Diabetes therapy

ea0041ep538 | Diabetes therapy | ECE2016

Liraglutide as additional treatment to insulin in patient with latent autoimmune diabetes in adults (LADA): a case report

Silko Iuliia , Nikonova Tatiana , Shestakova Marina

Introduction: LADA exhibits characteristics of both type 1 diabetes mellitus (DM) and type 2 DM. Patients with LADA usually have some components of metabolic syndrome. GLP-1 agonists have been widely used in type 2 DM. GLP-1 agonist therapies have shown some promising glucose lowering effect in T1DM. Almost no information is available on glucagon and incretin secretion in patients with LADA as well as effects on glucose and C-peptide levels.Case report: ...

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ea0041ep539 | Diabetes therapy | ECE2016

Patients’ understanding of hypoglycaemia in tertiary referral centers

Kim Mi-Kyung , Kim Nam Kyeong , Kim Eui Hyun , Park Keun-Gyu , Kim Hye-soon

Objective: Hypoglycemia is a common adverse event and one of the main obstacles to achieving good glycemic control to minimize the risk of diabetic complications in patients with diabetes. Therefore, most physicians try to reduce hypoglycemia events through education about hypoglycaemia, such as diabetes self-management education. In this study, we surveyed the actual insight about hypoglycemia, behavior of diabetic patients to avoid hypoglycemia and the fear of hypoglycemia.<...

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ea0041ep540 | Diabetes therapy | ECE2016

Impact of obesity on management of type 2 diabetes

Cheah Seong Keat , Duane Catherine , Durak Abigail , Sreenan Seamus , McDermott John , Tun Tommy Kyaw

Management of type-2 diabetes (T2D) should be individualised given recent increase in treatment options. There is a spectrum of phenotype of T2D from thinner patients who may be more insulin deficient to those who are overweight/obese and insulin resistant. We hypothesized that, if we are personalising treatment, thinner patients would be more likely to be treated with insulin secretagogues. To compare the management between these phenotypes, we reviewed 1007 patients with T2D...

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ea0041ep541 | Diabetes therapy | ECE2016

PPARG2 Pro12Ala, TNFα G(308)A and G(238)A, LIPC C(-514)T, ACE I/D, SLCO1B1 Val174Ala polymorphism as predictors of lipid-lowering response to statin therapy in patients with T2DM

Lebedeva Nadezhda Ol , K Vikulova Olga , Nikitin Alexei G , Shamkhalova Minara Sh , Shestakova Marina V

Aim: To evaluate the effect of PPARG2 Pro12Ala, TNFα G(308)A and G(238)A, LIPC C(-514)T, ACE I/D, SLCO1B1 Val174Ala polymorphism on the response to statins therapy in patients with type 2 diabetes mellitus (T2DM).Methods: We consecutively recruited patients with type 2 DM requiring lipid-lowering therapy according to current guidelines. Patients were started on either atorvastatin 10 or 20 mg. After 12 month of st...

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ea0041ep542 | Diabetes therapy | ECE2016

Add on exenatide treatment in obese type 2 diabetic patients under intensive insulin regiments

Sonmez Alper , Dinc Mustafa , Taslipinar Abdullah , Aydogdu Aydogan , Meric Coskun , Basaran Yalcin , Haymana Cem , Demir Orhan , Azal Omer

Introduction: Intensive insulin treatment in obese patients with type 2 diabetes (T2DM) is often difficult. Insulin dosages are much higher, which further increase weight gain and the risk of hypoglycemia. Glucagon like peptide 1 receptor agonists (GLP-1RAs) are the promising treatment modalities causing weight loss and reducing the risk of hypoglycemia. There is no published data about the effect of adding on GLP1RAs to obese T2DM patients with un-controlled glucose levels un...

