Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 41 | ECE2016 | Next issue

18th European Congress of Endocrinology

Eposter Presentations

Pituitary - Clinical

ea0041ep870 | Pituitary - Clinical | ECE2016

Association between serum IGF1 levels and liver fat content in patients with pituitary diseases

Petit Jean-Michel , Nguyen Amandine , Ricolfi Frederic , Aho Ludwig-Serge , Bouillet Benjamin , Fourmont Coralie , Loffroy Romaric , Lemaire Stephanie , Cercueil Jean-Pierre , Verges Bruno

Non-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome and type 2 diabetes. NAFLD is also seen in patients with endocrinopathies. However, the relationship between endocrinopathies and the development of NAFLD is not well known. Both GH and IGF1 are believed to be involved in the regulation of hepatic lipid metabolism.Objective: In this study, we set out to determine whether liver fat content (LFC) was associate...

ea0041ep871 | Pituitary - Clinical | ECE2016

Computer vision technology in the diagnosis of Cushing’s syndrome – advanced studies with a cohort matched by body mass index

Popp Kathrin H. , Kosilek Robert P. , Stalla Gunter K. , Stieg Mareike , Berr Christina M. , Reincke Martin , Witt Matthias , Wurtz Rolf P. , Schneider Harald J.

Introduction: Cushing’s syndrome (CS) is a rare disease characterized by clinical features that show overlap with the ‘metabolic syndrome’. Pilot studies regarding the use facial image analysis software as a novel diagnostic tool in acromegaly and CS have shown promising results. Distinguishing CS patients from patients that show similar features without true hypercortisolism remains a challenge in clinical practice. To address this particular problem, we evalua...

ea0041ep872 | Pituitary - Clinical | ECE2016

Endocrinologic outcomes of gamma knife radiosurgery for acromegaly: from an endocrine clinic

Uygur Meliha Melin , Deyneli Oguzhan , Yavuz Dilek Gogas

Although surgical resection is the usual initial treatment for patients with acromegaly, it does not always lead to a remission. Gamma knife radiosurgery (GKRS) is an important additional strategy for unresected clinically active pituitary adenomas.Objective: We evaluated retrospectively pituitary hormone status as well as the efficacy of GKRS for patients with acromegaly referred to our tertiary endocrinology clinic. Prognostic factors related to outcom...

ea0041ep873 | Pituitary - Clinical | ECE2016

Comorbidities and treatment patterns among patients with acromegaly in Sweden : a register-linkage population-based study

Lesen Eva , Granfeldt Daniel , Houchard Aude , Dinet Jerome , Berthon Anthony , Bjorholt Ingela , Johannsson Gudmundur

Introduction: Treatment of patients with acromegaly is complex, including surgery, pharmacotherapy and radiotherapy. The objective was to describe comorbidities and treatment patterns among patients with acromegaly in Sweden.Methods: Population-based study including all patients with a first diagnosis of acromegaly due to a pituitary adenoma in Sweden between 1 Jul 2005 and 31 Dec 2013. Data was obtained via linkage of the National Patient Register, Swed...

ea0041ep874 | Pituitary - Clinical | ECE2016

Discrepant GH and IGF-I values in the evaluation of treated acromegalic patients; an ongoing challenge. A meta-analysis

Kanakis George , Chrisoulidou Alexandra , Bargiota Alexandra , Efstathiadou Zoe , Papanastasiou Lamprini , Theodoropoulou Anastasia , Tigas Stylianos , Vassiliadi Dimitra , Tsagarakis Stylianos , Alevizaki Maria

Purpose: Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-I) are currently the principal biomarkers used to assess disease activity in acromegaly and any discrepancy between them renders interpretation of results inconclusive. The purpose of this study was to assess the frequency of discrepant results and identify parameters that might affect the emergence of this phenomenon.Methods: A systematic review of Medline and Scopus was performed (1987&...

ea0041ep875 | Pituitary - Clinical | ECE2016

Gender aspects in the biochemical control of acromegaly in Austria: evaluation of 607 cases from the Austrian Acromegaly Registry

Vila Greisa , Dobnig Harald , Knosp Engelbert , Schnack Christoph , Franz Holger , Finkenstedt Gerd , Leb Georg , Luger Anton

The Austrian Acromegaly Registry is an initiative of the Austrian Society for Endocrinology and Metabolism. This database includes 607 patients (54% females) followed in twelve centers. Mean treatment period is 10.7 years (range 0–50 years), the total number of patient-years is 6470. Here we report gender-specific differences in the presentation, therapy and biochemical control of acromegaly in patients included in this registry.Mean age at diagnosi...

ea0041ep876 | Pituitary - Clinical | ECE2016

ACRO-POLIS study: differences of symptoms and comorbidities in 472 acromegalic patients according the sex of patients and sources of clinical data

Caron Philippe , Chanson Philippe , Raverot Gerald , Tabarin Antoine , Cailleux Anne , Delemer Brigitte , Renoult Peggy Pierre , Houchard Aude , Cloitre Pauline , Brue Thierry

Introduction: Acromegaly is characterized by excessive secretion of GH and increased IGF-1 levels caused by benign pituitary adenoma. The ACRO-POLIS study describes symptoms and comorbidities of acromegaly at diagnosis in a large cohort of patients diagnosed between 2009 and 2014 in France.Methodology: Observational, cross-sectional, multicentre study included adult patients with acromegaly diagnosed for less than 5 years. Data were collected retrospecti...

ea0041ep877 | Pituitary - Clinical | ECE2016

“The incidence of central adrenal insufficiency in euvolaemic hyponatraemia. Results of a large prospective study”

Cuesta Martin , Slattery David , Garrahy Aoife , Hannon Anne Marie , Tatro Elizabeth , Gupta Saket , Sherlock Mark , Tormey William , Thompson Christopher J

Context: The syndrome of inappropriate antidiuresis(SIAD) is the commonest cause of hyponatraemia. Data on the aetiology of SIAD is mainly derived from retrospective studies, often with poor ascertainment of minimum criteria for correct diagnosis. Although central adrenal insufficiency(CAI) is known to cause euvolaemic hyponatraemia, the incidence of undiagnosed CAI in SIAD is unknown.Objective: To establish the incidence of CAI in SIAD.<p class="abs...

ea0041ep878 | Pituitary - Clinical | ECE2016

Perioperative plasma cortisol levels during transsphenoidal operation of pituitary adenoma in ACTH sufficiency and deficiency

Borg Henrik , Fjalldal Sigridur , Siesjo Peter , Kahlon Babar , Erfurth Eva Marie

Introduction: The demand of cortisol rises during stress and to avoid acute cortisol deficiency, patients undergoing transsphenoidal surgery at Skåne University Hospital (Sweden) receive peri- and postoperative substitution with hydrocortisone (HC), even at normal ACTH function. Some anesthetics are known to affect cortisol levels.This study aimed to assess the perioperative cortisol plasma levels during transsphenoidal surgery in ACTH sufficient an...

ea0041ep879 | Pituitary - Clinical | ECE2016

Does vitamin D status correlate with cardiometabolic risk factors in adults with growth hormone deficiency?

Uzunova Ivayla , Kirilov Georgi , Zacharieva Sabina , Zlatareva Naydenka , Kalinov Krassimir

Introduction: Apart from being individually associated with cardiometabolic health, Vitamin D and growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis are reported to interplay, with a positive correlation between IGF-1 and 25-hydroxyvitamin D (25(OH)D). These findings raise questions about the role of vitamin D for the adverse cardiovascular (CV) risk profile in hyposomatotropism. Thus, the aim of our study was to investigate the association between 25(OH)D and metabol...

ea0041ep880 | Pituitary - Clinical | ECE2016

Predictive factors of surgical outcomes in acromegaly: what’s new in 2016?

