ECE2015 Oral Communications Obesity (5 abstracts)
Serum glypican-4 levels and its association with cardiovascular risk predictor in women with polycystic ovary syndrome and healthy controls -- pilot study
Andrzej Milewicz 1 , Justyna Kuliczkowska-Plaksej 1 , Agnieszka Lenarcik-Kabza 1 , Anna Trzmiel-Bira 1 , Lidia Hirnle 1 , Urszula Zaleska-Dorobisz 1 , Felicja Lwow 2 , Lukasz Laczmanski 1 , Katarzyna Kolackov 1 , Natalia Sloka 1 & Diana Jedrzejuk 1
1Univeristy of Medicine, Wroclaw, Poland; 2University School of Physical Education, Wroclaw, Poland.
Glypican-4 (Gpc-4) is novel adipokine interact with insulin receptor and affects insulin sensitivity in proteoglycans. Gpc-4 serum levels show gender differences; females having higher levels than men, what can suggest mediation by sex hormones. We investigated serum Gpc-4 levels and its association with cardiovascular risk predictors in women (20–35 years old) with PCOS (n=62) and healthy control (n=43) presented different sex hormones profile. The following CVD risk predictors: BMI, waist circumference (WC), total fat (TF), androidal fat deposit (AFD), gynoidal fat deposit (GFD), AFD/GFD ratio (A/G), fasting serum glucose, insulin, HOMA, serum triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol) and hormonal profile LH, testosterone, androstenedione (Adione), SHBG, Free Androgens Index (FAI) were estimated. Gpc-4 was determined by commercial ELISA kit. Serum Gpc-4 levels in women with PCOS was statistically significant higher than in control group (2.61±1.17 vs 1.55±0.47 ng/ml). Serum Gpc-4 concentration positively correlated with BMI in both groups (P<0.001), but with WC (P<0.001), WHR (P=0.005), TF (P<0.001), AFD (P<0.001), GFD (P=0.008), A/G (P=0.002) only in PCOS group. Serum Gpc-4 concentration were correlated positively with fasting serum insulin and HOMA in PCOS women and in control group (for both and in each group P<0.001). We showed that Gpc-4 concentration positively statistically significant correlated with serum Adione and FAI levels in control group and we observed only the tendency in PCOS group (P=0.054) also with serum LH (P=0.071). This original observation give new light on the role of Gpc-4 in women health, but because of some limitations further study is require.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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