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ea0041ep543 | Diabetes therapy | ECE2016

The impact of insulin sensitisation with metformin on lung function in patients with type 2 diabetes mellitus and chronic obstructive pulmonary disease

Borozan Sanja , Stankovic Zoja , Subaric Irena

Introduction: Pathophysiologic mechanisms that connect type 2 diabetes mellitus (T2DM) and chronic obstructive pulmonary disease (COPD) are complex and still unknown as are any respiratory effects of antidiabetic agents. COPD increases insulin resistance by chronic inflammation, hypoxia and corticosteroid treatment while, on the other hand, insulin as an anabolic hormone stimulates post-prandial protein synthesis and oxidative phosphorylation in skeletal muscle so that insulin...

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ea0041ep544 | Diabetes therapy | ECE2016

Potential glycemic overtreatment in diabetics patients older than 70 years and comorbid conditions: real-life experience

Vicente Almudena , Olivar Monica , Cortes Claudia , Martinez Ana , Sastre Julia , Pena Virginia , Canovas Barbara , Lopez Jose

Background: Optimal glucose management in older people is currently unclear. Recent guidelines recommend avoiding tight glycemic targets in elderly patients with comorbidities because intensive control is unlikely to achieve benefit and they are at higher risk of hypoglycaemia.Objective: To estimate the prevalence of potential overtreatment in older adults with diabetes mellitus and comorbidities.Design: Cross-sectional study.<...

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ea0041ep545 | Diabetes therapy | ECE2016

Long-term effects of Stevia rebaduiana on glucose and lipid profile, adipocytokines, markers of inflammation and oxidation status in patients with metabolic syndrome

Kassi Eva , Landis George , Pavlaki Aikaterini , Lambrou George , Mantzou Aimilia , Androulakis Ioannis , Giannakou Andreas , Papanikolaou Eleni , Chrousos George

Introduction: Metabolic syndrome (MetS) is a cluster of interconnected factors that directly increase the risk of DM2 and CVD. Stevia rebaudiana (a low calorie natural sweetener) and its compounds are known for anti-hyperglycemic, anti-inflammatory, anti-oxidant, anti-hypertensive effects.Methods: Thirty-eight patients (age 47.3±10.3 years) (nmales=14, nfemales=24) with MetS (NCEP/ATPIII criteria) wer...

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ea0041ep546 | Diabetes therapy | ECE2016

Evaluation of three continuous glucose monitoring systems during exercise and meal challenges

Mader Julia K , Hajnsek Martin , Aberer Felix , Rumpler Markus , Zenz Sabine , Puffing Adelheid , El-Sayed Hesham , Baumann Petra , Sinner Frank , Pieber Thomas R

Introduction: Continuous glucose monitoring (CGM) has become an essential tool in diabetes management. In order to use CGM for treatment decisions, CGM systems have to be reliable over a wide range of glycemia as well as in situations with rapidly changing glucose levels such as exercise or in the postprandial state.Design: In this monocentric study we evaluated the performance of three commercially available CGM systems (Abbott Libre, Dexcom G4 Platinum...

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ea0041ep547 | Diabetes therapy | ECE2016

The effects of vitamin D on advanced glycation end-products in prediabetic and type 2 diabetic patients with vitamin D deficiency

Tekin Bahar , Bayram F. Buket , Yavuz Dilek Gogas

Aim: There is strong evidence regarding vitamin D being a risk factor for Type 2 Diabetes Mellitus (T2DM). In this study, we aimed to investigate the effects of vitamin D on advanced glycation end-products in prediabetic and type 2 diabetic patients with vitamin D deficiency.Methods: Forty type 2 diabetic patients, 40 prediabetic patients and 40 healthy controls with the levels of vitamin D <20 ng/ml were included in the study. All three groups were ...

