Diabetes (to include epidemiology, pathophysiology)

ea0041ep401 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Co-inheritance of PAX4 and BLK Mutations (MODY 7 and 9) in an 38-year-old African patient with ketosis-prone diabetes

Introduction: Ketosis-prone diabetes (KPD) is an emerging and uncommon form of diabetes characterized by patients who present with diabetic ketoacidosis without any immunological autoantibody to islet antigens of classic type 1 diabetes. KPD is mostly observed in African-American populations. Multiple, severe forms of β-cell dysfunction appear to underlie the pathophysiology of KPD. The PAX4 gene, causing Maturity-onset diabetes of the young (MODY) subtype 9, alr...

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ea0041ep402 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Calbindin-D9k in hypoxia-induced diabetes mellitus like model

Ahn Changhwan , Kim Kipoong , Ai Kang Song , Dinh Nam Tran , Jeung Eui-Bae

It has been proposed that cellular Ca2+ signals activate hormone secretion. In pancreatic β cells, which produce insulin, Ca2+ signals have been known to contribute to insulin secretion. Prior to this study, we confirmed that Calbindin-D9k (CaBP-9k) was responsible for regulation of the distribution of free calcium in the cytoplasm. We also confirmed that insulin-secreting β cells express CaBP-9k, and assumed that CaBP-9k play a role in β c...

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ea0041ep403 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Prevalence of diabetes mellitus in patients with hypercortisolism

Dreval Alexander , Trigolosova Irina , Kruglyakova Margarita , Komerdus Irina , Misnikova Inna , Kovaleva Yulia , Chekanova Anastasia , Barsukov Ilya , Molchanova Galina , Wolffenbuttel Bruce

Background: Early carbohydrate metabolism disorders (ECMDs) and diabetes mellitus (DM) are frequently associated with endogenous hypercortisolism (EG). Prevalence of secondary (sDM) in these cases are poorly investigated.Aim: We aimed to assess the prevalence of ECMDs and DM in patients with EG (pituitary-dependent Cushing disease (CD)) and adrenal-dependent Cushing (AC) and ACTH-ectopic syndrome (ACTHs) depending on gender and age.<p class="abstext"...

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ea0041ep404 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Alpha lipoic acid attenuates high fructose induced pancreatic toxicity

Topsakal Senay , Ozman Ozlem , Nihan Cankara Fatma , Yesilot Sukriye , Bayram Dilek , Genc Ozdamar Nilufer , Kayran Sumeyra

Objectives: Chronic consumption of high fructose corn syrup (HFCS) causes several problems like insulin resistance. The goal of the study was to investigate pancreatic damages induced by chronic HFCS consumption and protective effects of alpha-lipoic acid (ALA) on pancreatic cells.Methods: Wistar Albino, 4 months old, female rats and weighing 250300 g were randomly distributed into three groups each containing eight rats. Groups were HFCS group, HF...

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ea0041ep405 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

A novel E108D mutation of AVP-NPII gene in a Turkish patient with central diabetes insipidus

Ozcan Merve , Karaduman Tugce , Saglar Emel , Erdem Beril , Deniz Ferhat , Yonem Arif , Baskoy Kamil , Ahmet Ay Seyit , Oflaz Ofcan , Mergen Hatice

Familial central or neurohypophyseal diabetes insipidus (FNDI) results from insufficient production of antidiuretic hormone arginine vasopressin, which is caused by mutations in arginine vasopressin-neurophysin II gene (AVP-NPII). In this study, we present the clinical features of a male Turkish patient with autosomal dominant neurohypophyseal DI caused by a novel mutation (p.E108D). The prospective clinical data were collected for the proband patient and his family members. T...

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ea0041ep406 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Decreasing betatrophin levels during pregnancy in healthy women

Zielinska Anna , Maciulewski Rafal , Siewko Katarzyna , Poplawska-Kita Anna , Kozlowska Gabryela , Lipinska Danuta , Gorska Maria , Szelachowska Malgorzata

Introduction and aims: To date we have had some evidence that betatrophin is associated with insulin resistance. Some studies have demonstrated that betatrophin levels are elevated in type 2 diabetes, obesity and gestational diabetes. It has been shown that in mice betatrophin significantly improves beta cell function and glucose tolerance. This is the first study on betatrophin in which pregnant women were observed during all trimesters and in postpartum period to evaluate it...

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ea0041ep407 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

A rare form of pancreatic diabetes: a 25 year-follow-up

Cheikhrouhou Nesrine , Barka Ines , Elleuch Koussay , Slim Ines , Chaieb Larbi

Introduction: Fibrocalculous pancreatic diabetes is an uncommon type of diabetes mellitus due to chronic calcific non-alcoholic pancreatitis. It is associated to several particularities based on glycemic control and the occurrence of degenerative and metabolic complications, in addition to chronic pancreatitis complications.Observation: A 17-year-old male, with no familial history of diabetes and no alcohol consumption, was hospitalized in 1989 for keton...

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ea0041ep408 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Two neonatal diabetes cases with different mutations and treatments

Evliyaoglu Olcay , Ozcabi Bahar , Ataoglu Emel , Bucak Feride , Ercan Oya

Neonatal diabetes, is monogenic and can be due to different mutations. Here we report two patients with neoanatal diabetes, with two different mutations and treatments.Case 1 was a female infant of consanguineous parents born at 37 weeks of gestation with a birth weight of 1900 g. After birth she was followed for respiratory distress and hyperglycemia. Her blood glucose was controlled with glargine insulin and with rapid acting insulin when needed. Her p...

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ea0041ep409 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Functional analysis of G12E mutation of AVPR2 gene in Turkish patients with diabetes insipidus

Erdem Beril , Saglar Emel , Karaduman Tugce , Ozcan Merve , Deniz Ferhat , Mergen Hatice

Diabetes insipidus (DI) is a rare disorder which is characterized with inability to concentrate urine because of severe liquid-balance impairment. Mutations in AVPR2 gene is one of the causes of DI. AVPR2 is a G protein coupled receptor (GPCR) and its specific agonist is arginine vasopressin (AVP). When AVP binds to the AVPR2, which locates on the basolateral side of collecting duct principal cells of the kidney, it triggers accumulation of cAMP in the cell as a seconder messe...

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ea0041ep410 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Prevalence of biochemical hypoglycaemia in everyday practice

Zabuliene Lina , Pauliukiene Birute , Audrone Bagdziuniene Airida , Urboniene Jurgita

Oral glucose tolerance test (OGTT) is the main tool in population based screening for type 2 diabetes mellitus. Sometimes OGTT results are showing asymptomatic lowering of post-load blood glucose. Post-load plasma glucose (2hPG) level 3.9 mmol/l (70 mg/dl) and lower shows biochemical hypoglycaemia. Biochemical hypoglycaemia might be observed among individuals with abnormal glucose tolerance and in healthy population. The objective of the investigation was to assess a prevalenc...

