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Endocrine Abstracts (2015) 37 EP935 | DOI: 10.1530/endoabs.37.EP935

1Department of Endocrinology and Metabolism, Dişkapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey; 2The Audiology–Speech Impediment Unit, Dişkapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey; 3Department of Otolaryngology, Ministry of Health, Dişkapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey; 4Department of Internal Medicine, School of Medicine (Kastamonu), Hacettepe University, Ankara, Turkey.


Introduction: The relationship between hyperthyroidism and voice disorders has not been identified before. The aim of this study was to investigate the changes in the acoustic values in patients with subclinical thyrotoxicosis.

Methods: In this study, acoustic voice analysis was evaluated in a total of 115 cases. Sixty of 115 individuals (18 men and 42 women) had subclinical thyrotoxicosis, aged between 18 and 65 years, and all had no history of laryngeal surgery, no vocal complaints. These patients were compared with the control group consisting of 55 cases (18 men and 37 women) with similar characteristics. Acoustic and perceptual analyses are the most commonly used method in the assessment of voice quality. Kay CSL 4300 unit was used for acoustic voice analysis and as the operating parameters, F0 (fundamental frequency), Jitter, Rap (relative average perturbation), Shimmer, noise-to-harmonic ratio (NHR), and voice turbulence index (VTI) values were evaluated. The results were evaluated using the Mann–Whitney U statistical method.

Results: The performed acoustic analysis showed that mean values of the investigated parameters in patients were Jitter (%) 1.18, Shimmer (%) 4.00, Rap (%) 0.70, F0 (Hz) 209.85, VTI 0.05, and NHR (dB) 0.14. In the control group, the analyzed parameters were the following: Jitter (%) 0.96, Shimmer (%) 3.16, Rap (%) 0.57, F0 (Hz) 207.86, VTI 0.05, and NHR (dB) 0.12. There was no statistically significant difference between the control group and patients (P>0.05).

Conclusions: In our study, it was concluded that the moderate increase in thyroid hormones doesn’t affect the voice quality. Effect on the voice quality of the excess of thyroid hormones, such as clinical thyrotoxicosis was not evaluated. Therefore, further studies are needed to interpret the relationship between thyroid hormone and voice quality.

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