Lapoirie Marion , Vasiljevic Alexandre , Rabilloud Muriel , Lapras Veronique , Chinezu Laura , Trouillas Jacqueline , Jouanneau Emmanuel , Raverot Gerald

Introduction: In the era of personalized patient management in acromegaly, transsphenoidal surgery remains a treatment of choice in cases where surgical cure can be expected. In order to better target these patients and to assess the risk of persistence/progression disease, we evaluated clinical, hormonal, radiological and pathological predictors of surgical outcome in acromegaly.Methods: A single-institution retrospective study from 2009 to 2015 was per...

ea0041ep881 | Pituitary - Clinical | ECE2016

Outcomes of surgically treated nonfunctioning pituitary adenomas

Gruppetta Mark , Vassallo Josanne

Introduction: The sequelae of surgically treated non-functioning pituitary adenomas (NFPA) is an important area of study to help plan management. The aim was to study all Maltese patients who had a surgically treated NFPA and analyse the results of surgery, risk factors for tumour recurrence/regrowth and the role of postoperative radiotherapy.Materials and methods: One hundred and seventy-five patients were identified as having a NFPA of whom 77 had unde...

ea0041ep882 | Pituitary - Clinical | ECE2016

Metabolic state in ACTH insufficient & ACTH sufficient patients with hypopituitarism not treated for growth hormone deficiency (GHD): a comparative study

Miljic Dragana , Pekic Sandra , Doknic Mirjana , Stojanovic Marko , Petakov Milan , Popovic Vera

Background: Inadequate glucocorticoid (GC) replacement may be associated with overexposure to GC, which can adversely influence metabolic and cardio-vascular state of hypopituitary growth hormone deficient adult patients (A-GHD). In this study we compared metabolic profile of ACTH insufficient and sufficient patients in A-GHD not treated with GH.Patients and methods: A cohort of 260 patients (age 48.6±12 years and BMI 28.7±6.6 kg/m2)...

ea0041ep883 | Pituitary - Clinical | ECE2016

Disease activity and lifestyle influence the occurrence of cardiovascular risk factors and cardiovascular events in acromegaly

Sardella Chiara , Cappellani Daniele , Urbani Claudio , Manetti Luca , Marconcini Giulia , Tomisti Luca , Lupi Isabella , Rossi Giuseppe , Scattina Ilaria , Lombardi Martina , Di Bello Vitantonio , Marcocci Claudio , Martino Enio , Bogazzi Fausto

Context: Acromegalic patients have a high-risk cardiovascular profile. However, the determinants of cardiovascular risk factors and major cardiovascular events (MACE), which may develop after diagnosis of acromegaly, are not fully understood.Objectives: To identify the predictors for systemic comorbidities and MACE, after diagnosis of disease. The role of therapy for acromegaly on the occurrence of such complications was also evaluated.<p class="abst...

ea0041ep884 | Pituitary - Clinical | ECE2016

Hyperprolactinaemia causes and manifestation in outpatient practice

Zabuliene Lina , Petraviciute Modesta , Pauliukiene Birute , Audrone Bagdziuniene Airida , Urboniene Jurgita

Hyperprolactinaemia is a common endocrine disorder. Causes are related to physiological factors, pharmacological intervention and pathological conditions. There are a wide variety of drugs that can induce a significant hyperprolactinaemia frequently associated with clinical symptoms. The aim was to analyse clinical manifestation of hyperprolactinaemia in routine clinical practice.Material and methods: We conducted retrospective review of medical records ...

ea0041ep885 | Pituitary - Clinical | ECE2016

What is the outcome of nonfunctioning pituitary adenomas (NFPAs) after surgery and are there any factors to predict it: a multicenter study in Northern Spain

Galiana Rodriguez Caballero Maria , Valdes Gallego Nuria , Ares Jessica , Larranaga Ihintza , Hernandez Morhain Cecilia , Ollero Dolores , Gaztambide Sonia , Isasa Leire , Forga Lluis , Mouritz Marta , Suarez Lorena , Rodriguez Rosa , Corte Daniela , Delgado Elias , Sanchez Ragnarsson Cecilia , Suarez Lorena , Cacho Laura , Pertierra Joaquin , Rabal Antonio , Menendez Edelmiro

Introduction: There is scarcity of data on the recurrence and/or progression (R/P) rate in nonfunctioning pituitary adenomas (NFPAs) after surgery and the risk factors that can predict this outcome. So the aim of this study was to analyze a large series of NFPAs with a long follow-up after surgery, focusing on the evaluation of R/P rate and the risk factors associated with it.Methods: Retrospective cohort analysis of 164 patients with NFPAs from 3 differ...

ea0041ep886 | Pituitary - Clinical | ECE2016

Radiological vertebral fractures in patients with acromegaly treated with L-thyroxine

Maffezzoni Filippo , Frara Stefano , Maria Formenti Anna , Mezzone Monica , Cerri Luigi , Porcelli Teresa , Doglietto Francesco , Maroldi Roberto , Mazziotti Gherardo , Giustina Andrea

Acromegaly is associated with skeletal fragility and high risk of vertebral fractures (VFs), but the determinants of such a risk are still under investigation and it is not clear whether replacement therapies of coexistent hypopituitarism may influence prevalence and incidence of VFs. In this cross sectional study, fourty acromegaly patients (24 M, 16 F; median age, 57 years; range, 25–72), 20 with active disease, were evaluated for the effects of replacement therapy of c...

ea0041ep887 | Pituitary - Clinical | ECE2016

Long-term (19-month) control of urinary free cortisol with osilodrostat in patients with Cushing’s disease: results from an extension to the LINC-2 study

Pivonello Rosario , Hatipoglu Betul , Bertagna Xavier , Fleseriu Maria , Molitch Mark E , Shimizu Chikara , Tanaka Tomoaki , Shimatsu Akira , Biller Beverly M K , Ravichandran Shoba , Kandra Albert , Sauter Nicholas , Young Jacques

Introduction: During the 22-week LINC-2 study, the potent oral 11β-hydroxylase inhibitor osilodrostat normalized UFC in 15/19 (78.9%) patients with Cushing’s disease. Most common AEs were nausea, diarrhoea, asthenia, and adrenal insufficiency. This report describes 19-month results following an extension.Methods: Patients who were receiving clinical benefit at week 22 could enter the extension. Efficacy/safety is reported for patients who enter...

ea0041ep888 | Pituitary - Clinical | ECE2016

Evaluation of endothelial function and insulin sensitivity in patients with prolactinoma

Buket Bayram F , Tekin Bahar , Gogas Yavuz Dilek

Objective: Hyperprolactinemia has been reported to be associated with endothelial dysfunction, abnormalities of carbohydrate metabolism and insulin sensitivity. The aim of this study was to evaluate carbohydrate metabolism and endothelial function of our patients in outpatient clinics.Material and methods: In this cross-sectional study, currently or previously treated 87 hyperprolactinemic patients with PRL-secreting adenoma (fifty four with microadenoma...

ea0041ep889 | Pituitary - Clinical | ECE2016

Combined treatment with octreotide LAR and pegvisomant in patients with gigantism – acromegaly: clinical evaluation and genetic screening

Rostomyan Liliya , Mangupli Ruth , Castermans Emilie , Caberg Jean-Hubert , Camperos Paul , Cuauro Elvia , Bours Vincent , Daly Adrian F , Beckers Albert