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ea0041ep411 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Inpatient glycaemic variability and long-term mortality: a neglected diabetic parameter?

Timmons Joseph , Jones Gregory , Sainsbury Christopher , Cunningham Scott

Aim: To determine the association between recorded inpatient glycaemic variability and long-term mortality in patients with diabetes mellitus.Methods: Inpatient capillary blood glucose (CBG) readings from eight acute hospitals were included. Data was analysed from first admission within the dataset with >4 measured CBGs. 28 353 admissions were identified (24 181 type 2 DM, 4,172 type 1 DM). Matching parameters were: age, diabetes duration, admission ...

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ea0041ep412 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Reduction of autoimmune regulator Aire mRNA and number of Treg-cells in mesenteric lymph nodes in the offspring of rats with experimental gestational diabetes

Prozorova Tanya , Kamyshny Alex

Introduction: Formation of immunological tolerance to self antigens is an important mechanism that prevents the development of autoimmune diseases.Methods: With the help of molecular genetic and immunofluorescence techniques we investigated the effects of experimental gestational diabetes (EGD) on the level of mRNA expression of autoimmune regulator Aire and differentiation features of Foxp3+ cells in mesenteric lymph nodes in the offspring of...

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ea0041ep413 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Oral disposition index as a predictor of changes in glucose tolerance status over time

Nedel Barbara , Antoniolli Luciana , Pazinato Tassia , Piccoli Vanessa , Beer Mayara , Piccoli Sheila , Gerchman Fernando

Introduction: Type 2 diabetes (DM) is characterized by both insulin resistance and β-cell dysfunction. The oral disposition index (DIo), a measurement of β-cell function and insulin sensitivity, is considered the best predictor of progression to a worse GTS, although it was not well tested for regression to a better GTS.Objectives: To assess the validity of DIo and determine whether DIo predicts regression to a better GTS.<p class="abstext"...

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ea0041ep414 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

High prevalence of diabetes and pre-diabetes in psychiatry inpatients

Naidu Pratyusha , Churilov Leonid , Kong Alvin , Kanaan Richard , Wong Henry , Van Mourik Arielle , Yao Anthony , Cornish Elizabeth , Hart Graeme K , Owen-Jones Elizabeth , Robbins Raymond , Lam Que , Samaras Katherine , Zajac Jeffrey , Ekinci Elif I

Objective: To determine the prevalence and characteristics of psychiatry inpatients with type 2 diabetes and pre-diabetes, compared to psychiatry inpatients without diabetes.Research design and methods: Inpatients aged >30 years at the Austin psychiatry unit (February 2014April 2015) had HbA1c measurements as part of the Diabetes Discovery Initiative. Patients were divided into three groups diabetes (HbA1c ≥6.5%, 48 mmol/mol), pre-...

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ea0041ep415 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Twenty-four hour blood pressure monitoring in women with gestacional diabetes mellitus

Sanchez-Lechuga Begona , Lopez-Tinoco Cristina , Lopez Carmen , Tamayo Julian Andres , Mateo Isabel , Vilchez Francisco Javier , Aguilar Manuel

Gestational diabetes mellitus (GDM) is associated with an increased risk of pregnancy-induced hypertension (PIH). Ambulatory blood pressure monitoring (ABPM) has been used to screen for PIH and preeclampsia in normotensive type 1 diabetic women. To date, there are no data regarding ABPM in women with GDM. The aim of the study was to establish blood pressure (BP) profiles for pregnant with GDM, using ABPM and determine whether a BP pattern can define a population at risk for de...

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ea0041ep416 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Differences in the risk factors associated with diabetic retinopathy between type 1 and type 2 diabetes mellitus

Matuszewski Wojciech , Bandurska-Stankiewicz Elzbieta , Rutkowska Joanna , Myszka-Podgorska Katarzyna , Modzelewski Robert , Jalali Rakesh , Sosnowska Iwona

Introduction: The aim of the study was to examine the risk factors associated with diabetic retinopathy (DR) in adult patients with DM1 and DM2.Design: The study group consisted of adults patients with DM1 and DM2, diagnosed according to the WHO criteria. Risk factors for diabetic retinopathy were evaluated on the demographic data, medical history, clinical and biochemical parameters related to metabolic control of diabetes. We collected also ophthalmic ...

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ea0041ep417 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Abstract withdrawn....

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ea0041ep418 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

MiRNA-binding site polymorphisms of MODY genes associated with lipid profiles in Chinese patients with gestational diabetes mellitus

Wang Xiaojing , Li Wei , Gao Jinsong , Ma Liangkun , Fan Ping , Nie Min , Xiao Xinhua

Objective: Both MODY and GDM are characterized by pancreatic beta cell dysfunction. The study aimed to first investigate the associations between miR-SNPs of HNF4A, HNF1A and HNF1B genes and the GDM susceptibility and lipid profiles.Methods: The software PolymiRTS were used to screen miR-SNPs. Genotyping of SNPs was performed with TaqMan allelic discrimination assays in 839 GDM patients and 900 controls. Multivariable logistic ...

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ea0041ep419 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Association between 25-hydroxyvitamin D levels and diabetes

Papadakis Georgios , Kakava Kassiani , Pappa Theodora , Dogkas Nikolaos , Villiotou Vassiliki , Pappas Anastasios

Introduction: A significant body of literature supports that 25(OH)vitD deficiency is associated with insulin resistance. We studied the prevalence of 25(OH)vitD deficiency across the spectrum of glucose metabolism.Design: The study participants (441 total, 362 females (82.1%) and 79 males (17.9%)) had a mean age (±S.D.) of 64.59 (±9.44) years, range: 3292 years. The study population was divided into two groups: Individuals...

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ea0041ep420 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Molecular and clinical identification of A45T mutation in AQP2 gene

Karaduman Tugce , Ozcan Merve , Saglar Emel , Erdem Beril , Deniz Ferhat , Yonem Arif , Baskoy Kamil , Ay Seyit Ahmet , Oflaz Ofcan , Mergen Hatice

Diabetes insipidus (DI) is a disorder which is rarely seen and it is characterized by polydipsia and polyuria. Inadequate secretion of arginine vasopressin (AVP) from hypothalamus or inadequate response of kidney cells to AVP could be causes of DI. Therefore, any mutations in AVPR2, AVP and AQP2 genes which are the parts of that stimulation and response pathyway can cause DI. In this study, mutational analyse was performed for A45T mutation in AQP2 gene. We present a novel hom...

