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Endocrine Abstracts (2015) 37 EP880 | DOI: 10.1530/endoabs.37.EP880

1Department of Pathology, Training and Research Hospital, Erzurum, Turkey; 2Department of Internal Medicine, Training and Research Hospital, Erzurum, Turkey; 3Department of Endocrinology, Training and Research Hospital, Erzurum, Turkey.


Introduction and aim: Bethesda system for thyroid cytopathology has been widely used recently. Approximately 3–7% of thyroid fine-needle aspiration (FNA) biopsy is considered as malign. Suspicious or malign nodules should likely to be resected. Aim of this study is to confirm the diagnosis of malign or suspicious for malignity according to Bethesda classification in patients with nodular goitre after thyroidectomy.

Materials and methods: Results of FNA in totally 402 patients with nodular goitre were achieved from our hospital records. All of the patients had undergone totally or subtotals thyroidectomy. We re-evaluated retrospectively biopsy results postoperatively. We compared their preoperative FNA results.

Results: We described totally five patients whom FNA were malignity but results of postoperative biopsy were benign. We found false positive results as one 38-year-old patient with follicular adenoma, one 50-year-old patient with papillary thyroid cancer, and three patients (44.6±8.7 years) with suspicious for papillary thyroid cancer.

Conclusions: The malignity risk in classification of suspicious for malignity and malignity according to Bethesda reporting system is 60–75 and 97–99% respectively after thyroidectomy. Our findings demonstrate that our false positive results are lower than reported Bethesda classification in medically literature. Hyperplastic adenomatoid nodule, follicular adenoma, well-differentiate follicular carcinoma and papillary carcinoma follicular variant have several characteristic features in common. Therefore, difficulty of these lesions in pathologically evaluation may lead false positive results.

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