Endocrine Abstracts

Background: Management of obesity and overweight greatly improves glycemic control in type 2 diabetic (T2DM) patients and also provides positive impact in other cardiovascular risk factors in this population.

Objectives: Evaluate the impact of weight and weight variability in subclinical inflammation and comorbidities of T2DM patients, over the last decade.

Methods: Retrospective study of 1900 patients with T2DM, with a minimum of 2 years of follow-up and five evaluations at our Endocrinology outpatient clinic between 2005 and 2014. Patients under 18 years old, with secondary diabetes and BMI >40 kg/m² were excluded. The weight variation was calculated using the S.D. of BMI for each patient with 11.0±0.2 determinations per patient over a mean follow-up of 7.25±1.1 years. The main outcomes of management selected included: BMI, blood pressure, lipid profile, renal function and systemic inflammatory markers. Descriptive statistical methods were applied, t-test and Pearson’s correlations where used to continuous variables and the χ² in categorical ones.

Results: The 1900 patients were aged 61.2±0.3 years at the first observation and 769 were men. There was a statistically significant relationship between BMI and BMI variability for systolic blood pressure (P<0.001 and P=0.036), BMI for diastolic blood pressure (P<0.001), creatinine (P=0.049), uric acid (P<0.001); albuminuria (P<0.01), triglycerides P<0.001, HDL (P<0.001), and non HDH cholesterol (P<0.015); monocytes (P=0.008).

Conclusions: This retrospective study has the inherent limitations. Allows an insight to the problem by the data volume. The BMI and its variability in this population was associated with elevation of chronic inflammatory markers (monocytes), creatinine and lipid panel. These data reinforce the importance of weight control in T2DM patients.