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ea0041ep548 | Diabetes therapy | ECE2016

Intensive therapy with insulin pump in type 1 diabetes mellitus

Gouveia Ines , Neves Celestino , Oliveira Sofia , Neves Joao Sergio , Dias Claudia , Carvalho Davide

Background: Continuous subcutaneous insulin infusion (CSII), alongside multiple daily injections (MDI) are the most frequent therapeutic of type 1 Diabetes Mellitus (DM). We aimed to evaluate the effects of the transition from MDI to CSII in the treatment of type 1 DM.Patients and methods: This retrospective longitudinal study analysed patients that received treatment with CSII from 2006 to 2014. Our sample had 85 patients, 35 male (41.2%) and 50 female ...

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ea0041ep549 | Diabetes therapy | ECE2016

Potential use of embryonic antitumor modulator (EATM) for diabetes prevention and treatment

Aghajanova Yelena , Mkrtchyan Lilit

Introduction: Incidence of diabetes mellitus worldwide is on the rise, and better methods of prevention and treatment are needed. We evaluated the possible antidiabetic effect of embryonic antitumor modulator (EATM) created by Mkrtchyan, which reportedly exhibit anticancer, neuroprotective and immunomodulatory properties.Materials and methods: Rats with streptozotocin (STZ)-induced diabetes (55 mg/kg once i.p.) were injected EATM (1 mg/200 g rat body mas...

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ea0041ep550 | Diabetes therapy | ECE2016

Effects in weight loss and HbA1c after one year of use of dapaglifozina

de Linares Lidia Urbon Lopez , Soto Maria Cristina Crespo , Terroba Concepcion , Ventosa Marta , Martin Tomas , Calleja Maria del Mar , Cuellar Luis Angel

Changes in HbA1c and weight after 1 year on dapaglifozina added to the previous treatment.SGLT2 inhibitors are becoming a common and useful drug to treat type 2 diabetes.The inhibition of the sodium-glucose co transporters (SLGT2) inhibits also the glucose reabsorption in the proximale tubule and increases the glucose excreted in the urine.Therefore hyperglycemia decreases and so does weight as happens with t...

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ea0041ep551 | Diabetes therapy | ECE2016

An assessment of factors related with understanding education and knowledge of self-care among patients with diabetes mellitus: a cross sectional prospective study in two cities of Turkey

Dizdar Oguzhan S , Gul Ozen Oz , Baspinar Osman , Sisman Pinar , Cander Soner , Ersoy Canan

Background: The prevalence of the diabetes mellitus is rapidly increasing particularly in developing countries. For effective management of diabetes, patients must be actively involved in their care. The aim of the study was to assess the knowledge and self-care practices and contribution of the education to this knowledge level and glycemic control.Material methods: We formed patients groups consisting of 15 to 30 diabetic patients. Firstly, patients su...

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ea0041ep552 | Diabetes therapy | ECE2016

Associated antidiabetic treatment in a rural population with type 2 diabetes mellitus

Fernandez-Garcia Jose Carlos , Cortes-Salazar Carmen Maria

Objectives: To evaluate the characteristics of patients with type 2 diabetes mellitus (T2DM) attended in a rural primary care setting and to analyze associated antidiabetic treatment and metabolic control.Methods: Cross-sectional study which included patients with T2DM followed in a rural primary care setting. Data about age, sex, body mass index (BMI), associated antidiabetic treatment, and HbA1c was collected.Results: Seventy nin...

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ea0041ep553 | Diabetes therapy | ECE2016

Abstract withdrawn....

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ea0041ep554 | Diabetes therapy | ECE2016

Economic impact on the use of insulin pumps in diabetes type I – analysis on Portuguese real life results

Joaquim Ines , Vilaverde Joana , Barros Luisa , Diniz Isabel , Sabino Filipa , Boavida Jose Manuel , Cardoso Helena

Although, diabetes type I patients in Portugal have complete and free access to HbA1c management (via multiple daily injections) only a few percentage has been provided an insulin pump priority is given to children and women in fertile age trying to get pregnant. By the end of 2014, 1.150 insulin pumps had already been provided by the National Program of Insulin Pumps, but at least 3.000 patients with indication for insulin pump use were in waiting list. HbA1c pre-pump ...