Pituitary gigantism is a rare condition caused by growth hormone secreting lesions, where treatment is usually challenging, especially in cases with genetic predisposition. Aim: We studied a gigantism cohort from Venezuela for genetic defects and their response to treatment. Subjects: 160 somatotropinoma patients were evaluated at the University hospital (from 1985–2015); eight (6M) were diagnosed with acrogigantism and underwent genetic analysis including aCGH for Xq26.3...

ea0041ep890 | Pituitary - Clinical | ECE2016

High incidence of thyroid cancer among patients with acromegaly

Kaldrymidis Dimitrios , Papadakis Georgios , Tsakonas Georgios , Kaldrymidis Philippos , Flaskas Theofanis , Seretis Andreas , Pantazi Eleni , Kostoglou-Athanassiou Ifigenia , Peppa Melpomeni , Roussou Paraskevi , Diamanti-Kandarakis Evanthia

Introduction: Several studies have suggested that patients with acromegaly have an increased risk of thyroid, colorectal, breast and prostate tumors. We determined the prevalence of malignant neoplasms in patients with acromegaly in a single Greek Centre during the years 1995–2015.Methods: We evaluated cancer risk in a cohort of 110 patients (M/F 48/62, age 58.63±13.8 years, range 30–86) with acromegaly. Mean age at diagnosis of acromegaly...

ea0041ep891 | Pituitary - Clinical | ECE2016

Non-alcoholic fatty liver disease in patients with biochemically cured Cushing’s disease and non-functioning pituitary adenomas: role of adrenal insufficiency and growth hormone deficiency

Auer Matthias K , Stieg Mareike R , Stalla Gunter K

Objective: Nonalcoholic fatty liver disease (NAFLD) is a hallmark of the metabolic syndrome and has been shown to be an independent predictor of cardiovascular mortality. Although glucocorticoids and growth hormone are known to be implicated in its pathophysiology, it has only rarely been investigated in the context of patients with pituitary insufficiency or former cortisol excess.Design: Case-control study, including patients with biochemically control...

ea0041ep892 | Pituitary - Clinical | ECE2016

Early water intake restriction to prevent inappropriate antidiuretic hormone secretion following transsphenoidal surgery: low BMI predicts postoperative SIADH

Matsuyama Junko

Objective: The goals of this study were to assess the incidence of and risk factors for syndrome of inappropriate antidiuretic hormone secretion (SIADH) in patients following transsphenoidal surgery (TSS), and to validate the effectiveness of early prophylactic restriction of water intake.Design: Retrospective analysis was performed for 207 patients who had undergone TSS, including 156 patients not placed on early prophylactic water restriction. Sixty-fo...

ea0041ep893 | Pituitary - Clinical | ECE2016

Evaluation of pituitary functions in patients with traumatic maxillofacial fractures: preliminary results

Onur Daloglu Osman , Alper Kemaloglu C , Tanriverdi Fatih , Coruh Atilla , Ozyazgan Irfan , Karaca Zuleyha , Unluhizarci Kursad , Kelestimur Fahrettin

Introduction: Traumatic brain injury (TBI) is a worldwide public health problem and has been recently documented as a cause of neuroendocrine dysfunction. It has been shown that hypopituitarism may develop nearly 10–20% of the TBI patients, and most common pituitary hormone deficiency after TBI is growth hormone deficiency (GHD). To date no study has evaluated the relation between isolated maxillofacial fractures and pituitary dysfunction. Therefore we aimed to investigat...

ea0041ep894 | Pituitary - Clinical | ECE2016

Cardiac tissue Doppler echocardiographic evaluation of patients with prolactinoma treated with cabergoline

Arikan Durmaz Senay , Rasid Tasdelen Mustafa , Yildirim Nesligul , Cifci Aydin , Gungunes Askin

Introduction and aim: There are few side effects of cabergoline which is used for medical treatment of prolactinoma. For this reason, cabergoline is considered as first-line therapy of prolactinoma. However, chronic administration of high dose cabergoline in patients with prolactinoma may be associated with valvular heart disease. The aim of this study is to evaluate left ventricular systolic and diastolic functions by conventional and tissue Doppler echocardiography in patien...

ea0041ep895 | Pituitary - Clinical | ECE2016

Preoperative markers of Cushing’s disease remission after transsphenoidal endoscopic surgery

Gussaova Natalya , Tsoy Ulyana , Cherebllo Vladislav , Dalmatova Anna , Belousova Lidiya , Solntsev Vladislav , Grineva Elena

Purpose: Transsphenoidal endoscopic surgery (TSS) is the first-line treatment for Cushing’s disease (CD). However, persistence and recurrence of hypercortisolism after TSS considered important problem. In this case search for CD remission predictors is actual.Aim: To study the role of preoperative oral high-dose dexamethasone suppression test (HDDST) and pituitary MRI in the prognosis of CD remission after TSS.Materials and me...

ea0041ep896 | Pituitary - Clinical | ECE2016

Hypertension in acromegaly patients with obstructive sleep apnea

Tsoy Uliana , Korostovtseva Ljudmila , Sviryaev Yurij , Semenov Andrej , Vaulina Darya , Kravchenko Svetlana , Konradi Alexandra , Grineva Elena

Purpose: Hypertension is an independent factor of cardiovascular morbidity in acromegaly patients. Obstructive sleep disordered breathing (SDB) is the most common respiratory impairment in acromegaly and is considered one of the mechanisms underlying the development of hypertension in this disorder.Aim: To study blood pressure parameters and prevalence of hypertension in naïve acromegaly patients depending on the presence of moderate-to-severe obstr...

ea0041ep897 | Pituitary - Clinical | ECE2016

Cabergoline treatment in prolactinoma may not relate with dyslipidemia

Arikan Durmaz Senay , Carlioglu Ayse , Rasid Tasdelen Mustafa , Cifci Aydin , Gungunes Askin , Kalan Isilay

Introduction and aim: The metabolic changes of lipid profiles in prolactinoma treated with cabergoline are not completely clarified. The aim of this preliminary study is to evaluate changes of lipid profile in both of patients with functional hyperprolactinemia and prolactinoma before and after cabergoline treatment.Materials and methods: Twelve patients with prolactinoma who were treated with cabergoline (mean age 33.8±7.6 years and body mass index...

ea0041ep898 | Pituitary - Clinical | ECE2016

Decreased skin capacitance and elasticity may be reversible after treatment of Cushing’s syndrome

Karaca Zuleyha , Tarik Firat Sedat , Borlu Murat , Tanriverdi Fatih , Unluhizarci Kursad , Kelestimur Fahrettin

Background: Acne, stria and decreased skin elasticity are dermatological features of Cushing’s syndrome (CS). Although it is known that collagen mass in skin is decreased in CS and glucocorticoids play a role in acneiform skin lesions, the dermatological findings of CS has not previously been measured by reliable methods.Objective: The aim of the present study was to measure skin elasticity, capacitance, sebum content, pH and temperature in CS befor...

ea0041ep899 | Pituitary - Clinical | ECE2016

Surgical Treatment and outcome of TSH-producing pituitary adenoma

Burkhardt Till , Rotermund Roman , Sauer Nina , Matschke Jakob , Schmidt Nils-Ole , Flitsch Jorg

Objectives: TSH-producing pituitary adenomas account for 1–2% of all pituitary tumors and there is debate wether transsphenoidal surgery or medical treatment should be recommended as first-line treatment. This study summarizes the authors surgical experience and puts it into context of literature concerning non-surgical treatment of TSHomas.Methods: A retrospective analysis of 12 patients including imaging, laboratory testing, short-term and long-te...

ea0041ep900 | Pituitary - Clinical | ECE2016

Impact of the GH-receptor antagonist pegvisomant on mammographic breast density in postmenopausal acromegalic women

