Endocrine Abstracts

Germline mutations in the AIP gene predispose to the development of pituitary adenomas, most often GH secreting tumours. These patients often poorly respond to medical therapy with somatostatin analogues.There are two mechanisms suggested to be involved in this poor response.One suggests that the somatostatin-induced upregulation of the tumour suppressor gene Zac1 involves AIP. SSTR2 agonist treatment leads to AIP...

Prof. Márta Korbonits, MD, PhD, DSc, FRCP, is a clinical academic endocrinologist. She graduated in medicine at Semmelweis Medical School in Budapest and works in the Department of Endocrinology at Barts and the London School of Medicine, where she is Co-Centre Head. She shares her time between clinical patient care, clinical research and laboratory-based research as well as teaching at undergraduate and postgrad...