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ea0041ep555 | Diabetes therapy | ECE2016

Effects of GLP-1 analogues in the treatment of a population with DM2

Ivo Catarina , Nunes e Silva Joao , Simoes Helder , Lopes Luis , Passos Dolores , Marcelino Mafalda , de Castro Joao Jacome

The analogues of GLP-1(aGLP1) are a new class of anti-diabetic agents, administered subcutaneously for the treatment of Diabetes Mellitus type 2 (DM2). In the Portuguese market, there are two aGLP1 currently available: Liraglutide (once-daily administration) and Exenatide (once-weekly administration). They mimic the GLP-1, produced in the small intestine, stimulated by foods at this region, increasing the production of insulin, decreasing the satiety and slowing gastric emptyi...

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ea0041ep556 | Diabetes therapy | ECE2016

Effects of SGLT2 inhibitors in the treatment of a population with type 2 diabetes mellitus

Silva Joao , Ivo Catarina , Passos Dolores , Simoes Helder , Lopes Luis , Marcelino Mafalda , de Castro Joao Jacome

Introduction: The SGLT-2 inhibitors (InibSGLT2) are the newest class of non-insulin antidiabetic drugs (ANI) for type 2 diabetes mellitus (T2DM) treatment. Currently is only available in Portugal, dapagliflozin. This pharmacological class have shown benefits in metabolic control (reduction of 0.50.8% HbA1c) and in weight loss (13 kg).Objective: Evaluate the impact of InibSGLT2 in patients with T2DM followed in a Diabetes department.<p cla...

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ea0041ep557 | Diabetes therapy | ECE2016

Randomized clinical trial to compare the effects of glargine multidosis versus CSII therapy on metabolic and oxidative stress parameters in people with type 1 diabetes

de Adana Navas M Soledad Ruiz , Dominguez-Lopez Marta , Rubio Eleazara , Rodriguez Natalia Colomo , Cardona Isabel , Tapia M Jose , Morillas Virgina , Gonzlez Inmaculada , Rojo Gemma

Aims: There are few data comparing oxidative stress markers in CSII versus MDI/G We compared after randomization CSII (Continuous subcutaneous insulin infusion) vs MDI/G therapy (multiple doses of insulin with glargine) in DM1 people previously optimized at MDI/G being the primary objective assessment of metabolic control and oxidative stress.Assess oxidative stress and metabolic control in patients with type 1 diabetes (T1D) after randomization in CSII ...

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ea0041ep558 | Diabetes therapy | ECE2016

Dapagliflozin clinical experience and safety on patients with type 2 diabetes and obesity

del Mar Roca-Rodriguez Maria , Picon-Cesar Maria Jose , Omiste-Romero Antonio Jesus , Garcia-Perez Jorge , Aguilar-Diosdado Manuel

Introduction: New treatments of diabetes, such as dapagliflozin, improve global metabolic status beyond glycemic control.Aim: To evaluate tolerance to dapagliflozin and its effects on metabolic control in type 2 diabetes and obese patients attended in endocrinology offices.Material and method: A prospective study of patients with type 2 diabetes and obesity. In an intra-subject analysis, clinical and analytical data were evaluated ...

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ea0041ep559 | Diabetes therapy | ECE2016

Lixisenatide effects on liver function, lipids and blood pressure levels

del Mar Roca-Rodriguez Maria , Piedrola-Maroto Gonzalo , de Fuentes Maria Teresa Muros , Quesada-Charneco Miguel , Maraver-Selfa Silvia , Tapia-Guerrero M Jose , Cepero-Garcia Daniel , Orduna-Espinosa Rosa , Pechuan-Asensio Joaquin , Ferrandiz-Millon Elena , Galera-Martinez Purificacion , Vazquez-Gutierrez Mercedes , Mancha-Doblas Isabel

Introduction: New diabetes treatments, such as lixisenatide, improve global metabolic status beyond glycemic control.Aim: To evaluate lixisenatide effects on liver function, lipids and blood pressure levels in type 2 diabetes and obese patients attended in endocrinology offices.Material and method: This is a prospective study with a sample of 106 patients with type 2 diabetes and obesity. In an intra-subject analysis, clinical and ...