Muhammad Ammar , Ficarra Gianluca , Franck Sanne , Nazarri Elena , Tagliafico Alberto , Neggers Sebastian , Ferone Diego , Gatto Federico

Background: Acromegaly is a severe systemic condition characterized by elevated circulating levels of growth hormone (GH) and insulin-like growth factor I (IGF-I) and increased mortality and morbidity. The role of GH and IGF-I in mammary hyperplasia is well established and GH/IGF-I elevation has been hypothesized to favor neoplastic development. We recently demonstrated that premenopausal females with active acromegaly may display an increased mammographic breast density (MBD)...

ea0041ep901 | Pituitary - Clinical | ECE2016

High burden of illness at baseline in patients with uncontrolled acromegaly participating in the PAOLA study

Shimon Ilan , Raverot Gerald , Coculescu Mihail , Bolanowski Marek , Colao Annamaria , Kandra Albert , Resendiz Karina Hermosillo , Pedroncelli Alberto M , Gadelha Monica

Background: The Phase III PAOLA study assessed the efficacy and safety of pasireotide LAR versus continued treatment with octreotide LAR or lanreotide Autogel in patients with uncontrolled acromegaly. The current analysis investigated overall baseline characteristics and response rates to pasireotide according to co-morbidities.Methods: Patients were classified into five groups of co-morbidities related to acromegaly: glucose- (n=104), endocrine...

ea0041ep902 | Pituitary - Clinical | ECE2016

Craniopharyngiomas–35 years of experience in a central hospital’s Endocrinology Department

Oliveira Diana , Paiva Isabel , Guelho Daniela , Cardoso Luis , Vicente Nuno , Martins Diana , Lages Adriana , Ventura Mara , Paiva Sandra , Carrilho Francisco

Introduction: Craniopharyngiomas are rare epithelial tumors of the sellar and parasellar region, with high survival rates but with frequent tumor recurrence or persistence.Methods: Information collection from clinical records and review of the epidemiology, diagnosis, treatment and follow-up of patients with diagnosis of craniopharyngioma followed in an Endocrinology Department between 1980 and 2015. Statistical analysis using SPSS v. 22.0.<p class="...

ea0041ep903 | Pituitary - Clinical | ECE2016

Acromegalic cardiomyopathy: echocardiographic and CMR analysis

Casara Alvise , Dassie Francesca , Battocchio Marialberta , Parolin Matteo , Martini Chiara , De Carlo Eugenio , Mioni Roberto , Famoso Giulia , Tona Francesco , Fallo Francesco , Vettor Roberto , Corbetti Francesco , Maffei Pietro

Introduction: Acromegalic cardiomyopathy is characterized by myocardial hypertrophy and interstitial myocardial fibrosis at biopsy. We studied left ventricular hypertrophy -LVH- through echocardiography (-ECHO- 2-D standard echocardiography and Doppler analysis) and cardiac magnetic resonance (CMR) analysis. Myocardial fibrosis was studied with late enhancement technique (LE) and extracellular volume technique (ECV) at CMR.Methods: 25 patients -pts- (13 ...

ea0041ep904 | Pituitary - Clinical | ECE2016

Subarachnoid haemorrhage results in poor quality of life independent of pituitary hormone concentrations

Nagras Zainab , Klose Marianne , Poulsgaard Lars , Kosteljanetz Michael , Brennum Jannick , Feldt-Rasmussen Ulla

Introduction: Subarachnoid haemorrhage (SAH) is associated with a mortality rate of 30% and the survivors face significant morbidity including fatigue, isolation, depression and sleep disorders; factors affecting general health related quality of life (QoL). QoL is also known to be decreased in pituitary-hypothalamic insufficiency and tends to improve after treatment. SAH has been suggested to be a common cause of hypopituitarism by some whereas not by others. We aimed to inve...

ea0041ep905 | Pituitary - Clinical | ECE2016

Incidental finding of “Empty Sella” and prevalence of endocrine disturbances – a systematic review

Stieg Mareike , Auer Matthias , Stalla Gunter K , Kopczak Anna

Neuroimaging techniques have improved over the last years; hence an “empty sella” is more often incidentally diagnosed. The term “empty sella” describes a missing pituitary gland in the sella turcica. Up to now, it is not known if routine endocrine assessment is necessary in patients with primary empty sella syndrome (PES) without clinical suspicion or history of neuroendocrine disorders.We performed a systematic literature research u...

ea0041ep906 | Pituitary - Clinical | ECE2016

Quality of life in patients with acromegaly and the effect of somatostatin analogues

Kaldrymidis Dimitrios , Papadakis Georgios , Tsakonas Georgios , Kostoglou-Athanassiou Ifigenia , Kaldrymidis Philippos , Peppa Melpomeni , Roussou Paraskevi , Diamanti-Kandarakis Evanthia

Objective: Quality of life is currently considered a major factor in the assessment of disease outcome. The aim was to assess quality of life in acromegaly and the effect of somatostatin analogues on it.Design: This study included 101 patients with acromegaly, mean age 59.51±1.35 years (mean ± S.E.M.), with a disease duration of 12.88±0.96 years. All subjects completed the Acromegaly Quality of Life Questionnaire (AcroQoL) w...

ea0041ep907 | Pituitary - Clinical | ECE2016

Serum N-terminal pro brain natriuretic peptide level in patients with prolactinoma who were treated with caborgoline

Tasdelen Mustafa Rasid , Durmaz Senay Arikan , Yildirim Nesligul , Koc Eyup

Introduction and aim: Cabergoline, a long-lasting dopamine-agonist, is generally considered to be the safety drug for the treatment of prolactinoma. But, use of long time and high dose cabergoline may be a cause of cardiac valvulopathy in patient with prolactinoma. In present study, we aim to determine serum N-terminal probrain natriuretic peptide levels in patients with prolactinoma who were treated with cabergoline.Materials and methods: Thirty patient...

ea0041ep908 | Pituitary - Clinical | ECE2016

Vitamin D status of adults with growth hormone deficiency

Uzunova Ivayla , Kirilov Georgi , Zacharieva Sabina , Kalinov Krassimir

Introduction: Vitamin D and growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis are reported to interplay at both endocrine and paracrine levels, with a positive correlation between IGF-1 and 25-hydroxyvitamin D (25(OH)D) in healthy subjects. Hyposomatotropism is among the conditions predisposing to lower vitamin D status due to several direct and indirect mechanisms. Thus, the aim of our study was to evaluate vitamin D status in a representative sample of adults with ...

ea0041ep909 | Pituitary - Clinical | ECE2016

Renal function in acromegaly – experience from a portuguese centre

Bello Carlos Tavares , Fonseca Ricardo , Santos Francisco Sousa , Capitao Ricardo , Duarte Joao Sequeira , Vasconcelos Carlos

Introduction: The Nephron is a known target organ of the Growth Hormone/Insulin-like factor-1 axis. They influence glomerular and tubular function having an important physiological role in water and electrolyte balance, especially in Acromegaly. The aim of the study was to investigate renal function in acromegalic patients during active disease and remission and evaluate hormonal impact on renal function markers.Methods: A retrospective, longitudinal, ob...

ea0041ep910 | Pituitary - Clinical | ECE2016

High mean platelet volume in prolactinoma treated with cabergoline

Durmaz Senay Arikan , Tasdelen Mustafa Rasid , Carlioglu Ayse , Cifci Aydin , Gungunes Askin