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ea0041ep421 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The prevalence of insulin resistance in the Turkish population

Kaya Ahmet , Turan Elif , Uyar Mehmet , Bayram Fahri , Turan Yasar

Introduction: We aimed to investigate the homeostasis model assessment of insulin resistance (HOMA-IR) and relation of HOMA-IR with age, sex and body mass index (BMI) and the prevalence of diabetes in Turkish population of different regions.Methods: Cross-sectional observational study was done in the frame of Turkish prevalence of insulin resistance multicenter study. The study sample consisted of volunteers from seven different regions of Turkey. Weight...

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ea0041ep422 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The antropometric and metabolic parametres in women with previous gestational diabetes mellitus during a 30-month observation

Rutkowska Joanna , Bandurska-Stankiewicz Elzbieta , Myszka-Podgorska Katarzyna , Wiatr-Bykowska Dorota , Matuszewski Wojciech , Olszewska Monika

Introduction: The aim of the study was to assess antropometric and metabolic parametres in women with previous gestational diabetes mellitus (GDM) during a 30-month observation.Design: Our prospective study cohort consisted of 367 women with GDM diagnosed according to WHO criteria. Oral glucose tolerance test (OGTT) was performed during 6-10 weeks and 12, 18, 24, 30 months after delivery. On every 6th month between 12th and 30th month after delivery we e...

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ea0041ep423 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Diabetes and glycemic control in acute heart failure: complications, hospital stay and prognosis

Paredes Silvia , Lopes Melina , Ramos-Lopes Margarida , Araujo David , Cardoso Rosa , Monteiro Ana Margarida , Pimentel Teresa , Marques Olinda , Alves Marta

Introduction: Few studies have evaluated the impact of type 2 diabetes on the prognosis of acute heart failure (HF). This study assessed the effect of diabetes and glycemic control on complications, hospital stay and prognosis in patients with acute HF.Methods: Retrospectively, databases of 428 hospitalized patients by acute HF were analyzed, 201 diabetic patients and 227 controls. Statistical analysis was done using SPSS, considering statistical signifi...

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ea0041ep424 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Glycemic control improves in patients with diabetes type 1 after transition from pediatric to adult care

Kraljevic Ivana , Baretic Maja , Renar Ivana Pavlic

Aim: The aim of the study was to compare HbA1c levels in patients with type 1 diabetes before and 3 months after the transition from pediatric to adult endocrinology clinic.Methods: Retrospective analysis of the data from 88 young adults with type 1 diabetes was done. The consecutive patients were recruited in their last year of pediatric care and then transferred to the adult endocrinologist care. A group of 25 randomly chosen patients underwent structu...

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ea0041ep425 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Patients with impaired fasting glucose exhibit a more frequent non-dipper or riser blood pressure pattern compared with normoglycemic patients

Fernandez-Garcia Jose Carlos , Cortes-Salazar Carmen Maria , de la Cruz-Troca Juan Jose , Garcia-Arnes Juan Antonio , Aranda-Lara Pedro

Objectives: To study blood pressure circadian pattern in patients with impaired fasting glucose (IFG) evaluated with ambulatory blood pressure monitoring (ABPM).Methods: Cross-sectional study evaluating patients taken from the Spanish ABPM Registry. Normoglycemia was defined as glucose <100 mg/dl and IFG as glucose 100125 mg/dl. All patients underwent 24-h ABPM with a Spacelabs ambulatory blood pressure system. ABPM was performed according to s...

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ea0041ep426 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Diagnostic and therapeutic stratagies in maturity onset diabetes of the young

Oliveira Sofia , Neves Celestino , Esteves Cesar , Pignatelli Duarte , Carvalho Davide

Background: Maturity onset diabetes of the young (MODY) has an estimated prevalence of 15% in the diabetic population, but misdiagnosis as type 1 or type 2 diabetes is common. It comprises a heterogeneous group of monogenic diseases characterized by primary dysfunction of β cell, young onset, autosomal dominant inheritance, without autoimmunity and without ketosis. Early diagnosis remains a challenge with important future implications, since it allows treatment opti...

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ea0041ep427 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Characterization of a pediatric population with type 1 diabetes at transition to adult health care

Oliveira Joana , Domingues Mariana , Belo Sandra , Caetano Joana Serra , Cardoso Rita , Dinis Isabel , Baptista Nanci , Freitas Paula , Carvalho Davide , Mirante Alice

Introduction: Type 1 diabetes (T1D) is an important endocrine disease in the pediatric age group. The shift from pediatrics to adult health care providers is a critical period for adolescents with diabetes.Objective: Characterization of a pediatric population with T1D moved to adult health care between January/2001April/2015.Methods: Cross-sectional study with retrospective analysis of medical records.R...

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ea0041ep428 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Waist circumference and diabetes risk in Colombian population

Zambrano Monica , Buendia Richard

Increased waist circumference is a cardiovascular risk factor, currently we have the cutoff value of International Diabetes Federation (IDF) or by Latin-American standards; in Colombia has not studies where showing the relationship between increased waist circumference and the risk of diabetes. This study aims to show the relationship between increased waist circumference by IDF criteria or Latin-American criteria and the risk of diabetes.Methodology: Cr...

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ea0041ep429 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Oral fructose does not acutely affect circulating FGF21 in mice

Bielohuby Maximilian , Sommerfeld Mark , Schwahn Uwe , Winkel Angelika , Herling Andreas , Tennagels Norbert

Impaired glucose tolerance and insulin sensitivity are established hallmarks of diabetes and it was speculated that also fructose tolerance could be impaired. However, investigation of fructose tolerance has been hampered by the lack of easy accessible pharmacodynamic markers. In humans, the hormone FGF21 has recently been demonstrated to be a sensitive pharmacodynamic marker responding to an oral fructose bolus and exhibiting a divergent secretion pattern in obese diabetic an...

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ea0041ep430 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Changes in the expression level of transcription factor Foxp3 in rat’s pancreatic lymph nodes under streptozotocin-induced diabetes and metformin administration

Kamyshny Alex , Putilin Denis

Introduction: Type 1 diabetes mellitus is a T-cell mediated autoimmune disease characterized by the destruction of β-cells of the pancreas. Numerous studies have demonstrated the key role of FoxP3+ regulatory T-cells in the development of type 1 diabetes.Aim: The aim of research: 1) to determine the expression patterns of transcription factor FoxP3 in the pancreatic lymph node cells in animal model of diabetes mellitus and 2) to assay an effect of m...

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ea0041ep431 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Diabetic case treated by steroid

Abusahmin Hussam , Bondugulapati Rao , Dixon Antony

Introduction: Isolated eosinophilic pancreatitis is very rare disease and usually occurs either as hyperoesinophylia syndrome or as part of eosinophilic gastroenteritis.Case report: A 55-year-old man presented to his general practitioner (GP) with a 3 week history of flu-like symptoms, pruritis, weight loss and diarrhoea. Initial investigations showed eosinophilia (32.2 ×109/l) and a normal random glucose.He was see...

