Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

Oral Communications

Steroids, developmental and paediatric endocrinology

ea0037oc5.1 | Steroids, developmental and paediatric endocrinology | ECE2015

Maternal microbiota regulate glucocorticoids levels and placental development in mice

Al-Asmakh Maha , Hedin Lars , Pettersson Sven

The gut microbiota contributes to postnatal development and maturation by influencing barrier functions of the intestinal wall, the development of the immune system, and the utilisation of nutrients. Recent studies have also implicated a role in the prenatal period since the maternal gut microbiota is altered during pregnancy with a potential role in the regulation of glucose homeostasis and protection against preterm birth. Using as a model system germ-free mice that have nev...

ea0037oc5.2 | Steroids, developmental and paediatric endocrinology | ECE2015

Vitamin D decreases in vitro glucocorticoid sensitivity via down regulation of glucocorticoid receptor expression

Ansari Narjes Nasiri , Spilioti Eliana , Kalotychou Vasiliki , Dalagiorgou Geena , Moutsatsou Paraskevi , Papavassiliou Athanasios , Kassi Eva

Introduction: Glucocorticoids (GCs) are used in the treatment of chronic inflammatory or autoimmune diseases. However, patients are often resistant to the GC effects. Response to GCs is triggered through glucocorticoid receptor (GR). An important regulator of GR activity is the FKBP5. FKBP5 binds to co-chaperones promoting a conformation with lower cortisol affinity. The number of GRs is another determinant of GC sensitivity; GR expression is regulated by the nuclear ...

ea0037oc5.3 | Steroids, developmental and paediatric endocrinology | ECE2015

Activators of AMP-activated protein kinase regulate adipocyte aldosterone secretion and mineralocorticoid receptor signalling

White Anna , Cat Aurelie Nguyen Dinh , Montezano Augusto , Salt Ian , Touyz Rhian

The increasing global prevalence of obesity requires urgent intervention to limit the anticipated surge of associated cardiometabolic morbidity and mortality. The energy sensor AMP-activated protein kinase (AMPK) is one proposed target for treating metabolic disorders and is downregulated in adipose tissue of obese insulin resistant individuals. Given the strong relationship between metabolic syndrome and overactivity of the renin-angiotensin-aldosterone system (RAAS) we inves...

ea0037oc5.4 | Steroids, developmental and paediatric endocrinology | ECE2015

Adipose tissue-specific androgen generation fuels an adverse metabolic phenotype in patients with polycystic ovary syndrome

O'Reilly Michael , Kempegowda Punith , Gathercole Laura , Taylor Angela , Bujalska Iwona , Tomlinson Jeremy , Arlt Wiebke

Insulin resistance and androgen excess are the cardinal features of polycystic ovary syndrome (PCOS). The severity of hyperandrogenism and metabolic dysfunction in PCOS are closely correlated, but underlying mechanisms remain poorly understood. Aldoketoreductase type 1C3 (AKR1C3) is an important source of adipose androgen generation, activating androstenedione to testosterone (T). We postulated that AKR1C3 plays a critical role linking androgen metabolism and...

ea0037oc5.5 | Steroids, developmental and paediatric endocrinology | ECE2015

Pituitary hormone secretion profiles in IGSF1 deficiency syndrome

Joustra Sjoerd , Roelfsema Ferdinand , Endert Erik , Ballieux Bart , van Trotsenburg Paul , Fliers Eric , Corssmit Noortje , Bernard Daniel , Oostdijk Wilma , Wit Jan-Maarten , Pereira Alberto , Biermasz Nienke

Context: Loss-of-function of immunoglobulin superfamily 1 (IGSF1) causes an X-linked syndrome of central hypothyroidism, macroorchidism, and variable prolactin deficiency, GH deficiency in childhood, delayed pubertal testosterone rise, and/or obesity. The clinical features advert towards a pivotal role for IGSF1 in the pituitary gland, but detailed knowledge on pituitary hormone secretion in this syndrome is lacking.Objective: To study detailed ...