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Endocrine Abstracts (2015) 37 EP670 | DOI: 10.1530/endoabs.37.EP670

ECE2015 Eposter Presentations Pituitary: basic and neuroendocrinology (62 abstracts)

The dynamics of anthropometric and hormonal parameters in adolescents (boys) with physical and sexual development during therapy with thyroid medications

Utkir Mavlonov 1, , Yulduz Urmanova 1, , Shakhlo Babakhodgaeva 1, , Feruza Khodgaeva 1, & Nazira Rikhsieva 1,

1Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan; 2Bukhara Endocrine Regional Clinic, Bukhara, Uzbekistan.

The purpose of research: To study the dynamics of anthropometric and hormonal indicators of adolescent boys with physical and sexual development (ZFPR) and iodine deficiency disorders (IDD), received treatment for 12 months replacement therapy of thyroid (jodomarin, L-thyroxine, Berlin-Chemie).

Material and methods: We have inspected and examined the whole for the period from 30th May 2012 to 15th October 2013 1066 adolescent boys in different regions of Uzbekistan. In the city of Bukhara and four districts of Bukhara region were examined 523 adolescents (boys) in Namangan region – 200, in Tashkent – 343, aged 11–17 years. The main contingent made up of college students and schools.

In the future, selected 163 patients with various disorders of growth and sexual development was carried spectrum of research includes the study of endocrine status, clinical, biochemical, and hormonal.

Among these patients, we have selected a further 60 adolescents with ZFPR (delayed puberty and growth)+IDD from the city of Bukhara and Bukhara region, which were carried out additional studies (TSH, T4, X-ray hand, skull, EEG, Echo-EG, etc.) and anthropometric estimates the dynamics before and 12 months after replacement therapy with thyroid (jodomarin 100 and 150 mg/day, L-thyroxine 25 and 50 μg/day).

The results of the study: At 3, 6, and 12 months after treatment with thyroid dynamics in patients with mental retardation+IDD there was a significant improvement in hormonal parameters, namely, the mean values of TSH and free T4 (P<0.05). If the growth rate in patients with CP+IDD before treatment was 5.3±0.2 cm/year, after 12 months of treatment with thyroid averaged 6.3±0.3 cm/year (6.6–9.6 cm/year), and absolute increase growth in 12 months in average: 8.1±0.4 cm.

Conclusions: Thus, on the basis of completed research can be concluded that therapy with thyroid cancer in patients with mental retardation+IDD significantly improves both hormonal and anthropometric indicators, which confirms the need for primary prevention of IDD among children and adolescents.

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