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ea0041ep432 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Predictive value of risk factors for the progression from prediabetes to type 2 diabetes

Tankova Tsvetalina , Chakarova Nevena , Dakovska Lilya , Atanassova Iliana , Kirilov Georgi

Background: Diabetes and prediabetes have become major public health problems in recent decades.Objectives: The aim of the study was to evaluate the predictive value of risk factors on progression from prediabetes to type 2 diabetes.Materials and methods: A total of 383 subjects (213 females, 170 males), mean age 51.93±13.47 years and mean BMI 29.11±5.3 kg/m2, divided in three groups 147 with normal gluc...

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ea0041ep433 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Cause-of-death trends for diabetes mellitus over 20 years

Suh Sunghwan , Kim Mi-Kyung , Park Mi-Kyoung , Kim Duk Kyu

Background: Recently, diabetic mortality is lower than ever before, likely due to dramatic improvements in diabetes care. This study set to analyze changes in the cause of death in type 2 diabetes mellitus (T2DM) in the past 20 years.Methods: All subjects were T2DM patients over the age of 30 whose death certificates were issued at six hospitals in the Busan metropolitan area from 2010 to 2014. The patients were excluded if they had been clinically diagn...

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ea0041ep434 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The part of taste in cephalic phase of insulin secretion

Pospisilova Hana , Duskova Michaela , Jandikova Hana , Sramkova Monika , Macourek Michal , Starka Luboslav

Background: Secretion of insulin by beta-cells of the islets of Langerhans is a very complex dynamic process that includes basal and stimulated insulin secretion. Two phases, one early and one late, can be distinguished in insulin secretion. The early phase is characterised by the secretion of preformed insulin granules, lasts about 15 min and is formed by cephalic and gastrointestinal components. The cephalic phase of insulin secretion starts by stimulating visual, olfactory ...

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ea0041ep435 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Relation between uric acid and lipid profiles in patients with type 2 diabetes

Kim Eui-Hyun , Bae Kwi-Hyun , Jeon Jae-Han , Choi Yeon-Kyung , Kim Mi-Kyung , Kim Hye-Soon , Park Keun-Gyu , Seo Hyun-Ae

Aims: High level of uric acid is known to associate with stroke, coronary artery disease and metabolic syndrome. Some epidemiologic studies suggested that high uric acid level is connected with dyslipidemia. However, this relationship was not examined in type 2 diabetic patients. This study was conducted to investigate the association between serum uric acid level and lipid profiles in type 2 diabetic patients.Methods: A total of 972 type 2 diabetes pati...

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ea0041ep436 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Thyroid dysfunction among Greek type 1 and type 2 diabetic patients attending an outpatient clinic

Barmpari Maria , Kokkorou Maria , Micheli Anastasia , Alexiou Irene , Spanou Elefteria , Noutsou Marina , Thanopoulou Anastasia

Introduction: The aim of this study was to determine the prevalence of thyroid dysfunction in Greek patients with type 1 (T1DM) and type 2 (T2DM) diabetes as well as its possible relation to glycemic control and to diabetic complications.Patients and methods: A total of 990 patients (60.7% men) with T1DM or T2DM, consecutively followed in the Outpatient Diabetes Clinic, participated in the study. In every patient anthropometric and biochemical measuremen...

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ea0041ep437 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Study on role of TNF-α and oxidative stress in pathogenesis of type 2 diabetes mellitus

Saatov Talat , Ibragimov Zafar , Irgasheva Sanobarxon , Ibragimova Elvira , Zainutdinov Bakhodir , Mustafakulov Mukhammadjon

Aim: The work was initiated to study TNF-α gene polymorphism and parameters of oxidative stress in patients with type 2 diabetes mellitusMaterials and methods: We examined 41 healthy subjects and 20 patients with diabetes mellitus to study G308A (rs1800629) polymorphism in TNF-α gene by means of allele-specific PCR method (AS-PCR). Rates of lipid peroxidation (LP) were determined by concentration of malon dialdehyde (MDA); catalase activity was...

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ea0041ep438 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The change of adherence to a process quality-of-care-indicator after the initiation of clinical audit in Korea

Kim Soo-Kyung , Kim Se-Hwa , Han Kyung Do , Kim Eun-Mi , Cho Jin-Sook , Park Seok O , Park Tea Sun , Cho Yong-Wook

Background: Adherence to recommended guideline for monitoring of glucose control and screening of diabetic complications has been demonstrated to prevent the chronic complications of diabetes. In Korea, the clinical audit for quality of diabetes care has been started in 2011. The aim of this study is to investigate the change of adherence to a process quality-of-care-indicator in diabetes after the initiation of audit in Korea.Methods: This retrospective...

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ea0041ep439 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The effect of processes measures of diabetes care and medication adherence on the developments of chronic diabetic complications

Kim Soo-Kyung , Kim Se-Hwa , Han Kyung Do , Kim Eun-Mi , Cho Jin-Sook , Park Seok O , Park Tae Sun , Cho Yong-Wook

Background: Regular monitoring of glucose control and screening of diabetic complication and adherence to treatment are cornerstones for prevention of chronic diabetic complications. The aim of this study is to investigate the association between quality of diabetes care and the development of chronic diabetes complications.Methods: This retrospective study was performed using the national health insurance claims database from the Health Insurance Review...

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ea0041ep440 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The effect of vitamin D on rat pancreatic beta cells in vitro

Kostoglou-Athanassiou Ifigenia , Papageorgiou Eustathia , Vlachodimitris Ioannis , Markopoulos Christos , Karatzas Theodoros , Koutsilieris Michael

Introduction: Vitamin D is currently known for its effects on the bone and muscle systems as well as for its pleiotropic and antiproliferative effects. The relationship between vitamin D and diabetes mellitus is in the focus of scientific research. Vitamin D deficiency has been found to be associated with the development of diabetes mellitus type 1 as well as with poor glycemic control in diabetes mellitus type 2.Aim: The aim was to study the effect of v...

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ea0041ep441 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The effect of melatonin on rat pancreatic beta cells in vitro

Kostoglou-Athanassiou Ifigenia , Papageorgiou Eustathia , Vlachodimitris Ioannis , Markopoulos Christos , Karatzas Theodoros , Koutsilieris Michael

Introduction: Melatonin is a hormone mainly synthesized and secreted by the pineal gland. It is involved in the orchestration of circadian rhythms its levels being elevated during the hours of darkness in the human. Melatonin may have other pleiotropic functions in the human organism. In particular, it may be involved in the regulation of glucose metabolism and the pathogenesis of diabetes.Aim: The aim was to study the effect of melatonin on rat islet ce...

