Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2015) 37 EP892 | DOI: 10.1530/endoabs.37.EP892

ECE2015 Eposter Presentations Thyroid cancer (90 abstracts)

Lymphonodal metastases in incidental thyroid microcarcinomas verified by sentinel lymph node biopsy of jugulo-carotid chain

Merima Oruci 1 , Ivan Markovic 1, , Nada Santrac 1 , Igor Djurisic 1 , Marko Buta 1 , Gordana Pupic 3 , Dusica Gavrilovic 4 & Radan Dzodic 1,


1Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia; 2Medical School, University of Belgrade, Belgrade, Serbia; 3Department of Pathology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia; 4Institute for Oncology and Radiology of Serbia, Data Center, Belgrade, Serbia.

Introduction: The aim of this study was to determine frequency of lymphonodal metastases in jugulo-carotid chain (JCC) and central neck compartment in incidental thyroid microcarcinomas (ITMC), as well as to examine whether sentinel lymph node (SLN) biopsy of JCC is an accurate technique to select patients with true positive, but clinically and ultrasonically negative lymph nodes, for modified radical neck dissection (MRND).

Materials and methods: Out of all patients operated in our Institution from 2004 to 2013 for multinodal goitre, Hashimoto’s thyroiditis, adenomas, Graves’ disease or increase of serum calcitonin concentration, for the purpose of this study, we have selected 117 who had ITMC and were surgically treated with total thyroidectomy (lobectomy in only one patient), sampling or complete dissection of central lymph nodes and SLN biopsy in JCC. As a standard procedure, SLN mapping was performed with 0.2 ml of 1% methylene blue dye injected just beneath thyroid gland capsule. SLNs were examined by frozen section and if positive, additional MRND was done. Hystopathological analysis showed 108 papillary, six medullary, and three combined papillary and medullary thyroid microcarcinomas <1 cm in diameter.

Results: Multicentric carcinomas were recorded in 39.32% of patients. In patients with lymphonodal metastases (24.79%), JCC metastases were found in 7.69% and central in 20.51%. Specificity and sensitivity of method are 100 and 57.14%, positive and negative predictive values are 100 and 97.3%. Method’s accuracy is 97.39%.

Conclusion: Data showed high percentage of metastases in central neck compartment. SLN biopsy is a method more precise than clinical examination and ultrasonography in detection of ITMC lateral lymphonodal metastases in N0 patients. Using SLN biopsy for intraoperative assessment of lateral compartment one can avoid unnecessary MRND, as well as prevent under-treatment of patients with good prognosis. In addition, this method helps optimizing ablative radioiodine treatment.

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