Endocrine Abstracts

Estrogen receptor (ER) is the defining feature of luminal breast cancers, where it functions as a transcription factor. ER requires associated proteins to interact with the DNA, including the pioneer factors FoxA1 and GATA3, both of which mediate where in the genome ER resides. In the absence of FoxA1, ER binding and transcriptional activity is diminished, even in endocrine resistant contexts. We have utilized ChIP-seq in primary tumor material, coupled with functional analysi...

The European Journal of Endocrinology Prize is awarded to a candidate who has contributed significantly to the advancement of the knowledge in the field of endocrinology through publication. Further information on the prize can be found at http://www.ese-hormones.org/prizes/. This year’s recipient is Professor Jason Carroll. The prize will be presented as pa...