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ea0041ep442 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Implementation of guidelines in a large outpatient Diabetes Clinic

Kokkorou Maria , Barmpari Maria , Micheli Anastasia , Alexiou Irene , Spanou Elefteria , Noutsou Marina , Thanopoulou Anastasia

Introduction: The aim of the study is to determine whether the guidelines on glycemic control and cardiovascular risk factors are being followed in everyday clinical practice and to describe the lifestyle habits and the wellbeing of patients with Type1 or Type 2 diabetes.Patients and methods: A total of 990 patients with diabetes consecutively followed in the Outpatient Diabetes Clinic were studied (60.8% men). Clinical and laboratory parameters and livi...

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ea0041ep443 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The content of adipocytokines (resistin, adiponectin) in type 1 diabetic patients associated with the amounts of fat component

Dydyshka Yuliya , Shepelkevich Alla , Sosedkova Alexandra , Lobashova Veronika

Background and aims: Adipocytokines produced by adipose tissue cells, and their action is often systemic in nature. Connection of some adipocytokines (resisttin) with the development of autoimmune diseases such as type 1 diabetes (T1DM) is a perspective view. Therefore, the aim of study was to assess the association between adipocytokines (resisttin, adiponectin) and content of fat mass in T1DM.Materials and methods: Ninety-five patients with T1DM (60 wo...

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ea0041ep444 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Association of eating behaviors and demographic profiles of Filipino adults with type 2 diabetes mellitus seen in a Tertiary Hospital

Harvey Aguilar Anthony , Anthony Sandoval Mark , Jimeno Cecilia , Paz-Pacheco Elizabeth

Background: Patients with type 2 diabetes face daily challenges in making dietary choices that are influenced by eating behaviors. Recognition of eating behaviors and associated demographic profiles could aid in individualizing dietary plans and direct nutrition programs in forming cost-effective measures.Objective: The goal of this study is to identify differences in eating behaviors across demographic profiles of Filipinos with type 2 diabetes.<p c...

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ea0041ep445 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Functional characterization of a large deletion in the AVPR2 gene causing severe nephrogenic diabetes insipidus in a Turkish family

Saglar Emel , Erdem Beril , Karaduman Tugce , Ozcan Merve , Deniz Ferhat , Mergen Hatice

Changes in arginine vazopression type 2 receptor (AVPR2) gene mostly lead to a rare hereditary polyuric disease, X-linked nephrogenic diabetes insipidus (NDI). The disease is characterized by the production of large amounts of urine and an inability to concentrate urine in response to the antidiuretic hormone vasopressin. In our previous study we have identified a novel 388 bp deletion in the AVPR2 gene in a patient with NDI and in his family. For fu...

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ea0041ep446 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Microbiological profile in diabetic foot infections: identification and susceptibility profile of bacteria isolated in 5 years in a Portuguese tertiary care hospital

de Sousa Lages Adriana , Oliveira Patricia , Costa e Silva Nuno , Guelho Daniela , Cardoso Luis , Vicente Nuno , Martins Diana , Oliveira Diana , Ventura Mara , Carrilho Francisco

Introduction: The diagnosis of infected ulcer is mainly clinical. The goals of the microbiological studies are identification of the pathogen and evaluation of susceptibility to antibiotics to minimize exposure to drugs and selection of resistant strains.Methods: Retrospective cohort study; Data collection: 1 January 2010 to 31 December 2014. Were included wound samples of aspirate, nonsurgical/surgical exudate, pus from abscesses and bone fragments from...

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ea0041ep447 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The association between the FTO gene and gestational diabetes mellitus

Beysel Selvihan , Alp Yunus , Alparslan Pinarli Ferda , Cakal Erman , Yesilyurt Ahmet , Delibasi Tuncay

Introduction: Common polymorphisms of the fat mass and obesity associated gene (FTO) is known to associate with increased obesity and diabetes mellitus type 2. This was the first study to investigate the association between the rs9939609 FTO gene polymorphism and gestational diabetes mellitus (GDM) in Turkish women.Patients and methods: The case-control study included 203 gestational diabetes and 191 non-diabetic pregnant controls. Anthropometric and bio...

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ea0041ep448 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Clinical inertia in type 2 diabetes mellitus without insulin treatment

Silva Joao , Ivo Catarina , Lopes Luis , Passos Dolores , Simoes Helder , Marcelino Mafalda , Jacome de Castro Joao

Introduction: Clinical inertia applied to type2 Diabetes Mellitus (T2DM) treatment, is defined as a lack of treatments intensification of patients who are not in HbA1c target. Clinical inertia leads to a postponement of new therapeutic introduction, with all complications associated with a poor metabolic control. In Portugal there are only studies that show good or poor metabolic control but do not mention clinicians attitude towards these values. Recently publishe...

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ea0041ep449 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Stress hyperglycemia ratio as a marker of disease severity in hospitalized patients with acute pyelonephritis

Sousa Santos Francisco , Fonseca Margarida , Paosinho Ana , Cruz Ines , Sequeira Duarte Joao , Gouveia Clotilde , Mello e Silva Alberto , Vasconcelos Carlos

Introduction: Hyperglycemia (irrespective of the presence of diabetes) has been associated with worse outcomes in hospitalized patients with a variety of diseases, namely critical illness. It is been recently proposed that a relative hyperglycemia Stress Hyperglycemia Ratio (SHR) might be even better associated with disease outcomes. We studied how SHR correlated with various morbidity parameters in hospitalized patients due to acute pyelonephritis.<p class="...

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ea0041ep450 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Reactive hypoglycemia: effectiveness of dietary regimen in a Tunisian population

Khatib Maria , Kandara Hajer , Grira Wafa , Chikhrouhou H , BenSalem Laila , BenSlama Cloud

Introduction: Reactive hypoglycemia (RH) is characterized by postprandial hypoglycemic disorder aggravated by the ingestion of high glycaemic index (GI) foods.The aim of this study was to evaluate the effectiveness of dietary regimen recommended for patients with RH.Methods: This interventional prospective study included 20 patients consulted with symptoms suggesting RH, duration of monitoring was one month. Data had been ...

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ea0041ep451 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Gut microbiota and diet in patients with various glucose tolerance

Egshatyan Lilit , Kashtanova Daria , Popenko Anna , Tkacheva Olga , Tyakht Alexander , Alexeev Dmitry , Karamnova Natalia , Boytsov Sergey

Background: Type 2 diabetes (T2D) is a progressive disease. The gut microbiota has recently been identified as a new potential diabetes risk factor.Design: To investigate the gut microbiota composition in association with the dietary patterns in patients with different glucose tolerance we analyzed 92 patients: with normal glucose tolerance (n=48), prediabetes (n=24) and T2D (n=20). Metagenomic analysis was performed using 16Sr...