Introduction and aim: Mean platelet volume (MPV) is a new important indicator of platelet activity in atherosclerosis. Elevated MPV is associated with the presence of more metabolically active platelets. The aim of our study is to evaluate whether change of MPV value is associated with cabergoline treatment in patients with prolactinoma.Materials and methods: Thirty patients with prolactinoma (mean age 33.4±8.5 years and body mass index (BMI): 28.1&...

ea0041ep911 | Pituitary - Clinical | ECE2016

Serum cortisol in the early post operative period after transphenoidal surgery to predict adrenal insufficiency

Gonzalez-Molero Inmaculada , Gonzalo-Marin Monserrat , Selfa Silvia Maraver , Garcia Laura Gonzalez , Naghib Rida , Romero Stella Gonzalez , Arnes Juan Garcia , Arraez Miguel Angel , Tinahones Francisco

Adrenal insufficiency is a common complication of transsphenoidal surgery (TSS) for pituitary adenoma. It is very important to identify patients requiring glucocorticoid replacement, minimising risks of adrenal insufficiency.Aim: To assess the performance of early (3° day) post-TSS 08:00 a.m. cortisol measurement to detect and exclude secondary adrenal insufficiency.Methods: We selected patients undergoing TSS in our hospital ...

ea0041ep912 | Pituitary - Clinical | ECE2016

A neurosarcoidosis case with pituitary stalk involvement manifesting as hypogonadism and hyperprolactinemia

Nar Asli , Iyidir Ozlem Turhan , Firat Sevde Nur , Tutuncu Neslihan Bascil

Sarcoidosis is a multisystem granulomatous disease of unknown cause. The prevalence of neurosarcoidosis is about 5–15%. Hypothalamo-pituitary sarcoidosis is even rarer (<1% of cases evaluated for sellar and stalk lesions).Case Report: A 33-year-old man presented to urology department with erectile dysfunction which started six months ago. Hormonal evaluation revealed gonadotropin deficiency and hyperprolactinemia (Total testosterone: 30.5 ng/dl,...

ea0041ep913 | Pituitary - Clinical | ECE2016

An attempt to prepare local Guidelines for Management of Syndrome of Inappropriate ADH Secretion (SIADH) in a District General Hospital in the UK

Talapatra Avraneel , O'Connell Ian , Talapatra Indrajit

Aim: To establish the local Guidelines for management of SIADH.Methods: The European and NIH Guidelines are considered.Discussion: Diagnosis: Patients admitted with hyponatraemia are first assessed clinically for their hydration status. Those who are euvolaemic should have their urine sodium checked (if <30 mmol/l, hypothyroidism is suspected and if >30 mmol/l either SIADH or Addison’s disease is suspected). Hypothyroi...

ea0041ep914 | Pituitary - Clinical | ECE2016

The association between adenoma size classification and the hormone hypersecretion in acromegaly

Soares Luana F , Outuki Giovana , Ludwig Natasha G , Miksza Daniele R , Fiorenzano Gracielle R , Mattos Alexandro Marcio S , Carrilho Alexandre J F , Mazzuco Tania L

Introduction: Acromegaly is a chronic disease caused by growth hormone (GH) oversecretion. A pituitary macroadenoma is found in mostly of cases, but the secretion pattern of GH and insulin-like growth factor 1 (IGF-1) and the natural history of somatotropinomas are heterogeneous. The objective of the present study was to evaluate the relationship between tumor size, GH and IGF-1 levels in patients diagnosed with acromegaly.Methods: A cross-sectional, obs...

ea0041ep915 | Pituitary - Clinical | ECE2016

Prolactin measurements improve the diagnostic accuracy of inferior petrosal sinus sampling

Uygur Meliha Melin , Yasar Mehmet , Deyneli Oguzhan , Yavuz Dilek Gogas

Introduction: Inferior petrosal sinus sampling for ACTH is the current gold standard test for the differentiation of pituitary Cushing disease from the ectopic ACTH syndrome. Early studies with İPSS reported a diagnostic sensitive and specificity approaching 100%, additional experience has shown a false negative rate of 1-10%. This has been due to either technical problem with unsuccessful petrosal sinus catheterization or anomalous venous drainage of the pituitary. The ...

ea0041ep916 | Pituitary - Clinical | ECE2016

Acromegaly: is there a need for colorectal cancer screening?

Wang Yawen , Hammersen Stefanie , Moskopp Dag

Objective: Acromegaly is characterized by chronic hypersecretion of growth hormone (GH) with increased concentration of IGF-1. There have been controversial debates over the question whether elevated GH levels indicate high risk of developing colorectal neoplasm. There is no clear guideline indicating the need for colorectal cancer screening for acromegalics. We evaluated the colonoscopic findings in our series of patients to analyze the prevalence of risk. Should patients wit...

ea0041ep917 | Pituitary - Clinical | ECE2016

The role of p16 and MDM2 gene polymorphisms in tumorigenesis and characteristics of prolactinoma

Turgut Seda , Ilhan Muzaffer , Turan Saime , Karaman Ozcan , Yaylim Ilhan , Kucukhuseyin Ozlem , Tasan Ertugrul

Introduction: Prolactinomas are thought to arise from the proliferation of a mutated pituitary stem cell which is subjected to the growth stimuli of several permissive factors, although the pathogenetic mechanisms underlying the tumorigenesis still remain unclear. The present study aimed to investigate the role of p16 (540C→G and 580C→T) and MDM2 (SNP309T→G) gene polymorphisms in tumorigenesis and characteristics of prolactinoma.Methods...

ea0041ep918 | Pituitary - Clinical | ECE2016

Clinical proofs for necessity of macroprolactinemia screening

Ilovayskaya Irena , Dreval Alexander , Krivosheeva Yulia , Osipova Tatiana

Prevalence of macroprolactin in serum (>40%) can be a cause of asymptomatic hyperprolactinemia. However, there is still lack of evidence how to manage with symptomatic patients with macroprolactinemia.We analyzed clinical data and monomeric prolactin levels in 85 women of reproductive age with hyperprolactinemia: NonTumor hyperprolactinemia (NT, n=31), MIcroadenomas (MI, n=32), MAcroadenomas (MA, n=22). Prolactin levels 171...

ea0041ep919 | Pituitary - Clinical | ECE2016

Cardiovascular effects of obstructive sleep apnea syndrome (OSAS) on acromegaly

Karaca Zuleyha , Dogan Hatice , Ismailogullari Sevda , Kalay Nihat , Tanriverdi Fatih , Unluhizarci Kursad , Caglar Asli Sezgin , Kelestimur Fahrettin

Introduction: Acromegaly is known to be associated with obstructive sleep apnea syndrome (OSAS) in about 60–70% of the cases. Both OSAS and acromegaly are thought to be responsible from cardiovascular diseases and endothelial dysfunction. The aim of the present study was to investigate the role of OSAS on cardiovascular effects of acromegaly.Materials and Methods: 25 patients with acromegaly and 7 healthy volunteers were enrolled into the study. Car...

ea0041ep920 | Pituitary - Clinical | ECE2016

Fatigue and subjective complaints in patients with active and controlled acromegaly: a cross sectional multi-center study

Zimmermann Anca , Zwerenz Rudiger , Droste Michael , Schofl Christof , Strasburger Christian J , Plockinger Ursula , Honegger Jurgen , Millaku Bledar , Beutel Manfred E , Weber Matthias M

Introduction: Acromegalic patients (AP) often report fatigue and chronic subjective complaints. We aimed to investigate in more detail these aspects in AP, dependent on disease activity, age, gender, medication and pituitary insufficiency (PI).Patients/methods: Cross sectional, 124 patients (M/W 51/73, age 58.3±14.7 years, 49/75–active/controlled disease). The patients completed the Multidimensional Fatigue Inventory (MFI-20) and the Giessen Su...

