Endocrine Abstracts

Introduction: Osteoporosis is a well-known and extremely debated side effect of glucocorticoid therapy being able to generate vertebral fractures even at low doses. Our study highlights the need for better prevention through improved doctor-patient communication and correct implementation of available screening tools.

Methods: Since August–December 2014 we distributed to 85 rheumatic patients a self-compiled questionnaire. We recorded patient data and their awareness on current recommendations, osteoporosis screening/treatment information. Hospital’s electronic database provided DXA and radiographic results.

Results: Study included 72/85 women, median age 57.5 years, 38/85 rheumatoid arthritis, 20/85 systemic lupus erythematous, and 27/85 other diseases, median disease duration 72 months. 55/85 (64.70%) received <7.5 mg/day, whilst 30/85 (35.29%) received >7.5 mg/day for >3 months. 40/85 (47.05%) have undergone a DXA and 24/40 (60%) have osteoporosis and bisphosphonate treatment. Only 51/85 (60%) is aware of this therapy risk. FRAX 10 years probability of osteoporotic fractures was >20% in 9/24 (37.5%) patients. Only 31/85 (36.47%) were aware that smoking cessation is recommended, 62/85 (72.94%) knew excessive alcohol intake must be avoided and 20/85 (23.52%) were aware of the need for weight-bearing activities. Only 50/85 (58.82%) have a radiographic imaging of the spine and 10/50 (20%) have vertebral fractures on radiography. 70/85 (82.35%) have received vitamin D supplements.

Conclusion: Study revealed a lack of proper screening for glucocorticoid osteoporosis and a high percentage of patients not aware of existing recommendations regarding lifestyle modifications needed for prevention. Clinicians should make more efforts for patient to properly understand this risk, to know the ways to diminish it and, last but not least, the utility of early diagnostic and treatment.

Disclosure: This work received financial support through the project entitled ‘CERO – Career profile: Romanian Researcher’, grant number POSDRU/159/1.5/S/135760, cofinanced by the European Social Fund for Sectoral Operational Programme Human Resources Development 2007–2013’.