Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2015) 37 EP752 | DOI: 10.1530/endoabs.37.EP752

ECE2015 Eposter Presentations Pituitary: clinical (121 abstracts)

The comparison of echocardiographic parameters, carotid intima thickness, arterial stiffness and plasma soluble CD40 ligand levels in active and inactive acromegalic patients

Guven Baris Cansu 1 , Nusret Yilmaz 1 , Atakan Yanikoglu 2 , Sebahat Ozdem 3 , Aytul Yildirim 2 , Gultekin Suleymanlar 4 & Hasan Altunbas 1

1Akdeniz Universty Faculty of Medicine, Endocrinology and Metabolism, Antalya, Turkey; 2Akdeniz Universty Faculty of Medicine, Cardiology, Antalya, Turkey; 3Akdeniz Universty Faculty of Medicine, Biochemistry, Antalya, Turkey; 4Akdeniz Universty Faculty of Medicine, Nephrology, Antalya, Turkey.

Introduction: In acromegalic patients, the increased mortality and morbidity are generally due to cardiovascular, metabolic, respiratory and cerebrovascular diseases, so early diagnosis and treatment of cardiovascular lesions may save lives. The aim of this study is to find out the any possible difference in terms of carotid intima media thickness (CIMT), indices of arterial stiffness, soluble CD40 ligand (sCD40L) and some echocardiographic parameters between active and inactive acromegalic patients.

Methods: The study involved 26 active, 24 inactive acromegalic patients and 20 healthy subjects. 47 of 50 acromegalic patients had underwent transsphenoidal surgery and 41 of 50 patients were using somatostatin analogues at least 6 months and nine patients have no treatment after transsphenoidal surgery. CIMT, arterial stiffness, sCD40L and some echocardiographic parameters were compared.

Results: The study showed that CIMT and indices of arterial stiffness were higher in acromegalic group (P=0.003 and P=0.008 respectively). Left ventricular diastolic dysfunctions were comparable between groups, whereas the left ventricle mass index, DOPPTEI and left atrial diameter were higher, and ejection fraction was lower in acromegalic patients. CIMT, arterial stiffness, sCD40L and parameters of echocardiography were comparable in patients with active and inactive patients.

Discussion: Getting the disease under control hormonally didn’t cause a reduction in the subclinical cardiovascular risk. This can point out that in acromegalic patients the structural and functional damage may be due to long-term exposure to excess growth hormone/IGF1.

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