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Endocrine Abstracts (2015) 37 EP1066 | DOI: 10.1530/endoabs.37.EP1066

1Pontificia Universidade Católica de Campinas, Campinas, Brazil; 2GEMOCA – Laboratory of Cancer Molecular Genetics, University of Campinas, Campinas, Brazil.


Introduction: Graves’ ophthalmopathy (GO) varies from minor changes to visible face disfigurement which may compromise the visual capacity and the aesthetics of the patient. These deformities affect the quality of life in both functional and emotional senses. There are some questionnaires designed to evaluate the patient’s health, quality of life and relationship with a specific disease. The use of these questionnaires is recommended to improve the quality of care and, mainly, to identify patients who are in need of psychological support. However, they need to be validated in each country.

Methods: We evaluated 140 consecutive Brazilian GD patients investigating the severity of their ophthalmopathy (Clinical Activity Score), and quality of life, according to the questionnaire on quality of life in Graves’ ophthalmopathy (GO-QoL).

Results: The patients were divided in two groups according their initial CAS. Group 1 (CAS 0 or 1), n=108, and group 2 (CAS>2), n=32. There were no differences in age, duration of disease and gender between the groups. However, group 1 had better results concerning the score of total visual functioning (P<0.005) and the score of total appearance (P<0.0001); patients in group 2 were more affected on simple tasks such as moving around the house (P<0.05), walking outdoors (P<0.005), reading (P<0.05), watching TV (P<0.005). In addition, this group had a worse score on self-confidence (P<0.0001) and felt hindered from doing something they wanted to do because of GO (P<0.05).

Conclusion: GO significantly affects the quality of life and the use of the GO-QoL questionnaire permitted to identify patients who deserve specific attention.

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