ea0041ep921 | Pituitary - Clinical | ECE2016

Quality of life, neurocognitive status and frequency of hypopituitarism following brain injury

Meriem Bensalah , Mustapha Nebal , Lyes Cherfi , Benaissa Abdenebi , Mustapha Guenane , Zahra Kemali , Samia Ould Kablia

Background: Post traumatic Hypopituitarism (PTHP) is common, its prevalence is about 30%.Aim: The aim is firstly to assess the frequency and predictive factors of hypopituitarism 3 and 12 months following Brain injury (BI) in a simple of 133 victims of moderate to severe BI in two neighbors’ hospitals in the east of Algiers. Secondly is to evaluate the quality of life and neurocognitive status of this cohort.Method: Hypopituit...

ea0041ep922 | Pituitary - Clinical | ECE2016

Clinical characteristics of giant pituitary adenomas

Ilovayskaya Irena , Dreval Alexander , Krivosheeva Yulia , Stashuk Galina

Our Pituitary Tumour Registry includes data about 346 patients with pituitary macroadenomas: 142 non-functional adenomas (NFA) including 18 (12.7%) giant, 62 macroprolactinomas – 6 (9.7%) giant, 141 somatotropinomas – 6 (4.3%) giant. We analysed clinical features of these 30 giant pituitary tumors (<40 mm at least one of the sizes): 18 NFA (11 Females; 7 Males), 6 prolactinomas (3 Females; 3 Males), 6 somatotropinomas (3 Females; 3 Males). Patients with giant NFA...

ea0041ep923 | Pituitary - Clinical | ECE2016

Recurrent meningitis secondary to medically induced CSF leakage in the setting of a pituitary macroprolactinoma

Yahia Seifeldin , Page Simon

A 49 year old gentleman was diagnosed with a pituitary macroprolactinoma at Leicester Royal Infirmary (LRI) (Baseline prolactin 8000 mU/l). He was treated with Cabergoline 0.5 mg twice/week. He developed CSF rhinorrhoea shortly after treatment was commenced and was listed for repair under the neurosurgical team at Queen’s Medical Centre (QMC). Six weeks later, while visiting Wales, he was admitted to Bangor hospital with headaches and vomiting. CSF cultures were positive ...

ea0041ep924 | Pituitary - Clinical | ECE2016

Coexidence of neuroendocrine tumor of the lung and pituitary adenoma – pitfalls in diagnosing acromegaly - case report

Sztembis Joanna , Orłowska-Florek Renata , Świder Grzegorz

Acromegaly is caused by growth hormone-secreting adenoma in more then 95% cases. Ectopic secretion of GH-RH is a rare cause of acromegaly accounting for less than 1% of all cases. The most frequent source of ectopic GHRH is bronchial carcinoid. Clinical and biochemical findings are similar in both conditions. A distinction of pituitary vs extrapituitary acromegaly is important in planning effective management and both reasons should be considered in the diagnostic process....

ea0041ep925 | Pituitary - Clinical | ECE2016

Macroprolactinemia: prevalence and clinical characteristics in a cohort of hyperprolactinemic patients assessed for macroprolactinemia

Prokop Joanna , Santo Raquel Espirito , Sabino Teresa , Godinho Conceicao , Agapito Ana

Macroprolactin is a collective term for a heterogenous group of high molecular mass forms of prolactin with minimal bioactivity in vivo. Objective: to determine prevalence of macroprolactinemia (macroPRL) and clinical characteristics of patients with hyperprolactinemia (hyperPRL) who underwent assessment for macroPRL in Endocrinology outpatient clinic.Methods: We reviewed the medical records of 54 patients who were evaluated for macroPRL between...

ea0041ep926 | Pituitary - Clinical | ECE2016

Pituitary tuberculosis: a cause of giant cell granulomatous hypophysitis presented with hypopituitarism

Nasiroglu Imga Narin , Demir Onal Eda , Kahraman Ercan , Berker Dilek , Guler Serdar

Introduction: Giant cell granulomatous hypophysitis is a rare chronic inflammatory disorder of the pituitary gland. It is generally presents with a clinic of sellar mass lesion with pituitary insufficiency. Histologically it is characterized by composites of histiocytes, plasma cells and giant cells with or without areas of necrosis. Tuberculosis is a very rare cause of secondary granulomatous hypophysitis. We report a case presented with hypopituitarism symptoms due to tuberc...

ea0041ep927 | Pituitary - Clinical | ECE2016

Results of transsphenoidal surgery and somatostatin analogues therapies and their combination in acromegaly

Trigolosova Irina , Dreval Alexander , Panteleeva Evgenia , Molchanova Galina , Chikh Irina

Introduction: Data on transsphenoidal surgery (TSS) and effect of somatostatin analog therapy (SSA) in acromegaly different among medical centers. We analyzed the data on TSS, SSA and their combination in acromegalic patients of Moscow region.Design: In this study 117 acromegalic patients (25 males and 92 females, 55.0 (IQR 44 – 62) years) were eligible for participation, of whom 34 were newly-diagnosed aromegaly (NA group) (macroadenoma (macro)- 80...

ea0041ep928 | Pituitary - Clinical | ECE2016

Bone metabolism in acromegaly

Giampietro Antonella , Chiloiro Sabrina , Mormando Marilda , Bima Chiara , Bracaccia Maria Elena , Piacentini Serena , Tartaglione Linda , Iacovazzo Donato , Bianchi Antonio , De Marinis Laura

Aim: To evaluate calcium and bone metabolism in a monocentric series of acromegaly patients (pts), treated with pegvisomant (PEG) alone or in association to long acting somatostatine analogs.Patients and methods: All pts with at least 24 consecutive months PEG treatment (alone or in combination with SSA) were enrolled. All pts had been tested at least twice/year for biochemical acromegaly-disease evaluation and annually for calcium metabolism and for bon...

ea0041ep929 | Pituitary - Clinical | ECE2016

Clinical management of pituitary teratomas and safety of rhgh replacement therapy: a case report

Chiloiro Sabrina , Giampietro Antonella , Bima Chiara , Bracaccia Maria Elena , De Marinis Laura

Teratomas comprise 0.5% of all intracranial tumors. 15 cases of sellar teratoma have been described in the last 24 years (yrs). A 29-yrs female pan-hypopituitaric patient (pt) was admitted to our Pituitary Unit. At 6-yrs age, for polyuria and growth delay, an endocrine evaluation revealed diabetes insipidus and hypopituitarism. Cranial contrasted-MRI (cc-MRI) showed pituitary stalk thickening and a low intensity suprasellar lesion. Histological examination (HE) was suggestive ...

ea0041ep930 | Pituitary - Clinical | ECE2016

Pituitary apoplexy induced remission in a macroadenoma Cushing Disease

Souteiro Pedro , Belo Sandra , Costa Maria Manuel , Bettencourt-Silva Rita , Magalhaes Daniela , Queiros Joana , Freitas Paula , Castro Ligia , Pereira Josue , Carvalho Davide

Introduction: Pituitary macroincidentalomas are rare, being found in only 0.2%–0.3% of the patients that undergo imaging studies for an unrelated reason. The majority of them are non-functioning adenomas.Case Report: Woman, 77 years-old, with type 2 diabetes mellitus, hypertension and primary hypothyroidism. She was referred to Endocrinology due to a pituitary incidentaloma (18 mm of maximal diameter, with extension to the cavernous sinus and to the...

ea0041ep931 | Pituitary - Clinical | ECE2016

Diabetes insipidus as a predictor of weight gain in craniopharyngeoma patients

Polovina Tanja Skoric , Kraljevic Ivana , Solak Mirsala , Dusek Tina , Kastelan Darko

Craniopharyngeoma patients have reduced quality of life and increased cardiovascular mortality because of severe obesity present in about 50% of patients. In the present study we analysed postoperative body mass index (BMI) in craniopharyngeoma patients depending on the presence of the diabetes insipidus (DI).We retrospectively analyzed 19 craniopharyngeoma patients (male:female=12:7, age 31.2 years, range 9–67) treated at our Department since 2001....

ea0041ep932 | Pituitary - Clinical | ECE2016

“What’s the best approach to perioperative, immediate post op and 6 week post op cortisol assessment and replacement in patients undergoing transsphenoidal pituitary surgery?”

