Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

Oral Communications

Calcium, vitamin D and bone

ea0037oc3.1 | Calcium, vitamin D and bone | ECE2015

Effect of GNAS transcript manipulation on human mesenchymal stem cells differentiation towards osteocyte cell lineage: insight into the pathophysiology of ectopic ossification in GNAS-related disorders

Elli Francesca Marta , Boldrin Valentina , Parazzi Valentina , Ragni Enrico , Bordogna Paolo , Spada Anna , Lazzari Lorenza , Mantovani Giovanna

Epi/genetic defects at the imprinted GNAS locus, that encodes the α subunit of the stimulatory G protein (Gsα), have been associated with a heterogeneous group of rare diseases, termed as Pseudohypoparathyroidism. Most GNAS-based disorders have the common feature of episodic de novo formation of heterotopic ossifications (HO) in subcutaneous tissues. The mosaic tissue distribution of HO suggests that pathogenesis involves an abnormal differentiation of precu...

ea0037oc3.2 | Calcium, vitamin D and bone | ECE2015

The association of sclerostin serum levels with sclerostin expression in bone

Bravenboer Nathalie , Visser Ruben , Mons Dirk Jan , Oostlander Angela , Sohl Eveline , van Essen Hub , de Jongh Renate , Lips Paul , Heijboer Annemieke , den Heijer Martin

Sclerostin is a major negative regulator of osteoblastic activity at tissue level. Serum sclerostin levels have been associated with bone mineral density and increased fracture risk. However, the relation between serum levels and expression on tissue levels is unknown. The aim of this study was to investigate this relationship. We used serum samples and bone biopsies from 26 patients that were available from a large randomised clinical trial, investigating with the effect of r...

ea0037oc3.3 | Calcium, vitamin D and bone | ECE2015

Klotho expression in long bones is critical for FGF23 production during renal failure

Kaludjerovic Jovana , Komaba Hirotaka , Sato Tadatoshi , Ishii Takenobu , Olauson Hannes , Larsson Tobias , Lanske Beate

Klotho (KL) is a type-I-membrane protein required for FGF23 to bind FGFR1 and modulate mineral ion homeostasis. Loss of either KL or FGF23 results in severe mineralisation defects. We recently found that membrane KL is expressed in osteoblasts and osteocytes, which are major sites of FGF23 syntheses. To investigate the role of bone-specific KL in mineral ion homeostasis and the progression of bone mineralisation defects in chronic kidney disease, we generated a mouse strain wi...

ea0037oc3.4 | Calcium, vitamin D and bone | ECE2015

Cardiovascular risk factors in patients with medically observed and operated primary hyperparathyroidism

Colak Sevgi , Aydogan Berna Imge , Canpolat Asena Gokcay , Kaya Cansin Tulunay , Sahin Mustafa , Corapcioglu Demet , Uysal Ali Riza , Emral Rifat

Introduction: It is known that patients with primary hyperparathyroidism (PHPT) have an increased cardiovascular morbidity and mortality. In our study, we aimed to investigate the cardiovascular risk factors in medically observed and operated PHPT patients.Materials and methods: Twenty-nine medically observed (group A), 25 pre-operative (group B) and 23 post-operative (group C) patients with PHPT and 26 normocalcemic patients as control group (group D) w...

ea0037oc3.5 | Calcium, vitamin D and bone | ECE2015

Three-year safety and efficacy data for recombinant human parathyroid hormone, rhPTH(1-84), in the treatment of adults with hypoparathyroidism: the RACE study

Clarke Bart L , Mannstadt Michael , Vokes Tamara J , Rothman Jeffrey , Warren Mark L , Denham Douglas S , Levine Michael A , Lagast Hjalmar , Bilezikian John P , Shoback Dolores M

Hypoparathyroidism is a rare endocrine deficiency due to inadequate amounts of parathyroid hormone (PTH) and is characterised by hypocalcaemia and hyperphosphataemia. Current management regimens with large amounts of oral calcium and active vitamin D do not adequately control mineral homeostasis and can lead to complications in many patients. The phase III REPLACE and RELAY clinical trials established the efficacy and safety of once-daily s.c. injection of r...