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ea0041ep452 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Circulating adipokine levels and insulin resistance in type 2 diabetes mellitus and metabolic syndrome

Zehra Sitwat , Hingorjo Mozaffer Rahim , Imran Erum , Qureshi Masood Anwar

Objectives: The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly with obesity being a major risk factor. Adipocytes, besides storing fat, release a number of adipokines. Our study explored the association of leptin and resistin released by adipocytes in the pathogenesis of T2DM in context of metabolic syndrome.Methods: This was a cross sectional study in which we measured plasma levels of insulin, leptin and resistin in 50 healthy non-...

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ea0041ep453 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Frequency of diabetes and thyroid autoantibodies in patients with type 1 diabetes and their siblings

Kim Chan Jong , Oh Ka Young , Kim Yun Hee , Yang Eun Mi

Background: We investigated the frequency of autoimmune thyroid and diabetes antibodies in patients with type 1 diabetes mellitus (T1DM), their siblings, and controls.Methods: Glutamic acid decarboxylase antibodies (GADA), islet cell antibodies (ICA), insulin autoantibodies (IAA), and thyroid antibodies were identified in all subjects.Results: The rates of positive GADA and IAA were significantly higher in probands compared to sibl...

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ea0041ep454 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

PAI-1 polymorphism in patients with diabetes

Shyshko Volha , Mokhort Tatjana , Gonchar Alexander , Konstantinova Elena , Tsapaeva Natalia

Background: Plasminogen activator inhibitor-1 (PAI-1) refers to group of is a serine protein inhibitors. It inhibits fibrinolysis and contributes to angiogenesis and atherogenesis processes. 4G/5G polymorphism was found to be associated with increased risk for cardiovascular diseases. It was of special interest to study PAI-1 polymorphism in patients with diabetes.Aim: Aim to study PAI-1 polymorphism in patients with type 2 diabetes (T2D) and concomitant...

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ea0041ep455 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Metabolic syndrome as independent risk factor of poor glycemic control in type 2 diabetic patients

Buendia Richard G , Velandia Sonia , Tobon Catalina , Espinosa Adelaida , Contreras Alejandra , Sanchez Margarita , Paz Oscar , Viscaino Eleonora , Paez Amanda , Morales Alejandra

Type 2 diabetes is considered a disease of epidemic proportions, its control is important to prevent macro and microvascular complications.This study aims to determine the factors associated with poor glycemic control, defined as HbA1c >7% in type 2 diabetic patients of cardiovascular risk program of the Central Hospital of National Police in ColombiaMethodology: This is a descriptive cross-sectional study, where it is performe...

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ea0041ep456 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Serum vitamin D levels in patients with gestational diabetes mellitus

Zengin Arif , Ahbab Suleyman , Ataoglu Esra , Turker Betul Cavusoglu , Cakir Evrim

Background: Insulin resistance and diabetes mellitus are associated with decreased serum vitamin D level. Therefore, we evaluate the 25-OH-vitamin D in GDM. This study was performed to evaluate the serum vitamin D levels in GDM patients.Methods: This study consisted of 38 patients with GDM who followed up in Haseki Training and Research Hospitals Endocrinology outpatient clinic. GDM was diagnosed with 50 g (if postprandial 1 h >130199 mg/...

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ea0041ep457 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Acute pancreatitis and diabetic ketoacidosis in non-diabetic psychotic patient

Oueslati Ibtissem , Khiari Karima , Elfeleh Emna , Mchirgui Nadia , Bchir Najla , Abdallah Nejib Ben

Introduction: Simultaneous occurrence of acute pancreatitis and diabetic ketoacidosis represents a very rare complication of antipsychotic medications.Herein we report the case of acute pancreatitis and diabetic ketoacidosis in a non-diabetic patient while on treatment with haloperidol, chlorpromazine and carbamazepineCase report: Mr. Z A is a 50-year-old non-diabetic man who was diagnosed with psychotic disorder and treated with h...

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ea0041ep458 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Identification of LADA in normal weight diabetic Albanian population

Husi Gerond , Golemi Ersida , Ylli Dorina , Kelmendi Matilda , Furreraj Thanas , Hoxha Violeta , Petrela Elizana , Ylli Zamira , Kolici Emirvina

Background: Latent autoimmune diabetes of adults (LADA) constitutes 510% of the population with diabetes. Early diagnosis of LADA prevents misdiagnostification of type 2 diabetes and helps in the optimal treatment of patients, while maintaining a residual B cell function and delaying the time of their destruction.Aim: The aim of the study identifying groups with higher risk of LADA in an Albanian population.Material and metho...

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ea0041ep459 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The risk of developing of obstructive sleep apnea syndrome in type 2 diabetes mellitus patients in Uzbek population

Ismailov S I , Esimova D M , Muminova S U , Sultanova F T , Gulyamova Kh R

Actuality: According to WHO, 36% of patients with type 2 diabetes mellitus (T2DM) suffer from obstructive sleep apnoe syndrome (OSAS), which is one of global problems of modern medicine. International classification of sleep disorders identified that 24% of men and 9% of women with T2DM observe symptoms of OSAS. Sleep apnea has a negative effect on the function of the beta cells of the pancreas and insulin sensitivity. Obstructive sleep apnea has a negative impact on the quali...

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ea0041ep460 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Importance of determination of albuminuria in patients with newly diagnosed type 2 diabetes mellitus

Prystupiuk Lev , Naumova Liudmyla , Prystupiuk Maksym , Naumova Marianna , Prystupiuk Oleksandr

Introduction: Worldwide, patients with type 2 diabetes mellitus (T2DM) compose 9095% of total number of diabetics. 10% of people aged under 60 years are affected with T2DM, also are 1020% of people aged 6069 years, and 1520% over the age of 70 years. The risk of diabetes may reach 3040% during lifetime due to other factors than age. T2DM is characterised by higher development of cardiovascular lesions, which even more worsens the condition of the ...

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ea0041ep461 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Procrastination and glycemic control of gestational diabetes – preliminary report

Ilias Ioannis , Milionis Charalambos , Linardi Anastasia , Koukkou Eftychia , Tselebis Athanasios , Nikopoulou Stamatina

Introduction: Psychological dimensions of gestational diabetes mellitus (GDM) are not adequately studied and related research is limited. Procrastination as a personality trait is involved in many aspects of daily life; it has not been studied in relation to GDM.Aim: To assess procrastination in insulin-treated women with GDM.Patients-methods: A total of 15 women (mean age +S.D.: 33+4 years) diagnosed with GDM betwee...

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ea0041ep462 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Factors associated with increased irisin levels in type 1 diabetes mellitus

Ates Ihsan , Kaplan Mustafa , Mese Duygu , Erdogan Kubra , Yuksel Mahmut , Topcuoglu Canan , Yilmaz Nisbet , Guler Serdar

Aims: We aimed to determine the irisin level in patients with type 1 diabetes mellitus (T1DM) and to examine the relation of irisin level with inflammation and autoimmunity.Methods: This study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Anti-glutamic acid decarboxylase (Anti-GAD), islet cell antibody (ICA), insulin autoantibody levels of the patients have been measured at the time they were included in the study and were recorded fro...