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ea0041ep560 | Diabetes therapy | ECE2016

Predictive factors in the management and the prognosis of Korean women with gestational diabetes mellitus

Kwon Min Jeong , Hong Seoyoung , Kwon Younju , Kwon Yonghee , Kim Seonhung , Kim Hyunjun , Lee Yunje , Kim Taekyoon , Lee Soonhee , Park Jeon Hyun

Introduction: Gestational diabetes mellitus (GDM) of increasing prevalence, lacks factors known to predict the prognosis of GDM. The correlations between levels of Oral Glucose Tolerance Test (OGTT) and BMI before pregnancy and the clinical progress of GDM were evaluated.Methods: Data of pregnant women diagnosed as GDM in Busanpaik hospital from January 1, 2010 to February 28, 2015 were studied. Correlations between patients OGTT in gestational age...

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ea0041ep561 | Diabetes therapy | ECE2016

Non-surgical reversal of type 2 diabetes mellitus

Lulsegged Abbi

A 44-year-old woman with a history of Bartters syndrome wanted a second opinion. Her height was 1.54 m, weight 69 kg, waist circumference 102 cm, BP 112/74. A OGTT was arranged because of her waist circumference. Fasting glucose 8.9 mmol/l, 2-hour glucose 20.2 mmol/l, HbA1c 7.9% consistent with type 2 diabetes mellitus. She started taking metformin. However she was keen to pursue lifestyle driven reversal of type 2 diabetes and so a low carbohydrate diet was recommended restri...

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ea0041ep562 | Diabetes therapy | ECE2016

Insulin pump therapy-a different solution for treating diabetes type I

Pejaković Sladana , Tešić Dragan , Stokić Edita , Milankov Andrijana , Prodanović Jovana , Perčić Ivanka , Mitrović Milena , Kovačev-Zavišić Branka

Introduction and aim: Continuous subcutaneous insulin infusion via insulin pump is the most efficient way of imitating physiological insulin secretion, and it also provides better management of diabetes, lower rate of hypoglicemic episodes, better quality of life and prevention of long-term complications of diabetes mellitus. Aim of the research was to determine effects of subcutaneous insulin infusion therapy on parameters of glycoregulation during the two years trial.<p ...

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ea0041ep563 | Diabetes therapy | ECE2016

Make sense of insulin

Suarez Ana Delia Santana , Arroyo Sara Quintana , Calero Carmen Acosta , Leon Claudia Arnas , Martin Francisco Javier Martinez

Background: Insulin-related peptides are found in Cnidaria (the most ancient animals with differentiated tissues including a nervous system, dating from 600 million years ago) and their nucleotide sequence has been highly preserved ever since. In mammals the binding of insulin to its receptor causes a cascade of actions, the main one being translocation of GLUT4 glucose transporters to the plasma membrane allowing influx of glucose into the adipose and striated muscle cells. B...

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ea0041ep564 | Diabetes therapy | ECE2016

GLP-1-RAs treatment in type 2 diabetes and obesity patients

Porcel Jose Alvaro Romero , Lloclla Eyvee Arturo Cuellar , Gordillo Guillermo Martinez de Pinillos , Perez Fernando Garcia , Muros Mariola Mendez , Pena Jose Ignacio Fernandez , Fernandez-Ladreda Mariana Tome , de Quiros Juan Manuel Garcia , Lopez Jose Ignacio Fernandez , Leon Maria Victoria Cozar

Introduction: Assessing the effect of GLP 1 receptor agonist on metabolic control and weight loss in obesity and type 2 diabetes patients.Description of methods: A retrospective descriptive study involving type 2 diabetes patients and BMI >30 kg/m2, who started treatment with GLP-1-RAs during the years 20122014. Variables analyzed: weight and HbA1c at the begging, 6 months, 1 and 2 years; regimen at baseline and after GLP-1-RAs; inci...