Tariq Adnan , Bhatt Dhruti , Graveling Alex , Abraham Prakash , Mahmoud Kamel , MacRury Sandra , Bevan John

Introduction: There is great variation in management of perioperative cortisol management in patient’s undergoing pituitary surgery across UK Hospitals. We evaluated safety and effectiveness of standards followed in ARI. The aim of audit was to confirm safety, improve knowledge and change practice for better patient care if needed based on information gained from the available data.Description of methods/design: We evaluated 30 patients who have und...

ea0041ep933 | Pituitary - Clinical | ECE2016

Obstructive hydrocephalus and intracranial hypertension caused by a giant pituitary non-functioning adenoma

Silva-Fernandez Julia , Garcia-Ruiz Rafael , Gomez-Alfonso Francisco Javier , Val-Zaballos Florentino Del , Garcia-Manzanares Alvaro , Lopez-Iglesias Maria , Gomez-Garcia Ines R

Introduction: Patients with large non-functioning pituitary macroadenomas often have symptoms due to varying degree of hypopituitarism and/or mass effect on visual structures, while presentation with hydrocephalus is extremely uncommon.Case report: We describe an 82-year-old man who was referred to the Neurology department of our hospital because of rapidly progressive memory loss. The patient was in good health until ten weeks earlier, when he insidious...

ea0041ep934 | Pituitary - Clinical | ECE2016

The outcomes of the transsphenoidal adenomectomy in patients with acromegaly

Tsiberkin Alexander , Cherebillo Vladislav , Tsoi Ulyana , Dalmatova Anna , Belousova Lydia , Grineva Elena

Introduction: Acromegaly is a chronic disorder caused by growth hormone (GH) hyperproduction which leads to significant morbidity and mortality primarily due to cardiovascular and respiratory complications. Pituitary adenoma is the main cause of GH’s hyperproduction. By current guidelines transsphenoidal surgery (TSS) is the first-line treatment in acromegaly patients.Aim: To evaluate the results of TSS in acromegaly patients 6 months after surgery....

ea0041ep935 | Pituitary - Clinical | ECE2016

A rare case of ulcerative colitis coexisting with lymphocytic hypophysitis

Rendeci Serkan , Cifci Aydin , Arikan Durmaz Senay , Gungunes Askin , Tan Sinan

Background and aim: Lymphocytic hypophysitis is heterogeneous inflammatory processes of the pituitary gland and may cause isolated hormone deficiency, but rarely occurs as panhypopituitarism. We aim to present a rare case of ulcerative colitis coexisting with lymphocytic hypophysitis.Case report: A 42-years old woman with ulcerative colitis was applied for our department of internal medicine with hypoglycemia. Her capillary blood glucose levels were foun...

ea0041ep936 | Pituitary - Clinical | ECE2016

Mesocorticotropinoma- associated Nelson’s syndrome: 28 years of follow-up

Marcusan Alexandra , Morar Andra , Carsote Mara , Dumitru Pop Dan , Ghervan Cristina , Emanuela Georgescu Carmen , Valea Ana

Introduction: Nelson’s syndrome (NS) is an exceptionally rare condition diagnosed sometimes after bilateral suprarenalectomy for Cushing’s disease (CS) involving rapid enlargement of a pre-existing ACTH-secreting pituitary tumor. The clinical picture varies from hyperpigmentation, headache and visual disturbance to diabetes insipidus and hypopituitarism if the hypothalamic-pituitary portal system is disrupted or normal pituitary tissue is destroyed by the adenoma. Th...

ea0041ep937 | Pituitary - Clinical | ECE2016

Trial design of a phase III, multicentre, randomised, double-blind, placebo-controlled, 48-week study to evaluate the safety and efficacy of osilodrostat in patients with Cushing’s disease

Feelders Richard A , Heaney Anthony , McBride Karen , Hilliard Annie , Tian Chuan , Sauter Nicholas , Auchus Richard J

Background: Osilodrostat is an oral inhibitor of 11β-hydroxylase (CYP11B1), the enzyme that catalyses the final step in cortisol biosynthesis. In a 22-week, phase II study, osilodrostat treatment normalised mean urinary free cortisol (mUFC) in 78.9% (15/19) of patients with uncontrolled Cushing’s disease and was well tolerated. The present phase 3 study is designed to confirm the safety and efficacy of osilodrostat in patients with uncontrolled Cushing’s disease...

ea0041ep938 | Pituitary - Clinical | ECE2016

Tolosa Hunt syndrome involving the pituitary: a case report

Polat Sefika Burcak , Topaloglu Oya , Bal Ercan , Ersoy Reyhan , Cakır Bekir

Introduction: Tolosa Hunt syndrome (THS) is described as unilateral orbital pain associated with paresis of one or more of the third, fourth and/or sixth cranial nerves caused by a granulomatous inflammation in the cavernous sinus, superior orbital fissure or orbit. Pituitary gland is rarely involved in this syndrome. Herein we represented a case with hypophysitis with Tolosa Hunt who was operated with the suspicion of pituitary adenoma.Case: A 63-year-o...

ea0041ep939 | Pituitary - Clinical | ECE2016

Clinical features of thyrotropin secreting pituitary adenomas

Uzum Ayse Kubat , Dogru Hulya , Selcukbiricik Ozlem Soyluk , Gul Nurdan , Tanakol Refik , Aral Ferihan

Introduction: Thyrotropin-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism and represent <1% of all pituitary adenomas. The majority of TSHomas (70%) secrete TSH alone, while mixed adenomas are not infrequent.Design: Herein, we reported the findings of six patients with TSHoma (mean age 44 yr, 4 female, 2 male). Mean TSH value was 15.1 mIU/L (3.3–38.0) who were followed-up in our department.Result...

ea0041ep940 | Pituitary - Clinical | ECE2016

A novel case of pituitary metastasis presented as the syndrome of inappropriate antidiuretic hormone: an unexpected association

Zuhur Sayid Shafi , Kuzu Idris , Erol Rumeysa Selvinaz , Altuntas Yuksel

Introduction: Although the syndrome of inappropriate antidiuretic hormone (SIADH) has connection with various malignant tumors, the pituitary metastasis of malignant tumors are generally associated with diabetes insipidus.Case report: A 59 years old male patient presented to emergency service with frequent syncope attacks, nausea, loss of appetite and fatigue that began 2 weeks prior to admission. Marked obtundation was found on physical examination. The...

ea0041ep941 | Pituitary - Clinical | ECE2016

The relationship between pituitary hormone levels and magnetic resonance imaging findings in diabetes insipidus patients

Ates Ramazan , Mert Meral , Macit Melih , Cirak Musa , Polat Ozlem , Hatipoglu Sadik Sami

Introduction: Diabetes insipidus (di) is a water metabolism disorder caused by antidiuretic hormone pathologies. In this study, we evaluated, retrospectively, pituitary hormone profiles and pituitary magnetic resonance imaging (mri) findings of patients with di.Material and methods: After local ethic committee approval, 300 patients were evaluated retrospectively. Patients with a history of pituitary surgery and/or radiotherapy were excluded. Luteinizing...