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ea0041ep463 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Interleukin-6, interleukin-15 concentrations and insulin resistance in autoimmune diabetes

Siewko Katarzyna , Zielinska Anna , Maciulewski Rafal , Poplawska-Kita Anna , Telejko Beata , Lipinska Danuta , Gorska Maria , Szelachowska Malgorzata

Background: Interleukin-15 and -6 play a role in an inflammation, autoimmune, infectious and cancerous processes. Their increased concentrations were observed in psoriasis, asthma, multiple sclerosis and type 2 diabetes. However, the role of IL-15 and IL-6 in autoimmune diabetes (AD) pathogenesis is still unknown.Aim: The aim of our study was to assay circulating IL-15 and IL-6 levels in newly diagnosed AD patients, their I° relatives and healthy co...

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ea0041ep464 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The importance of gender difference in evaluation of relationship between MPV and serum biochemical parameters in type 2 diabetic patients

Okuturlar Yildiz , Kocoglu Hakan , Seker Omer , Erismis Betul , Ozdemir Bahar , Mert Meral , Serin Sibel Ocak , Hursitoglu Mehmet , Harmankaya Ozlem , Kumbasar Abdulbaki

Introduction: Increased mean platelet volume (MPV) is an independent risk factor for thromboembolism, stroke and myocardial infarction. In this study we tried to emphasize the importance of gender difference in evaluation of relationship between MPV and serum biochemical parameters in type 2 diabetic patients.Methods: A total of 509 patients with diabetes mellitus who hospitalized due to several causes were retrospectively evaluated. Age, gender, other c...

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ea0041ep465 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Descriptive observational study of a group of diabetic patients admitted to Hospital Punta De Europa from Gibraltar area health field during the year 2015

Recio Carmen Bautista , Fernandez-Ladreda Mariana Tome , Duarte Daniel Gonzalez

Objectives: The prevalence of diabetic patients admitted in hospitals close to 20% in some series. Our goal is to determine the prevalence of diabetic patients assessed by interclinical calls from different medical and surgical specialties that have been entered during 2015 in our Hospital, in order to describe the characteristics that these diabetic patients.Material and methods: We present 116 patients evaluated by interclinical consultation request fo...

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ea0041ep466 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Influence of hypercalcemia and elevated parathyroid hormone level in the development of type 2 diabetes

Brutskaya-Stempkovskaya Elena , Shepelkevich Alla

Status of carbohydrate metabolism in patients with primary hyperparathyroidism (PGPT) has been studied extensively in recent years, but the results of studies on the impact of long-term elevated levels of parathyroid hormone and hypercalcemia on the risk of type 2 diabetes continues to be in the discussion.Objective: To study is to examine the prevalence of type 2 diabetes in patients with manifested and asymptomatic PGPT.Materials...

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ea0041ep467 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Hypertension in type 2 diabetes mellitus: associated treatment and degree of control

Fernandez-Garcia Jose Carlos , Cortes-Salazar Carmen Maria

Objectives: To evaluate the prevalence of hypertension in patients with type 2 diabetes mellitus (T2DM) and to analyze the clinical characteristics, the degree of achieved control and the associated antihypertensive treatment.Methods: Cross-sectional study which included patients with T2DM followed in a primary care setting. Data about age, sex, associated antihypertensive treatment, systolic blood pressure (SBP) and diastolic blood pressure (DBP) was co...

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ea0041ep468 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Earlier development of diabetes mellitus type 2 as a consequence to psychological and physiological stress

Shaheen Samrah , Akram Maleeha , Jahan Sarwat , Raja Ghazala Kokab , Kazmi Syed Ali Raza , Raza Abida , Naseem Afzaal Ahmed , Qayyum Mazhar , Rizvi Syed Shakeel Raza

Diabetes mellitus type 2 (DM-2) is a disorder characterized by high blood glucose levels in the context of insulin resistance and relative insulin deficiency. DM-2 is typically an outcome of combinations of hereditary elements of impaired insulin release and insulin resistance, and natural variables like obesity, overeating, absence of activity, aging and stress. A number of hormones, such as cortisol and growth (GH), have insulin-antagonistic effects. Cortisol is a predominan...

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ea0041ep469 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The differences in insulin doses and the risk of hypoglycemia in 2 distinct days in the Romania diabetes futsal team

Cosma Daniel-Tudor , Silaghi Alina Cristina , Silaghi Horatiu , Veresiu Ioan Andrei

In type 1 diabetes athletes, the proper adjustments of insulin doses and carbs intake are essential in order to avoid a hypoglycemic event that could affect the sport performances.The aim of the study was to assess the risk of hypoglycemia, the insulin and glycemic variability in 2 different days (with and without physical activity) in a group of nine players with type 1 diabetes, members of the Romania diabetes futsal team (twice European champion)....

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ea0041ep470 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Type 2 diabetes and obesity

Nadira Fafa , Djamila Meskine , Lamia Kedad , Saida Fedala

Introduction: Type 2 diabetes is one of the most common not transmised disease in the world. Obesity is the main risk factor for type 2 diabetes. Both conditions are responsible of a significant increase in morbidity and mortality.The aim of our study was to determine the prevalence of diabetes and fasting hyperglycemia in the general population and to compare this prevalence in obese and non-obese subjects.Methods: This is a descr...

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ea0041ep471 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Prevalence of dyslipidemia screened by Accutrend GCT

Nadira Fafa , Djamila Meskine , Saida Fedala , Lamia Kedad

Introduction: Obesity and especially abdominal obesity is therefore often associated with atherogenic dyslipidemia which lead to cardiovascular complications.The aim of our study was to analyze the distribution of cholesterol and triglycerids and to determine the prevalence of dyslipidemia in the Algerian adult population and their variation depending on the presence or absence of obesity.Methodology: Capillary samples using a vali...

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ea0041ep472 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Patients with type 2 diabetes mellitus have an elevated prevalence of cardiovascular disease

Carlos Fernandez-Garcia Jose , Maria Cortes-Salazar Carmen

Objectives: To evaluate the prevalence of cardiovascular disease (CVD) and associated risk factors in patients with type 2 diabetes mellitus (T2DM) attended in a rural primary care setting.Methods: Cross-sectional study which included patients with T2DM followed in a rural primary care setting. Data about several cardiovascular risk factors was collected (age, sex, smoking, hypertension and dyslipidemia). Also, data about coronary heart disease (CHD) and...