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ea0041ep565 | Diabetes therapy | ECE2016

The effect of diabetes on the duration and cost of treatment in patients with acute ischemic stroke

Guldiken Baburhan , Namli Merve , Celik Burak , Celik Mehmet , Bulbul Buket Yilmaz , Guldiken Sibel

Diabetes is an important risk factor for ischemic stroke. Hyperglycemia observed in acute ischemic stroke is accepted as a poor prognostic factor. In the present study, our aim is to investigate the effect of diabetes on the duration and cost of treatment in acute ischemic stroke.Three hundred sixty two acute ischemic stroke patients that were hospitalized in the university neurology clinic in 2015 were retrospectively evaluated. Patients that have diabe...

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ea0041ep566 | Diabetes therapy | ECE2016

Quality of life domains are affected in caregivers of people with type 2 diabetes: results from a literature review

Miranda Michele , Llahana Sofia

Background/aims: Caregivers play a crucial role in self-management of long-term conditions. The aim of this literature review was to explore the impact that Type 2 diabetes has on the caregivers quality of life (QoL) and its significance in integrated healthcare.Methods: A search was undertaken in CINAHL, MEDLINE, BNI and ASSIA using combinations of the following keywords limited to adults, humans and published in English in the last 10 years: 1: c...

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ea0041ep567 | Diabetes therapy | ECE2016

Effects of gender on IGF1 changes after initial basal insulin analog therapy in the type 2 diabetics

Cander Soner , Gul Ozen Oz , Sisman Pinar , Koca Nizameddin , Dizdar Oguzhan Sitki , Aydin Taner , Guclu Metin , Sarandol Emre , Ersoy Canan

Introduction: Serum IGF1 levels declined particularly with hyperglycemia in diabetic patients and lower IGF1 levels has been suggested to be associated with the development of diabetes. IGF1 levels appear to increase with the improvement in glycemic control in diabetic patients but do not reach normal levels. Also, it affected by gender; in this study we aimed to investigate effects of gender on IGF1 changes with basal insulin analogs.Methods: The serum ...

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ea0041ep568 | Diabetes therapy | ECE2016

Half of three regimen for treatment of T2 DM in low income populations

Mashahit Mohamed , Hammad Ahmed

According to the seventh edition of diabetes atlas, 415 million persons all over the world are diabetics requiring more than 680 billion US $ annually for their management. Diabetes affects middle and low socio economic countries than developed countries. The ADA/EASD guidelines included drug price as one of the criteria to choose from different classes. Incretin based therapy are new classes for treatment of T2 DM with low incidence of hypoglycemia and modest weight loss, but...

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ea0041ep569 | Diabetes therapy | ECE2016

Combined metformin-associated lactic acidosis and euglycaemic ketoacidosis

Schwetz Verena , Eisner Florian , Schilcher Gernot , Eller Kathrin , Plank Johannes , Lind Alice , Pieber Thomas R , Mader Julia K , Eller Philipp

Introduction: In metformin-associated lactic acidosis with renal dysfunction inhibition of hepatic gluconeogenesis by drug accumulation may aggravate fasting induced-ketoacidosis. We report the occurrence of metformin-associated lactic acidosis with concurrent euglycemic ketoacidosis in three patients with renal failure.Cases: The first patient was a 79-year-old woman who suffered from chronic kidney disease stage IIIa after traumatic uninephrectomy, and...

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ea0041ep570 | Diabetes therapy | ECE2016

The effect of liraglutide in patients with type 2 diabetes mellitus: clinical and metabolic characteristics

Maric Andreja , Premosa Tea , Medjimurec Sonja , Mikolaj Kiric Maja , Molnar Dunja

Introduction: In patients with non-controlled type 2 diabetes mellitus (DM2) and obesity treated with oral therapy, liraglutide treatment should improve glycemic and metabolic control.Materials and methods: Retrospective descriptive study. Liraglutide treatment was started in 46 outpatients with uncontrolled DM2. The effect of therapy was evaluated between September 2013 and January 2016. Age, sex, duration of diabetes, weight, BMI, HbA1c, fasti...