ea0041ep942 | Pituitary - Clinical | ECE2016

A rare case of acromegaly concomitant with pancreatic adenocarcinoma

Durmaz Senay Arikan , Gungunes Askin , Oguz Dilek , Yalcin Selim , Turhan Nesrin

Background and aim: Acromegaly is a rare endocrine disease and is associated with an increased prevalence of colorectal cancer and pre-malignant tubular adenomas, and also may be associated with other organ malignancies such as breast and thyroid. We report a rare case of acromegaly concomitant with adenocarcinoma arising from pancreas.Case report: A 52-year-old man who was diagnosed with acromegaly two years ago referred our outpatient clinic. After dia...

ea0041ep943 | Pituitary - Clinical | ECE2016

Complete pituitary regression with immunosupressive treatment in a patient with ANCA negative wegener granulomatosis

Kilicli Fatih , Dokmetas Hatice , Kaya Zeynep , Cengiz Ekrem

Introduction: Wegener granulomatosis is a necrotizing granulomatous small-vessel vasculitis. It typically affects the upper respiratory tract, lungs, and kidneys but can involve virtually any organ including the pituitary. Pituitary involvement in wegener granumatosis is rare.Case: A 50-year-old woman was admitted to the hospital with severe dyspne for 2 years and stridor for a month. During her hospitalization, her sodium level was noted to be persisten...

ea0041ep944 | Pituitary - Clinical | ECE2016

The prevalence of metabolic syndrome in adult patients with long-standing hypopituitarism who receive adequate supplemental therapy

Zwolak Agnieszka , Swirska Joanna , Dudzinska Marta , Kurowska Maria , Daniluk Jadwiga , Tarach Jerzy S

Introduction: Hypopituitarism is characterized by the absence of pituitary hormones. Depending on what pituitary hormones are missing and what is the etiology of hypopituitarism, its clinical manifestation varies. Apart from evident symptoms and signs of hypopituitarism due to hormonal insufficiencies, several studies reveal that long-standing hypopituitarism, including particularly absence of GH, is related to higher risk of metabolic syndrome.Objective...

ea0041ep945 | Pituitary - Clinical | ECE2016

Sudden global health impairment in a male patient– could it be hypohysitis?

Bursuc Anamaria , Belceanu Alina Daniela , Armasu Ioana , Constantinescu Georgiana Andreea , Esanu Anda , Manciuc Carmen , Crumpei Felicia , Vulpoi Carmen

Introduction: Hypophysitis is a chronic inflammatory condition of the pituitary gland which typically presents with hypopituitarism and a pituitary mass. The disease is rare, with an estimated incidence of 1/9000000. Most reported cases are in women during peripartum period and only approximately 15% of reported cases occur in males.Case report: Male patient, aged 57, smoker, with a history of hypertension, just returned from India, presented with anorex...

ea0041ep946 | Pituitary - Clinical | ECE2016

Coincidence of subarachnoidal hemorrhage and pituitary apoplexy

Oruk Gonca , Apayadin Melda , Yilmaz Husnu , Yuceer Nurullah , Pamuk Baris

Pituitary apoplexy is a rare and life-threatening disorder often requiring emergency neurosurgical intervention to preserve vision and prevent cerebral herniation syndrome. Infarction or hemorrhage of an enlarged pituitary gland or pituitary tumor is the most common cause of pituitary apoplexy. Early recognition of this disorder is essential for preventing permanent visual loss or death; however, pituitary apoplexy often mimics subarachnoid hemorrhage, which in some cases may ...

ea0041ep947 | Pituitary - Clinical | ECE2016

A case of acromegaly presenting with lacrimal gland hypertrophy

Cakir Mehtap

Introduction: Acromegaly is a chronic endocrine disorder caused by excess growth hormone (GH) secretion. Hypersecretion of GH causes increased IGF-1 secretion from the liver which in turn leads to a series of multisystemic complications including somatic overgrowth and multiple comorbidities.Case report: Thirty-nine-year-old female patient was seen in ophthalmology outpatient clinic with the complaint of a mass inside the right upper eyelid. On ophthalmo...

ea0041ep948 | Pituitary - Clinical | ECE2016

Frequency and predictive factors of acute adrenal insufficiency following brain injury

Meriem Bensalah , Lyes Cherfi , Aissa Abdennebi , Mustapha Guenane , Zahra Kemali , Samia Ould Kablia

Background: Biological diagnosis of adrenal insufficiency (AI) is very difficult in the setting of critical illness like in traumatic brain injury (TBI), and the cut off defining AI need more precision.Aim: The aim is to assess the frequency and predictive factors of AI in a simple of 277 victims of moderate to severe BI in two neighbors’ hospitals in the east of Algiers.Method: Between November 2009 and December 2013, 277 pat...

ea0041ep949 | Pituitary - Clinical | ECE2016

High monocyte/HDL-cholesterol ratio in men with hypogonadotrophic hypogonadism

Cadırcı Kenan , Keskin Havva , Durmaz Şenay , Arslan Abdulmuttalip , Sevimli Hakan , Carlıoğlu Ayşe

Aim: In a previous study, we demonstrated elevated mean platelet volume in isolated hypogonadotrophic hypogonadism (IHH) is associated with high cardiovascular risk. Monocyte count/HDL-cholesterol ratio (MHR) is a new inflammatory marker showing cardiovascular risk. The purpose of this study is to evaluate (MHR) in men with hypogonadotrophic hypogonadism.Method: This study includes 31 men with isolated hypogonadotrophic hypogonadism without previous trea...

ea0041ep950 | Pituitary - Clinical | ECE2016

Ketoconazole in Cushing’s disease management

Oliveira Sofia , Neves Joao , Neves Celestino , Belo Sandra , Freitas Paula , Pignatelli Duarte , Castedo Jose , Vinha Eduardo , Oliveira Ana , Carvalho Davide

Background: Transphenoidal surgery is still the best initial therapy for Cushing’s disease (CD), with a high probability of cure and few risks or complications. However, pharmacotherapy has a role as primary or adjunctive therapy: when surgery is delayed, in case of postoperative persistence or recurrence of hypercortisolism, or while waiting for radiotherapy effectiveness. Ketoconazole, a steroidogenesis inhibitor, is nowadays the main drug used to CD control by reducing...

ea0041ep951 | Pituitary - Clinical | ECE2016

Primary empty sella syndrome-is it familial?

Machenahalli Pratibha , Shotliff Kevin

Introduction: Empty sella syndrome is a condition in which sella turcica is partially or completely filled with CSF resulting in a displacement of normal pituitary gland. Primary empty sella is due to inherent weakness of diaphragm sella or to an increase in intracranial pressure which promotes herniation of arachnoid membranes in to pituitary fossa. More common in middle aged obese female and headache is the most common presenting symptom. It may be associated with one or mor...

ea0041ep952 | Pituitary - Clinical | ECE2016

A case of post-traumatic ACTH deficiency followed by Cushing syndrome prediagnosis

Gorar Suheyla , Ademoglu Esra Nur , Dolu Suleyman , Uyar Seyit

Pitüitary ACTH deficiency is one cause of secondary adrenal insufficiency. Genetic factors, autoimmunity, infiltrative disease, cranial trauma can cause ACTH deficiency. Hyperpigmented skin lesions are expected in primary adrenal insufficiency while they are very rare in secondary adrenal insufficiency. Striae are characterized by linear smooth bands of atrophic appearing skin. They are mostly associated with obesity, pregnancy, hypercortisolism/Cushing syndrome. Striae a...