Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

ea0037oc4.1 | Diabetes | ECE2015

Novel glucagon receptor antagonist peptides improve glycaemic control and partially protect against streptozotocin induced diabetes in mice

O'Harte Finbarr , McShane Laura , Irwin Nigel

Glucagon receptor KO mice are resistant to the clinical manifestations of diabetes induced by streptozotocin (STZ) and retain normal glycaemic control and glucose tolerance. In the present study the effects of chronic (18 days) once daily i.p. administration of two different glucagon receptor antagonists (GRA); desHis1Pro4Glu9-glucagon (GRA-1) and its related acylated peptide desHis1Pro4Glu9(Lys12PAL)...

ea0037oc4.2 | Diabetes | ECE2015

Complement factor 5 deficiency leads to defective insulin receptor processing and severe systemic insulin resistance

Kikuchi Takuya , Gutierrez Dario A , Anderson-Baucum Emily K , Bolus W Reid , Hubler Merla J , Palmisano Brian T , McGuinness Owen P , Hasty Alyssa H

Activation of complement factor 5 (C5) produces the anaphylatoxin C5a and the proinflammatory cytolytic complex C5b-9. Recent studies have shown that C5a receptor (C5aR) deficiency leads to improved systemic and white adipose tissue (WAT) insulin sensitivity. This phenotype is considered to be due to the potent inflammatory potential of signalling through C5aR; however, the pleiotropic functions of C5 in inflammation and metabolism remain to be elucidated. We investigated the ...

ea0037oc4.3 | Diabetes | ECE2015

Chronic, long-term administration of Vardenafil improves endothelial function and corrects hypogonadism in patients with type 2 diabetes mellitus. A longitudinal, prospective, randomized, placebo-controlled, double blind, clinical trial

Santi Daniele , Guidi Alessandro , Granata Antonio , Pignatti Elisa , Bozic Roberto , Zaza Stefano , Roli Laura , Trenti Tommaso , Carani Cesare , Simoni Manuela

Background: Endothelial dysfunction leads to cardiovascular complications in type 2 diabetes mellitus (T2DM), through a reduction of nitric oxide (NO)-mediated relaxation. Phosphodiesterase-5 inhibitors (PDE5i) have hemodynamic effects, improving NO levels.Aim: To investigate if long term, chronic treatment with the PDE5i Vardenafil improves systemic endothelial function in men with T2DM.Methods: A longitudinal, prospective, invest...

ea0037oc4.4 | Diabetes | ECE2015

Islet stellate cell isolated from Goto-Kakizaki rats affects β-cell function

Sun Zilin , Li Fengfei , Chen Bijun , Li Ling , Zha Min , Xu Wei , Zhou Shaoxia , Bachem M G

Background: Evidence suggests that pancreatic stellate cells (PSCs) are present in intra-/peri-islets in type 2 diabetes mellitus (T2DM). We isolated stellate cell from islets (ISC) of Goto-Kakizaki (GK) rats. Given these cells are intra-islets, which possibly affect the biological behavior of β-cell. This study was designed to determine the effects of ISC isolated from fibrotic islets of GK rats on β-cell function and survival.Methods: ISC was...

ea0037oc4.5 | Diabetes | ECE2015

Efficacy of mesenchymal stem cells transplantation on glycaemic profile in streptozotocin induced diabetic Wistar rat

Bhansali Shobhit , Kumar Vinod , Saikia Uma Nahar , Jha Vivekanand , Bhansali Anil , Dutaa Pinaki

Introduction: Bone marrow is an abundant source of adult stem cells that can differentiate into various cell types. Administration of mesenchymal stem cells (MSCs) in irradiated diabetic rat model has transiently shown to decrease blood glucose level. This study examines the effect of high dose and multiple injections of MSCs on glycaemic profile, their localisation and regeneration of islet in diabetic Wistar rat.Methods: The study was carried out in ma...