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ea0041ep571 | Diabetes therapy | ECE2016

Analysis and metabolic evaluation in a standard clinical setting of a group of patients 7 years after a clinical trial with sensor-augmented pump (SAP)

Dominguez-Lopez Marta , Colomo Rdriguez Natalia , Soledad Ruiz de Adana Navas M

Background and objective: Several trials showed that sensor-augmented pump (SAP) therapy is safe and effective to reduce hypoglycemic events and improve glicemic control with high treatment satisfaction. Nevertheless patient adherence and sensor use in trials usually decrease with time. Our objective was to evaluate metabolic control and adherence and sensor use after initiation of SAP in a clinical trial.Methods: In 2008 we recruited 25 patients in trea...

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ea0041ep572 | Diabetes therapy | ECE2016

Ameliorative effects of Treculia Africana aqueous seed extract on hyperglycemia and testicular histopathological alterations in alloxan-diabetic rats

Ukwenya Victor , Osinubi Abraham

Introduction: Treculia Africana (TA) has been used as an anti-inflammatory agent by the Yoruba people of West Africa and is also known to be a component of an ancient anti-diabetic remedy used in the Western and Middle belt areas of Nigeria. This study was conducted to investigate the anti-hyperglycemic property of the aqueous seed extract of Treculia Africana (TAE) and also to evaluate the potential of this extract in reversing the toxicity inflicted by expe...

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ea0041ep573 | Diabetes therapy | ECE2016

The influence of α-lipoic acid to endothelial dysfunction and adipokines balance in patients with type 2 diabetes and essential hypertension in the presence of unfavorable genetic polymorphism

Shalimova Anna , Belovol Alexander , Bobronnikova Lesya , Kochueva Marina , Psareva Valentina , Kirichenko Natalya

The aim: To establish unfavorable genetic polymorphisms on the development of comorbidity of DM2 and EH in Ukrainian population and to evaluate the effectiveness of α-lipoic acid appointment (α-LC) in complex therapy in patients with 3-4 crossed unfavorable genetic polymorphisms.The primary examination of 167 patients with DM2 in combination with EH showed that A/C and C/C genotypes of AGTR1, Pro/Pro genotype of PPARγ2, Arg/Arg ...

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ea0041ep574 | Diabetes therapy | ECE2016

Role of community pharmacists in the prevention and management of the metabolic syndrome in Albania

Pistja Edmond , Themeli Alba

Background: The metabolic syndrome is a cluster of diabetes and cardiovascular risk factors and its prevalence is alarmingly high in Albania, affecting nearly 20% of the adult population. There is lack of information about the role of community pharmacists in the care of patients with the metabolic syndrome.Objective: To assess the awareness and opinions of community pharmacists about the metabolic syndrome and identify the services they provide for iden...

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ea0041ep575 | Diabetes therapy | ECE2016

Galangin, a dietary flavonoid improves antioxidant status and reduces hyperglycemia mediated oxidative stress in streptozotocin-induced diabetic rats

Al-Numair Khalid S , Veeramani Chinnadurai , Govindasamy Chandramohan , Alsaif Mohammed A

Objective: This study was planned to examine the effect of galangin on hyperglycemia mediated oxidative stress in streptozotocin (STZ)-induced diabetic rats.Methods: Diabetes was induced by intraperitoneal administration of low dose of STZ (40 mg/kg body weight (BW)) into male albino Wistar rats. Galangin (8 mg/kg BW) or glibenclamide (600 μg/kg BW) was given orally daily once for 45 days to normal and STZ-induced diabetic rats.<p class="abstext...