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ea0041ep473 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Insulin secretion several years after type 1 diabetes diagnosis: case reports

Margarida Monteiro Ana , Paredes Silvia , Alves Marta

Introduction: Currently, type 1 diabetes (T1D) is defined by the autoimmune destruction of the pancreatic β cells that culminates in dependence on exogenous insulin, typically 13 years after diagnosis. This ability to maintain a residual function of pancreatic β cells is, however, heterogeneous, appearing to be worst if the disease is early diagnosed. Recently, it was demonstrated that many type 1 diabetic patients produce small amounts of insulin decades after...

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ea0041ep474 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Pregnancy diabetes in a patient with phenylketonuria: when the diet is complicated

Gonzalo Marin Montserrat , Jose Sanchez Torralbo Francisco , Gonzalez Molero Inmaculada , Morillas Jimenez Virginia , Abuin Fernandez Jose , Contreras Bolivar Victoria , Olveira Fuster Gabriel , Tinahones Madueno Francisco

Precedents: Thirty-nine year old Woman. Classic phenylketonuria diagnosed for neonatal screening in Germany. Good adherence to the diet from the infancy, with good metabolic control. Not response to test with BH4.Pregnancy in 2007 with good controls of phenylalanine (Phe). Son with congenital cardiopathy.Evolution: In 2013 she planed new pregnancy, departing from very good controls (<4 mg/dl) and ingestion of 2224 Phe&#14...

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ea0041ep475 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

‘Metabolic endotoxemia’ in the presence and absence of type 2 diabetes mellitus

Egshatyan Lilit , Tkacheva Olga , Boytsov Sergey , Osipov Georgy

Background: Type 2 diabetes mellitus (T2DM) is a condition of multi-factorial origin, involving several molecular mechanisms related to the intestinal micro-biota for its development. The micro-biota able to favor systemic exposure to the lipopolysaccharides (LPS), large glycolipids derived from the outer membrane of Gram-negative bacteria. LPS can cause a condition of metabolic endotoxemia characterized by low-grade inflammation, insulin resistance.<p class="a...

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ea0041ep476 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Mast cell a new player in Type 2 diabetes

Hammdy Nehal , Salam Randa , El Ghaffar Negwa Abd , Mahmoud Eman

Introduction: Mast cells are critical effectors in inflammatory diseases, including cardiovascular and metabolic diseases and their associated complications. These cells exert their physiological and pathological activities by releasing granules containing histamine, cytokines, chemokines, and proteases, including mast cell-specific chymases and tryptases.Aim of the study: To detect the role of mast cell in diabetic obese and correlation to different dia...

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ea0041ep477 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Knowledge, and behaviors of Albanian nurses in primary care toward diabetes mellitus type 2 risk factors reduction

Themeli Alba , Pistja Edmond

Introduction: The rising incidence of diabetes mellitus type 2 in Albania intensifies the need for effective health education for diabetes risk factors reduction among nurses and other health care practitioners.Purpose: The purpose of this study was to develop a description of nurses knowledge about, attitudes toward, practice behaviors related to Diabetes mellitus type 2 risk reduction.Methods: We surveyed 50 primary care nu...

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ea0041ep478 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Evaluation of metabolic parameters of gestational diabetics in postpartum period

Turker Fatih , Ahbab Suleyman , Ataoglu Esra , Cavusoglu Turker Betul , Cakir Evrim

Background: Gestational diabetes mellitus (GDM) is the high blood glucose levels in pregnant women. GDM have high risk for type 2 diabetes mellitus after pregnancy. Therefore, we evaluated postpartum DM frequency and metabolic parameters of the patients who had GDM in this study.Methods: It was enrolled 40 patients, who had high glucose level during fasting or/and after meal and abnormal glucose level during OGTT in 2428 weeks, in endocrinology out...

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ea0041ep479 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

How changed face of gestational diabetes mellitus within 12 years in Turkey

Dinccag Nevin , Idiz Cemile , Ozel Sevda , Gedik Selda , Gul Nurdan , Turker Fulya , Tekin Sakin , Tanrikulu Seher , Hacisahinoglu Hulya , Uzum Ayse

Backgrounds and aims: We aimed to determine final status of carbohydrate (CHO) intolerance of women with GDM who were followed between 3 months and 10 years after delivery.Materials and methods: Two hundred and fourty participants with GDM history were enrolled into study and divided into two groups. [Group I: 40 women (38.0±6.3 years) who had delivery before 11±2 years ago, Group II: 200 women (34.0±5.1 years) who had delivery within 3&#1...

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ea0041ep480 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Does education effect the rates of prophylactic vaccination in elderly diabetics?

Altay Mustafa , Ates Ihsan , Altay Fatma Aybala , Kaplan Mustafa , Akca Omer , Ozkara Adem

Introduction: This study is performed for inspecting vaccination rates in geriatric patients, negatory effects leading to unvaccination and changes occuring in vaccination rates by patient education.Methods: This study is planned in a combination of two formats: retrospectively for determining last 5 years vaccination rates of patients and prospectively for determining the change in vaccination rates after patient education. Totally 579 diabetic pa...

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ea0041ep481 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Influence of obesity and carbohydrate metabolism disorders in GLP-1 levels in women with history of gestational diabetes mellitus

Maraver-Selfa Silvia , Jose Picon-Cesar Maria , Molina-Vega Maria , Mancha-Doblas Isabel , Tinahones-Madueno Francisco

Introduction: There is a reduction of the incretin effect in patients with type 2 diabetes secondary to altered secretion of incretin hormones and/or failed of its action.Objective: To study the GLP-1 secretion pattern after an oral glucose tolerance test (OGTT) in postpartum reassessment of women with previous GDM.Materials and methods: Prospective epidemiological study of 48 women with a history of GDM. We evaluated age, history ...

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ea0041ep482 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Unstable expression of GPRC6A in human pancreatic β-cells

Perego Silvia , Sansoni Veronica , Banfi Giuseppe , Lombardi Giovanni

Introduction: GPRC6A is a widely expressed seven-transmembrane G-protein coupled receptor mediating L-α-amino acids signaling (mainly, arginine, lysine, and ornithine), which has been proposed as receptor for osteocalcin. By interacting with GPRC6A, in β-cells, osteocalcin is thought to modulate the glucose-induced insulin secretion. However, GPRC6A functions have been studied only in rodents or in rodents-derived cells.Aim of th...

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ea0041ep483 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Estimation risk model as a new method of insulin-induced lipohypertrophy diagnostics in diabetic patients

Volkova Natalya , Davidenko Ilya , Porksheyan Maria , Rudakova Julya

Introduction: Lipohypertrophy (LH) is a chronic complication of diabetes mellitus that caused by frequent subcutaneous injections of insulin. Nowadays, LH were modified due to good quality modern insulin and expansion their concentration. As a result, some difficulties of diagnosis were appeared.Design: The aim of this study has been to develop the estimation risk model of insulin induced LH in diabetic patients. This study was done on 140 diabetic patie...

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18th European Congress of Endocrinology

BiosciAbstracts