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17th European Congress of Endocrinology

Oral Communications


ea0037oc2.1 | Reproduction | ECE2015

Decanoic acid inhibits androgen production in vitro and in vivo by regulating HSD3B2: a promising drug candidate for the management of hyperandrogenism in polycystic ovary syndrome

Lee Bao Hui , Tan Huey Min , Li Yu , Zhang Zhiwei , Indran Inthrani Raja , Li Jun , Yong Eu Leong

Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder characterized by hyperandrogenism in women, with a high incidence of insulin resistance. Decanoic acid (DA), a naturally occurring 10-carbon fatty acid, has been shown to improve insulin sensitivity and lipid profile in an in vivo model of diabetes without the induction of weight gain. However, the effects of DA on androgen production has not been explored.Aim: The objective o...

ea0037oc2.2 | Reproduction | ECE2015

Lipid accumulation product as a surrogate marker of metabolic syndrome in different phenotypes of polycystic ovary syndrome

Macut Djuro , Antic Ivana Bozic , Bjekic-Macut Jelica , Milutinovic Danijela Vojnovic , Ilic Dusan , Popovic Bojana , Bogavac Tamara , Kastratovic-Kotlica Biljana , Stanojlovic Olivera , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Petakov Milan , Damjanovic Svetozar

Introduction: Lipid accumulation product (LAP) has been validated as good surrogate marker for the presence of metabolic syndrome (MetS) in general population. The aim of this study was to evaluate LAP in different PCOS phenotypes and to determine its association with MetS.Methods: We evaluated 365 PCOS women (PCOS: 25.05±6.24−kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (contro...

ea0037oc2.3 | Reproduction | ECE2015

Restoration of fertility in hypogonadal LH receptor null background male mice by a constitutive active mutant FSH receptor

Oduwole Olayiwola , Peltoketo Hellevi , Poliandri Ariel , Vengadabady Laura , Huhtaniemi Ilpo

The gonadotropic hormones, LH and FSH are critical regulators of normal sexual functions including steroidogenesis and gametogenesis. Their essential role is underscored by the development of various hypogonadal phenotypes arising from genetic mutations. Constitutive activation of their cognate receptors also disturbs their function. We earlier showed that transgenic expression of an activating mouse Fshr mutant (mFSHRD580H) in granulosa c...

ea0037oc2.4 | Reproduction | ECE2015

Low free testosterone is associated with hypogonadal symptoms in men with normal total testosterone levels: results from the European Male Ageing Study

Antonio Leen , Wu Frederic , O'Neill Terrence , Pye Stephen , Carter Emma , Finn Joseph , Laurent Michael , Huhtaniemi Ilpo , Rutter Martin , Rastrelli Giulia , Forti Gianni , Bartfai Gyorgy , Casanueva Felipe , Kula Krzysztof , Punab Margus , Giwercman Aleksander , Claessens Frank , Decallonne Brigitte , Vanderschueren Dirk

Background: During ageing, total testosterone (TT) declines and SHBG increases, resulting in a greater decline of free testosterone (FT) compared to TT. However, guidelines suggest using TT to diagnose androgen deficiency and to reserve FT only for men with borderline TT. We investigated if isolated low FT or isolated low TT was associated with androgen-related endpoints in healthy men.Methods: 3369 community-dwelling men, aged 40–79, were included....

ea0037oc2.5 | Reproduction | ECE2015

Bisphenol A-induced epithelial-mesenchymal transition was reversed with a phytoestrogen, genistein via oestrogen receptor and downregulation of transforming growth factor-beta signalling pathway

Kim Ye-Seul , Hwang Kyung-A , Choi Kyung-Chul

Epithelial–mesenchymal transition (EMT) is an important process appeared in tumour migration or progression, which is activated by 17β-estradiol (E2). As a typical endocrine disrupting chemical (EDC), bisphenol A (BPA) has a potential to promote EMT and migration of oestrogen responsive cancers. On the contrary, genistein (GEN) as a phytoestrogen is known to have chemopreventive effects in diverse cancers. In the present study, the effects of BPA and GEN o...