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ea0041ep576 | Diabetes therapy | ECE2016

Trends and differences between sexes in control of diabetes and cardiovascular risk factors from 2004 to 2014

Vicente Almudena , Cortes Claudia , Olivar Monica , Martinez Ana , Sastre Julia , Marco Amparo , Luque Ines , Lopez Jose

Background: Poorer control of risk factors for cardiovascular disease (cvd) has been reported in diabetic women compared with men.Objective: To investigate whether control of diabetes and risk factors for cvd differ between sexes in a cohort of diabetic patients monitored at an outpatient endocrinology clinic from 2004 till 2014.Design: Observational, retrospective cohort study.Patients and methods: A cohort ...

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ea0041ep577 | Diabetes therapy | ECE2016

Antidepressant treatment worsens metabolic control in type 2 diabetes mellitus

Fernandez-Garcia Jose Carlos , Cortes-Salazar Carmen Maria

Objectives: To evaluate the use of antidepressant drugs in patients with type 2 diabetes mellitus (T2DM) and to analyse if these drugs are associated with a more deteriorated metabolic control.Methods: Cross-sectional study which included patients with T2DM followed in a primary care setting. Data about age, sex, T2DM evolution, body mass index (BMI), HbA1c and associated antidepressant treatment was collected. Statistical analysis was performed with SPS...

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ea0041ep578 | Diabetes therapy | ECE2016

The need of change in the treatment options for diabetes in acute ischemic stroke

Guldiken Baburhan , Celik Burak , Namli Merve , Bulbul Buket Yilmaz , Celik Mehmet , Guldiken Sibel

Diabetes that is an important risk factor for ischemic stroke should also be well-treated in acute ischemic stroke patients for the secondary prevention against the next strokes. In the present study, we investigated the rate of the treatment changes in diabetic acute ischemic stroke patients during their stay at hospital.One hundred twelve acute diabetic ischemic stroke patients that were hospitalized in the university neurology clinic were retrospectiv...

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ea0041ep579 | Diabetes therapy | ECE2016

Effect of short term GLP-1 modifying therapy on intima media thickness

Taskiran Bengur , Cansu Guven Baris , Bahadir Eylem , Mutluay Ruya

Atherosclerosis is the major cause of death in type 2 DM. Increased intima media thickness (IMT) denotes subclinical atherosclerosis. Endothelial cells express GLP-1 receptors. There are a few studies regarding the effect of GLP-1 system modifying agents on IMT. Although most of them indicates decreased IMT, the results are contradictory.We aimed to compare the effect of sitagliptin, vildagliptin, and exenatide on IMT measurement in type 2 DM.<p clas...

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ea0041ep580 | Diabetes therapy | ECE2016

Protocol for the hyperglycemia and diabetes mellitus in hospitalization

Perez-Rodriguez Jose , Maria Calderon-Vicente Dulce , Martin-Iglesias David , Alrramadan Mubarak , Victoria Cantero Maria , Jose Guillen Maria , Aranda-Regules Santiago

Introduction and objectives: Hyperglycemia is present in about 25% of hospitalized patients. His control is common deficient. Consequently it increases the average stay, infection rates and mortality. In order to improve we present a comprehensive protocol.Methods: We developed algorithms of subcutaneous insulin therapy for non-critical patients, insulin therapy i.v. for critical patients, management of hypoglycemia, fasting situations, diabetic ketoacid...

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ea0041ep581 | Diabetes therapy | ECE2016

Diabetic hyperlipidemia: from guidelines into clinical practice

Qasim Bayar

Diabetes mellitus (DM) is associated with significant morbidity and mortality despite steadily improving standards of care. Coronary heart disease (CHD) is by far the most common cause of death in individuals with diabetes.A characteristic pattern, termed diabetic dyslipidemia, consists of specifically mild to marked elevation of triglyceride-rich lipoproteins (VLDLs) and VLDL remnants concentrations and low levels of HDL-C. Raised serum triglycerides an...

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18th European Congress of Endocrinology

BiosciAbstracts