurements of group B were also detected lower than group C and D but this did not reach to statistical significance. Results of CIMT measurement, serum sCD40L, IL-8 and hs-CRP levels showed no significant difference between groups. In 12 patients with low 25OHD within group A, FMD was increased to an average of 6.7% from 4.4% after vitamin D replacement (P=0.04).
Discussion: Endothelium-dependent vasodilatation was impaired in PHPT patients, particularly in medically treatment group, compared to control group. Vitamin D supplementation provide improvement in FMD measurements in medically followed PHPT patients with low 25OHD levels. The information that vitamin D replacement makes an improvement in endothelial dysfunction in PHPT patients with low 25OHD is a new contribution to the literature of our study.
Disclosure: This work was supported by Foundation of Ankara University Faculty of Medicine.
16 - 20 May 2015
European Society of Endocrinology