ECE2015 Eposter Presentations Calcium and Vitamin D metabolism (96 abstracts)
Is vitamin D receptor gene polymorphism TaqI effect the occurrence and subtype of Hashimoto's thyroiditis?
Fulya Akin 1 , Bedia Guleryuz 2 , Sebehat Turgut 3 , Senay Topsakal 1 , Guzin Fidan Yaylali 1 , Melek Tunc Ata 3 & Mukaddes Mergen Dalyanoglu 3
1Department of Endocrinology and Metabolism, Faculty of Medicine, Pamukkale University, Denizli, Turkey; 2Department of Internal Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey; 3Department of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Background: Hashimoto’s thyroiditis (HT) is a common autoimmune disease of thyroiditis. There is a relation with Vitamin D levels, vitamin D receptor (VDR) and HT reported. More than 30 gene polymorphisms are found in VDR gene. The most common four types of polymorphisms studied in autoimmune disease are FokI (exon 2), BsmI (intron 8), ApaI (intron 8) and TaqI (exon 9). The aim of this study is to investigate the association between VDR TaqI gene polymorphism and HT subtypes.
Methods: We performed a case-control study that included 139 cases with HT (50 euthyroid, 50 subclinical hypothyroid, 39 overt hypothyroid patients) and 50 healthy control. Subjects were collected from Endocrinology Clinic. VDR gene polymorphisms TaqI were typed by RFLP.
Results: At the TaqI genotype distribution, 34% TT genotype, 38% Tt genotype and 28% tt genotype were identified in the control group. TT genotype in 46.9%, Tt genotype in 32.7% and tt genotype in 20.4% were identified in the euthyroid group. TT genotype in 55.1%, Tt genotype in 38.8% and tt genotype in 6.1% were detected in subclinical hypothyroid group. In evident hypothyroid group TT genotype in 31.6%, Tt genotype in 55.3% and tt genotype in 13.2% identified. In euthyroid group and subclinical hypothyroidism group TT genotype, in the evident hypothyroidism groups and the control group Tt genotype was detected at the highest rate.
Conclusion: Statistically significant differences was observed when all HT group compared with the control group according to TaqI genotype distribution. There is relationship between VDR TaqI gene polymorphism and HT. This study showed that VDR TaqI gene polymorphism may be predisposed to the HT occurrence.
Disclosure: Grant numbers 2012 TPF6.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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