Endocrine Abstracts (2015) 37 EP372 | DOI: 10.1530/endoabs.37.EP372

Biorhythms of contrinsular hormones in pregnant with type 1 diabetes receiving insulin with pump therapy and multiple injections

Tatsiana Mokhort1, Tatsiana Skryplionak2, Olga Pancratova2 & Vladislav Rimashevskiy3


1Belarusian State Medical University, Minsk, Belarus; 2«Mother and Child» National Research Center, Minsk, Belarus; 3Belarusian Medical Academy of Post-graduated Education, Minsk, Belarus.


Pregnancy affects on the course type 1 diabetes (T1D), which is a result of changes in the production of hormones and their biorhythms.

Aim: To examine circadian biorhythms of contrinsular hormones (BCh) contribution in the morning postprandial glycaemia depending on the type insulin therapy.

Materials and methods: The study involved of 91 pregnant with T1D in 31–34 weeks on a background the maximum insulin resistance. Evaluation of circadian BCh (cortisol, progesterone, and placental lactogen) held on the results of the ELISA (DRG, Germany) serum samples, picks up in 0300, 0700, 1200, 1700, and 2200 h.

Results: The estimation of cortisol levels dynamics in acrophase marked invariable, which accounted at 0700 h, and minifase at 0300 h regardless of the type of insulin therapy. The acrophase of placental lactogen accounted at 1700 h, at the same time minifase at 2200 h and does not depend on the type of insulin therapy. The opposite results we get after estimation of progesterone levels. Progesteron acrophase accounted at 1700 h on the pump therapy and at 2200 h on multiple injections of insulin. Minifase of progesterone in both cases accounted at 0700 h.

Conclusion: Expressed of insulin resistance in the first half of the day determine the need for the use of high carb ratios for breakfast in order to achieve target levels of postprandial glycaemia is caused by cortisol acrophase and not placental lactogen and progesterone, which are laminated to the maximum mezor these hormones in third trimester. The use of pump insulin therapy accompanied by a shift of progesterone acrophase.

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